Visible Light-Responsive Selenium Nanoparticles Combined with Sonodynamic Therapy to Promote Wound Healing

In this paper, we synthesized selenium nanoparticles (SeNPs) that could be effectively excited by pure yellow light (YL) source to enhance antibacterial ability. Meanwhile, YL could also play the role of anti-inflammatory and promote wound healing. In addition, in order to overcome the problem of low penetration depth of photodynamic therapy (PDT), SeNPs were encapsulated with polyethylenimine (PEI), then modified with the sound sensitive agent indocyanine green (ICG), realizing the combined photoacoustic therapy to promote the healing of wounds infected by drug-resistant bacteria. The antibacterial efficiency of methicillinresistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) reached more than 99% in in vitro and in vivo experiments within 10 min, which could safely and quickly kill drug-resistant bacteria to repair and heal wounds.

Automated summary

In this study, selenium nanoparticles (SeNPs) were synthesized to enhance antibacterial ability using pure yellow light (YL) source. YL also showed anti-inflammatory and wound healing properties. To overcome the low penetration depth issue in photodynamic therapy (PDT), SeNPs were encapsulated with polyethylenimine (PEI) and modified with indocyanine green (ICG) to achieve combined photoacoustic therapy for promoting healing of drug-resistant bacteria-infected wounds. In vitro and in vivo experiments demonstrated that the antibacterial efficiency of methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) exceeded 99% within 10 minutes, effectively killing drug-resistant bacteria and promoting wound repair.