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The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms

ACTA PHARMACEUTICA SINICA B (2023)

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Correction for: Klotho alleviates indoxyl sulfate-induced heart failure and kidney damage by promoting M2 macrophage polarization

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Review Plant Sciences

Panax ginseng against myocardial ischemia/reperfusion injury: A review of preclinical evidence and potential mechanisms

Jinjin Chen et al.

Summary: This study aimed to clarify the protective effects of Panax ginseng and its active ingredients against myocardial ischemia-reperfusion (I/R) injury. Through a comprehensive analysis of relevant literature, it was found that Panax ginseng and its active components can protect the myocardium and prevent myocardial I/R injury by regulating oxidative stress related proteins, inflammatory cytokines, and apoptosis factors.

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Article Chemistry, Multidisciplinary

Dapagliflozin attenuates pressure overload-induced myocardial remodeling in mice via activating SIRT1 and inhibiting endoplasmic reticulum stress

Fang-fang Ren et al.

Summary: The study reveals the potential therapeutic effect of Dapagliflozin (DAPA) in treating heart failure by inhibiting endoplasmic reticulum stress-related apoptosis. DAPA was found to reduce the expression of key proteins while promoting the expression of cardioprotective proteins in cardiomyocytes in vitro experiments.

ACTA PHARMACOLOGICA SINICA (2022)

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Review Cardiac & Cardiovascular Systems

Non-coding RNAs: key regulators of reprogramming, pluripotency, and cardiac cell specification with therapeutic perspective for heart regeneration

Hannah J. Hunkler et al.

Summary: Myocardial infarction leads to the loss of cardiomyocytes and heart failure. The only curative treatment for heart failure currently is heart transplantation, but it has limitations. Cellular reprogramming and defined differentiation protocols offer new possibilities for cell therapy, and non-coding RNAs have been shown to regulate these processes.

CARDIOVASCULAR RESEARCH (2022)

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Article Cardiac & Cardiovascular Systems

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC

Theresa A. McDonagh et al.

Summary: All experts involved in the development of the guidelines have declared their interests, and the declarations have been compiled and published in a supplementary report. The report can be accessed on the ESC website. The supplementary data provide background information and detailed discussion of the data that form the basis for the guidelines.

EUROPEAN JOURNAL OF HEART FAILURE (2022)

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Article Plant Sciences

Salvianolic acid B and ferulic acid synergistically promote angiogenesis in HUVECs and zebrafish via regulating VEGF signaling

Jing Chen et al.

Summary: This study demonstrated the significant pro-angiogenic effects of Guanxinning Tablet (GXNT) and its major components, Sal B and FA, in enhancing vascular growth by regulating the expression of VEGF receptors and ligands. Further research is needed to explore the molecular interactions between these compounds and the key regulators in neovascularization.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Comparative efficacy of five Chinese medicine injections for treating dilated cardiomyopathy with heart failure: A Bayesian network meta-analysis

Xinfu Cao et al.

Summary: The combination of Chinese medicine injections (CMIs) with Western medicine (WM) showed significant improvements in treating dilated cardiomyopathy with heart failure (DCM-HF). Among the CMIs studied, Xinmailong injection combined with WM demonstrated the best performance in treating DCM-HF, followed by Shenmai injection and Huangqi injection. More high-quality studies are needed to further support these findings.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Cardiac & Cardiovascular Systems

The complex network of mTOR signalling in the heart

Sebastiano Sciarretta et al.

Summary: mTOR integrates various signals in the cardiovascular system, playing both adaptive and maladaptive functions in cardiac development and response to stress. Modulating mTOR may hold promise as a therapeutic strategy for cardiac diseases.

CARDIOVASCULAR RESEARCH (2022)

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Article Cell Biology

Perturbed ER homeostasis by IGF-IIRα promotes cardiac damage under stresses

Sudhir Pandey et al.

Summary: The heart, as a dynamic pumping organ, is constantly working to maintain blood supply, but is vulnerable to various stresses, especially oxidative stress. This study demonstrates the crucial role of IGF-IIR alpha in endoplasmic reticulum stress induction, inhibiting cellular stress coping proteins and increasing pro-apoptotic factors, ultimately leading to cardiomyocyte damage.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2022)

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Article Integrative & Complementary Medicine

Qishen Taohong Granule as Adjuvant Therapy for Improving Cardiac Function and Quality of Life in Patients with Chronic Heart Failure: A Randomized Controlled Trial

Li Xing-xing et al.

Summary: This study confirmed that Chinese medicine Qishen Taohong Granule can significantly improve cardiac function and quality of life in patients with chronic heart failure as an adjuvant therapy.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2022)

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Review Pharmacology & Pharmacy

Potential role of mitochondria-associated endoplasmic reticulum membrane proteins in diseases

Hui Mao et al.

Summary: This review introduces important proteins involved in the structure and functions of MAMs, and effectively summarizes their roles in the pathophysiology of various diseases.

BIOCHEMICAL PHARMACOLOGY (2022)

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Article Plant Sciences

Investigation of the effective components inhibited macrophage foam cell formation in Ophiopogonis Radix

YuShan Tian et al.

Summary: Ophiopogonis Radix extract significantly inhibits macrophage foam cell formation and increases antioxidant capacity in macrophage cells. Through the specific active components methylophiopogonanone A and methylophiopogonanone B, Ophiopogonis Radix effectively prevents the development of atherosclerosis.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Synergy of Yiqi and Huoxue components of QishenYiqi formula in ischemic stroke protection via lysosomal/inflammatory mechanisms

Yule Wang et al.

Summary: This study explores the chemical basis and molecular mechanism of the anti-stroke therapy of QSYQ and its components YQ and HX. The results show that YQ and HX components synergistically protect the brain from cerebral ischemia/reperfusion injury by regulating inflammation and autophagy. These findings shed new light on the understanding of the traditional Chinese medicine principle of tonifying Qi and activating blood, particularly in ischemic stroke.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Multidisciplinary Sciences

Glycyrrhiza uralensis promote the metabolism of toxic components of Aconitum carmichaeli by CYP3A and alleviate the development of chronic heart failure

Lulu Ni et al.

Summary: This study found that Glycyrrhiza promotes the metabolism of toxic components of Aconitum by upregulating the expression of CYP3A, reducing the content of heart failure-related markers, and improving the myocardial energy metabolism disorder, thus alleviating the development of congestive heart failure.

PLOS ONE (2022)

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Article Physiology

Comparison between concentric-only, eccentric-only, and concentric-eccentric resistance training of the elbow flexors for their effects on muscle strength and hypertrophy

Shigeru Sato et al.

Summary: This study compared the effects of different training methods on muscle strength and hypertrophy of the elbow flexors. The results showed that eccentric training and concentric-eccentric coupled training had similar effects on muscle strength and thickness, while concentric training contributed less to the training effects.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2022)

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NADPH Oxidases in Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction

James P. Teuber et al.

Summary: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases play crucial roles in regulating oxidative stress, redox signaling, and the development of heart failure with preserved ejection fraction (HFpEF). HFpEF is associated with various systemic pathologies and multiple organ dysfunctions. NOX enzymes are involved in diastolic function and several HFpEF-associated comorbidities in animal models.

ANTIOXIDANTS (2022)

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NO2 exposure contributes to cardiac hypertrophy in male mice through apoptosis signaling pathways

Shaoyang Ji et al.

Summary: This study found that exposure to NO2 can cause cardiac eccentric hypertrophy and cardiac dysfunction, primarily through apoptotic signaling pathways.

CHEMOSPHERE (2022)

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Article Cardiac & Cardiovascular Systems

NT-proBNP/BNP ratio for prognostication in European Caucasian patients enrolled in a heart failure prevention programme

Claire Sweeney et al.

Summary: The study found that the NT-proBNP/BNP ratio was inversely associated with the future development of heart failure and left ventricular dysfunction risk. However, the study does not support routine simultaneous measurement of BNP and NT-proBNP in heart failure prevention programs among European, Caucasian patients.

ESC HEART FAILURE (2022)

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Ethnopharmacology, Phytochemistry, Pharmacology, Toxicology and Clinical Applications of Radix Astragali

Chun-hong Zhang et al.

