Detection of Sialic Acid and Imaging of Cell-Surface Glycan Using a Fluorescence-SERS Dual Probe

Review Chemistry, Analytical

Raman Spectroscopy and Imaging in Bioanalytics

Dana Cialla-May et al.

ANALYTICAL CHEMISTRY (2022)

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Pillar[5]arene-Based Fluorescent Sensor Array for Biosensing of Intracellular Multi-neurotransmitters through Host-Guest Recognitions

Yuxiao Mei et al.

Summary: This article describes a new supramolecular fluorescent probe that efficiently identifies largescale neurotransmitters and enables high-throughput analysis using principal component analysis.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Chemistry, Multidisciplinary

An Optical Probe for Real-Time Monitoring of Self-Replicator Emergence and Distinguishing between Replicators

Joydev Hatai et al.

Summary: Self-replicating systems are crucial for the study of life synthesis and origin, but traditional monitoring methods have limitations in throughput and requirements. To address these issues, we have developed a fluorescent molecular probe capable of real-time monitoring of the replication process, discriminating different replicators based on their chemical composition. This technique significantly reduces analysis time and sample quantities, and opens doors for high-throughput experimentation in protocell environments.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Chemistry, Analytical

Live-cell profiling of membrane sialic acids by fluorescence imaging combined with SERS labelling

Jian Lv et al.

Summary: The study presents a highly efficient and convenient two-step tagging strategy for live-cell profiling of membrane sialic acids using fluorescence imaging and SERS labeling. By using tumor markers as model proteins, sialic acids can be partitioned into distinct space domains, allowing for classification of various types of cells. This strategy provides a robust and versatile platform for highly detailed analysis of cell surface saccharide profiles, with potential applications in optical biosensing and molecular diagnosis.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Multidisciplinary

Photoproximity Labeling of Sialylated Glycoproteins (GlycoMap) Reveals Sialylation-Dependent Regulation of Ion Transport

Claudio F. Meyer et al.

Summary: Sialylation, an important post-translational modification of proteins, plays crucial roles in neurodevelopment, oncogenesis, and immune response. This study establishes a mu Map proximity labeling platform to investigate the functional consequences of sialylation on cell-surface glycoproteins and intracellular metabolites.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Chemistry, Multidisciplinary

Simultaneous Visualization of Dual Intercellular Signal Transductions via SERS Imaging of Membrane Proteins Dimerization on Single Cells

Chen Dong et al.

Summary: A highly sensitive and specific surface-enhanced Raman scattering (SERS) strategy was proposed to simultaneously image dual homodimerizations of membrane proteins on single live cells. Networking of AuNPs-based dual-recognition probes (dual-RPs) and SERS tags via proximity ligation-assisted catalytic hairpin assembly (CHA) was used to enhance the SERS effect. This strategy provides a good method for high-sensitivity monitoring of membrane proteins dimerizations-based multiple intercellular signal transductions in a natural and complex cellular microenvironment.

ACS NANO (2022)

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Article Biochemistry & Molecular Biology

Elucidating cell surface glycan imbalance through SERS guided metabolic glycan labelling: An appraisal of metastatic potential in cancer cells

Madhukrishnan Murali et al.

Summary: In this study, the differential glycosylation pattern in cancer cell lines was elucidated using the metabolic glycan labelling (MGL) and surface-enhanced Raman scattering (SERS) technique. The technique revealed a linear relationship between glycan expression and metastatic potential in different cancer cells.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2022)

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Assays for the identification and quantification of sialic acids: Challenges, opportunities and future perspectives

Jack Cheeseman et al.

Summary: Sialic acid is a crucial biomarker for a variety of diseases, including cardiovascular disease, diabetes, and different types of cancer. Its levels fluctuate with inflammation and tumor presence, leading to the development of various assays for its detection and quantification.

BIOORGANIC & MEDICINAL CHEMISTRY (2021)

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Article Chemistry, Analytical

In Situ Determination of Sialic Acid on Cell Surface with a pH-Regulated Polymer Enzyme Nanoreactor

Juan Qiao et al.

Summary: A pH-regulated enzyme nanoreactor was developed for in situ detection of sialic acid on living cell surfaces, demonstrating high specificity feasibility in analysis.

ANALYTICAL CHEMISTRY (2021)

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Review Immunology

The Role of Sialic Acids in the Establishment of Infections by Pathogens, With Special Focus on Leishmania

Taina Cavalcante et al.

Summary: Sialic acids (Sias) play important roles in cell communication, infection, and survival of pathogens on the cell surface. More than 20 pathogens can incorporate Sias from hosts to enhance survival inside the host, especially evident in Leishmania infection.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Review Neurosciences

Sialometabolism in Brain Health and Alzheimer's Disease

Punam Rawal et al.

Summary: Sialic acids play a crucial role in regulating neuronal functions and microglial homeostasis in the brain. Dysfunctions in sialic acid metabolism may contribute to microglial dysfunction and neuroinflammation in diseases such as Alzheimer's.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Chemistry, Multidisciplinary

Sialic Acid as a Biomarker Studied in Breast Cancer Cell Lines In Vitro Using Fluorescent Molecularly Imprinted Polymers

Zahra El-Schich et al.

