☆ 4.7 Review

The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases

FRONTIERS IN ENDOCRINOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

Gut Microbiota and Cardiovascular Disease: Symbiosis Versus Dysbiosis

Antonis A. Manolis et al.

Summary: The gut microbiome interacts with the cardiovascular system and dysbiosis can lead to increased risk of cardiovascular diseases. Factors such as altered metabolites, increased gut permeability, and disrupted microbiome content are involved. Therapeutic interventions that promote a healthy microbiome may reduce the incidence of cardiovascular diseases.

CURRENT MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Trimethylamine oxide: a potential target for heart failure therapy

Shichao Lv et al.

Summary: Heart failure is a clinical syndrome in the late stage of cardiovascular disease, and research shows that the gut microbiota metabolite TMAO is associated with adverse outcomes in HF. Lowering TMAO levels may improve the prognosis of HF patients.

HEART (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis

Marco Witkowski et al.

Summary: The study demonstrates that TMAO increases the risk of cardiovascular events and affects platelets and vascular tissue factor TF. Experimental results indicate that TMAO enhances arterial thrombosis potential by inducing the expression of TF and VCAM1.

CARDIOVASCULAR RESEARCH (2022)

添加到收藏夹

Review Gastroenterology & Hepatology

The potential utility of fecal (or intestinal) microbiota transplantation in controlling infectious diseases

Rohma Ghani et al.

Summary: Disruption to the intestinal microbiota increases the risk of infection, and restoring its composition is a potential strategy to mitigate this risk. Fecal microbiota transplantation is currently the major therapeutic approach, with potential use in treating other infectious diseases.

GUT MICROBES (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Emerging Role of the Gut Microbiome in Cardiovascular Disease: Current Knowledge and Perspectives

Panagiotis D. Papadopoulos et al.

Summary: The collection of normal microorganisms in our gut plays a significant role in our health, while dysbiosis in the gut microbial pool has been proven to be crucial in the pathophysiology of various diseases, including cardiovascular disease. In addition to traditional risk factors, research has also highlighted the involvement of gut bacteria and their metabolites in the pathogenesis of CVD.

BIOMEDICINES (2022)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

The heart and gut relationship: a systematic review of the evaluation of the microbiome and trimethylamine-N-oxide (TMAO) in heart failure

Kelley M. Anderson et al.

Summary: There is a growing body of research on the bidirectional relationship between the human gut microbiome and cardiovascular disease, including heart failure. A systematic review on the evaluation and testing of the gut biome in patients with heart failure found that patients with heart failure had lower biodiversity in fecal samples compared to controls. Trimethylamine-N-oxide (TMAO) is associated with the development, severity, and poor outcomes of heart failure.

HEART FAILURE REVIEWS (2022)

添加到收藏夹

Article Nutrition & Dietetics

Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1

Sa Zhou et al.

Summary: This study revealed the mechanistic link between TMAO and atherosclerosis risk, showing that TMAO induces vascular inflammation. It was found that TMAO suppresses the expression of AMPK and SIRT1, while AMPK and SIRT1 play important roles in regulating ROS and inflammation. Glutathione and probiotics can relieve TMAO-induced atherosclerosis.

NUTRIENTS (2022)

添加到收藏夹

Review Nutrition & Dietetics

Gut Microbiota-Derived Metabolites and Cardiovascular Disease Risk: A Systematic Review of Prospective Cohort Studies

Raul Sanchez-Gimenez et al.

Summary: Gut microbiota-derived metabolites, including trimethylamine N-oxide, bile acids, and branched-chain amino acids, are associated with adverse cardiovascular events and cardiovascular disease.

NUTRIENTS (2022)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Vegetarianism, microbiota, and cardiovascular health: looking back, and forward

Amudha Kumar et al.

Summary: Cardiovascular diseases (CVDs) are the leading cause of death globally, and an unhealthy diet is a major modifiable risk factor for CVD. Plant-based diets (PBDs) have been suggested to decrease the incidence of various cardiovascular diseases. This review explores the spectrum of PBDs, their mechanisms for improving cardiovascular health, challenges in dietary intervention studies, and the importance of PBDs for environmental sustainability, climate change, and animal welfare.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2022)

添加到收藏夹

Review Microbiology

Microbial metabolites and heart failure: Friends or enemies?

Xiaofeng Lu et al.

