4.7 Article

Identification of copper metabolism-related subtypes and establishment of the prognostic model in ovarian cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Article Gastroenterology & Hepatology

COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma

Mi Yang et al.

Summary: The study revealed a novel role of Cu in promoting radioresistance in hepatocellular carcinoma (HCC) by disrupting Cu-Fe homeostasis through the inhibition of the HIF1 alpha/CP loop by COMMD10, enhancing ferroptosis and radiosensitivity.

JOURNAL OF HEPATOLOGY (2022)

Article Immunology

Stemness Refines the Classification of Colorectal Cancer With Stratified Prognosis, Multi-Omics Landscape, Potential Mechanisms, and Treatment Options

Zaoqu Liu et al.

Summary: This study deciphers two stemness clusters in colorectal cancer (CRC), which have stratified prognosis, multi-omics landscape, potential mechanisms, and treatment options. It provides new insights into the heterogeneity of cancer stemness and sheds light on optimizing decision-making in immunotherapy and chemotherapy.

FRONTIERS IN IMMUNOLOGY (2022)

Article Oncology

The Role of the Extracellular Matrix and Tumor-Infiltrating Immune Cells in the Prognostication of High-Grade Serous Ovarian Cancer

Yuri Belotti et al.

Summary: In this study, a 19-gene TME-related HGSOC prognostic genetic panel was identified using bioinformatics methods, and an association between tumor-infiltrating immune cells and mortality rates was found.

CANCERS (2022)

Article Health Care Sciences & Services

Identification and Validation of a Gene Signature for Lower-Grade Gliomas Based on Pyroptosis-Related Genes to Predict Survival and Response to Immune Checkpoint Inhibitors

Guichuan Lai et al.

Summary: Pyroptosis-related gene signature has a significant impact on the prognosis and efficacy of immune checkpoint inhibitors (ICIs) in lower-grade gliomas (LGGs). High-risk patients have worse survival outcomes and distinct differences in tumor immune microenvironment, mutation status, and response to therapy compared to low-risk patients. These findings are valuable in predicting prognosis and guiding ICIs treatment for LGG patients.

JOURNAL OF HEALTHCARE ENGINEERING (2022)

Article Respiratory System

P2RY14 downregulation in lung adenocarcinoma: a potential therapeutic target associated with immune infiltration

Ting Xu et al.

Summary: This study investigated the relationship between P2RY14 and the prognosis of lung adenocarcinoma (LUAD) patients. The findings suggest that high expression of P2RY14 is associated with better prognosis in LUAD patients. Additionally, P2RY14 may be involved in LUAD immune invasion.

JOURNAL OF THORACIC DISEASE (2022)

Review Biochemistry & Molecular Biology

Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment

Vivien Low et al.

Summary: Metabolite exchange in the tumor microenvironment is not only a source of energy and nutrients for growing tumors, but also plays a crucial role as signaling molecules in regulating oncogenic pathways. Understanding how the interconnected metabolome of the tumor microenvironment drives cancer progression is of great importance for cancer treatment and prevention.

SCIENCE SIGNALING (2022)

Article Immunology

Development of a copper metabolism-related gene signature in lung adenocarcinoma

Wuguang Chang et al.

Summary: This study reveals the prognostic value of copper metabolism-related genes in lung adenocarcinoma and their potential role in guiding immunotherapy. The low-risk group exhibits longer overall survival and higher immune cell infiltration levels, suggesting potential benefits from immunotherapy.

FRONTIERS IN IMMUNOLOGY (2022)

Article Endocrinology & Metabolism

Machine learning to construct sphingolipid metabolism genes signature to characterize the immune landscape and prognosis of patients with uveal melanoma

Hao Chi et al.

Summary: This study aimed to establish a reliable signature based on sphingolipid metabolism genes (SMGs) for assessing immunotherapy response and prognosis in patients with uveal melanoma (UVM). The results showed that the 4-SMGs signature and nomogram had excellent predictive performance and provided a new perspective for assessing pre-immune efficacy.

