Vitamin D improves hepatic steatosis in NAFLD via regulation of fatty acid uptake and β-oxidation

Article Gastroenterology & Hepatology

Inverse Association Between Serum 25-Hydroxyvitamin D and Nonalcoholic Fatty Liver Disease

Shuai Yuan et al.

Summary: This study conducted a bidirectional Mendelian randomization to explore the association between serum 25-hydroxyvitamin D and NAFLD. It found that increased vitamin D levels may play a role in preventing NAFLD in European populations.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2023)

添加到收藏夹

Editorial Material Gastroenterology & Hepatology

Gut-specific inhibition of PPARα as a novel approach of NAFLD treatment

Lanjing Zhang et al.

HEPATOLOGY (2023)

添加到收藏夹

Editorial Material Gastroenterology & Hepatology

NAFLD, MAFLD and obesity: brothers in arms?

Mariana Verdelho Machado et al.

Summary: The year 2022 witnessed significant progress in both the NAFLD and obesity fields. Advancements in pharmacological treatment offer the potential for replacing bariatric surgery, while the application of artificial intelligence helps in evaluating histological effects of new drugs. Moreover, personalized screening for hepatocellular carcinoma in patients with NAFLD has also seen improvement.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2023)

添加到收藏夹

Review Immunology

Obesity and dysregulated innate immune responses: impact of micronutrient deficiencies

Frank Vrieling et al.

Summary: Obesity is linked to complications such as diabetes, atherosclerosis, and increased infection risk due to dysfunctional innate immune responses. Nutrient availability plays a crucial role in innate immune cell function. While obesity is associated with overnutrition of macronutrients, deficiencies in micronutrients like Vitamin D and zinc are common. Micronutrients have important immunomodulatory roles, which are explored in this review. Future research is needed to enhance understanding of these micronutrients and explore their supplementation in improving innate immune cell function during obesity.

TRENDS IN IMMUNOLOGY (2023)

添加到收藏夹

Review Endocrinology & Metabolism

Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD)

Li Rong et al.

Summary: Non-alcoholic fatty liver disease (NAFLD), now renamed as metabolic (dysfunction) associated with fatty liver disease (MAFLD), is a series of diseases characterized by excessive lipid deposition in the liver and often accompanied by obesity, diabetes, dyslipidemia, abnormal blood pressure, and other metabolic disorders. While changes in diet and lifestyle are recognized as non-drug treatment strategies, current drug therapies mainly target the pathogenic factors, key links of pathogenesis, and related metabolic disorders of NAFLD. There is still a lack of specific drugs, but treatments based on the enterohepatic axis, targeting gut microbiota, and new metabolism-regulating drugs are emerging.

FRONTIERS IN ENDOCRINOLOGY (2023)

添加到收藏夹

Review Endocrinology & Metabolism

MAFLD: a multisystem disease

Rosaria Maria Pipitone et al.

Summary: Nonalcoholic fatty liver disease (NAFLD), affecting a significant portion of both general and dysmetabolic populations, is an emerging cause of chronic liver disease and its complications. A recently proposed name for this disease, Metabolic dysfunction-Associated Fatty Liver Disease (MAFLD), highlights the bidirectional interplay between fatty liver and metabolic alterations, and emphasizes the need to assess fatty liver independently from other causes of liver disease. The peculiarity of NAFLD/MAFLD lies in its association with not only liver-related events, but also extrahepatic events, particularly cardiovascular and cancer-related. This review summarizes the available evidence supporting NAFLD/MAFLD as a multisystemic disease and explores the potential mechanisms underlying its association with extrahepatic disorders.

THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM (2023)

添加到收藏夹

Review Endocrinology & Metabolism

Epidemiological characteristics and management of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in China: A narrative review

Ran Lu et al.

Summary: With the rapid industrialization and westernized lifestyle in China, the prevalence of non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) is significantly increasing, posing a major public health concern. This narrative review aims to provide an overview of the burden and characteristics of NAFLD/NASH in China by analyzing relevant literature.

DIABETES OBESITY & METABOLISM (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARα Activation in Rats Fed High-Fat Diet

Wenwen Shen et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease characterized by an imbalance of lipogenesis and lipid catabolism. Peroxiredoxin 6 (PRDX6) has been found to play a role in the pathogenesis and progression of NAFLD, but its role in liver lipid catabolism is not well understood.

