Sargassum horneri extracts loaded nanostructured lipid carriers: Preparation, physicochemical properties, and in vitro antioxidant activity studies

This study tried to establish optimal conditions for Sargassum horneri extracts loaded nanostructured lipid carriers (SHE-NLCs). Therefore, we observed various physicochemical analyzes, sugar and phenolic contents, and antioxidants while storing the SHE-NLCs for 28 days at different SHE addition amounts (0%-0.5%) and storage temperatures (25 and 65 degrees C). All SHE-NLCs stored at 25 degrees C showed a small hydrodynamic diameter (20.1-25.4 nm) and high encapsulation efficiency (64.1%-89.3%) for 28 days. As the amount of SHE increased, the pH and electrical conductivity of SHE-NLCs significantly decreased and increased, respectively (p < 0.05). Also, at 25 C, prevented a sharp decrease in the total phenolic content and antioxidant activity of SHE-NLCs as the storage period increased compared to 65 degrees C. SHE 0.25% loaded NLCs can stably maintain the formulation structure for 28 days at room temperature while being an amount sufficiently containing the functionality of SHE.

Automated summary

This study aimed to determine the optimal conditions for Sargassum horneri extracts loaded nanostructured lipid carriers (SHE-NLCs). Physicochemical analyses, sugar and phenolic contents, and antioxidants were observed while storing the SHE-NLCs at different addition amounts and temperatures. The study found that SHE-NLCs stored at 25 degrees C exhibited small diameter and high encapsulation efficiency. Moreover, a lower temperature prevented the decrease in phenolic content and antioxidant activity during storage.