期刊
SCIENCE ADVANCES
卷 9, 期 18, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abq7553
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By performing single-cell RNA sequencing of the ventricular-subventricular zone, researchers found that neural stem cells enter a state of deep quiescence and suppress the production and differentiation of glutamatergic neurons, leading to rapid silencing of pallial germinal activity.
The ventricular-subventricular zone (V-SVZ) is the largest neurogenic region of the postnatal forebrain, contain-ing neural stem cells (NSCs) that emerge from both the embryonic pallium and subpallium. Despite of this dual origin, glutamatergic neurogenesis declines rapidly after birth, while GABAergic neurogenesis persists through-out life. We performed single-cell RNA sequencing of the postnatal dorsal V-SVZ for unraveling the mechanisms leading to pallial lineage germinal activity silencing. We show that pallial NSCs entera state of deep quiescence, characterized by high bone morphogenetic protein (BMP) signaling, reduced transcriptional activity and Hopx expression, while in contrast, subpallial NSCs remain primed for activation. Induction of deep quiescence is par-alleled by a rapid blockade of glutamatergic neuron production and differentiation. Last, manipulation of Bmpr1a demonstrates its key role in mediating these effects. Together, our results highlight a central role of BMP signaling in synchronizing quiescence induction and blockade of neuronal differentiation to rapidly silence pallial germinal activity after birth.
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