The versatile role of Serpina3c in physiological and pathological processes: a review of recent studies

Murine Serpina3c belongs to the family of serine protease inhibitors (Serpins), clade A and its human homologue is SerpinA3. Serpina3c is involved in some physiological processes, including insulin secretion and adipogenesis. In the pathophysiological process, the deletion of Serpina3c leads to more severe metabolic disorders, such as aggravated non-alcoholic fatty liver disease (NAFLD), insulin resistance and obesity. In addition, Serpina3c can improve atherosclerosis and regulate cardiac remodeling after myocardial infarction. Many of these processes are directly or indirectly mediated by its inhibition of serine protease activity. Although its function has not been fully revealed, recent studies have shown its potential research value. Here, we aimed to summarize recent studies to provide a clearer view of the biological roles and the underlying mechanisms of Serpina3c.

Automated summary

Murine Serpina3c, a member of the Serpins family, has been shown to play roles in insulin secretion, adipogenesis, and the regulation of metabolic disorders such as NAFLD, insulin resistance, and obesity. Furthermore, Serpina3c has been found to have potential implications in atherosclerosis and cardiac remodeling after myocardial infarction. Its functions are largely mediated by the inhibition of serine protease activity. This article aims to summarize recent studies on Serpina3c to provide a comprehensive understanding of its biological roles and underlying mechanisms.