ANTIOXIDANTS & REDOX SIGNALING (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Liver-derived metabolites as signaling molecules in fatty liver disease

Umur Keles et al.

Summary: Excessive fat accumulation in the liver is a major health threat globally, with unresolved deposition leading to various diseases. The interaction between metabolites released from the liver and other organs plays a crucial role in the development of fatty liver disease.

CELLULAR AND MOLECULAR LIFE SCIENCES (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Uncoupling proteins: are they involved in vitamin D3 protective effect against high-fat diet-induced cardiac apoptosis in rats?

Zienab Alrefaie et al.

Summary: This study assessed the effects of high-fat diet (HFD) and vitamin D3 supplementation on cardiac apoptosis, inflammation, oxidative stress, and cardiac uncoupling proteins (UCPs) 2&3 expression. The findings indicate that HFD increases cardiomyocyte apoptosis, inflammation, and oxidative burden on the heart, while vitamin D3 supplementation mitigates these effects through downregulation of UCP3 expression.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Vitamin D-3 enhances the effects of omega-3 oils against metabolic dysfunction-associated fatty liver disease in rat

Bassem Refaat et al.

Summary: This study found that omega-3 oils and/or vitamin D-3 could alleviate metabolic dysfunction-associated fatty liver disease, with omega-3 oils showing better effects as compared to vitamin D-3 monotherapy, while the combination therapy group displayed the greatest improvements.

BIOFACTORS (2022)

添加到收藏夹

Article Nutrition & Dietetics

Safety and tolerability of high-dose daily vitamin D3 supplementation in the vitamin D and type 2 diabetes (D2d) study-a randomized trial in persons with prediabetes

Karen C. Johnson et al.

Summary: This study assessed the safety and tolerability of high-dose daily vitamin D3 supplementation. The results showed that in a high-risk population for diabetes who were appropriately monitored for safety, 4000 IU per day of vitamin D3 supplementation was safe and well tolerated, without increasing the risk of adverse events or serious adverse events.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Vitamin D3 Treatment Alters Thyroid Functional Morphology in Orchidectomized Rat Model of Osteoporosis

Branka Sosic-Jurjevic et al.

Summary: Vitamin D and thyroid hormones play essential roles in the prevention and treatment of osteoporosis, but there is currently no data about a possible connection between vitamin D treatment and the thyroid in the context of osteoporosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Chemistry, Medicinal

Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis

Zhiqi Feng et al.

Summary: This study reports a series of novel triazolone derivatives as PPAR alpha/delta dual agonists, with compound H11 showing potent and well-balanced PPAR alpha/delta agonistic activity. H11 also exhibited strong anti-NASH effects in preclinical models, indicating its potential for treating NASH and other inflammatory and fibrotic diseases.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Effect of serum vitamin D on metabolic associated fatty liver disease: a large population-based study

Yaqi Guan et al.

Summary: This study found a nonlinear relationship between serum vitamin D and metabolic associated fatty liver disease (MAFLD). A negative correlation between serum vitamin D and MAFLD was detected when the serum vitamin D level was ≥ 44.6 nmol/L, while below this level, serum vitamin D might promote the progression of MAFLD.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis

Chanbin Lee et al.

Summary: The prevalence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is higher in men than premenopausal women. This study demonstrates that formyl peptide receptor 2 (FPR2) levels are regulated by estrogen, and that FPR2 contributes to NAFLD resistance in female mice.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Review Endocrinology & Metabolism

Non-alcoholic fatty liver disease and type 2 diabetes: An update

Chi-H Lee et al.

Summary: The global prevalence of non-alcoholic fatty liver disease (NAFLD) is rising and is closely related to type 2 diabetes. Recent studies have shown the detrimental impact of type 2 diabetes on liver-related diseases and mortality, as well as the negative effect of NAFLD on type 2 diabetes and associated adverse clinical outcomes. Clinical care pathways and guidelines have been developed to tackle these health threats. Several antidiabetic agents have shown promising results in hepatic benefits. However, lack of awareness of this problem remains a major challenge, especially among clinicians outside the field of hepatology and gastroenterology.