Summary: Radix Astragali (RA), a traditional Chinese medicine derived from the dried root of Astragalus species, contains bioactive constituents such as triterpene glycosides, flavonoids, saponins, and alkaloids which exert pharmacological activities on various systems. Recent studies on RA have provided a comprehensive overview of its resources, ethnopharmacology, phytochemistry, pharmacology, toxicology, clinical applications, and patents, guiding further development of therapeutic agents derived from RA.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2021)

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The effect of ginsenosides on depression in preclinical studies: A systematic review and meta-analysis

Yunna Kim et al.

Summary: Many ginsenosides have been shown to be effective for major depressive disorder through several preclinical studies. The meta-analysis results show that ginsenosides can alleviate depressive symptoms and have significant antidepressant effects.

JOURNAL OF GINSENG RESEARCH (2021)

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Review Pharmacology & Pharmacy

Energy metabolism disorders and potential therapeutic drugs in heart failure

Yanan He et al.

Summary: Heart failure is a global public health issue caused by severe energy metabolism disorders leading to insufficient heart energy supply. Current therapies focus on symptomatic treatment by reducing heart rate and cardiac load, but there are no drugs targeting cardiac energy metabolism.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Cardiac & Cardiovascular Systems

The impact of cardiomotor rehabilitation on endothelial function in elderly patients with chronic heart failure

Juming Chen et al.

Summary: The study found that cardiac exercise rehabilitation can improve cardiac ejection and myocardial function in elderly patients with chronic heart failure, promote vitality, proliferation, and invasion of peripheral blood EPC, and enhance angiogenesis and endothelial function by upregulating the PI3K/AKT pathway to increase eNOS and VEGF expression.

BMC CARDIOVASCULAR DISORDERS (2021)

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Article Cell Biology

Ubiquitin-specific protease 2 regulates Ang II-induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing β-catenin in vitro

Qiong Xu et al.

Summary: The study identified USP2 as a potential therapeutic target in cardiac fibrosis, with its inhibition suppressing CFs proliferation and collagen synthesis while regulating beta-catenin deubiquitination and stabilization. These findings suggest that USP2 may have therapeutic potential for treating cardiac fibrosis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Plant Sciences

Exploring the protective effects of PNS on acute myocardial ischaemia-induced heart failure by Transcriptome analysis

Xu Chen et al.

Summary: The study confirmed the cardioprotective effects of PNS and its involvement in metabolic processes through the PPAR signaling pathway in HF treatment. PNS was found to upregulate genes, particularly those related to energy metabolism, and the PPAR alpha pathway was identified as a key mechanism for the protective function of PNS. The inhibition of PPAR alpha abolished the beneficial effects of PNS, suggesting that PPAR alpha may be a potential target for HF treatment.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Mechanisms dissection of the combination GRS derived from ShengMai preparations for the treatment of myocardial ischemia/reperfusion injury

Weiwei Yang et al.

Summary: The combination GRS, consisting of ginsenoside Rbl, ruscogenin, and schisandrin, exhibited significant cardioprotective effects against myocardial ischemia/reperfusion (MI/R) injury through modulation of energy metabolism, suppression of inflammation, and oxidative stress.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Ophiopogonin D alleviates diabetic myocardial injuries by regulating mitochondrial dynamics

Weiwei Li et al.

Summary: The study revealed that OP-D could alleviate lipid accumulation and mitochondrial injury in diabetic mouse hearts and palmitic acid-stimulated cardiomyocytes, potentially exerting a cardioprotective effect through regulating mitochondrial dynamics.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Chemistry, Multidisciplinary

A SIRT1 Activator, Ginsenoside Rc, Promotes Energy Metabolism in Cardiomyocytes and Neurons

Qingxia Huang et al.

Summary: The study confirms that ginsenoside Rc promotes the activity of SIRT1, leading to improved mitochondrial function and energy metabolism, thus enhancing cardio- and neuroprotective functions.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Biochemistry & Molecular Biology

Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7

Youyou Li et al.

Summary: The knockout of miR-214 in VSMCs significantly alleviates Ang II-induced hypertension, reduces systolic blood pressure, inhibits vascular medial thickness, blunts the response of blood vessels to various stimuli, and reverses vascular dysfunction. The mechanism involves a crosstalk between AT1R signaling and TGF-beta/Smad signaling pathways. The results suggest that miR-214 could be a potential therapeutic target for hypertension treatment.

FASEB JOURNAL (2021)

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Gallic acid for cancer therapy: Molecular mechanisms and boosting efficacy by nanoscopical delivery

Milad Ashrafizadeh et al.

Summary: Cancer research focuses on tackling therapy resistance and developing new anti-cancer compounds, where plant-derived phytochemicals like gallic acid play a significant role in targeting cancer cells. Gallic acid shows promising anti-tumor activities by down-regulating molecular pathways involved in cancer progression, and nano-vehicles have been developed to improve its bioavailability and effectiveness in tumor suppression.

FOOD AND CHEMICAL TOXICOLOGY (2021)

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Article Medicine, Research & Experimental

Schizandrin B attenuates hypoxia/reoxygenation injury in H9c2 cells by activating the AMPK/Nrf2 signaling pathway

Bo Zhao et al.

Summary: Schizandrin B exerts cardioprotection against H/R injury in H9c2 cells through activation of the AMPK/Nrf2 pathway, demonstrating antioxidant and anti-inflammatory activities.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Biophysics

Mechanism of total glucosides of paeony in hypoxia/reoxygenation-induced cardiomyocyte pyroptosis

Xiyue Yan et al.

Summary: The study demonstrated that total glucosides of paeony (TGP) alleviates hypoxia/reoxygenation-induced pyroptosis in cardiomyocytes by modulating the miR-181a-5p/ADCY1 axis.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2021)

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Article Emergency Medicine

Clinical relationship between blood concentration and clinical symptoms in aconitine intoxication

So Young Jeon et al.

Summary: Aconitine, a toxic substance with potential therapeutic effects, can be fatal due to its high toxicity and low safety margin. Research has shown that there is no direct correlation between blood concentration of aconitine and clinical manifestations, with patients having slower symptom development but more severe clinical manifestations when blood concentration is below a certain level.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2021)

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Article Pharmacology & Pharmacy

Ferulic Acid Ameliorates Isoproterenol-Induced Heart Failure by Decreasing Oxidative Stress and Inhibiting Cardiocyte Apoptosis via Activating Nrf2 Signaling Pathway in Rats

Xi-Juan Zhang et al.

Summary: This study found that ferulic acid (FA) ameliorated heart failure (HF) by reducing oxidative stress and inhibiting cardiocyte apoptosis via activating the Nrf2 pathway.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2021)

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Water-soluble alkaloids extracted from Aconiti Radix lateralis praeparata protect against chronic heart failure in rats via a calcium signaling pathway

Xin Xu et al.

Summary: The study demonstrated that the AWA extract has beneficial effects in rats with AAC-induced chronic heart failure, improving cardiac function, hypertrophy, fibrosis, and apoptotic status. These effects are possibly related to the regulation of calcium signaling through the altered expression of RyR2 and SERCA2a.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2021 Update A Report From the American Heart Association

Salim S. Virani et al.

Summary: The American Heart Association, in partnership with the National Institutes of Health, publishes annual statistics on heart disease, stroke, and cardiovascular risk factors, including the impact of health behaviors and factors on cardiovascular health. The Statistical Update covers a range of clinical heart and circulatory conditions, providing data on quality of care, procedures, and economic costs. It serves as a critical resource for various stakeholders seeking the best available data on these factors and conditions.

CIRCULATION (2021)

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Article Medicine, Research & Experimental

Chlorogenic acid protects human chondrocyte C28/I2 cells from oxidative stress-induced cell death through activation of autophagy

Sahib Zada et al.

Summary: The study demonstrates that chlorogenic acid (CGA) protects human chondrocytes against H2O2-induced apoptosis by decreasing apoptosis markers, increasing anti-apoptotic markers, and activating antioxidant response proteins through autophagy induction.

LIFE SCIENCES (2021)

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Article Plant Sciences

Global gene expression analysis using RNA-seq reveals the new roles of Panax notoginseng Saponins in ischemic cardiomyocytes

Shaoxian Chen et al.