Summary: The gut microbiome has recently been found to be associated with heart failure (HF), a global health issue characterized by cardiac dysfunction. Although the underlying mechanism is still unclear, studies have suggested that microbial metabolites influenced by dietary factors may affect the development of HF. This review focuses on the advances and potential therapeutic targets in HF related to trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), and bile acids (BAs), as well as the potential application of microbial metabolites in HF therapy.

FRONTIERS IN MICROBIOLOGY (2022)

添加到收藏夹

Review Endocrinology & Metabolism

Microbiome Medicine: Microbiota in Development and Management of Cardiovascular Diseases

Yogesh Garg et al.

Summary: The gut microbiome has a significant impact on heart health, with metabolic pathways and interactions with the immune system playing a key role. Alterations in the gut microbiome can lead to cholesterol deposition and damage heart health. By targeting the gut microbiome and regulating metabolic pathways, heart function can be improved and cardiovascular diseases can be prevented.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Trimethylamine N-oxide and its precursors in relation to blood pressure: A mendelian randomization study

Han Wang et al.

Summary: This study utilized Mendelian Randomization to reveal a causal relationship between TMAO and its precursors with blood pressure, suggesting that mediating the generation of TMAO may be beneficial for lowering blood pressure.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Microbiota-derived short-chain fatty acids: Implications for cardiovascular and metabolic disease

Yingdong Lu et al.

Summary: SCFAs play a key role in maintaining intestinal integrity, anti-inflammation, modulating glucolipid metabolism, blood pressure, and activating the gut-brain axis, with recent advances suggesting a promising way to prevent and treat CVDs through controlling SCFAs.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

添加到收藏夹

Article Nutrition & Dietetics

Effects of Gut Microbiota and Metabolites on Heart Failure and Its Risk Factors: A Two-Sample Mendelian Randomization Study

Qiang Luo et al.

Summary: This study used Mendelian randomization analysis to reveal the causal effect of gut microbiota and metabolites on heart failure and its risk factors. The results showed that candida and campylobacter were not associated with higher incidence of heart failure, while increasing concentration of shigella was associated with higher risks of myocarditis and hypertrophic cardiomyopathy. In addition, increased concentration of candida was associated with higher risk of chronic kidney disease, and betaine was associated with higher risks of heart failure and myocardial infarction.

FRONTIERS IN NUTRITION (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Trimethylamine N-Oxide Generated by the Gut Microbiota: Potential Atherosclerosis Treatment Strategies

Botao Zhu et al.

Summary: Cardiovascular diseases, particularly atherosclerotic cardiovascular diseases, are a major global burden. Emerging research on gut microbiota has revealed the significant role of trimethylamine oxide (TMAO), a metabolite from gut microbes, in atherosclerosis. Targeting TMAO may offer potential therapeutic strategies for atherosclerosis.

CURRENT PHARMACEUTICAL DESIGN (2022)

添加到收藏夹

Review Nutrition & Dietetics

Significance of Gut Microbiota and Short-Chain Fatty Acids in Heart Failure

Peng Zhao et al.

Summary: This review primarily focuses on the relationship between the gut microbiota and its major metabolites, such as short-chain fatty acids (SCFAs), and heart failure (HF), aiming to explore effective treatments for HF by targeting SCFAs and improve patients' quality of life.

NUTRIENTS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Diet-gut microbiota interactions on cardiovascular disease

Xufei Zhang et al.

Summary: Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality worldwide. The gut microbiota plays a vital role in CVD development and can be influenced by dietary nutrients. The crosstalk between diet and microbiota regulates CVD progression through various mechanisms, including endotoxemia, inflammation, gut barrier dysfunction, and lipid metabolism dysfunction. Microbial metabolites such as trimethylamine-N-oxide (TMAO), secondary bile acids (BAs), short chain fatty acids (SCFAs), and aromatic amino acids (AAAs) contribute to CVD pathogenesis. Dietary interventions targeting the gut microbiota may serve as novel strategies for CVD management.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2022)

添加到收藏夹

Review Food Science & Technology

The impact of probiotics, prebiotics, and synbiotics on the biochemical, clinical, and immunological markers, as well as on the gut microbiota of obese hosts

Tatiane Ferreira da Silva et al.

Summary: Obesity is considered a global epidemic, with evidence showing that the intestinal microbiota may influence the pathogenesis of obesity. Modifying the composition of the gut microbiota through probiotic, prebiotic, and synbiotic supplementation is seen as a potential treatment option for obese individuals, impacting gene expression, metabolism, and adipose tissue development positively. Further research is needed to fully understand the mechanisms of action of probiotics and prebiotics on human health in relation to obesity.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2021)

添加到收藏夹

Review Medicine, General & Internal

TMAO as a biomarker of cardiovascular events: a systematic review and meta-analysis

Luigina Guasti et al.