JOURNAL OF DIABETES INVESTIGATION (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Empirically derived dietary pattern and odds of non-alcoholic fatty liver diseases in overweight and obese adults: a case-control study

Nasir Talenezhad et al.

Summary: This study investigated the relationship between dietary patterns and non-alcoholic fatty liver disease (NAFLD) in overweight and obese adults. The results showed that the western dietary pattern, which includes fast food, refined grains, liquid oil, pickles, high-fat dairy, sweet desserts, red meat, tea, and coffee, was associated with an increased risk of NAFLD.

BMC GASTROENTEROLOGY (2022)

添加到收藏夹

Article Endocrinology & Metabolism

American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD)

Kenneth Cusi et al.

Summary: This article provides evidence-based recommendations for the diagnosis and management of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) for endocrinologists, primary care clinicians, and other stakeholders. The guideline includes 34 evidence-based clinical practice recommendations and contains relevant citations.

ENDOCRINE PRACTICE (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Resolution of, and Risk of Incident Non-alcoholic Fatty Liver Disease With Changes in Serum 25-hydroxy Vitamin D Status

Yejin Kim et al.

Summary: This retrospective cohort study found that maintaining adequate serum 25(OH)D concentrations may be beneficial for both the prevention and resolution of NAFLD.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

添加到收藏夹

Editorial Material Gastroenterology & Hepatology

Metabolic and genetic contributions to NAFLD: Really distinct and homogeneous?

Elizabeth K. Speliotes et al.

JOURNAL OF HEPATOLOGY (2022)

添加到收藏夹

Article Nutrition & Dietetics

L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKβ-AMPK signaling pathway

Juanjuan Liang et al.

Summary: L-theanine alleviates nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKK beta-AMPK signaling pathway.

NUTRITION & METABOLISM (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Additional treatment of vitamin D for improvement of insulin resistance in non-alcoholic fatty liver disease patients: a systematic review and meta-analysis

Dwijo Anargha Sindhughosa et al.

Summary: Vitamin D supplementation has beneficial effects on improving insulin resistance in NAFLD patients, as evidenced by reduced HOMA-IR and ALT levels, but no significant effect on AST levels.

SCIENTIFIC REPORTS (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Vitamin D and Beta Cells in Type 1 Diabetes: A Systematic Review

Josephine Yu et al.

Summary: The prevalence of type 1 diabetes is rising steadily and vitamin D may contribute to this increase. This systematic review examined studies on vitamin D and type 1 diabetes, finding strong associations between low vitamin D levels and type 1 diabetes. Animal studies and human trials also suggest that vitamin D treatment or supplementation can be beneficial in reducing the risk of type 1 diabetes. Maintaining optimal circulating 25-hydroxyvitamin D levels may help to prevent or delay the development of type 1 diabetes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Genetic and Diet-Induced Animal Models for Non-Alcoholic Fatty Liver Disease (NAFLD) Research

Christina-Maria Flessa et al.

Summary: Due to the adoption of western-type lifestyles and eating habits, the incidence of non-alcoholic fatty liver disease (NAFLD) has been rapidly increasing worldwide. This highlights the need to understand the molecular mechanisms driving the pathogenesis of this chronic disease and develop new approved treatments. Animal models play a crucial role in achieving these goals. Although there is no perfect mouse model for human NAFLD yet, several models have been developed through dietary interventions, genetic manipulations, and/or administration of chemical substances. In this article, we present the most commonly used mouse models in NAFLD research, for the entire disease spectrum or for specific stages. We also discuss the advantages and disadvantages of each model, as well as the challenges faced by researchers aiming to develop and use animal models for translational research in NAFLD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Obesity-Associated Vitamin D Deficiency Correlates with Adipose Tissue DNA Hypomethylation, Inflammation, and Vascular Dysfunction

Imaduddin Mirza et al.

Summary: The study suggests that vitamin D deficiency may contribute to adipokine hypomethylation, inflammation, and vascular dysfunction in obesity. Higher degrees of deficiency are associated with lower DNA methylation and increased expression of inflammatory adipokines. Additionally, moderate and severe deficiency are correlated with impaired vascular reactivity and increased arterial stiffness.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Endocrinology & Metabolism

The association between major dietary patterns with the risk of non-alcoholic fatty liver disease, oxidative stress and metabolic parameters: A case-control study

Fateme Moradi et al.