Summary: RNA-seq analysis revealed that Panax Notoginseng Saponins (PNS) protect cardiomyocytes from apoptosis induced by myocardial ischemia by regulating cell cycle, DNA repair process, cardiac hypertrophy, PI3K/Akt and AMPK signaling pathways, and non-coding RNAs.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Ginsenoside Rb1 ameliorates cardiotoxicity triggered by aconitine via inhibiting calcium overload and pyroptosis

Min Wang et al.

Summary: This study demonstrated that Ginsenoside Rb1 can alleviate aconitine-induced cardiotoxicity by regulating calcium channels, reducing calcium levels, restoring calcium homeostasis, and inhibiting apoptosis and pyroptosis in both rat and human induced pluripotent stem cell-derived cardiomyocytes.

PHYTOMEDICINE (2021)

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Article Plant Sciences

The discovery of Q-markers of Qiliqiangxin Capsule, a traditional Chinese medicine prescription in the treatment of chronic heart failure, based on a novel strategy of multi-dimensional radar chart mode evaluation

Liangliang He et al.

Summary: This study proposed a new strategy to discover the Q-markers of QLQX, laying an important foundation for its quality control improvement. Seven compounds were screened out as the Q-markers, showing reasonable compatibility contribution and high content in QLQX, preferable pharmacological effect on CHF, as well as good bioavailable characteristics and high target hits in system pharmacology.

PHYTOMEDICINE (2021)

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Article Medicine, Research & Experimental

Ginsenoside Rg2 protects cardiomyocytes against trastuzumab-induced toxicity by inducing autophagy

Guang Liu et al.

Summary: Ginsenoside Rg2 can protect breast cancer patients' cardiomyocytes from trastuzumab-induced cardiotoxicity by activating autophagy.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Cell Biology

Misoprostol treatment prevents hypoxia-induced cardiac dysfunction through a 14-3-3 and PKA regulatory motif on Bnip3

Matthew D. Martens et al.

Summary: This study revealed the cardioprotective effect of misoprostol during neonatal hypoxic injury by modulating Bnip3 function; further demonstrated the importance of Bnip3 phosphorylation in regulating cardiomyocyte function and necroinflammation; and identified a potential pharmacological mechanism for preventing neonatal hypoxic injury.

CELL DEATH & DISEASE (2021)

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Article Cardiac & Cardiovascular Systems

Thromboembolism in Heart Failure Patients in Sinus Rhythm Epidemiology, Pathophysiology, Clinical Trials, and Future Direction

Andrew Y. Lin et al.

Summary: Patients with heart failure are at high risk for thromboembolic events, regardless of atrial fibrillation. The benefits of oral anticoagulation in heart failure patients in sinus rhythm are uncertain, but recent studies suggest that low-dose direct-acting oral anticoagulants may improve outcomes and reduce thromboembolic events.

JACC-HEART FAILURE (2021)

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Review Integrative & Complementary Medicine

Traditional Chinese Medicine for adjuvant treatment of breast cancer: Taohong Siwu Decoction

Huajuan Jiang et al.

Summary: Breast cancer is a major threat to women's health worldwide, with HER-2 positive breast cancer being highly malignant, easily recurrent and metastatic. Taohong Siwu Decoction can treat breast cancer by reducing blood vessel and lymphangiogenesis, showing potential for clinical application.

CHINESE MEDICINE (2021)

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Article Medicine, Research & Experimental

Cardioprotection of Panax Notoginseng saponins against acute myocardial infarction and heart failure through inducing autophagy

Dandan Wang et al.

Summary: Panax Notoginseng saponins (PNS), the extract of Panax notoginseng, exerts cardioprotective effects in acute myocardial infarction by inducing cardiomyocyte autophagy, inhibiting platelet aggregation, enhancing endothelial cell migration and angiogenesis. PNS and its main constituents Rg1 and Rd also directly inhibit platelet aggregation in healthy subjects and enhance glucose deprivation-induced autophagy in cardiomyocytes. These findings provide insights for drug development from natural products against ischemic heart diseases and heart failure post myocardial infarction.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Biochemistry & Molecular Biology

Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure

Mark F. McCarty

Summary: Measures such as controlling oxidative and endoplasmic reticulum stress, supporting effective bioactivity, preventing a reduction in cardiomyocyte pH, and boosting the production of protective hormones can be effective in preventing and controlling ventricular hypertrophy/heart failure syndrome. In addition, nutraceutical, dietary, and lifestyle measures may also serve as primary prevention strategies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Orthopedics

PLGA/β-TCP composite scaffold incorporating cucurbitacin B promotes bone regeneration by inducing angiogenesis

Wen-Xiang Cheng et al.

Summary: The study demonstrates that CuB can enhance angiogenesis in vitro and promote neovascularization and bone regeneration in a rat model. CuB-incorporated scaffold showed improved mechanical properties and successfully stimulated angiogenic signaling pathways, highlighting its potential as a therapeutic agent in tissue engineering for bone repair.

JOURNAL OF ORTHOPAEDIC TRANSLATION (2021)

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Review Medicine, General & Internal

Can the calcium-regulating hormones counteract the detrimental impact of pro-inflammatory damage-associated molecular patterns in the development of heart failure?

Satenik H. Adamyan et al.

Summary: Growing evidence indicates the significant role of inflammation in heart failure, with innate immunity potentially playing a complex role in immune-driven HF by releasing DAMPs.

JOURNAL OF INVESTIGATIVE MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

NT-proBNP/BNP ratio for prognostication in European Caucasian patients enrolled in a heart failure prevention programme

Claire Sweeney et al.

Summary: Guidelines support the use of BNP and NT-proBNP for risk stratification in heart failure prevention programs. However, a study in a Caucasian population did not find routine simultaneous measurement of both BNP and NT-proBNP to be warranted for predicting HF or LVD.

ESC HEART FAILURE (2021)

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Article Oncology

Tanshinone IIA attenuates heart failure via inhibiting oxidative stress in myocardial infarction rats

Ruijuan Chen et al.

Summary: The study demonstrated that Tanshinone IIA (TIIA) improved cardiac dysfunction and fibrosis in heart failure (HF) by inhibiting oxidative stress. The reversal of abnormal expression levels of related indicators was observed in both HF rats and Angiotensin II-treated cardiac fibroblasts, with Nox4 playing a regulatory role in the inhibitory effects of TIIA on HF and cardiac fibrosis.

MOLECULAR MEDICINE REPORTS (2021)

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Article Cell Biology

Receptor interacting protein 3 kinase, not 1 kinase, through MLKL-mediated necroptosis is involved in UVA-induced corneal endothelium cell death

Zhen Yu et al.

Summary: The study reveals that RIPK3 plays a critical role in UVA-induced cell death in CE, suggesting its potential as a protective target for CECs.

CELL DEATH DISCOVERY (2021)

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Article Cardiac & Cardiovascular Systems

Association of Systemic Immune-Inflammation Index With Short-Term Mortality of Congestive Heart Failure: A Retrospective Cohort Study

Yiyang Tang et al.

Summary: In critically ill patients with CHF, a high level of SII effectively predicts high 30- and 90-day and hospital mortalities, as well as a high risk of occurrence of MACEs. However, there is no significant correlation between SII and readmission rate.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Plant Sciences

Anti-aging function and molecular mechanism of Radix Astragali and Radix Astragali preparata via network pharmacology and PI3K/Akt signaling pathway

Pin Gong et al.

Summary: Radix Astragali (RA) and Radix Astragali preparata (RAP) have significant anti-aging effects, with RAP showing a more pronounced effect. Their mechanisms of action are mainly related to the balance of oxidative stress and activation of the PI3K/Akt signaling pathway.

PHYTOMEDICINE (2021)

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Article Cell Biology

Knockout RAGE alleviates cardiac fibrosis through repressing endothelial-to-mesenchymal transition (EndMT) mediated by autophagy

Lu Zhang et al.

Summary: Research suggests that knockout of RAGE reduces cardiac fibrosis and improves heart function by inhibiting EndMT mediated by excessive autophagy, with autophagy inhibitors also contributing to reducing EndMT and cardiac fibrosis.