Summary: The study indicates a significant association between high TMAO levels and cardiovascular events as well as all-cause mortality, suggesting it may be a new CVD risk factor.

INTERNAL AND EMERGENCY MEDICINE (2021)

添加到收藏夹

Review Microbiology

Gut microbiota in human metabolic health and disease

Yong Fan et al.

Summary: The intestinal microbiota plays a significant role in human metabolic health, potentially contributing to the development of common metabolic disorders when dysregulated. Current research is shifting towards cause-and-effect studies and utilizing high-throughput human multi-omics data to identify potential molecular mechanisms behind these associations.

NATURE REVIEWS MICROBIOLOGY (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Preventive and therapeutic role of betaine in liver disease: A review on molecular mechanisms

Cheng Wang et al.

Summary: Betaine, a water-soluble quaternary amine-type alkaloid found in various foods, has shown to have preventive and therapeutic effects on liver diseases through multiple molecular mechanisms such as inhibiting inflammatory response, improving insulin resistance, reducing endoplasmic reticulum stress, alleviating liver oxidative stress, increasing autophagy, remodeling intestinal flora, and regulating epigenetic modification. Important molecular targets for the improvement of liver diseases by betaine include NF-kappa B, AMPK, PPAR-alpha/gamma, LXR alpha, Akt, TLR4, and Caspase-3 signaling pathways. These findings provide a basis for further research into the pathogenesis of liver diseases and the potential of betaine in clinical treatment.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

添加到收藏夹

Review Nutrition & Dietetics

Role of Gut Microbiota and Their Metabolites on Atherosclerosis, Hypertension and Human Blood Platelet Function: A Review

Asim K. Duttaroy

Summary: Recent data have shown a strong association between gut microbiota and cardiovascular disease risk factors such as atherosclerosis, inflammation, obesity, insulin resistance, platelet hyperactivity, and plasma lipid abnormalities. Targeting gut microbiota and their metabolites may have therapeutic benefits in treating CVD.

NUTRIENTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

New frontiers in flavin-dependent monooxygenases

Renata A. G. Reis et al.

Summary: Flavin-dependent monooxygenases play important roles in biological processes, with recent research focusing on formation of reactive intermediates and catalytic mechanisms. Novel catalysis by different N-oxidases and their relevance to organisms are discussed. Additionally, some FMOs are crucial for the virulence of human pathogens and have biomedical importance in antibiotic resistance.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

添加到收藏夹

Review Peripheral Vascular Disease

Trimethylamine N-Oxide (TMAO), Diet and Cardiovascular Disease

Minu S. Thomas et al.

Summary: The link between plasma TMAO levels and CVD risk is established in epidemiological research, but the role of dietary precursors in determining TMAO levels is still inconclusive. Recent studies show positive associations between plasma TMAO concentrations and various CVD risk factors, but the impact of dietary choline and carnitine on chronic plasma TMAO levels and CVD risk requires further investigation.

CURRENT ATHEROSCLEROSIS REPORTS (2021)

添加到收藏夹

Review Nutrition & Dietetics

Can diet modulate trimethylamine N-oxide (TMAO) production? What do we know so far?

Karen Salve Coutinho-Wolino et al.

Summary: Nutrients and bioactive compounds in food can reduce the production of harmful metabolite TMAO by modulating the gut microbiota and influencing specific enzymes in the liver. However, further clinical studies are needed to evaluate the effectiveness, dosage, and timing of intervention of these dietary components on TMAO levels.

EUROPEAN JOURNAL OF NUTRITION (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Dietary phosphatidylcholine supplementation reduces atherosclerosis in Ldlr-/- male mice2

Paulina Aldana-Hernandez et al.

Summary: Choline is an essential nutrient that plays a role in various biological processes, and the form of dietary choline intake can influence the development of atherosclerosis. Increased intake of phosphatidylcholine in the diet may reduce the risk of atherosclerosis but is associated with higher plasma TMAO levels.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

添加到收藏夹

Article Cell Biology

Fecal Microbiota Transplantation Is a Promising Method to Restore Gut Microbiota Dysbiosis and Relieve Neurological Deficits after Traumatic Brain Injury

Donglin Du et al.

