期刊
CHEMISTRYSELECT
卷 8, 期 18, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202204985
关键词
Aryl iodide; Pd-Cu catalyzed; Pyrazole; Pyrazole-linked oxazole; Sonogashira reaction
An efficient method for synthesizing new pyrazole-linked oxazoles through a palladium-catalyzed Sonogashira coupling reaction was developed. Pyrazole-linked oxazole derivatives and 5-chloro-3-methyl-1-phenyl-N-(3-arylprop-2-yn-1-yl)-1H-pyrazole-4-carboxamide derivatives were obtained from the reaction of 5-chloro-3-methyl-1-phenyl-N-(prop-2-phenyl)-1H-pyrazole-4-carboxamide with aryl iodides having nitro group and aryl iodides with electron-donating groups, respectively. The prepared products were characterized using FT-IR, (HNMR)-H-1, and (CNMR)-C-13 spectroscopies.
An efficient method is developed for synthesizing new pyrazole-linked oxazoles through a palladium-catalyzed Sonogashira coupling reaction. In this method, from the reaction of 5-chloro-3-methyl-1-phenyl-N-(prop-2-phenyl)-1H-pyrazole-4-carboxamide with aryl iodides having nitro group and aryl iodides with electron-donating groups, pyrazole-linked oxazole derivatives and 5-chloro-3-methyl-1-phenyl-N-(3-arylprop-2-yn-1-yl)-1H-pyrazole-4-carboxamide derivatives were obtained respectively. The prepared products were characterized using FT-IR, (HNMR)-H-1, and (CNMR)-C-13 spectroscopies.
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