CELL DEATH & DISEASE (2021)

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Article Medicine, Research & Experimental

Salvianolic Acid A Protects H9C2 Cardiomyocytes from Doxorubicin- Induced Damage by Inhibiting NFKB1 Expression Thereby Downregulating Long-Noncoding RNA (lncRNA) Plasmacytoma Variant Translocation 1 (PVT1)

Yumeng Wu et al.

Summary: SalA can protect H9C2 cells from Dox-induced injury and apoptosis by inhibiting NF-kappa B signaling pathway and expression of apoptotic proteins.

MEDICAL SCIENCE MONITOR (2021)

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Article Cell Biology

Hypertrophy-Reduced Autophagy Causes Cardiac Dysfunction by Directly Impacting Cardiomyocyte Contractility

Christiane Ott et al.

Summary: Cardiac remodeling and contractile dysfunction are major causes of hypertrophy-associated heart failure, characterized by accumulation of modified proteins due to impaired autophagy-lysosomal pathway in aged and diseased hearts. Autophagy inducer rapamycin has cardioprotective effects by improving cardiomyocyte autophagy and contractility. Endothelin 1 (ET-1) decreases autophagy and cardiomyocyte contractility, similar to siAtg5-treated cells and TAC-mice, highlighting the crucial role of autophagy in cardiomyocyte contractility and cardiac performance.

CELLS (2021)

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Dual Activity of Ginsenoside Rb1 in Hypertrophic Cardiomyocytes and Activated Macrophages: Implications for the Therapeutic Intervention of Cardiac Hypertrophy

Shihua Wang et al.

Summary: This study demonstrates that Ginsenoside Rb1 protects against cardiac hypertrophy by suppressing inflammatory mechanisms. In cardiomyocytes, Rb1 directly counteracts prohypertrophic substances and maintains mitochondrial function. In macrophages, Rb1 reduces inflammation by inhibiting phosphorylation and decreasing the production of inflammatory mediators.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Engineering, Biomedical

Local delivery of a senolytic drug in ischemia and reperfusion-injured heart attenuates cardiac remodeling and restores impaired cardiac function

Ju-Ro Lee et al.

Summary: This study demonstrates that local injection of senolytic drug-loaded nanoparticles can selectively kill stress-induced senescent cells in infarcted heart, reducing inflammatory cytokines and promoting normal cell survival. Further efferocytosis of apoptotic senescent cells by macrophages leads to restoration of cardiac function after myocardial ischemia-reperfusion injury. Importantly, local injection of senolytic drug does not cause systemic toxicity, unlike systemic administration, highlighting the therapeutic potential of senolysis in infarcted myocardium.

ACTA BIOMATERIALIA (2021)

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Article Medicine, Research & Experimental

Schisandra chinensis polysaccharides prevent cardiac hypertrophy by dissociating thioredoxin-interacting protein/thioredoxin-1 complex and inhibiting oxidative stress

Xiaowen Shi et al.

Summary: The study demonstrated that the antioxidative effects of SCP in attenuating oxidative stress were mediated through the regulation of the TXNIP/Trx-1 pathway, potentially making TXNIP a therapeutic target for treating cardiac hypertrophy.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Medicine, Research & Experimental

Danhong injection alleviates cerebral ischemia/reperfusion injury by improving intracellular energy metabolism coupling in the ischemic penumbra

Miaolin Zeng et al.

Summary: The study found that DHI can improve neurological function, reduce cerebral infarction, alleviate cerebral edema, improve microcirculatory perfusion, inhibit apoptosis, enhance neuronal survival, reduce oxidative stress, restore cytoplasmic glycolytic activity, increase PDH activity by inhibiting the HIF1 alpha/ PDK1 pathway, thereby eliminating the inhibitory effect of CI/R on mitochondrial metabolism.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Medicine, Research & Experimental

Nanoparticle conjugation of ginsenoside Rb3 inhibits myocardial fibrosis by regulating PPARα pathway

Yi Zhang et al.

Summary: The study demonstrated that nanoparticles conjugated with ginsenoside Rb3 (NpRb3) can directly impact the remodeling of myocardial energy metabolism and improve myocardial fibrosis by regulating the PPAR alpha pathway. The findings suggest that NpRb3 could serve as a potential drug carrier for the treatment of myocardial fibrosis.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Oncology

Immunosuppressive activity is attenuated by Astragalus polysaccharides through remodeling the gut microenvironment in melanoma mice

Guiqing Ding et al.

Summary: The study demonstrates that Astragalus polysaccharides can modulate the immune function in tumor-bearing mice by remodeling the gut microbiota, particularly by reducing the number of myeloid-derived suppressor cells. Results from 16S rRNA analysis show that APS significantly regulates various microorganisms, with changes in abundance related to the increase of metabolites that promote tumor growth.

CANCER SCIENCE (2021)

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Review Biochemistry & Molecular Biology

Molecular mechanisms of cell death in neurological diseases

Diane Moujalled et al.

Summary: Cell death plays a critical role in the pathogenesis of neurological diseases and brain cancers, with abnormal activation of PCD pathways being a common feature. Controlling PCD pathways may be a key component of future therapeutic strategies for these diseases.

CELL DEATH AND DIFFERENTIATION (2021)

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Article Biochemistry & Molecular Biology

Alleviation of glucolipotoxicity-incurred cardiomyocyte dysfunction by Z-ligustilide involves in the suppression of oxidative insult, inflammation and fibrosis

Yiqiu Cao et al.

Summary: Z-ligustilide may have a potential therapeutic effect in glucolipotoxicity-induced cardiomyocyte dysfunction by regulating cell oxidative injury, inflammation, and fibrosis.

CHEMISTRY AND PHYSICS OF LIPIDS (2021)

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Article Integrative & Complementary Medicine

Effects of Danhong Injection on Peri-Procedural Myocardial Injury and Microcirculatory Resistance in Patients with Unstable Angina Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study

Wen-long Xing et al.

Summary: The study showed that Danhong Injection can reduce myocardial injury and potentially preserve microvascular function in patients with unstable angina undergoing elective PCI.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2021)

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Article Mathematical & Computational Biology

Angelica sinensis Polysaccharide Alleviates Myocardial Fibrosis and Oxidative Stress in the Heart of Hypertensive Rats

Xiaolong Song et al.

Summary: The study demonstrated that ASP extracted from Angelica sinensis effectively prevented hypertensive heart disease in rats by inhibiting myocardial fibrosis, suppressing myocardial apoptosis, and alleviating oxidative stress.

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE (2021)

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Review Biochemistry & Molecular Biology

A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrener-gic β-blockers with Clinically Relevant Drugs-An Overview

Naina Mohamed Pakkir Maideen et al.

Summary: Adrenergic β-blockers are commonly used to treat various conditions such as hypertension and heart diseases. They are primarily metabolized by enzyme CYP2D6, with potential interactions with drugs that inhibit or induce this enzyme. Additionally, β-blockers can interact both pharmacokinetically and pharmacodynamically with other medications, as well as with certain herbs.

CURRENT DRUG METABOLISM (2021)

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Article Pharmacology & Pharmacy

Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway

Yanjun Chen et al.

Summary: Astragalus polysaccharide (APS) demonstrated its ability to prevent ferroptosis in a murine model of experimental colitis and human Caco-2 cells by inhibiting the NRF2/HO-1 pathway.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Astragaloside IV prevents acute myocardial infarction by inhibiting the TLR4/MyD88/NF-κB signaling pathway

Hui Shi et al.

Summary: Astragaloside IV acts on MyD88 and improves myocardial injury, inflammation, and collagen deposition, alleviating acute myocardial infarction-induced cardiac damage. These findings suggest that Astragaloside IV may be an effective treatment for AMI.

JOURNAL OF FOOD BIOCHEMISTRY (2021)

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Article Chemistry, Analytical

Rapid screening and identification of anticoagulation component from carthami flos by two-dimensional thrombin affinity chromatography combined with HPLC-MS/MS

Yanru Qiao et al.

Summary: The study revealed that hydroxysafflor yellow A, an active component in safflower, has anticoagulant effects and can prolong clotting time by interacting with thrombin, making it a potential anticoagulant drug for the treatment of thrombosis.

