期刊
ACTA PHARMACEUTICA SINICA B
卷 13, 期 5, 页码 1919-1955出版社
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2023.02.005
关键词
Natural ingredients; Chronic heart failure; Cardiac remodeling; Chinese medicinal herbs; Traditional Chinese medicine formula; Multiple targets; Constituent compatibility; Synergistic effects
Traditional Chinese medicine (TCM) has multiple targets for the treatment of chronic heart failure (CHF) and can regulate molecular mechanisms to combat different pathological processes of CHF. This review analyzes the application of TCM in different stages of CHF and summarizes the bioactive ingredients in Chinese medicinal herbs and their multiple molecular mechanisms for treating CHF.
Chronic heart failure (CHF) is a severe public health problem with increasing morbidity and mortality, any treatment targeting a single session is insufficient to tackle this. CHF is characterized by reduced cardiac output resulting from neurohumoral dysregulation and cardiac remodeling, which might be related to oxidative stress, inflammation, endoplasmic reticulum stress, apoptosis, autophagy, mito-chondrial function, and angiogenesis. These molecular mechanisms interact with each other through crosstalk. Historically, Chinese medicinal herbs have been widely applied in the treatment of CHF, and therapeutic effects of Chinese medicinal herbs and their ingredients have been scientifically confirmed over the past decades. Traditional Chinese medicine (TCM) with multiple components can confront the different pathogenesis of CHF through multiple targets. This review analyzes commonly used TCM patent drugs and TCM decoctions that are applicable to different stages of CHF based on clin-ical trials. Diverse bioactive ingredients in Chinese medicinal herbs have been found to treat CHF via multiple molecular mechanisms. This review comprehensively covers the key works on the effects and underlying mechanisms of TCM, herbal ingredients and synergistic effects of constituent compatibility in treating CHF, providing additional ideas to address this threat.(c) 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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