FRONTIERS IN ENDOCRINOLOGY (2022)

Article Oncology

Dysregulated FOXM1 signaling in the regulation of cancer stem cells

Gulab Sher et al.

Summary: Since the introduction of the cancer stem cell paradigm, significant progress has been made in understanding the role of cancer stem cells (CSCs) in tumor biology, including metastasis and drug resistance. The transcription factor FOXM1 has emerged as a key regulator of CSCs, involved in their formation, maintenance, and functionality. This review summarizes the evidence for the mechanisms by which FOXM1 promotes stemness in different types of cancers and highlights its prognostic importance.

SEMINARS IN CANCER BIOLOGY (2022)

Review Oncology

Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy

Peijie Zheng et al.

Summary: Elesclomol is an anticancer drug that targets mitochondrial metabolism to suppress cancer growth. It induces cell death by modulating copper levels and exhibits significant toxicity to various cancer cells. The research progress provides a possibility for the reapplication of Elesclomol and suggests combination therapy with other drugs.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Article Immunology

Natural killer cell-related prognosis signature characterizes immune landscape and predicts prognosis of HNSCC

Hao Chi et al.

Summary: This study established a reliable signature based on genes related to NK cells in HNSCC, providing a new perspective for assessing immunotherapy response and prognosis. The 17-NRGs signature demonstrated excellent predictive performance and offered new perspectives for evaluating pre-immune efficacy, facilitating future precision immuno-oncology research.

FRONTIERS IN IMMUNOLOGY (2022)

Article Genetics & Heredity

A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration

Hao Chi et al.

Summary: This study constructed a prognostic model for HNSCC using anoikis-related genes (ANRGs) and found differential immune status and drug sensitivity between high-risk and low-risk groups. In addition, through DCA analysis, the researchers demonstrated the potential clinical benefit of the model in the clinical practice.

FRONTIERS IN GENETICS (2022)

Article Genetics & Heredity

Machine learning-based characterization of cuprotosis-related biomarkers and immune infiltration in Parkinson's disease

Songyun Zhao et al.

Summary: This study aimed to identify potential novel biomarkers of Parkinson's disease by biomarker analysis and explore immune cell infiltration during the onset of cuprotosis. It was found that cuprotosis-related genes intervene in the progression of Parkinson's disease through immune cell infiltration.

FRONTIERS IN GENETICS (2022)

Article Cell Biology

Cuprotosis Programmed-Cell-Death-Related lncRNA Signature Predicts Prognosis and Immune Landscape in PAAD Patients

Hao Chi et al.

Summary: In this study, the relationship between cuprotosis programmed-cell-death-related lncRNAs (CRLs) and pancreatic cancer was investigated. A risk-rating system for prognosis was developed based on CRLs, which showed strong correlations with clinicopathological characteristics, tumor microenvironment, immunotherapy response, and chemotherapy sensitivity. The study provides a novel approach for evaluating pre-immune effectiveness and has implications for precision immuno-oncology research.
Article Neurosciences

A Bioinformatics-Based Analysis of an Anoikis-Related Gene Signature Predicts the Prognosis of Patients with Low-Grade Gliomas

Songyun Zhao et al.

Summary: In this study, anoikis-related genes were used to identify subtypes and construct a prognostic model for low-grade glioma (LGG) patients. The study also revealed differences in the immune microenvironment and pathways between different subtypes. The risk score was identified as an independent prognostic factor in LGG patients and was associated with poor prognosis. The high-risk group showed higher immune cell infiltration, tumor mutation load, and therapeutic response to immune checkpoint blockers.

BRAIN SCIENCES (2022)

Article Oncology

Expression of hub genes of endothelial cells in glioblastoma-A prognostic model for GBM patients integrating single-cell RNA sequencing and bulk RNA sequencing

Songyun Zhao et al.

Summary: In this study, a 4-gene signature for GBM was constructed and validated using single-cell RNA-seq and bulk RNA-seq data, which has important implications for guiding the treatment of GBM.

BMC CANCER (2022)

Review Oncology

Connecting copper and cancer: from transition metal signalling to metalloplasia

Eva J. Ge et al.