JOURNAL OF SEPARATION SCIENCE (2021)

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Review Medicine, Research & Experimental

Heart failure with preserved ejection fraction based on aging and comorbidities

Ying Lin et al.

Summary: HFpEF is a leading cause of hospitalizations and mortality in individuals aged 65 and above, with complex pathophysiology and difficulties in diagnosis. While treatment for HF with reduced ejection fraction has progressed rapidly, HFpEF poses a significant challenge due to the failure of current HF drugs to improve outcomes, highlighting the need for further research on the relationships between HFpEF, aging, and comorbidities.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

Schisandrol A Attenuates Myocardial Ischemia/Reperfusion-Induced Myocardial Apoptosis through Upregulation of 14-3-3θ

Shuaishuai Gong et al.

Summary: Schisandrol A (SA) extracted from Schisandra chinensis has significant cardioprotective effects against myocardial ischemia/reperfusion (MI/R) injury and hypoxia/reoxygenation (H/R)-induced cardiomyocyte injury. The mechanisms may involve the inhibition of cardiomyocyte apoptosis through upregulation of 14-3-3 theta.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Cell Biology

Hydroxysafflor Yellow A Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Calcium Overload and Apoptosis

Jingxue Ye et al.

Summary: This study demonstrates the protective effect of Hydroxysafflor yellow A (HSYA) against myocardial ischemia/reperfusion injury by reducing calcium overload and apoptosis, mainly targeting L-type calcium channels (LTCC).

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Pharmacology & Pharmacy

Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis

Renyikun Yuan et al.

Summary: The study revealed that CuB exerts anti-tumor effects in NSCLC by inducing pyroptosis through directly binding to Toll-like receptor 4 (TLR4) and activating the NLRP3 inflammasome, leading to Gasdermin D (GSDMD) cleavage. Additionally, CuB enhances mitochondrial reactive oxygen species (ROS) production, mitochondrial membrane protein Tom20 accumulation, and cytosolic calcium (Ca2+) release, ultimately promoting pyroptosis in NSCLC cells. A dosage-independent suppression of lung tumor growth was observed in mice treated with CuB, with 0.75 mg/kg showing a superior antitumor effect compared to Gefitinib.

PHARMACOLOGICAL RESEARCH (2021)

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Article Neurosciences

Protective effects of tetramethylpyrazine on dysfunction of the locus coeruleus in rats exposed to single prolonged stress by anti-ER stress mechanism

Yun Hou et al.

Summary: This study investigated the role of ER stress in PTSD and found that TMP effectively improved LC-NE dysfunction and reduced anxiety response. TMP showed significant neuroprotective effects and therapeutic potential for PTSD-like symptoms.

PSYCHOPHARMACOLOGY (2021)

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Article Medicine, Research & Experimental

Astragaloside IV alleviates heart failure by regulating SUMO-specific protease 1

Juan Liu et al.

Summary: Astragaloside IV (AS-IV) improved cardiac function by reducing ROS and H2O2 levels, inhibiting myocardial cell apoptosis, reducing mitochondrial damage, and suppressing HF-induced Senp1 overexpression.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Nutrition & Dietetics

Curcumin, an Inhibitor of p300-HAT Activity, Suppresses the Development of Hypertension-Induced Left Ventricular Hypertrophy with Preserved Ejection Fraction in Dahl Rats

Yoichi Sunagawa et al.

Summary: Curcumin, a p300 histone acetyltransferase (HAT) inhibitor, has been found to prevent hypertension-induced left ventricular hypertrophy (LVH) development, without affecting blood pressure and systolic function.

NUTRIENTS (2021)

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Article Biotechnology & Applied Microbiology

Astragalus Polysaccharides Enhance the Immune Response to OVA Antigen in BALB/c Mice

Yumei Zhou et al.

Summary: Vaccination is a crucial method to prevent the transmission of infectious diseases, and selecting an appropriate adjuvant is key in vaccine development. Astragalus polysaccharide (APS) is a non-toxic immunomodulator that enhances immune responses. This study analyzed the effects of APS on the immune response to ovalbumin in mice.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Physiology

The Composite of 3, 4-Dihydroxyl-Phenyl Lactic Acid and Notoginsenoside R1 Attenuates Myocardial Ischemia and Reperfusion Injury Through Regulating Mitochondrial Respiratory Chain

Li Yan et al.

Summary: The combination of 3,4-dihydroxyl-phenyl lactic acid and notoginsenoside R1 showed a stronger effect on ischemia and reperfusion injury by inhibiting different molecular pathways and signaling cascades, improving heart function and reducing myocardial damage.

FRONTIERS IN PHYSIOLOGY (2021)

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Review Physiology

Asymmetry and Heterogeneity: Part and Parcel in Cardiac Autonomic Innervation and Function

Tjitske E. Zandstra et al.

Summary: The cANS plays a crucial role in cardiac adaptation, with anatomical and functional differences affecting the treatment of cardiac diseases. The neglect of right ventricle studies and the lack of human research on certain principles highlight the importance of further investigations in this area.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Hemodynamic Determinants of Activity Measured by Accelerometer in Patients With Stable Heart Failure

Massar Omar et al.

Summary: Lower daily activity recorded by accelerometer is associated with decreased cardiac index at rest and during exercise in patients with heart failure with reduced ejection fraction.

JACC-HEART FAILURE (2021)

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Review Endocrinology & Metabolism

The Role of Thioredoxin/Peroxiredoxin in the beta-Cell Defense Against Oxidative Damage

Jennifer S. Stancill et al.

Summary: Oxidative stress is implicated in pancreatic beta-cell damage in type 1 and type 2 diabetes, potentially leading to dysfunction and death of beta cells. Beta cells are vulnerable to oxidative damage but have high expression of antioxidant enzymes which may help maintain their function and survival.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Plant Sciences

Ginsenoside Rb1 attenuates age-associated vascular impairment by modulating the Gas6 pathway

Shiye Ke et al.

Summary: Our study found that in aged mice, the expression of senescence proteins and cellular adhesion molecules were significantly increased, resulting in impaired endothelium-dependent thoracic aorta relaxation. However, treatment with Rb1 decreased the expression of these proteins and preserved endothelium-dependent relaxation. Additionally, Rb1 treatment also reduced calcium and collagen deposition in aged mice, suggesting its potential as an anti-aging vascular impairment agent.

PHARMACEUTICAL BIOLOGY (2021)

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Article Medicine, General & Internal

Survival analysis of patients with heart failure in the Ecuadorian Andean population

Alvaro Francisco Gudino-Gomezjurado et al.

Summary: This study analyzed survival in 228 heart failure patients and found that factors such as etiology, ethnicity, creatinine levels, and age were closely associated with prognosis. Global survival rates were similar to those in other international studies.

MEDWAVE (2021)

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Article Integrative & Complementary Medicine

The Role of Ophiopogonin D in Atherosclerosis: Impact on Lipid Metabolism and Gut Microbiota

Ya-Xin Zhang et al.

Summary: The study demonstrates that OPD treatment significantly reduces the development of atherosclerosis, improves lipid levels and liver steatosis, and decreases the relative abundance of Erysipelotrichaceae genera associated with cholesterol metabolism in gut microbiota. OPD may attenuate atherosclerosis by inhibiting mTOR phosphorylation and lipid metabolism signaling pathways, in addition to altering gut microbiota composition and fecal metabolites.

AMERICAN JOURNAL OF CHINESE MEDICINE (2021)

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Review Medicine, Research & Experimental

Molecular mechanisms of anthracycline cardiovascular toxicity

Anna Narezkina et al.

Summary: Anthracyclines are effective chemotherapeutic agents commonly used in cancer treatment, but their use can lead to cardiovascular toxicity such as cardiomyopathy and heart failure.

CLINICAL SCIENCE (2021)

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Article Health Care Sciences & Services

Effects of alprostadil combined with tanshinone Ila injection on microcirculation disorder, outcomes, and cardiac function in AMI patients after PCI

Yang Lu et al.

Summary: The combination of alprostadil and tanshinone IIa injection can effectively improve cardiac function, reduce the occurrence of MACEs, and is recommended for AMI patients after PCI.