Summary: This study found a significant relationship between dietary patterns and non-alcoholic fatty liver disease. Adherence to a western dietary pattern is associated with an increase in the odds of non-alcoholic fatty liver disease, while adherence to a healthy dietary pattern is associated with a lower odds of non-alcoholic fatty liver disease.

JOURNAL OF DIABETES AND METABOLIC DISORDERS (2022)

添加到收藏夹

Article Public, Environmental & Occupational Health

Long-term drinking behavior change patterns and its association with hyperuricemia in chinese adults: evidence from China Health and Nutrition Survey

Bowen Zhu et al.

Summary: The change patterns of quitting and continued drinking in males are strongly associated with increased risks of hyperuricemia. Early drinking behaviors such as liquor intake, high drinking frequency, and alcohol consumption are positively correlated with hyperuricemia. There was no statistical correlation observed between drinking behaviors and hyperuricemia in females.

BMC PUBLIC HEALTH (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review

Aunchalee Jaroenlapnopparat et al.

Summary: This study aimed to investigate the association of vitamin D-related genetic variations with nonalcoholic fatty liver disease (NAFLD). The results revealed multiple genetic variations associated with NAFLD, highlighting the importance of vitamin D in the pathogenesis of this disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Microbiology

Yinchen Linggui Zhugan decoction ameliorates high fat diet-induced nonalcoholic fatty liver disease by modulation of SIRT1/Nrf2 signaling pathway and gut microbiota

Hui Jiang et al.

Summary: Yinchen Linggui Zhugan decoction (YLZD) can ameliorate HFD-induced NAFLD in rats by modulating the SIRT1/Nrf2 signaling pathway and gut microbiota.

FRONTIERS IN MICROBIOLOGY (2022)

添加到收藏夹

Article Nutrition & Dietetics

The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial

May M. Cheung et al.

Summary: This study found that combined magnesium and vitamin D treatment may be more effective in increasing serum 25OHD concentrations compared to vitamin D supplementation alone in overweight and obese individuals, and it also has the potential to lower baseline systolic blood pressure.

NUTRITION (2022)

添加到收藏夹

Review Medicine, General & Internal

Mechanistic insights into the peroxisome proliferator-activated receptor alpha as a transcriptional suppressor

Tomoki Yagai et al.

Summary: NAFLD is a common liver disease characterized by excessive lipid accumulation in the liver, which can progress to NASH, leading to liver dysfunction and fibrosis. Studies have shown that PPAR alpha plays a key role in hepatic lipid metabolism and its agonists may be novel drugs for treating NASH.

FRONTIERS IN MEDICINE (2022)

添加到收藏夹

Article Nutrition & Dietetics

Specific Strains of Faecalibacterium prausnitzii Ameliorate Nonalcoholic Fatty Liver Disease in Mice in Association with Gut Microbiota Regulation

Wenbing Hu et al.

Summary: This study found that certain strains of F. prausnitzii can significantly improve symptoms of NAFLD in mice and regulate the gut microbiota. These strains enhance the production of short-chain fatty acids, modulate specific microbial communities, and alter related metabolic pathways, suggesting their potential therapeutic effects on NAFLD.

NUTRIENTS (2022)

添加到收藏夹

Review Nutrition & Dietetics

Vitamin D and Visceral Obesity in Humans: What Should Clinicians Know?

Prapimporn Chattranukulchai Shantavasinkul et al.

Summary: The effects of vitamin D on adipose tissue biology and modulation in human obesity are still inconclusive. While the anti-inflammatory effects of vitamin D are evident and consistent, its effects on adipocyte differentiation, adipogenesis, energy metabolism, and adipokine levels remain uncertain.

NUTRIENTS (2022)

添加到收藏夹

Article Nutrition & Dietetics

Ferulic Acid Prevents Nonalcoholic Fatty Liver Disease by Promoting Fatty Acid Oxidation and Energy Expenditure in C57BL/6 Mice Fed a High-Fat Diet

Zhixin Luo et al.

Summary: Ferulic acid (FA) has a protective effect on high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) by activating PPARα to decrease triacylglycerol accumulation and increase energy expenditure.