Summary: The study demonstrates that traumatic brain injury alters gut microbiota, while fecal microbiota transplantation can restore dysbiosis and alleviate neurological deficits possibly through the TMA-TMAO-MsrA signaling pathway.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria

Signe Abitz Winther et al.

Summary: In individuals with type 2 diabetes and albuminuria, higher levels of choline, carnitine, and a combined score of the four metabolites in the TMAO pathway were associated with an increased risk of renal function decline, but not with all-cause mortality or cardiovascular disease.

PLOS ONE (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

TMA/TMAO in Hypertension: Novel Horizons and Potential Therapies

Wan-Qin Zhang et al.

Summary: Hypertension, as the most prevalent chronic disease and risk factor for various diseases, has been linked with novel gut microbiota and its metabolites, suggesting potential new interventions for treatment. Further research is needed to explore the relationship between hypertension and TMA/TMAO for clinical applications.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases

Siyu He et al.

Summary: TMA and TMAO, derived from gut microbiota, may be potential risk factors for cardiovascular diseases, with controversial roles and potential involvement of TMA in disease progression. Further exploration of the relationship between TMA, TMAO, and CVD could provide novel insights for diagnosis and therapy.

CARDIOVASCULAR TOXICOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Temporal Course of Plasma Trimethylamine N-Oxide (TMAO) Levels in ST-Elevation Myocardial Infarction

Mohammad A. Almesned et al.

Summary: The gut metabolite TMAO has prognostic value in STEMI patients, and its levels post-PCI fluctuate, which may have prognostic implications for infarct size, especially in patients with impaired renal function.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Article Oncology

Trimethylamine-N-oxide-stimulated hepatocyte-derived exosomes promote inflammation and endothelial dysfunction through nuclear factor-kappa B signaling

Xiang Liu et al.

Summary: Research shows that TMAO can stimulate hepatocytes to release Exos that induce inflammation and cell apoptosis, impair cell migration, and inhibit endothelium-dependent vasodilation in VECs. The miRNAs carried by these TMAO-Exos are different from those in the TMAO-free group, potentially targeting genes involved in inflammation and endothelial function. Activation of the NF-Kappa B signaling pathway by TMAO-Exos is also observed.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Review Urology & Nephrology

Activation of AQP2 water channels by protein kinase A: therapeutic strategies for congenital nephrogenic diabetes insipidus

Fumiaki Ando

Summary: Congenital nephrogenic diabetes insipidus is primarily caused by mutations in the vasopressin type 2 receptor, resulting in impaired water reabsorption and polyuria. Current treatments are not effective in reducing excessive urine excretion. Research suggests that disrupting the AKAP-PKA interaction may provide a promising therapeutic strategy for this condition.

CLINICAL AND EXPERIMENTAL NEPHROLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide

Woongjae Yoo et al.

Summary: It was found that chronic exposure to a high-fat diet can increase levels of circulating trimethlamine N-oxide, a potentially harmful metabolite generated by gut microbiota.

SCIENCE (2021)

添加到收藏夹

Article Microbiology

Higher Trimethylamine-N-Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria

Silke Rath et al.

Summary: The gut microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) is associated with an increased risk for cardiovascular diseases. While meat intake did not directly predict TMAO plasma levels, it was linked to TMA-forming bacteria. Additionally, advancing age was strongly associated with TMAO levels, demonstrating a functional role of gut microbiota in the aging process.

MSYSTEMS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Angiotensin II and the Cardiac Parasympathetic Nervous System in Hypertension

Julia Shanks et al.

Summary: The RAAS plays a critical role in modulating the parasympathetic nervous system, particularly in the context of hypertension. Ang II influences cardiovascular homeostasis by regulating vagal activity. The inhibitory effect on cardiac vagal tone by RAAS and the impact of Ang II on arterial baroreflex function are important areas of research.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Medical Laboratory Technology

Trimethylamine N-Oxide is Associated with Heart Failure Risk in Patients with Preserved Ejection Fraction

Zengxiang Dong et al.

Summary: The level of TMAO is closely associated with the risk of HFpEF and is an independent risk factor in patients with HFpEF. TMAO is also correlated with BUN, creatinine, and NT-proBNP in HFpEF patients.

LABORATORY MEDICINE (2021)

添加到收藏夹

Article Medical Laboratory Technology

Trimethylamine N-Oxide is Associated with Heart Failure Risk in Patients with Preserved Ejection Fraction

Zengxiang Dong et al.