ANNALS OF PALLIATIVE MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

CGRP derived from cardiac fibroblasts is an endogenous suppressor of cardiac fibrosis

Wenqun Li et al.

CARDIOVASCULAR RESEARCH (2020)

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Article Cardiac & Cardiovascular Systems

Anti-fibrotic effects of curcumin and some of its analogues in the heart

Armita Mahdavi Gorabi et al.

HEART FAILURE REVIEWS (2020)

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Article Plant Sciences

Two new tanshinone derivatives from the rhizomes of Salvia miltiorrhiza and their antiviral activities

Zhao-Kun Yin et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2020)

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Review Cardiac & Cardiovascular Systems

Oxidative stress and inflammation in the evolution of heart failure: From pathophysiology to therapeutic strategies

Alberto Aimo et al.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2020)

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Article Cell Biology

Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis

Fu Peng et al.

CELL PROLIFERATION (2020)

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Article Plant Sciences

Pectin lyase-modified red ginseng extract improves glucose homeostasis in high fat diet-fed mice

Go Woon Kim et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Article Chemistry, Multidisciplinary

Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies

Qiong Lai et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Article Cell Biology

Endothelial autophagy deficiency induces IL6-dependent endothelial mesenchymal transition and organ fibrosis

Yuta Takagaki et al.

AUTOPHAGY (2020)

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Review Integrative & Complementary Medicine

A Systematic Review and Meta-Analysis on a Disease in TCM: Astragalus Injection for Gathering Qi Depression

Yanxiang Ha et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

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Article Cell Biology

Therapeutic effects of higenamine combined with [6]-gingerol on chronic heart failure induced by doxorubicin via ameliorating mitochondrial function

Jianxia Wen et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Peripheral Vascular Disease

Ligustrazine prevents basilar artery remodeling in two-kidney-two-clip renovascular hypertension rats via suppressing PI3K/Akt signaling

Beilin Zhang et al.

MICROVASCULAR RESEARCH (2020)

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Review Cardiac & Cardiovascular Systems

Reappraising the role of inflammation in heart failure

Luigi Adamo et al.

NATURE REVIEWS CARDIOLOGY (2020)

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Review Pharmacology & Pharmacy

Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony

Lingling Zhang et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Article Plant Sciences

The role of ginsenoside Rb1, a potential natural glutathione reductase agonist, in preventing oxidative stress-induced apoptosis of H9C2 cells

Hui-Jie Fan et al.

JOURNAL OF GINSENG RESEARCH (2020)

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Article Marine & Freshwater Biology

Chiral toxicity of muscone to embryonic zebrafish heart

Ming Li et al.

AQUATIC TOXICOLOGY (2020)

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Article Immunology

Hydroxysafflor yellow A inhibits hypoxia/reoxygenation-induced cardiomyocyte injury via regulating the AMPK/NLRP3 inflammasome pathway

Jing-xue Ye et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Multidisciplinary Sciences

The Synthetic Curcumin Analogue GO-Y030 Effectively Suppresses the Development of Pressure Overload-induced Heart Failure in Mice

Kana Shimizu et al.

SCIENTIFIC REPORTS (2020)

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Article Biotechnology & Applied Microbiology

Evaluation of Zhenwu Decoction Effects on CYP450 Enzymes in Rats Using a Cocktail Method by UPLC-MS/MS

Li-li Hong et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Pharmacology & Pharmacy

Shenmai Injection Improves Energy Metabolism in Patients With Heart Failure: A Randomized Controlled Trial

Shao-mei Wang et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy

Cheng Zeng et al.

REDOX BIOLOGY (2020)

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Review Pharmacology & Pharmacy

Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia-reperfusion injury

Jin Wang et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Pharmacology & Pharmacy

Curcumin attenuates bevacizumab-induced toxicity via suppressing oxidative stress and preventing mitochondrial dysfunction in heart mitochondria

Nima Shokouhi Sabet et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Ginsenoside Rg3 protects heart against isoproterenol-induced myocardial infarction by activating AMPK mediated autophagy

Gui-Zhi Sun et al.

CARDIOVASCULAR DIAGNOSIS AND THERAPY (2020)

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Article Medicine, Research & Experimental

Paeoniflorin Attenuates Myocardial Fibrosis in Isoprenaline-induced Chronic Heart Failure Rats via Inhibiting P38 MAPK Pathway

Mao Liu et al.

CURRENT MEDICAL SCIENCE (2020)

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Article Pharmacology & Pharmacy

Pharmacokinetic Study of Ferulic Acid Following Transdermal or Intragastric Administration in Rats

Na Yan et al.

AAPS PHARMSCITECH (2020)

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Article Cell Biology

Vanillic Acid Alleviates Acute Myocardial Hypoxia/Reoxygenation Injury by Inhibiting Oxidative Stress

Xiuya Yao et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Cardiac & Cardiovascular Systems

Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-Fibrotic Protein Synthesis During Cardiac Fibrosis

Jiangbin Wu et al.

CIRCULATION RESEARCH (2020)

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Review Cardiac & Cardiovascular Systems

Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities

Ilona Cuijpers et al.

BASIC RESEARCH IN CARDIOLOGY (2020)

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Article Integrative & Complementary Medicine

The protective effects of liguzinediol on congestive heart failure induced by myocardial infarction and its relative mechanism

Qi Chen et al.

CHINESE MEDICINE (2020)

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Article Pharmacology & Pharmacy

Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion InjuryviaSuppressing NLRP3 Inflammasome and Activating Autophagy

Jingxue Ye et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Plant Sciences

Total glucosides of paeony: A review of its phytochemistry, role in autoimmune diseases, and mechanisms of action

Huajuan Jiang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

MMP9 inhibition increases autophagic flux in chronic heart failure

Shyam S. Nandi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Cardiomyocyte microvesicles: proinflammatory mediators after myocardial ischemia?

Patrick Malcolm Siegel et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2020)

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Review Peripheral Vascular Disease

Pathophysiology of Diuretic Resistance and Its Implications for the Management of Chronic Heart Failure

Christopher Stuart Wilcox et al.

HYPERTENSION (2020)

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Article Biochemistry & Molecular Biology

Study on structure characterization of pectin from the steamed ginseng and the inhibition activity of lipid accumulation in oleic acid-induced HepG2 cells

Lili Jiao et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Chemistry, Analytical

Analysis of the active components and metabolites of Taohong Siwu decoction by using ultra high performance liquid chromatography quadrupole time-of-flight mass spectrometry

Xianchun Duan et al.

JOURNAL OF SEPARATION SCIENCE (2020)

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Article Cell Biology

Crude Radix Aconiti Lateralis Preparata (Fuzi) with Glycyrrhiza Reduces Inflammation and Ventricular Remodeling in Mice through the TLR4/NF-κB Pathway

Ping Yan et al.

MEDIATORS OF INFLAMMATION (2020)

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Article Multidisciplinary Sciences

Cells of the adult human heart

Monika Litvinukova et al.

NATURE (2020)

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Article Cell Biology

Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions

Longyong Xu et al.

NATURE CELL BIOLOGY (2020)

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Article Medicine, Research & Experimental

Renin-angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure

Milene Tavares Fontes et al.

CLINICAL SCIENCE (2020)

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Article Integrative & Complementary Medicine

The Efficacy and Safety of Compound Danshen Dripping Pill Combined with Percutaneous Coronary Intervention for Coronary Heart Disease

Cailan Li et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Exploring the In Vivo Existence Forms (23 Original Constituents and 147 Metabolites) of Astragali Radix Total Flavonoids and Their Distributions in Rats Using HPLC-DAD-ESI-IT-TOF-MSn

Li-Jia Liu et al.

MOLECULES (2020)

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Article Cell Biology

Ophiopogonin D Increases SERCA2a Interaction with Phospholamban by Promoting CYP2J3 Upregulation

Jia Wang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Review Biochemistry & Molecular Biology

CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases

Xavier Heim et al.

BIOMEDICINES (2020)

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Editorial Material Cardiac & Cardiovascular Systems

Angiotensin receptor-neprilisyn inhibitors: Are their beneficial effects mediated through diastolic or systolic function improvement?

