4.8 Article

TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Disentangling glial diversity in peripheral nerves at single-nuclei resolution

Aldrin K. Y. Yim et al.

Summary: Using single-nuclei RNA sequencing, this study analyzed the diversity of cell types in peripheral nerves and identified a novel myelinating Schwann cell subtype that is depleted in ALS cases. These findings serve as a valuable reference for future studies of nerve biology and disease.

NATURE NEUROSCIENCE (2022)

Article Clinical Neurology

Syngeneic murine glioblastoma models: reactionary immune changes and immunotherapy intervention outcomes

Vijay Letchuman et al.

Summary: The choice of the appropriate syngeneic murine model is critical for immunotherapy research on glioblastoma as it can impact the translatability of the results from mouse to human trials.

NEUROSURGICAL FOCUS (2022)

Article Oncology

CCR1 and CCR5 mediate cancer-induced myelopoiesis and differentiation of myeloid cells in the tumor

Serena Zilio et al.

Summary: CCR1 and CCR5 and their ligands are a master immunological hub activated by several tumor derived factors, playing a crucial role in tumor progression.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

Article Surgery

CD44-Mediated Poor Prognosis in Glioma Is Associated With M2-Polarization of Tumor-Associated Macrophages and Immunosuppression

Yong Xiao et al.

Summary: CD44 is positively correlated with malignancy grade and negatively associated with prognosis in glioma. CD44 predominantly expresses in the mesenchymal subtype of GBM and is closely related to glioma immunity. At the single-cell level, CD44 is expressed in malignant tumor cells, tumor-associated macrophages, and T cells in GBM.

FRONTIERS IN SURGERY (2022)

Article Oncology

Immunosuppressive TREM2(+) macrophages are associated with undesirable prognosis and responses to anti-PD-1 immunotherapy in non-small cell lung cancer

Hongyu Zhang et al.

Summary: This study reveals the presence of a TAM subtype associated with immunotherapy response in non-small cell lung cancer (NSCLC), specifically, the TREM2 positive TAMs. NSCLC patients with high infiltration of TREM2(+) TAMs show advanced tumor progression and poor prognosis, as well as unique molecular characteristics. Low TREM2(+) TAMs predict higher response rates to PD-1-based immunotherapy.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2022)

Review Neurosciences

TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

Rui-Yang Li et al.

Summary: TREM2 is an important immune receptor that can impact lipid metabolism in both the central nervous system and the periphery, and may have implications for the pathogenesis of AD. Through pathways including inflammation, insulin resistance, and AD pathology, the association between TREM2 and AD may be mediated by altered lipid metabolism.

MOLECULAR NEURODEGENERATION (2022)

Article Oncology

Lipid-Associated Macrophages Are Induced by Cancer-Associated Fibroblasts and Mediate Immune Suppression in Breast Cancer

Eleonora Timperi et al.

Summary: This study identifies a novel lipid-associated macrophage subpopulation with immune suppressive functions and provides new leads for therapeutic interventions in triple-negative breast cancer.

CANCER RESEARCH (2022)

Article Immunology

DCBLD1 Overexpression Is Associated With a Poor Prognosis in Head and Neck Squamous Cell Carcinoma

Ling-ling Fu et al.

Summary: DCBLD1 is highly expressed in head and neck squamous cell carcinoma and is associated with poor patient prognosis. Further research is needed to investigate the underlying mechanism.

FRONTIERS IN IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis

Ping Yang et al.

Summary: Our study reveals that the scavenger receptor CD36 is upregulated in metastasis-associated macrophages (MAMs) and deletion of CD36 in MAMs attenuates liver metastasis in mice. MAMs contain more lipid droplets and have the unique capability to engulf tumor cell-derived long-chain fatty acids carried by extracellular vesicles. These lipid-enriched vesicles are preferentially partitioned into macrophages via CD36, fueling their tumor-promoting activities and creating a highly immunosuppressive tumor microenvironment (TME) in liver metastasis.

NATURE COMMUNICATIONS (2022)

Article Gastroenterology & Hepatology

TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms

Aitor Esparza-Baquer et al.

Summary: The study revealed that TREM-2 is upregulated in liver cancer tissue and mouse models of liver regeneration and HCC. Trem-2(-/-) mice developed more liver tumors after DEN administration, showing exacerbated liver damage, inflammation, oxidative stress, and hepatocyte proliferation. Trem-2 plays a protective role in hepatocarcinogenesis through different pleiotropic effects.
Article Biochemistry & Molecular Biology

STAB: a spatio-temporal cell atlas of the human brain

Liting Song et al.

Summary: The human brain, the most complex organ, can now be dissected at the single-cell level with the help of single-cell RNA sequencing technologies. STAB, a database containing single-cell transcriptomes from multiple brain regions and developmental periods, provides insights into cell compositions, regional differences, and temporal dynamics in the human brain, aiding in understanding brain development and neuropsychiatric disorders.

NUCLEIC ACIDS RESEARCH (2021)

Article Multidisciplinary Sciences

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Tatenda Mahlokozera et al.

Summary: The research reveals that the E3 ubiquitin ligase TRIM26 promotes SOX2 stability in a unique manner, consequently enhancing the tumorigenicity and tumor-forming ability of GSCs.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

Targeting TREM2 on tumor-associated macrophages enhances immunotherapy

Mikhail Binnewies et al.