Summary: The study confirmed significantly elevated plasma levels of TMAO in HFpEF patients compared to controls, and identified a relationship between TMAO and HFpEF risk.

LABORATORY MEDICINE (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family

Jingjing Du et al.

Summary: Betaine can prevent obesity and metabolic syndrome by improving gut microbiota dysbiosis. Akkermansia muciniphila plays a crucial role in regulating the effects of betaine and increasing strains that produce short-chain fatty acids (SCFAs).

GUT MICROBES (2021)

添加到收藏夹

Review Nutrition & Dietetics

The Gut Microbial Metabolite Trimethylamine N-Oxide and Hypertension Risk: A Systematic Review and Dose-Response Meta-analysis

Xinyu Ge et al.

ADVANCES IN NUTRITION (2020)

添加到收藏夹

Review Nutrition & Dietetics

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

Estefania Sanchez-Rodriguez et al.

NUTRIENTS (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Trimethylamine N-oxide and cardiovascular outcomes in patients with chronic heart failure after myocardial infarction

Xiang Zhou et al.

ESC HEART FAILURE (2020)

添加到收藏夹

Article Microbiology

Potential TMA-Producing Bacteria Are Ubiquitously Found in Mammalia

Silke Rath et al.

FRONTIERS IN MICROBIOLOGY (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

The Gut Axis Involvement in Heart Failure Focus on Trimethylamine N-oxide

Andrea Salzano et al.

HEART FAILURE CLINICS (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Destructive Role of TMAO in T-Tubule and Excitation-Contraction Coupling in the Adult Cardiomyocytes

Bu Jin et al.

INTERNATIONAL HEART JOURNAL (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Plasma Trimethylamine N-Oxide and Risk of Cardiovascular Events in Patients With Type 2 Diabetes

Mikael Croyal et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

添加到收藏夹

Review Nutrition & Dietetics

Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis

Mohammed Iddir et al.

NUTRIENTS (2020)

添加到收藏夹

Article Microbiology

Gut microbiota-derived indole 3-propionic acid protects against radiation toxicity via retaining acyl-CoA-binding protein

Hui-wen Xiao et al.

MICROBIOME (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Targeting the human microbiome and its metabolite TMAO in cardiovascular prevention and therapy

Lisa Dannenberg et al.

PHARMACOLOGY & THERAPEUTICS (2020)

添加到收藏夹

Review Cell Biology

The Tubulin Code in Microtubule Dynamics and Information Encoding

Antonina Roll-Mecak

DEVELOPMENTAL CELL (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Focus on the Role of NLRP3 Inflammasome in Diseases

Roberta Fusco et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

The Association between Trimethylamine N-Oxide and Its Predecessors Choline, L-Carnitine, and Betaine with Coronary Artery Disease and Artery Stenosis

Fei Guo et al.

CARDIOLOGY RESEARCH AND PRACTICE (2020)

添加到收藏夹

Review Nutrition & Dietetics

The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases

Natalia Arias et al.

NUTRIENTS (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

Kelly S. Swanson et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

添加到收藏夹

Review Cell Biology

Implication of Gut Microbiota in Cardiovascular Diseases

Wenyi Zhou et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

添加到收藏夹

Review Nutrition & Dietetics

Gut Microbiota in Hypertension and Atherosclerosis: A Review

Barbara J. H. Verhaar et al.

NUTRIENTS (2020)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019 Update From the GBD 2019 Study

Gregory A. Roth et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

添加到收藏夹

Review Microbiology

Human gut microbiota/microbiome in health and diseases: a review

Eman Zakaria Gomaa

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Trimethylamine-N-oxide (TMAO) increased aquaporin-2 expression in spontaneously hypertensive rats

Min Liu et al.

CLINICAL AND EXPERIMENTAL HYPERTENSION (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Effects of Probiotic Supplementation on Trimethylamine-N-Oxide Plasma Levels in Hemodialysis Patients: a Pilot Study

Natalia A. Borges et al.

PROBIOTICS AND ANTIMICROBIAL PROTEINS (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis

Zehua Li et al.

LABORATORY INVESTIGATION (2019)

添加到收藏夹

Review Endocrinology & Metabolism

Heart failure in the patient with diabetes: Epidemiology, aetiology, prognosis, therapy and the effect of glucose-lowering medications

David S. H. Bell et al.