Summary: Copper is a essential nutrient with both beneficial and toxic properties to cells. Recent progress in transition metal signaling has led to new connections between researchers from different disciplines, with potential for translating basic research into clinical therapies for diseases. The relationship between copper and cancer is particularly important, with opportunities for leveraging disease vulnerabilities through copper-dependent signaling pathways.

NATURE REVIEWS CANCER (2022)

Review Biochemistry & Molecular Biology

Copper metabolism as a unique vulnerability in cancer

Vinit C. Shanbhag et al.

Summary: Over the past 25 years, significant progress has been made in identifying and characterizing proteins that regulate the uptake, intracellular trafficking and export of copper. While copper is essential for growth and development in humans and other mammals, it is also a limiting nutrient for cancer cell growth and proliferation. Oral copper chelators have been shown to have anti-neoplastic and anti-metastatic effects in animals and humans.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Review Medicine, Research & Experimental

Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance

Sreya Bagchi et al.

Summary: This article highlights the significance of immune checkpoint inhibitors in cancer immunotherapy and the research findings on the changes in local and systemic immune cells after treatment. It emphasizes the need for understanding the requirements for an effective and safe antitumor immune response following ICI therapy.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021 (2021)

Article Multidisciplinary Sciences

Enhancing web search result clustering model based on multiview multirepresentation consensus cluster ensemble (mmcc) approach

Ali Sabah et al.

Summary: The study proposes an enhanced multiview multirepresentation consensus clustering ensemble method to improve web search result clustering performance. By utilizing multiple views of data representations, the method creates diverse candidate solutions and selects high-quality overlapping clusters, demonstrating improvements in clustering methods and enhancing WSRC performance compared to single-view clustering models.

PLOS ONE (2021)

Article Nutrition & Dietetics

Serum and Whole Blood Cu and Zn Status in Predicting Mortality in Lung Cancer Patients

Katarzyna Zablocka-Slowinska et al.

Summary: Alterations in circulating Cu and Zn are found to be negative predictors of survival in neoplastic patients, particularly in lung cancer cases. This study aimed to investigate the relationships between Cu and Zn status in blood with all-cause mortality in lung cancer patients, finding a positive association with serum Cu levels and Cu:Zn ratio. However, the strongest predictor of mortality remains the advanced clinical stage of the disease.

NUTRIENTS (2021)

Article Oncology

Mesothelin-Specific CAR T Cells Target Ovarian Cancer

Esther Schoutrop et al.

Summary: The study demonstrates the therapeutic potential of MSLN-CAR T cells against ovarian cancer, despite challenges in achieving persistent tumor control. The findings highlight the importance of immune checkpoint pathways in limiting CAR T-cell persistence in the ovarian tumor microenvironment.

CANCER RESEARCH (2021)

Review Oncology

Second-Generation Jak2 Inhibitors for Advanced Prostate Cancer: Are We Ready for Clinical Development?

Paul Beinhoff et al.

Summary: Prostate cancer is a significant health concern for men, typically treated with androgen deprivation therapy. However, some patients develop lethal castrate-resistant prostate cancer, necessitating the search for new treatment strategies.

CANCERS (2021)

Review Biochemistry & Molecular Biology

Ovarian Cancer Immunotherapy and Personalized Medicine

Susan Morand et al.

Summary: Response to immunotherapy in ovarian cancer is limited, but stratification by tumor biomarkers may improve predictiveness. Future directions include utilizing these biomarkers to select ideal candidates, increasing the likelihood of success with immunotherapy in ovarian cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Genetics & Heredity

P2RY14 Is a Potential Biomarker of Tumor Microenvironment Immunomodulation and Favorable Prognosis in Patients With Head and Neck Cancer

Qingxiang Li et al.

Summary: This study investigated the correlation between immune/stromal/estimate scores and survival prognosis in head and neck squamous cell carcinoma, identifying P2RY14 as a predictive biomarker. The research also explored the potential role of P2RY14-driven signaling pathways in immune remodeling of the tumor microenvironment.