NUTRIENTS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Baicalein Prevents Fructose-Induced Hepatic Steatosis in Rats: In the Regulation of Fatty Acid De Novo Synthesis, Fatty Acid Elongation and Fatty Acid Oxidation

Pan Li et al.

Summary: Baicalein (BAL), a compound extracted from Traditional Chinese Medicine, has potential therapeutic effects for liver diseases. The study found that BAL improved fructose-induced hepatic steatosis by regulating fatty acid synthesis, elongation, and oxidation.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Article Genetics & Heredity

Effect of Aerobic Exercise on Lipid Metabolism in Rats With NAFLD

Tongxi Zhou et al.

Summary: This study aimed to investigate the intervention effect of exercise on lipid metabolism in NAFLD rats. The results showed that moderate-intensity aerobic exercise can reduce the levels of cholesterol, triglycerides, and free fatty acids in the serum, and increase the level of high-density lipoprotein cholesterol, indicating its potential therapeutic effect on NAFLD.

FRONTIERS IN GENETICS (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

NAFLD: Mechanisms, Treatments, and Biomarkers

Fatiha Nassir

Summary: Nonalcoholic fatty liver disease (NAFLD), also known as metabolic-associated fatty liver disease (MAFLD), is a common liver disease worldwide that is closely linked to the obesity epidemic. Currently, there is no specific pharmacological treatment available for NAFLD due to incomplete understanding of its mechanisms, lack of accurate and inexpensive imaging tools, and inadequate non-invasive biomarkers. NAFLD can lead to metabolic-associated steatohepatitis (NASH), liver fibrosis, and hepatocellular carcinoma.

BIOMOLECULES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effects of Resveratrol Administration in Liver Injury Prevention as Induced by an Obesogenic Diet: Role of Ruminococcaceae

Inaki Milton-Laskibar et al.

Summary: The study demonstrates that resveratrol administration can improve non-alcoholic fatty liver disease through modulating gut microbiota composition. Resveratrol effectively reduces liver weight and serum cholesterol levels while increasing HDL cholesterol levels. It also prevents obesogenic diet-induced liver damage by improving liver steatosis and inflammation. The results of gut microbiota sequencing show a complex relationship between certain bacteria from the Ruminococcaceae family and hepatic markers.

BIOMEDICINES (2022)

添加到收藏夹

Article Nutrition & Dietetics

Association between serum 25-hydroxy vitamin D concentrations and mortality among individuals with metabolic dysfunction-associated fatty liver disease: a prospective cohort study

Ji-Juan Zhang et al.

Summary: This study suggests a nonlinear inverse association between serum 25(OH)D concentrations and all-cause mortality among patients with MAFLD/NAFLD, with a threshold effect at approximately 50.0 nmol/L of serum 25(OH)D.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Lifestyle Improvements and Vitamin D Supplementation Play an Important Role in the Prevention of Childhood Diabetes

Erdi Xu et al.

Summary: This study investigated the characteristics of insulin secretion and 25-hydroxyvitamin D3 (25(OH)D3) levels in children with obesity. The results showed that childhood obesity is associated with increased blood glucose levels, higher incidence of abnormal glucose metabolism and diabetes, and decreased levels of 25(OH)D3. Lifestyle improvements and vitamin D supplementation play a crucial role in preventing childhood diabetes.

DISEASE MARKERS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

The value of combining the simple anthropometric obesity parameters, Body Mass Index (BMI) and a Body Shape Index (ABSI), to assess the risk of non-alcoholic fatty liver disease

Maobin Kuang et al.

Summary: This study found that combining BMI with ABSI can better identify obesity-related NAFLD risk in the general population, and it is significantly better than using BMI, WC, or ABSI alone.

LIPIDS IN HEALTH AND DISEASE (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

High-fat diet combined with dextran sulfate sodium failed to induce a more serious NASH phenotype than high-fat diet alone

Yan Zhou et al.

Summary: This study found that adding DSS to a high-fat diet can induce NASH-related liver fibrosis. The composite NASH animal model created in this study may be more accurate in simulating the development of NAFLD compared to the model induced by HFD alone.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Peroxisome Proliferator-Activated Receptor α Has a Protective Effect on Fatty Liver Caused by Excessive Sucrose Intake

Tomomi Yamazaki et al.