Evangelos Oikonomou et al.

HELLENIC JOURNAL OF CARDIOLOGY (2020)

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Review Medicine, General & Internal

Efficacy of ticagrelor in the treatment of stable coronary heart disease A protocol of systematic review

Qing-ning Gao

MEDICINE (2020)

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Article Cell Biology

Klotho alleviates indoxyl sulfate-induced heart failure and kidney damage by promoting M2 macrophage polarization

Jing Lv et al.

AGING-US (2020)

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Article Pharmacology & Pharmacy

Pharmacokinetics and distribution of schisandrol A and its major metabolites in rats

Xu Liu et al.

XENOBIOTICA (2019)

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Article Chemistry, Multidisciplinary

Sevoflurane postconditioning protects against myocardial ischemia/reperfusion injury by restoring autophagic flux via an NO-dependent mechanism

Shi-gang Qiao et al.

ACTA PHARMACOLOGICA SINICA (2019)

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Article Cardiac & Cardiovascular Systems

Cardiomyocyte-specific deficiency of HSPB1 worsens cardiac dysfunction by activating NFB-mediated leucocyte recruitment after myocardial infarction

Yana Wang et al.

CARDIOVASCULAR RESEARCH (2019)

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Article Critical Care Medicine

TOTAL SALVIANOLIC ACID INJECTION PREVENTS ISCHEMIA/REPERFUSION-INDUCED MYOCARDIAL INJURY VIA ANTIOXIDANT MECHANISM INVOLVING MITOCHONDRIAL RESPIRATORY CHAIN THROUGH THE UPREGULATION OF SIRTUIN1 AND SIRTUIN3

Dan-Dan Huang et al.

SHOCK (2019)

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Review Biochemistry & Molecular Biology

Autophagy in endothelial cells and tumor angiogenesis

Marco B. Schaaf et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Article Biochemistry & Molecular Biology

Structures of the heart specific SERCA2a Ca2+-ATPase

Aljona Sitsel et al.

EMBO JOURNAL (2019)

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Article Cardiac & Cardiovascular Systems

Risk prediction model for long-term heart failure incidence after epirubicin chemotherapy for breast cancer - A real-world data-based, nationwide classification analysis

Gyorgy Fogarassy et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Schizandrin protects H9c2 cells against lipopolysaccharide-induced injury by downregulating Smad3

Xuehua Zhang et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2019)

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Article Chemistry, Medicinal

Ginseng Extract Modified by Pectin Lyase Inhibits Retinal Vascular Injury and Blood-Retinal Barrier Breakage in a Rat Model of Diabetes

Eunsoo Jung et al.

JOURNAL OF MEDICINAL FOOD (2019)

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Article Plant Sciences

Astragaloside IV alleviates heart failure by promoting angiogenesis through the JAK-STAT3 pathway

Yan-Bo Sui et al.

PHARMACEUTICAL BIOLOGY (2019)

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Article Plant Sciences

Discovery of the mechanisms and major bioactive compounds responsible for the protective effects of Gualou Xiebai Decoction on coronary heart disease by network pharmacology analysis

Li Chong et al.

PHYTOMEDICINE (2019)

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Article Medicine, Research & Experimental

Sodium ferulate inhibits myocardial hypertrophy induced by abdominal coarctation in rats: Involvement of cardiac PKC and MAPK signaling pathways

Min Luo et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Biochemistry & Molecular Biology

The Coming Decade of Cell Death Research: Five Riddles

Douglas R. Green

CELL (2019)

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Article Cell Biology

Sodium tanshinone IIA sulfonate prevents the adverse left ventricular remodelling: Focus on polymorphonuclear neutrophil-derived granule components

Shuai Mao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Article Rheumatology

Autophagy mediates 2-methoxyestradiol-inhibited scleroderma collagen synthesis and endothelial-to-mesenchymal transition induced by hypoxia

Chaofan Liu et al.

RHEUMATOLOGY (2019)

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Article Pathology

被撤回的出版物: Angelica polysaccharide alleviates oxidative response damage in HaCaT cells through up-regulation of miR-126 (Retracted article. See vol. 126, 2022)

Xijun Zhang et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2019)

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Article Clinical Neurology

Getting to the Heart of the Matter: Migraine, Triptans, DHE, Ditans, CGRP Antibodies, First/Second-Generation Gepants, and Cardiovascular Risk

Paul G. Mathew et al.

HEADACHE (2019)

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Article Integrative & Complementary Medicine

The Efficacy and Safety of Xinmailong Injection in Patients with Chronic Heart Failure: A Multicenter Randomized Double-Blind Placebo-Controlled Trial

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Targeting the PI3K/STAT3 axis modulates age-related differences in macrophage phenotype in rats with myocardial infarction

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Article Cardiac & Cardiovascular Systems

Effect of paeoniflorin on cardiac remodeling in chronic heart failure rats through the transforming growth factor β1/Smad signaling pathway

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Selective effects of ginseng pectins on galectin-3-mediated T cell activation and apoptosis

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CARBOHYDRATE POLYMERS (2019)

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Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction

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UHPLC-HRMSn Analysis Reveals the Dynamic Metabonomic Responses of Salvia miltiorrhiza Hairy Roots to Polysaccharide Fraction from Trichoderma atroviride

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BIOMOLECULES (2019)

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HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways

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Relationship of atherogenic index of plasma and mean platelet volume with ejection fraction in ischemic and nonischemic heart failure

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Ginsenoside Rb3 protects cardiomyocytes against hypoxia/reoxygenation injury via activating the antioxidation signaling pathway of PERK/Nrf2/HMOX1

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Ginsenoside Rb3 regulates energy metabolism and apoptosis in cardiomyocytes via activating PPARα pathway

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Treating oxidative stress in heart failure: past, present and future

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EUROPEAN JOURNAL OF HEART FAILURE (2019)

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Cardiomyocyte calcineurin is required for the onset and progression of cardiac hypertrophy and fibrosis in adult mice

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Physicochemical characterizations of polysaccharides from Angelica Sinensis Radix under different drying methods for various applications

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Curcumin improves exercise performance of mice with coronary artery ligation-induced HFrEF: Nrf2 and antioxidant mechanisms in skeletal muscle

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Effects of the combination of tanshinone IIA and puerarin on cardiac function and inflammatory response in myocardial ischemia mice

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Allicin attenuates pathological cardiac hypertrophy by inhibiting autophagy via activation of PI3K/Akt/mTOR and MAPK/ERK/mTOR signaling pathways

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Schisandrin C targets Keap1 and attenuates oxidative stress by activating Nrf2 pathway in Ang II-challenged vascular endothelium

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The influence and mechanism of ligustilide, senkyunolide I, and senkyunolide A on echinacoside transport through MDCK-MDR1 cells as blood-brain barrier in vitro model

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Panax notoginseng saponins attenuate cardiomyocyte apoptosis through mitochondrial pathway in natural aging rats

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Cardioprotective Effect of Hydroxysafflor Yellow A via the Cardiac Permeability Transition Pore

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Schisandrol B and schisandrin B inhibit TGF beta 1-mediated NF-kappa B activation via a Smad-independent mechanism

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Ophiopogonin D alleviates cardiac hypertrophy in rat by upregulating CYP2J3 in vitro and suppressing inflammation in vivo

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NF-κB-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis

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Astragaloside IV protects against the pathological cardiac hypertrophy in mice

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A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia

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Characteristics and Antioxidant Activity of Lignans in Schisandra chinensis and Schisandra sphenanthera from Different Locations

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Endostatin Stimulates Proliferation and Migration of Myofibroblasts Isolated from Myocardial Infarction Model Rats

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Nucleolin mediated pro-angiogenic role of Hydroxysafflor Yellow A in ischaemic cardiac dysfunction: Post-transcriptional regulation of VEGF-A and MMP-9

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An integrated evidence-based targeting strategy for determining combinatorial bioactive ingredients of a compound herbal medicine Qishen Yiqi dripping pills

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Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway

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Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes

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Ginsenoside Rb1 inhibits autophagy through regulation of Rho/ROCK and PI3K/mTOR pathways in a pressure-overload heart failure rat model