Summary: Research has identified a correlation between TREM2(+) tumor-associated macrophages (TAMs) and exhausted CD8(+) tumor-infiltrating lymphocytes (TILs), with therapy targeting TREM2 showing potential in promoting anti-tumor immunity.

CELL REPORTS (2021)

Article Neurosciences

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Ana Rita Pombo Antunes et al.

Summary: By utilizing single-cell RNA sequencing and CITE-seq, this study reveals the complexity of the immune landscape in glioblastomas, including conserved populations of dendritic cells and macrophages. The results indicate that microglia-derived tumor-associated macrophages dominate in newly diagnosed tumors, but are replaced by monocyte-derived TAMs in recurrences.

NATURE NEUROSCIENCE (2021)

Article Multidisciplinary Sciences

Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice

Kathleen M. Schoch et al.

Summary: The study found that transient reduction of Trem2 messenger RNA levels in APP/PS1 mice significantly reduced plaque deposition and attenuated microglial association around plaques. The results suggest that Trem2 reduction may activate microglia and aid in plaque removal.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Oncology

Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma

Erin F. Simonds et al.

Summary: This study compared the tumor immune microenvironments of ICI-responsive and ICI-refractory tumors, identifying T cells and dendritic cells as key factors associated with ICI sensitivity. Mouse models suggested that poor antigen presentation in the brain may contribute to ICI resistance in GBM. Rational immunotherapeutic combinations targeting DCs and PD-L1+ tumor-associated macrophages showed promising results in vivo.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

p38 MAPK signaling in M1 macrophages results in selective elimination of M2 macrophages by MEK inhibition

Daniel Baumann et al.

Summary: M2 macrophages are more sensitive to MEK inhibition-induced cell death, while activation of the p38 MAPK pathway in M1 macrophages renders them resistant to MEK inhibition-induced cell death. This indicates that MEK inhibitors can selectively eliminate M2 macrophages from the tumor microenvironment.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Biochemical Research Methods

Preparation and culture of bone marrow-derived macrophages from mice for functional analysis

Gotaro Toda et al.

Summary: This protocol details the collection and differentiation of bone marrow cells into bone marrow-derived macrophages for assessing macrophage function. For more information on the protocol's use and execution, refer to Toda et al. (2020).

STAR PROTOCOLS (2021)

Review Biochemistry & Molecular Biology

The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

Aleksandra Deczkowska et al.

Article Biochemistry & Molecular Biology

TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

Martina Molgora et al.

Article Cell Biology

Extracellular SQSTM1 as an inflammatory mediator

Borong Zou et al.

AUTOPHAGY (2020)

Article Cell Biology

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

Felipe J. Nunez et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Biochemistry & Molecular Biology

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

Diego Adhemar Jaitin et al.

Article Biochemistry & Molecular Biology

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

Cyril Neftel et al.

Review Oncology

Immunotherapy of Primary Brain Tumors: Facts and Hopes

Robin A. Buerki et al.

CLINICAL CANCER RESEARCH (2018)

Article Pathology

High TREM2 expression correlates with poor prognosis in gastric cancer

Xiaojing Zhang et al.

HUMAN PATHOLOGY (2018)

Article Biochemistry & Molecular Biology

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease

Tyler K. Ulland et al.

Article Biochemistry & Molecular Biology

DAPK2 is a novel regulator of mTORC1 activity and autophagy

Y. Ber et al.

CELL DEATH AND DIFFERENTIATION (2015)

Article Biochemistry & Molecular Biology

Role of MAPK signal pathways in differentiation process of M2 macrophages induced by high-ambient glucose and TGF-β1

Ning Su et al.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2015)

Article Cardiac & Cardiovascular Systems

Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques

Timo Froemel et al.

BASIC RESEARCH IN CARDIOLOGY (2013)

Article Biochemistry & Molecular Biology

Gremlin-1 Is an Inhibitor of Macrophage Migration Inhibitory Factor and Attenuates Atherosclerotic Plaque Growth in ApoE-/- Mice

Iris Mueller et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Multidisciplinary Sciences

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

Myoung Sook Han et al.

SCIENCE (2013)

Article Immunology

Pulmonary CCL18 Recruits Human Regulatory T Cells

Cecile Chenivesse et al.

JOURNAL OF IMMUNOLOGY (2012)

Article Immunology

A Novel and Divergent Role of Granzyme A and B in Resistance to Helminth Infection

Wiebke Hartmann et al.

JOURNAL OF IMMUNOLOGY (2011)

Article Multidisciplinary Sciences

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax

Jamie I. Fletchera et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Immunology

Cutting edge: TREM-2 attenuates macrophage activation

Isaiah R. Turnbull et al.

JOURNAL OF IMMUNOLOGY (2006)

Article Medicine, Research & Experimental

Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance

HM Marriott et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)

Review Chemistry, Medicinal

The biology of p38 kinase: A central role in inflammation

GL Schieven

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2005)

Review Biochemistry & Molecular Biology

The roles of IFNγ in protection against tumor development and cancer immunoediting

H Ikeda et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2002)