Summary: PPAR-alpha prevents fatty liver caused by excessive sucrose intake through regulating SREBP-1c target gene expression and liver TG accumulation. Gender differences may be related to the expression level of PPAR-gamma.

BIOMEDICINES (2022)

添加到收藏夹

Article Nutrition & Dietetics

Associations of serum multivitamin levels with the risk of non-alcoholic fatty liver disease: A population-based cross-sectional study in US adults

Hongye Peng et al.

Summary: This study investigated the association between serum vitamin levels and the risk of non-alcoholic fatty liver disease (NAFLD). The results showed that serum levels of vitamin C, D, B6, and B9 were negatively correlated with NAFLD risk, while levels of vitamin A and E were positively correlated with NAFLD risk.

FRONTIERS IN NUTRITION (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Prevalence of sarcopenia using different methods in patients with non-alcoholic fatty liver disease

Naiade Silveira Almeida et al.

Summary: This study evaluated the prevalence of sarcopenia in patients with NAFLD using different diagnostic methods and its association with clinical-anthropometric parameters. The results showed that sarcopenia was not common in NAFLD patients without fibrosis, and the prevalence of probable sarcopenia varied depending on the diagnostic method used.

WORLD JOURNAL OF HEPATOLOGY (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Genetic variants in promoter region of TFR2 is associated with the risk of non-alcoholic fatty liver disease in a Chinese Han population: a case-control study

Xinting Pan et al.

Summary: In a Chinese Han population, the rs4434553 polymorphism in TFR2 may be an independent influencing factor associated with the susceptibility to NAFLD. Additionally, the rs10247962 and rs1052897 SNPs had multiplicative interactions with age in relation to NAFLD risk.

GASTROENTEROLOGY REPORT (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Vitamin D Promotes Remyelination by Suppressing c-Myc and Inducing Oligodendrocyte Precursor Cell Differentiation after Traumatic Spinal Cord Injury

Ning Li et al.

Summary: The study showed that VitD treatment improved hindlimb movement in rats post-TSCI, but those with prior deficiency did not benefit. Maintaining sufficient VitD levels was essential for preserving myelin integrity after injury.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

添加到收藏夹

Article Medicine, General & Internal

Correlation Between 25 Hydroxyvitamin D Levels and Nonalcoholic Fatty Liver Disease in Chinese Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

Lei Xiu et al.

Summary: The serum 25-(OH)D level was significantly lower in patients with T2DM complicated by NAFLD compared to those with T2DM alone. Furthermore, lower levels of 25-(OH)D were associated with the presence of liver fibrosis in patients with T2DM and NAFLD. Hence, 25-(OH)D may serve as an independent predictor of liver fibrosis in diabetic patients with NAFLD.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Association and interaction between vitamin D level and metabolic syndrome for non-alcoholic fatty liver disease

Salam Bennouar et al.

Summary: This study found a positive association between severe vitamin D deficiency and NAFLD, with a higher risk in women than in men. The association in men may be partially masked by obesity. In women, there was a significant additive interaction between MS and severe vitamin D deficiency.

JOURNAL OF DIABETES AND METABOLIC DISORDERS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sulfated glucuronomannan hexasaccharide G6S1 enhanced lipolysis and lipophagy via PPARα pathway

Min Cai et al.

Summary: The highly sulfated glucuronomannan hexamer G6S1 was found to enhance lipophagy in hepatocytes, reducing the number and size of lipid droplets. It increased the expression of lipolysis-related proteins and promoted lipid turnover by enhancing PPAR alpha expression. These effects were inhibited by autophagy inhibitor 3-MA and PPAR alpha inhibitor MK-886, suggesting that G6S1 promotes lipophagy through PPAR alpha activation.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Effect of vitamin D3 supplementation on hepatic lipid dysregulation associated with autophagy regulatory AMPK/Akt-mTOR signaling in type 2 diabetic mice

Hyewon Lim et al.

Summary: Vitamin D-3 was found to improve insulin resistance, liver damage, and plasma lipid profiles in diabetic mice. Furthermore, it ameliorated hepatic lipid dysregulation by activating the autophagy regulatory AMPK/Akt-mTOR signaling pathway in these mice.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

添加到收藏夹

Article Sport Sciences

Combined Beneficial Effect of Voluntary Physical Exercise and Vitamin D Supplementation in Diet-induced Obese C57BL/6J Mice

Alexandra Marziou et al.