FRONTIERS IN GENETICS (2021)

Review Cell Biology

Ovarian-Cancer-Associated Extracellular Vesicles: Microenvironmental Regulation and Potential Clinical Applications

Priyakshi Kalita-de Croft et al.

Summary: Ovarian cancer is one of the most diagnosed gynecological cancers in women, often diagnosed at an advanced stage due to the lack of effective early screening. Extracellular vesicles play a crucial role in the tumor microenvironment of ovarian cancer, with potential applications in diagnosis, delivery of therapeutic agents, and disease monitoring.
Article Biotechnology & Applied Microbiology

Bioinformatics analysis reveals the competing endogenous RNA (ceRNA) coexpression network in the tumor microenvironment and prognostic biomarkers in soft tissue sarcomas

Dandan Zou et al.

Summary: Soft tissue sarcomas (STSs) are rare and heterogeneous mesenchymal neoplasms. In this study, immune scores and stromal scores of STS patients were evaluated using RNA sequencing data from the TCGA database. A ceRNA network was established through bioinformatics analysis and several TME-related biomarkers with prognostic value were identified, showing potential for prognostic prediction and immune therapy in STS patients.

BIOENGINEERED (2021)

Article Evolutionary Biology

Screening of Important Factors in the Early Sepsis Stage Based on the Evaluation of ssGSEA Algorithm and ceRNA Regulatory Network

Liou Huang et al.

Summary: The study identified 5 immune cells with significant changes in the early stage of septic shock, and the construction of a ceRNA network will help explore the pathogenesis of septic shock.

EVOLUTIONARY BIOINFORMATICS (2021)

Review Biochemistry & Molecular Biology

Copper Concentrations in Breast Cancer: A Systematic Review and Meta-Analysis

Leila Jouybari et al.

CURRENT MEDICINAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer

Anniina Farkkila et al.

NATURE COMMUNICATIONS (2020)

Review Medicine, Research & Experimental

The contribution of copper efflux transporters ATP7A and ATP7B to chemoresistance and personalized medicine in ovarian cancer

David Lukanovic et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Article Physiology

The molecular mechanisms of copper metabolism and its roles in human diseases

Ji Chen et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2020)

Review Medicine, Research & Experimental

Associations between hepatocellular carcinoma risk and rs3212227 and rs568408 polymorphisms: a systematic review and meta-analysis

Cunqing Kong et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)

Review Oncology

Aurora kinases in ovarian cancer

J. Alejandro Perez-Fidalgo et al.

ESMO OPEN (2020)

Review Medicine, General & Internal

Epithelial ovarian cancer

Stephanie Lheureux et al.

LANCET (2019)

Article Oncology

TIP: A Web Server for Resolving Tumor Immunophenotype Profiling

Liwen Xu et al.

CANCER RESEARCH (2018)

Article Multidisciplinary Sciences

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Sanjeev Mariathasan et al.

NATURE (2018)

Review Cell Biology

Mitochondrial metabolism and cancer

Paolo Ettore Porporato et al.

CELL RESEARCH (2018)

Review Immunology

Immune checkpoint inhibition in ovarian cancer

Junzo Hamanishi et al.

INTERNATIONAL IMMUNOLOGY (2016)

Review Biotechnology & Applied Microbiology

A survey of best practices for RNA-seq data analysis

Ana Conesa et al.

GENOME BIOLOGY (2016)

Article Biochemistry & Molecular Biology

The Molecular Signatures Database Hallmark Gene Set Collection

Arthur Liberzon et al.

CELL SYSTEMS (2015)

Article Oncology

Copper Signaling Axis as a Target for Prostate Cancer Therapeutics

Rachid Safi et al.

CANCER RESEARCH (2014)

Review Biochemistry & Molecular Biology

Charting the travels of copper in eukaryotes from yeast to mammals

Tracy Nevitt et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Article Biochemical Research Methods

ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking

Matthew D. Wilkerson et al.

BIOINFORMATICS (2010)

Review Immunology

The PD-1-PD-L pathway in immunological tolerance

T Okazaki et al.

TRENDS IN IMMUNOLOGY (2006)