CD71+ erythroid cells suppress T-cell effector functions and predict immunotherapy outcomes in patients with virus-associated solid tumors

Article Oncology

Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1/PD-L1 treatment efficacy

Haixia Long et al.

Summary: This study reveals a mechanism by which tumors exploit anemia-triggered erythropoiesis for myeloid transdifferentiation and immunosuppression.

CANCER CELL (2022)

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Review Biochemistry & Molecular Biology

Hematopoietic responses to SARS-CoV-2 infection

Shokrollah Elahi

Summary: Under physiological conditions, HSPCs in the bone marrow niches are responsible for regulating hematopoiesis, but they can be influenced by microbial agents and infection-induced mediators. This article reviews the impact of these factors on hematopoiesis and discusses how SARS-CoV-2 infection alters the hematopoietic system, including lymphopenia, thrombocytopenia, and hypercoagulability.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Article Immunology

Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis

Changlu Xu et al.

Summary: Immune-erythroid cells, a subset of erythroid precursors with immune characteristics, are present throughout human development and interact with various immune cells.

NATURE IMMUNOLOGY (2022)

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Article Microbiology

Differential Impact of SARS-CoV-2 Isolates, Namely, the Wuhan Strain, Delta, and Omicron Variants on Erythropoiesis

Suguru Saito et al.

Summary: This study reveals that SARS-CoV-2 variants have differential impacts on erythropoiesis, with CD45(+) erythroid cells exhibiting immunosuppressive properties and potentially contributing to anemia in COVID-19 patients. The findings provide important insights into the understanding of the effects of SARS-CoV-2 variants on erythropoiesis.

MICROBIOLOGY SPECTRUM (2022)

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Article Oncology

Intratumoral CD45+CD71+ erythroid cells induce immune tolerance and predict tumor recurrence in hepatocellular carcinoma

Jie Chen et al.

Summary: The study revealed that an accumulation of CD45(+)CD71(+) erythroid cells in HCC tissues could play a superior immunosuppressive role in the tumor microenvironment. They suppress T cells through generation of reactive oxygen species, IL-10, and TGF-beta, and their abundance in tumor tissue may serve as a valuable biomarker to predict HCC recurrence, with a prognostic value better than conventional scoring systems.

CANCER LETTERS (2021)

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Review Pharmacology & Pharmacy

The role of CD71+ erythroid cells in the regulation of the immune response

Tomasz M. Grzywa et al.

Summary: CECs play diverse roles in immune response, from affecting vulnerability to infectious diseases in neonates, regulating feto-matemal tolerance in pregnant women, to influencing immune response in patients with cancer. Their mechanisms include suppressing proinflammatory responses, decreasing T-cell proliferation and promoting T-cell differentiation into regulatory T-cells.

PHARMACOLOGY & THERAPEUTICS (2021)

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Article Cell Biology

Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity

Yuzhu Hou et al.

Summary: Tumor-induced Ter cells promote tumor progression by secreting ARTN, and local tumor ionizing radiation and anti-PD-L1 treatment can decrease Ter cell abundance and ARTN secretion. Recombinant erythropoietin can restore Ter cell numbers and ARTN concentration, and decreased expression of GFR alpha 3 is associated with favorable outcomes in melanoma patients undergoing immunotherapy. These findings suggest potential targets for improving outcomes after radiotherapy and immunotherapy.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Cell & Tissue Engineering

Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2

Shima Shahbaz et al.

Summary: The study found that COVID-19 patients have significantly enriched CD71+ erythroid precursors/progenitors in their blood circulation, which exhibit distinctive immunosuppressive properties and a strong negative correlation with T and B cell proportions. The expansion of these cells is negatively correlated with hemoglobin levels and they can be infected with SARS-CoV-2.

STEM CELL REPORTS (2021)

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Article Oncology

Expanded antigen-experienced CD160+CD8+effector T cells exhibit impaired effector functions in chronic lymphocytic leukemia

Najmeh Bozorgmehr et al.

Summary: The study found that CD160 was the most upregulated co-inhibitory receptor in patients with CLL, and its expression was associated with an exhausted T cell phenotype. EVs were identified as a source of CD160 in the plasma of CLL patients. Additionally, a dominantly proinflammatory cytokine profile, especially elevated interleukin-16, was observed in CLL patients' plasma.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Multidisciplinary Sciences

The immunoregulatory function of peripheral blood CD71+ erythroid cells in systemic-onset juvenile idiopathic arthritis

Hikaru Kanemasa et al.

