期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 9, 期 5, 页码 2706-2715出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.2c01523
关键词
graphene oxide; optical property; dental composites; antibacterial activity
The study found that by incorporating zinc oxide nanorods into graphene oxide, the color of the material can be improved, enhancing the antibacterial effect of dental composites and effectively inhibiting the growth of cariogenic bacteria.
Biofilm formation on resin composite surfaces is associated with the occurrence of secondary caries around restorations. As a promising antibacterial nanomaterial, graphene oxide is effective to suppress the viability of the cariogenic bacteria Streptococcus mutans (S. mutans). However, GO naturally expresses brown, which limits its potential application in dentistry. In this work, ZnO nanorod-decorated graphene oxide (GOn@ZnO) particles were synthesized via a facile hydrothermal method, and their optical property was regulated by changing the amount of seeded GO (n value) in the microemulsion. Among all hybrid particles, GO3@ZnO exhibited a bright gray color and lowest UV absorbance and therefore was selected as an optimal functional filler to produce dental composites with different loadings (0.1, 0.5, 1, and 3 wt %). The effects of GO3@ZnO loading on light transmittance, polymerization conversion, mechanical property, in vitro cell viability, and antibacterial effect of dental composites were systematically explored. The results exhibited that the 0.5 wt % GO3@ZnO-filled composite demonstrated comparable degree of conversion (60 s), higher flexural strength and modulus, and similar cell viability to the control. This composite also effectively inhibited the growth of S. mutans, giving a significantly lower bacterial concentration (3.9 x 107 CFU/mL) than the unfilled resin (8.5 x 107 CFU/mL) and the 0.5 wt % GO-filled composite (6.6 x 107 CFU/mL), respectively. The introduction of GO3@ZnO in dental composites could be a promising strategy to prevent secondary caries and extend service life.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据