DIABETES OBESITY & METABOLISM (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Utility of Plasma Concentration of Trimethylamine N-Oxide in Predicting Cardiovascular and Renal Complications in Individuals With Type 1 Diabetes

Signe A. Winther et al.

DIABETES CARE (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Duration and life-stage of antibiotic use and risk of cardiovascular events in women

Yoriko Heianza et al.

EUROPEAN HEART JOURNAL (2019)

添加到收藏夹

Article Medicine, General & Internal

Gut microbe-derived metabolite trimethylamine N-oxide activates the cardiac autonomic nervous system and facilitates ischemia-induced ventricular arrhythmia via two different pathways

Guannan Meng et al.

EBIOMEDICINE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction

Gurinder Bir Singh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Clinical Neurology

Gut Microbiota and Ischemic Stroke: The Role of Trimethylamine N-Oxide

Hyo Suk Nam

JOURNAL OF STROKE (2019)

添加到收藏夹

Article Medicine, General & Internal

Gut Microbial Metabolite Trimethylamine N-Oxide Is Related to Thrombus Formation in Atrial Fibrillation Patients

Dingxu Gong et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2019)

添加到收藏夹

Article Physiology

Trimethylamine N-Oxide Exacerbates Cardiac Fibrosis via Activating the NLRP3 Inflammasome

Xueling Li et al.

FRONTIERS IN PHYSIOLOGY (2019)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Amelioration of TMAO through probiotics and its potential role in atherosclerosis

Ahmad Ud Din et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2019)

添加到收藏夹

Article Medicine, Research & Experimental

L-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans

Robert A. Koeth et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

添加到收藏夹

Review Gastroenterology & Hepatology

Methods for Studying Gut Microbiota: A Primer for Physicians

Aditya N. Sarangi et al.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Trimethylamine N-Oxide, Circulating Endothelial Progenitor Cells, and Endothelial Function in Patients with Stable Angina

Ruey-Hsing Chou et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Review Clinical Neurology

Anxiety, Depression, and the Microbiome: A Role for Gut Peptides

Gilliard Lach et al.

NEUROTHERAPEUTICS (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Same Substrate, Many Reactions: Oxygen Activation in Flavoenzymes

Elvira Romero et al.

CHEMICAL REVIEWS (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Increased plasma trimethylamine-N-oxide is associated with incident atrial fibrillation

Gard F. T. Svingen et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2018)

添加到收藏夹

Article Hematology

Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk

W. Zhu et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2018)

添加到收藏夹

Article Biochemical Research Methods

Methodological considerations for the identification of choline and carnitine-degrading bacteria in the gut

Eleanor Jameson et al.

METHODS (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Trimethylamine-N-Oxide (TMAO)-Induced Impairment of Cardiomyocyte Function and the Protective Role of Urolithin B-Glucuronide

Monia Savi et al.

MOLECULES (2018)

添加到收藏夹

Article Medicine, General & Internal

Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts

R. Estruch et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Treatment of hypertension: The ESH/ESC guidelines recommendations

Cesare Cuspidi et al.

PHARMACOLOGICAL RESEARCH (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Innate and adaptive immunity in atherosclerosis

Kapka Miteva et al.

VASCULAR PHARMACOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Probiotic supplementation and associated infant gut microbiome and health: a cautionary retrospective clinical comparison

C. Quin et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Nutrition & Dietetics

Plasma concentration of trimethylamine-N-oxide and risk of gestational diabetes mellitus

Peiyun Li et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2018)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions

Paolo Raggi et al.

ATHEROSCLEROSIS (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential

Adam B. Roberts et al.

NATURE MEDICINE (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Trimethylamine N-Oxide: A Link among Diet, Gut Microbiota, Gene Regulation of Liver and Intestine Cholesterol Homeostasis and HDL Function

Marina Canyelles et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Review Medicine, Research & Experimental

Interaction between gut microbiome and cardiovascular disease

Jieting Peng et al.

LIFE SCIENCES (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism

Lin Ding et al.

LIPIDS IN HEALTH AND DISEASE (2018)

添加到收藏夹

Review Nutrition & Dietetics

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

Manuel H. Janeiro et al.

NUTRIENTS (2018)

添加到收藏夹

Review Nutrition & Dietetics

Dietary Choline Intake: Current State of Knowledge Across the Life Cycle

Alejandra M. Wiedeman et al.

NUTRIENTS (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Targeting Calpain for Heart Failure Therapy Implications From Multiple Murine Models

Yihui Wang et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors

Xinmin S. Li et al.