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Cardioprotection of Sheng Mai Yin a classic formula on adriamycin induced myocardial injury in Wistar rats

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Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review

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Stereochemical study of mouse muscone receptor MOR215-1 and vibrational theory based on statistical physics formalism

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Circulating endostatin and the incidence of heart failure

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Splenic leukocytes define the resolution of inflammation in heart failure

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Splenic leukocytes define the resolution of inflammation in heart failure

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Ginsenoside Rg1 Ameliorates Rat Myocardial Ischemia-Reperfusion Injury by Modulating Energy Metabolism Pathways

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MiR-665 aggravates heart failure via suppressing CD34-mediated coronary microvessel angiogenesis

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Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction

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Ophiopogonin D Reduces Myocardial Ischemia-Reperfusion Injury via Upregulating CYP2J3/EETs in Rats

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Trichosanthis Pericarpium Aqueous Extract Protects H9c2 Cardiomyocytes from Hypoxia/Reoxygenation Injury by Regulating PI3K/Akt/NO Pathway

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Potential Effectiveness of Chinese Patent Medicine Tongxinluo Capsule for Secondary Prevention After Acute Myocardial Infarction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Suppression of TGP on myocardial remodeling by regulating the NF-kappa B pathway

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Therapeutic efficacy and safety of Shexiang Baoxin Pill combined with trimetazidine in elderly patients with heart failure secondary to ischaemic cardiomyopathy A systematic review and meta-analysis

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Letter Cardiac & Cardiovascular Systems

Metabolic remodelling in heart failure revisited

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Evaluation of the effects of different treatment modalities on angiogenesis in heart failure patients with reduced/midrange ejection fraction via VEGF and sVEGFR-1

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Estradiol Treatment Initiated Early After Ovariectomy Regulates Myocardial Gene Expression and Inhibits Diastolic Dysfunction in Female Cynomolgus Monkeys: Potential Roles for Calcium Homeostasis and Extracellular Matrix Remodeling

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Hypoxia-Inducible Factor 1 alpha (HIF-1 alpha)/Vascular Endothelial Growth Factor (VEGF) Pathway Participates in Angiogenesis of Myocardial Infarction in Muscone-Treated Mice: Preliminary Study

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Bryonolic Acid Blocks Cancer Cell Clonogenicity and Invasiveness through the Inhibition of Fatty Acid: Cholesteryl Ester Formation

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Effects of Tao-Hong-Si-Wu decoction on acute blood stasis in rats based on a LC-Q/TOF-MS metabolomics and network approach

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Attenuation of the LPS-induced, ERK-mediated upregulation of fibrosis-related factors FGF-2, uPA, MMP-2, and MMP-9 by Carthamus tinctorius L in cardiomyoblasts

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Cardioprotective potential of curcumin against norepinephrine-induced cell death: a microscopic study

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Atractylodes lactone compounds inhibit platelet activation

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Cardioprotective effects of curcumin-loaded magnetic hydrogel nanocomposite (nanocurcumin) against doxorubicin-induced cardiac toxicity in rat cardiomyocyte cell lines

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Position paper of the European Society of Cardiology-working group of coronary pathophysiology andmicrocirculation: obesity and heart disease

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Schisandrin B Ameliorates Myocardial Ischemia/Reperfusion Injury Through Attenuation of Endoplasmic Reticulum Stress-Induced Apoptosis

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Protective effects on myocardial infarction model: delivery of schisandrin B using matrix metalloproteinase-sensitive peptide-modified, PEGylated lipid nanoparticles

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Liguzinediol Enhances the Inotropic Effect of Rat Hearts via Inhibition of Protein Phosphatase (PP1 and PP2A) Activities

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Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy

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JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

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miR-29c is implicated in the cardioprotective activity of Panax notoginseng saponins against isoproterenol-induced myocardial fibrogenesis

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Review Pharmacology & Pharmacy

Effects and mechanisms of compound Chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion

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Remote Ischaemic Preconditioning and Sevoflurane Postconditioning Synergistically Protect Rats from Myocardial Injury Induced by Ischemia and Reperfusion Partly via Inhibition TLR4/MyD88/NF-κB Signaling Pathway

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Astragaloside IV Prevents Cardiac Remodeling in the Apolipoprotein E-Deficient Mice by Regulating Cardiac Homeostasis and Oxidative Stress

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Ophiopogonin D and EETs ameliorate Ang II-induced inflammatory responses via activating PPARα in HUVECs

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Effects of Traditional Chinese Medicine Shensong Yangxin Capsules on Heart Rhythm and Function in Congestive Heart Failure Patients with Frequent Ventricular Premature Complexes: A Randomized, Double-blind, Multicenter Clinical Trial

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CHINESE MEDICAL JOURNAL (2017)

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Pathophysiology of heart failure and frailty: a common inflammatory origin?

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Immediate Effects of Acupuncture Treatment on Intra- and Inter-Limb Contributions to Body Support During Gait in Patients with Bilateral Medial Knee Osteoarthritis

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Hydroxysafflor yellow A promotes neovascularization and cardiac function recovery through HO-1/VEGF-A/SDF-1α cascade

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Article Integrative & Complementary Medicine

Gualou Xiebai decoction inhibits cardiac dysfunction and inflammation in cardiac fibrosis rats

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A Central Role for Monocyte-Platelet Interactions in Heart Failure

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Ophiopogonin D maintains Ca2+ homeostasis in rat cardiomyocytes in vitro by upregulating CYP2J3/EETs and suppressing ER stress

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Sesquiterpenes from Baizhu Stimulate Glucose Uptake by Activating AMPK and PI3K

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Liguzinediol protects against cardiac fibrosis in rats in vivo and in vitro

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Clinical effects of a standardized Chinese herbal remedy, Qili Qiangxin, as an adjuvant treatment in heart failure: systematic review and meta-analysis

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Ginsenoside Rg1 protects starving H9c2 cells by dissociation of Bcl-2-Beclin1 complex

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Contributory Risk and Management of Comorbidities of Hypertension, Obesity, Diabetes Mellitus, Hyperlipidemia, and Metabolic Syndrome in Chronic Heart Failure: A Scientific Statement From the American Heart Association

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Review Cardiac & Cardiovascular Systems

Aging and Autophagy in the Heart

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Cardiac Fibrosis The Fibroblast Awakens

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Fluid Volume Overload and Congestion in Heart Failure Time to Reconsider Pathophysiology and How Volume Is Assessed

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Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto--boswellic acid in combination on isoproterenol-induced myocardial injury in rats

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INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

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A randomized, double-blind, multicenter, placebo-controlled clinical study on the efficacy and safety of Shenmai injection in patients with chronic heart failure

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Elucidation of Transport Mechanism of Paeoniflorin and the Influence of Ligustilide, Senkyunolide I and Senkyunolide A on Paeoniflorin Transport through Mdck-Mdr1 Cells as Blood-Brain Barrier in Vitro Model

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MOLECULES (2016)

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Bevacizumab is superior to Temozolomide in causing mitochondrial dysfunction in human brain tumors

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Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway

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Inflammation as a therapeutic target in myocardial infarction: learning from past failures to meet future challenges

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TLR signalling and association of TLR polymorphism with cardiovascular diseases

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VASCULAR PHARMACOLOGY (2016)

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Salvianolic Acid B Alleviates Heart Failure by Inactivating ERK1/2/GATA4 Signaling Pathway after Pressure Overload in Mice

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PLOS ONE (2016)

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ADVANCES IN NUTRITION (2016)

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Article Integrative & Complementary Medicine

Shenmai injection as an adjuvant treatment for chronic cor pulmonale heart failure: a systematic review and meta-analysis of randomized controlled trials

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Review Cardiac & Cardiovascular Systems

Innate Immunity and the Failing Heart The Cytokine Hypothesis Revisited

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Review Cardiac & Cardiovascular Systems

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Induction of the CXC Chemokine Interferon-γ-Inducible Protein 10 Regulates the Reparative Response Following Myocardial Infarction

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Reduced in vivo skeletal muscle oxygen consumption in patients with chronic heart failure -: A study using Near Infrared Spectrophotometry (NIRS)

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Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial

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