Summary: CECs in SoJIA patients exhibit upregulated erythropoiesis-related genes and represent the largest expansion among other inflammatory diseases. Their levels correlate with inflammatory markers, and they may control excessive inflammation via immunoregulatory pathways involving arginase-2.

SCIENTIFIC REPORTS (2021)

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Article Immunology

Sex Matters: Physiological Abundance of Immuno-Regulatory CD71+Erythroid Cells Impair Immunity in Females

Siavash Mashhouri et al.

Summary: This study revealed significant sexual dimorphism in CECs, with female mice and human females exhibiting higher levels of CECs compared to males. CECs, particularly their progenitors CD45+CECs, showed enhanced immunomodulatory properties, suppressing T cell activation and proliferation through L-arginine depletion. The abundance of CECs in anemic mice and post-menstrual cycle women may contribute to immune suppression and susceptibility to infections like Bordetella pertussis.

FRONTIERS IN IMMUNOLOGY (2021)

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Editorial Material Hematology

Immunological consequences of extramedullary erythropoiesis: immunoregulatory functions of CD71+ erythroid cells

Shokrollah Elahi et al.

HAEMATOLOGICA (2020)

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Article Immunology

Galectin-9 and VISTA Expression Define Terminally Exhausted T Cells in HIV-1 Infection

Shima Shahbaz et al.

JOURNAL OF IMMUNOLOGY (2020)

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Review Hematology

How I treat cancer-associated anemia

Jeffrey A. Gilreath et al.

BLOOD (2020)

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Article Medicine, Research & Experimental

Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells

Li Yang et al.

JCI INSIGHT (2020)

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Article Microbiology

Selective Upregulation of CTLA-4 on CD8(+)T Cells Restricted by HLA-B*35Px Renders them to an Exhausted Phenotype in HIV-1 infection

Shokrollah Elahi et al.

PLOS PATHOGENS (2020)

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Article Immunology

CD71+ Erythroid Cells in Human Neonates Exhibit Immunosuppressive Properties and Compromise Immune Response Against Systemic Infection in Neonatal Mice

Shokrollah Elahi et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Oncology

Galectin-9 expression defines exhausted T cells and impaired cytotoxic NK cells in patients with virus-associated solid tumors

Isobel Okoye et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Article Gastroenterology & Hepatology

Lower Abundance and Impaired Function of CD71+ Erythroid Cells in Inflammatory Bowel Disease Patients During Pregnancy

Garett Dunsmore et al.

JOURNAL OF CROHNS & COLITIS (2019)

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Editorial Material Immunology

Neglected Cells: Immunomodulatory Roles of CD71+ Erythroid Cells

Shokrollah Elahi

TRENDS IN IMMUNOLOGY (2019)

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Article Multidisciplinary Sciences

Immune evasion before tumour invasion in early lung squamous carcinogenesis

Celine Mascaux et al.

NATURE (2019)

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Article Microbiology

CD71+ Erythroid Cells Exacerbate HIV-1 Susceptibility, Mediate trans-Infection, and Harbor Infective Viral Particles

Afshin Namdar et al.

MBIO (2019)

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Review Oncology

Mechanisms of resistance to immune checkpoint inhibitors

Russell W. Jenkins et al.

BRITISH JOURNAL OF CANCER (2018)

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Article Biochemistry & Molecular Biology

Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression

Yanmei Han et al.

CELL (2018)

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Article Immunology

CD71(+) Erythroid Suppressor Cells Promote Fetomaternal Tolerance through Arginase-2 and PDL-1

Cole Delyea et al.

JOURNAL OF IMMUNOLOGY (2018)

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Article Oncology

Extramedullary hematopoiesis secondary to malignant solid tumors: a case report and literature review

Youting Bao et al.

CANCER MANAGEMENT AND RESEARCH (2018)

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Review Hematology

Normal and pathological erythropoiesis in adults: from gene regulation to targeted treatment concepts

Peter Valent et al.

HAEMATOLOGICA (2018)

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Article Biochemistry & Molecular Biology

Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells

Lintao Zhao et al.

NATURE MEDICINE (2018)

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Review Physiology

Pathogenesis and Treatment Options of Cancer Related Anemia: Perspective for a Targeted Mechanism-Based Approach

Clelia Madeddu et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Article Gastroenterology & Hepatology

Mode of delivery by an ulcerative colitis mother in a case of twins: Immunological differences in cord blood and placenta

Garett Dunsmore et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

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Article Biochemistry & Molecular Biology

CD71+VISTA+ erythroid cells promote the development and function of regulatory T cells through TGF-β

Shima Shahbaz et al.

