期刊
CHEMISTRYSELECT
卷 8, 期 14, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202301062
关键词
trifluoromethyl; copper; diaryliodonium salts; arenes; fluoroform
A mild and efficient copper-mediated trifluoromethylation method was developed for the synthesis of trifluoromethylated arenes using readily available fluoroform and diaryliodonium salts. The reaction showed excellent functional group tolerance and provided good yields. This approach enables the straightforward incorporation of CF3 group into complex molecules, which is important for drug discovery applications.
A mild and efficient copper-mediated trifluoromethylation of diaryliodonium salts with readily available fluoroform has been developed. The reaction exhibits excellent functional group tolerance, affording trifluoromethylated arenes in good yields. This approach provides a straightforward incorporation of CF3 group into complex molecules for drug discovery.
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