EUROPEAN HEART JOURNAL (2017)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis

Gabriele Giacomo Schiattarella et al.

EUROPEAN HEART JOURNAL (2017)

添加到收藏夹

Article Endocrinology & Metabolism

Gut microbiota and obesity: implications for fecal microbiota transplantation therapy

Hormones-International Journal of Endocrinology and Metabolism (2017)

添加到收藏夹

Article Medicine, Research & Experimental

Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis

Hadi Khalil et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite

Kinga Jaworska et al.

PLOS ONE (2017)

添加到收藏夹

Article Toxicology

Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria

Marina Makrecka-Kuka et al.

TOXICOLOGY LETTERS (2017)

添加到收藏夹

Review Endocrinology & Metabolism

Trimethylamine-N-Oxide: Friend, Foe, or Simply Caught in the Cross-Fire?

Clara E. Cho et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)

添加到收藏夹

Review Nutrition & Dietetics

Bridging the Gap between Gut Microbial Dysbiosis and Cardiovascular Diseases

Kimberley Lau et al.

NUTRIENTS (2017)

添加到收藏夹

Article Physiology

Trimethylamine N-oxide Supplementation Abolishes the Cardioprotective Effects of Voluntary Exercise in Mice Fed a Western Diet

Hongqi Zhang et al.

FRONTIERS IN PHYSIOLOGY (2017)

添加到收藏夹

Article Physiology

Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide Contributes to Cardiac Dysfunction in Western Diet-Induced Obese Mice

Kui Chen et al.

FRONTIERS IN PHYSIOLOGY (2017)

添加到收藏夹

Article Physiology

Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress

Tiejun Li et al.

FRONTIERS IN PHYSIOLOGY (2017)

添加到收藏夹

Article Microbiology

Gut microbiota dysbiosis contributes to the development of hypertension

Jing Li et al.

MICROBIOME (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Interaction of IL-6 and TNF-α contributes to endothelial dysfunction in type 2 diabetic mouse hearts

Jonghae Lee et al.

PLOS ONE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Impaired renal function and dysbiosis of gut microbiota contribute to increased trimethylamine-N-oxide in chronic kidney disease patients

Kai-Yu Xu et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function

Eke G. Gruppen et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

Trimethylamine N-oxide (TMAO) as a New Potential Therapeutic Target for Insulin Resistance and Cancer

Jens Oellgaard et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Enterobacter aerogenes ZDY01 Attenuates Choline-Induced Trimethylamine N-Oxide Levels by Remodeling Gut Microbiota in Mice

Liang Qiu et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

Antibiotic use and microbiome function

Manuel Ferrer et al.

BIOCHEMICAL PHARMACOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Trimethylamine N-oxide in atherogenesis: impairing endothelial self-repair capacity and enhancing monocyte adhesion

GuoHua Ma et al.

BIOSCIENCE REPORTS (2017)

添加到收藏夹

Review Immunology

Role of intestinal microbiota and metabolites on gut homeostasis and human diseases

Lan Lin et al.

BMC IMMUNOLOGY (2017)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure

Chelsea L. Organ et al.

CIRCULATION-HEART FAILURE (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

Xiaolei Sun et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

HDL functionality in reverse cholesterol transport - Challenges in translating data emerging from mouse models to human disease

Miriam Lee-Rueckert et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

Weifei Zhu et al.

CELL (2016)

添加到收藏夹

Article Cell Biology

TNF-α Activates High-Mobility Group Box 1-Toll-Like Receptor 4 Signaling Pathway in Human Aortic Endothelial Cells

Won Seok Yang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Inflammatory cytokines in atherosclerosis: current therapeutic approaches

Dimitris Tousoulis et al.

EUROPEAN HEART JOURNAL (2016)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Trimethylamine N-oxide and prognosis in acute heart failure

Toru Suzuki et al.

HEART (2016)

添加到收藏夹

Article Gastroenterology & Hepatology

Novel Strategies for Applied Metagenomics

Jessica M. Moore-Connors et al.

INFLAMMATORY BOWEL DISEASES (2016)

添加到收藏夹

Article Microbiology

Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota

Ming-liang Chen et al.

MBIO (2016)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB

Marcus M. Seldin et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)

添加到收藏夹

Review Medicine, Research & Experimental

The Gut Microbial Endocrine Organ: Bacterially Derived Signals Driving Cardiometabolic Diseases

J. Mark Brown et al.

ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

Zeneng Wang et al.

