4.4 Article

Stimulation of the immune system by a tumor antigen-bearing adenovirus-inspired VLP allows control of melanoma growth

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biotechnology & Applied Microbiology

Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platform

Christopher Chevillard et al.

Summary: In this study, a previously designed ADDomer VLP platform was adapted to display multimeric array of large antigens using the SpyTag/SpyCatcher system. By decorating the newly designed VLP with glycosylated receptor binding domain of SARS-CoV-2, significant specific humoral response and strong neutralization titers were induced, surpassing those of COVID-19 convalescent patients.

MOLECULAR THERAPY (2022)

Article Immunology

Peptides-Coated Oncolytic Vaccines for Cancer Personalized Medicine

Sara Feola et al.

Summary: Oncolytic viruses (OVs) can work as in situ cancer vaccines by directly lysing cancer cells and releasing tumor antigens. However, this mechanism may not always induce a strong T cell response. Genetically modified OVs encoding tumor antigens or coating OVs with tumor antigens can enhance the priming efficiency. In this study, both approaches were tested and characterized for their efficacy as cancer vaccines. Both genetically modified oncolytic adenovirus and PeptiCRAd elicited T cells-specific anti-tumor responses, but PeptiCRAd showed advantages in fast presentation of tumor antigens and adaptability for personalized cancer vaccines.

FRONTIERS IN IMMUNOLOGY (2022)

Review Biotechnology & Applied Microbiology

Emerging concepts in the science of vaccine adjuvants

Bali Pulendran et al.

Summary: Adjuvants are vaccine components that enhance the immune response. Recent advances in understanding the molecular mechanisms and systems vaccinology have revitalized the science and development of novel adjuvants for use in vaccines against COVID-19 and future pandemics.

NATURE REVIEWS DRUG DISCOVERY (2021)

Editorial Material Multidisciplinary Sciences

THE DREAM VACCINE

Jon Cohen

Summary: Researchers are working on developing vaccines that can protect against multiple coronaviruses at once, aiming to enhance immunity against future coronavirus infectious diseases.

SCIENCE (2021)

Review Immunology

Protein-based antigen presentation platforms for nanoparticle vaccines

Brian Nguyen et al.

Summary: Modern vaccine design is moving towards minimalization, isolating antigens from pathogens to create safer vaccines. To combat global diseases, such as COVID-19, malaria, and AIDS, more effective next-generation vaccines are urgently needed. One approach to enhance the immunogenicity of vaccines involves using nanoparticle platforms to present antigens repetitively on their surface, improving antigen presenting cell uptake and B-cell activation.

NPJ VACCINES (2021)

Review Immunology

Accelerated COVID-19 vaccine development: milestones, lessons, and prospects

Karin Bok et al.

Summary: The US government's successful effort in developing COVID-19 vaccines involved integrating expertise and infrastructure from both the public and private sectors, resulting in the rapid advancement of multiple vaccine candidates being administered globally.

IMMUNITY (2021)

Article Multidisciplinary Sciences

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice

Alexander A. Cohen et al.

Summary: The study developed nanoparticles displaying the receptor binding domain (RBD) of SARS-CoV-2 and other animal coronaviruses, which induced cross-reactive antibody responses in mice. Immunization with mosaic RBD nanoparticles resulted in superior neutralization of heterologous viruses, providing a potential strategy for simultaneous protection against multiple coronaviruses.

SCIENCE (2021)

Review Virology

Virus-Like Particles as an Immunogenic Platform for Cancer Vaccines

Jerri C. Caldeira et al.

VIRUSES-BASEL (2020)

Article Pharmacology & Pharmacy

Shared neoantigens: ideal targets for off-the-shelf cancer immunotherapy

Wenyi Zhao et al.

PHARMACOGENOMICS (2020)

Review Virology

The Adenovirus Dodecahedron: Beyond the Platonic Story

Solene Besson et al.

VIRUSES-BASEL (2020)

Review Chemistry, Multidisciplinary

Power to the protein: enhancing and combining activities using the Spy toolbox

Anthony H. Keeble et al.

CHEMICAL SCIENCE (2020)

Article Multidisciplinary Sciences

Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization

Karl D. Brune et al.

SCIENTIFIC REPORTS (2016)

Review Pharmacology & Pharmacy

Poly(I:C) as cancer vaccine adjuvant: Knocking on the door of medical breakthroughs

Rachid Ammi et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Review Immunology

Vaccine adjuvant uses of poly-IC and derivatives

Karen Ao Martins et al.

EXPERT REVIEW OF VACCINES (2015)

Article Biochemistry & Molecular Biology

Structural Analysis and Optimization of the Covalent Association between SpyCatcher and a Peptide Tag

Long Li et al.

JOURNAL OF MOLECULAR BIOLOGY (2014)

Article Virology

Virus-induced humoral immunity: on how B cell responses are initiated

Franziska Zabel et al.

CURRENT OPINION IN VIROLOGY (2013)

Article Multidisciplinary Sciences

Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin

Bijan Zakeri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Immunology

Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns

Martin F. Bachmann et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Article Multidisciplinary Sciences

Detergent binding explains anomalous SDS-PAGE migration of membrane proteins

Arianna Rath et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biotechnology & Applied Microbiology

Exploiting lymphatic transport and complement activation in nanoparticle vaccines

Sai T. Reddy et al.

NATURE BIOTECHNOLOGY (2007)

Article Biochemistry & Molecular Biology

Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases

R Galinier et al.

BIOCHEMISTRY (2002)

Article Multidisciplinary Sciences

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

L Alexopoulou et al.

NATURE (2001)

Review Cell Biology

Antigen processing by the proteasome

PM Kloetzel

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)