期刊
SCIENCE ADVANCES
卷 9, 期 12, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abq3713
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Understanding the evolutionary origins and maintenance of alternative life history strategies is a major goal in evolutionary research. The study focused on the polymorphic Alba ALHS in Colias butterflies and aimed to determine its origins and evolutionary persistence. By using comparative genome-wide association study and population genomic analyses, the researchers found that Alba evolved once at the base of the genus and has been maintained via introgression and balancing selection. CRISPR-Cas9 mutagenesis was used to verify a putative cis-regulatory region of Alba, which likely acts as a modular enhancer for its induction.
Understanding the evolutionary origins and factors maintaining alternative life history strategies (ALHS) within species is a major goal of evolutionary research. While alternative alleles causing discrete ALHS are expected to purge or fix over time, one-third of the similar to 90 species of Colias butterflies are polymorphic for a female-limited ALHS called Alba. Whether Alba arose once, evolved in parallel, or has been exchanged among taxa is currently unknown. Using comparative genome-wide association study (GWAS) and population genomic analyses, we placed the genetic basis of Alba in time-calibrated phylogenomic framework, revealing that Alba evolved once near the base of the genus and has been subsequently maintained via introgression and balancing selec-tion. CRISPR-Cas9 mutagenesis was then used to verify a putative cis-regulatory region of Alba, which we identified using phylogenetic foot printing. We hypothesize that this cis-regulatory region acts as a modular enhancer for the induction of the Alba ALHS, which has likely facilitated its long evolutionary persistence. Commons License
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