CELL (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Hypertension Renin-Angiotensin-Aldosterone System Alterations

Luuk te Riet et al.

CIRCULATION RESEARCH (2015)

添加到收藏夹

Article Peripheral Vascular Disease

Gut Dysbiosis Is Linked to Hypertension

Tao Yang et al.

HYPERTENSION (2015)

添加到收藏夹

Letter Cardiac & Cardiovascular Systems

Probiotic therapy with Saccharomyces boulardii for heart failure patients: A randomized, double-blind, placebo-controlled pilot trial

Annelise C. Costanza et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Clarithromycin for stable coronary heart disease increases all-cause and cardiovascular mortality and cerebrovascular morbidity over 10 years in the CLARICOR randomised, blinded clinical trial

Per Winkel et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2015)

添加到收藏夹

Review Nutrition & Dietetics

TMAO: A small molecule of great expectations

Marcin Ufnal et al.

NUTRITION (2015)

添加到收藏夹

Review Medicine, General & Internal

Hyponatremia Associated with Heart Failure: Pathological Role of Vasopressin-Dependent Impaired Water Excretion

San-e Ishikawa

JOURNAL OF CLINICAL MEDICINE (2015)

添加到收藏夹

Article Medicine, General & Internal

Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure

M. Troseid et al.

JOURNAL OF INTERNAL MEDICINE (2015)

添加到收藏夹

Review Surgery

Influence of Intestinal Microbiota on Body Weight Gain: a Narrative Review of the Literature

Camila S. Cardinelli et al.

OBESITY SURGERY (2015)

添加到收藏夹

Review Immunology

Cholesterol, inflammation and innate immunity

Alan R. Tall et al.

NATURE REVIEWS IMMUNOLOGY (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

W. H. Wilson Tang et al.

CIRCULATION RESEARCH (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Variable t-tubule organization and Ca2+ homeostasis across the atria

Michael Frisk et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2014)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Trimethylamine-N-Oxide: A Carnitine-Derived Metabolite That Prolongs the Hypertensive Effect of Angiotensin II in Rats

Marcin Ufnal et al.

CANADIAN JOURNAL OF CARDIOLOGY (2014)

添加到收藏夹

Article Cell Biology

γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L-Carnitine to TMAO

Robert A. Koeth et al.

CELL METABOLISM (2014)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Probiotic Administration Attenuates Myocardial Hypertrophy and Heart Failure After Myocardial Infarction in the Rat

Xiaohong Tracey Gan et al.

CIRCULATION-HEART FAILURE (2014)

添加到收藏夹

Article Endocrinology & Metabolism

The Relationships Between Cardiovascular Disease and Diabetes: Focus on Pathogenesis

Jason C. Kovacic et al.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO)

Jianqiang Ma et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Cell Biology

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

Brian J. Bennett et al.

CELL METABOLISM (2013)

添加到收藏夹

Article Endocrinology & Metabolism

Endoplasmic Reticulum Stress Plays a Key Role in the Pathogenesis of Diabetic Peripheral Neuropathy

Sergey Lupachyk et al.

DIABETES (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

Robert A. Koeth et al.

NATURE MEDICINE (2013)

添加到收藏夹

Article Medicine, General & Internal

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

W. H. Wilson Tang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

添加到收藏夹

Article Gastroenterology & Hepatology

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

Anne Vrieze et al.

GASTROENTEROLOGY (2012)

添加到收藏夹

Review Multidisciplinary Sciences

Reciprocal interactions of the intestinal microbiota and immune system

Craig L. Maynard et al.

NATURE (2012)

添加到收藏夹

Review Cell Biology

Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery

Ting Gui et al.

MEDIATORS OF INFLAMMATION (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Diabetic HDL Is Dysfunctional in Stimulating Endothelial Cell Migration and Proliferation Due to Down Regulation of SR-BI Expression

Bing Pan et al.

PLOS ONE (2012)

添加到收藏夹

Review Gastroenterology & Hepatology

The bile salt export pump (BSEP) in health and disease

Ralf Kubitz et al.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Zeneng Wang et al.

NATURE (2011)

添加到收藏夹

Review Microbiology

Unravelling the effects of the environment and host genotype on the gut microbiome

Ayme Spor et al.

NATURE REVIEWS MICROBIOLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Qin et al.

NATURE (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

The NIH Human Microbiome Project

Jane Peterson et al.

GENOME RESEARCH (2009)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.