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TaCl5-Catalyzed Amidation of Carboxylic Acids with Amines

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CHEMISTRYSELECT
卷 8, 期 7, 页码 -

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WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202204298

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carboxylic acids; primary and secondary amines; tantalum(V) chloride; amidation

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Under the catalysis of 0.2 equiv. TaCl5, alkyl- and aryl-substituted carboxylic acids react with primary and secondary amines to selectively form carboxylic acid amides of various structures. The TaCl5-catalyzed amide formation reaction proceeds with equal selectivity in toluene and methylene chloride, hexane, diethyl ether, and 1,4-dioxane solutions.
The reaction of alkyl- and aryl-substituted carboxylic acids with primary and secondary amines under the action of 0.2 equiv. TaCl5 leads to selective formation of carboxylic acid amides of various structures. TaCl5-catalyzed formation of amides was demonstrated to proceed equally selectively both in toluene and methylene chloride, hexane, diethyl ether and 1,4-dioxane solutions.

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