PLOS BIOLOGY (2018)

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Review Cell Biology

Immunotherapy against cancer-related viruses

Haruko Tashiro et al.

CELL RESEARCH (2017)

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Review Biochemistry & Molecular Biology

Galectins and Carcinogenesis: Their Role in Head and Neck Carcinomas and Thyroid Carcinomas

Nadege Kindt et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Immunology

Erythroid Suppressor Cells Compromise Neonatal Immune Response against Bordetella pertussis

Garett Dunsmore et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Critical Care Medicine

Severe trauma and chronic stress activates extramedullary erythropoiesis

Ines G. Alamo et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2017)

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Review Oncology

iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics

Lesley Seymour et al.

LANCET ONCOLOGY (2017)

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Article Multidisciplinary Sciences

CD71+ erythroid suppressor cells impair adaptive immunity against Bordetella pertussis

Afshin Namdar et al.

SCIENTIFIC REPORTS (2017)

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Article Critical Care Medicine

Severe trauma and chronic stress activates extramedullary erythropoiesis

Ines G. Alamo et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2017)

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Review Immunology

Coinhibitory Receptor expression and immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic viral infections and Cancer

Isobel S. Okoye et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Review Immunology

Vaccines targeting helper T cells for cancer immunotherapy

Marit Meissen et al.

CURRENT OPINION IN IMMUNOLOGY (2017)

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Review Oncology

Resistance to PD1/PDL1 checkpoint inhibition

Jake S. O'Donnell et al.

CANCER TREATMENT REVIEWS (2017)

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Article Oncology

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

Yanfang Liu et al.

CANCER CELL (2016)

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Review Immunology

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

Jonathan M. Pitt et al.

IMMUNITY (2016)

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Article Biochemical Research Methods

Correlation of transferrin receptor (CD71) with Ki67 expression on stimulated human and mouse T cells: The kinetics of expression of T cell activation markers

Melika Motamedi et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2016)

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Article Medicine, Research & Experimental

Stress-associated erythropoiesis initiation is regulated by type 1 conventional dendritic cells

Taeg S. Kim et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

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Article Multidisciplinary Sciences

A perisinusoidal niche for extramedullary haematopoiesis in the spleen

Christopher N. Inra et al.

NATURE (2015)

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Article Multidisciplinary Sciences

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

Seth B. Coffelt et al.

NATURE (2015)

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Review Immunology

New insight into an old concept: role of immature erythroid cells in immune pathogenesis of neonatal infection

Shokrollah Elahi

FRONTIERS IN IMMUNOLOGY (2014)

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Review Biochemistry & Molecular Biology

Galectin-9 in tumor biology: A jack of multiple trades

Roy Heusschen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2013)

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Article Oncology

PD-1-Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Cecile Badoual et al.

CANCER RESEARCH (2013)

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Article Multidisciplinary Sciences

Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection

Shokrollah Elahi et al.

NATURE (2013)

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Review Oncology

Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms

Eran Elinav et al.

NATURE REVIEWS CANCER (2013)

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Article Oncology

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Douglas Hanahan et al.

CANCER CELL (2012)

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Article Biochemistry & Molecular Biology

Association of HLA-alleles with the immune regulation of chronic viral infections

Shokrollah Elahi et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

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Article Oncology

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

Myriam Labelle et al.

CANCER CELL (2011)

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Article Biochemistry & Molecular Biology

Protective HIV-specific CD8+ T cells evade Treg cell suppression

Shokrollah Elahi et al.

NATURE MEDICINE (2011)

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Review Oncology

Contribution of platelets to tumour metastasis

Laurie J. Gay et al.

NATURE REVIEWS CANCER (2011)

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Article

Analysis of Extramedullary Erythropoiesis in the Spleen by a Semiquantitative Method Using Indium-111

R. A. Rojer et al.

ACTA MEDICA SCANDINAVICA (2010)

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Editorial Material Oncology

The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM

Stephen B. Edge et al.

ANNALS OF SURGICAL ONCOLOGY (2010)

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Article Biochemistry & Molecular Biology

Artemin is oncogenic for human mammary carcinoma cells

J. Kang et al.

ONCOGENE (2009)

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Article Medicine, General & Internal

Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy:: randomised, double-blind, placebo-controlled trial

M Henke et al.

LANCET (2003)

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Article Multidisciplinary Sciences

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

EM Janssen et al.

NATURE (2003)

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CD71+ erythroid cells suppress T-cell effector functions and predict immunotherapy outcomes in patients with virus-associated solid tumors

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