Summary: Sialylations are crucial post-translational modifications in cellular events, especially in tumor cells where high levels of sialic acid (SA) expression are associated with increased invasive potential. The use of SA-MIPs as nanoprobes shows promise in detection and analysis of breast cancer cells.

APPLIED SCIENCES-BASEL (2021)

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Review Medicine, Research & Experimental

Sialic acid as a potential biomarker for cardiovascular disease, diabetes and cancer

Jack Cheeseman et al.

Summary: Elevated sialic acid concentration in plasma and serum is positively correlated with the presence of cardiovascular disease, diabetes, and malignant tumors. While not a specific marker, sialic acid shows promise as a marker for monitoring disease progression and treatment effectiveness.

BIOMARKERS IN MEDICINE (2021)

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Article Chemistry, Multidisciplinary

Machine Learning Aids Classification and Discrimination of Noncanonical DNA Folding Motifs by an Arrayed Host:Guest Sensing System

Junyi Chen et al.

Summary: An arrayed host:guest fluorescence sensor system can accurately discriminate and classify multiple different noncanonical DNA structures through selective molecular recognition. The sensor is highly selective and can distinguish between folds with subtle differences, such as native G-quadruplexes and those with bulges or vacancies. By forming heteroternary complexes with DNA strands, the host mediates the interaction between DNA and dye to modulate emission, and machine learning algorithms enable high-fidelity prediction of the folding state of unknown DNA strands.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Review Oncology

Insights into the role of sialylation in cancer progression and metastasis

Christopher Dobie et al.

Summary: The upregulation of sialyltransferases and hypersialylation on tumour cell surfaces are established hallmarks of various cancers, promoting tumour metastasis. Targeting sialylation as a potential anti-metastatic cancer treatment strategy shows promise in inhibiting tumour growth and spread.

BRITISH JOURNAL OF CANCER (2021)

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Glycoform Differentiation by a Targeted, Self-Assembled, Pattern-Generating Protein Surface Sensor

Ronny Peri-Naor et al.

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A novel glycosidase plate-based assay for the quantification of galactosylation and sialylation on human IgG

Osmond D. Rebello et al.

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Sialic acid metabolism as a potential therapeutic target of atherosclerosis

Chao Zhang et al.

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Pattern recognition of toxic metal ions using a single-probe thiocoumarin array

David G. Smith et al.

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Formation of disulphide linkages restricts intramolecular motions of a fluorophore: detection of molecular oxygen in food packaging

Sk Atiur Rahaman et al.

CHEMICAL COMMUNICATIONS (2019)

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A non-enzymatic electrochemical sensor for detection of sialic acid based on a porphine/graphene oxide modified electrode via indicator displacement assay

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Colorimetric determination of sialic acid based on boronic acid-mediated aggregation of gold nanoparticles

Titilope John Jayeoye et al.

MICROCHIMICA ACTA (2018)

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A Minimalist Approach for Distinguishing Individual Lanthanide Ions Using Multivariate Pattern Analysis

Biswajit Roy et al.

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Fluorescent probe with aggregation-induced emission characteristics for targeted labelling and imaging of cancer cells

Na Peng et al.

RSC ADVANCES (2017)

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Review Chemistry, Analytical

. Fluorescent sensing arrays for cations and anions

David G. Smith et al.

ANALYST (2017)

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New Insight of Tetraphenylethylene-based Raman Signatures for Targeted SERS Nanoprobe Construction Toward Prostate Cancer Cell Detection

Adukkadan N. Ramya et al.

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4-mercaptophenylboronic acid functionalized gold nanoparticles for colorimetric sialic acid detection

Supannee Sankoh et al.

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Fluorescence imaging for in situ detection of cell surface sialic acid by competitive binding of 3-(dansylamino)phenylboronic acid

Ruocan Qian et al.

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Sialic Acid-Imprinted Fluorescent Core-Shell Particles for Selective Labeling of Cell Surface Glycans

Sudhirkumar Shinde et al.

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Colorimetric viral detection based on sialic acid stabilized gold nanoparticles

Changwon Lee et al.

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A Photostable AIE Luminogen for Specific Mitochondrial Imaging and Tracking

Chris Wai Tung Leung et al.

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Specific Detection of D-Glucose by a Tetraphenylethene-Based Fluorescent Sensor

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Differential expression of the α2,3-sialic acid residues in breast cancer is associated with metastatic potential

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CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2010)

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Zhiyi Yao et al.

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Noninvasive Sialic Acid Detection at Cell Membrane by Using Phenylboronic Acid Modified Self-Assembled Monolayer Gold Electrode

Akira Matsumoto et al.

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Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins

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Coding of odors by a receptor repertoire

EA Hallem et al.

CELL (2006)

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SIALIC ACID IN CARDIOVASCULAR DISEASES

P. K. Nigam et al.

INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2006)

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Achievements and challenges of sialic acid research

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GLYCOCONJUGATE JOURNAL (2000)

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Detection of Sialic Acid and Imaging of Cell-Surface Glycan Using a Fluorescence-SERS Dual Probe

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