Summary: Combining physical exercise and vitamin D supplementation has beneficial effects on body weight management, glucose homeostasis, metabolic inflammation, and liver steatosis in obese mice. This combined strategy could be valuable in obesity management programs.

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE (2021)

添加到收藏夹

Article Nutrition & Dietetics

Low serum vitamin D concentrations are associated with obese but not lean NAFLD: a cross-sectional study

Qinqiu Wang et al.

Summary: This study found that a low serum vitamin D level is associated with NAFLD in obese participants but not in lean participants. Obese individuals with NAFLD had lower levels of serum vitamin D compared to obese individuals without NAFLD. Serum vitamin D level was negatively correlated with NAFLD prevalence in obese participants, and independently associated with NAFLD risk in this group.

NUTRITION JOURNAL (2021)

添加到收藏夹

Review Genetics & Heredity

The Role of Lipid Sensing Nuclear Receptors (PPARs and LXR) and Metabolic Lipases in Obesity, Diabetes and NAFLD

Emmanuel D. Dixon et al.

Summary: Nuclear receptors are ligand-dependent transcription factors with a crucial role in controlling metabolic activities, such as regulation of genes involved in lipid and glucose metabolism and inflammation. Their activity is essential in maintaining metabolic flexibility and is influenced by endogenous ligands.

GENES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Vitamin D ameliorates high-fat-diet-induced hepatic injury via inhibiting pyroptosis and alters gut microbiota in rats

Xiaolei Zhang et al.

Summary: Accumulating evidence suggests that vitamin D has a therapeutic effect on non-alcoholic fatty liver disease (NAFLD) by inhibiting pyroptosis and restoring gut microbiota balance, providing a novel mechanism for VD therapy against NAFLD.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Fenofibrate, a PPARα agonist, reduces hepatic fat accumulation through the upregulation of TFEB-mediated lipophagy

Jin Yoo et al.

Summary: The study demonstrates that fenofibrate can promote intracellular lipid clearance by activating TFEB and TFE3, leading to reduced hepatic fat accumulation. The lysosomal calcium signaling pathway appears to be critical in this process, suggesting a potential therapeutic target for NAFLD and cardiometabolic diseases.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

添加到收藏夹

Article Cell Biology

PGC-1α Protects against Hepatic Ischemia Reperfusion Injury by Activating PPARα and PPARγ and Regulating ROS Production

Chaoqun Wang et al.

Summary: PPAR alpha and gamma have been shown to be protective in hepatic ischemia/reperfusion injury. The coactivator PGC-1 alpha, which can coactivate both receptors, plays a protective role in hepatic I/R injury by regulating the activation of PPAR alpha and PPAR gamma. Antagonists of PPAR alpha or PPAR gamma can reduce the protective effect of PGC-1 alpha against hepatic I/R injuries.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

添加到收藏夹

Review Nutrition & Dietetics

Plasma Free Fatty Acid Concentration as a Modifiable Risk Factor for Metabolic Disease

Gregory C. Henderson

Summary: Plasma free fatty acid concentration is elevated in conditions like obesity, insulin resistance, and type 2 diabetes, posing a risk for metabolic diseases. Increased plasma FFA levels contribute to ectopic lipid deposition and metabolic dysfunction, while reducing FFA levels is expected to improve overall health. Lifestyle changes, such as diet, exercise, and sleep patterns, can impact plasma FFA concentration and modify metabolic disease risk.

NUTRIENTS (2021)

添加到收藏夹

Review Medicine, General & Internal

Vitamin D status in Mainland of China: A systematic review and meta- analysis

Wenhua Liu et al.

Summary: A systematic review and meta-analysis on the vitamin D status of the general population in Mainland China revealed a high prevalence of vitamin D deficiency and inadequacy in both adults and children/adolescents, with the inadequacy rate increasing with age. The study highlights the importance of addressing low vitamin D levels in the Chinese population, especially among adults.

ECLINICALMEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Berberine alleviates lipid metabolism disorders via inhibition of mitochondrial complex I in gut and liver

Muyu Yu et al.

Summary: The study indicated that BBR inhibits complex I in the gut and liver, leading to the suppression of lipid metabolism and improvement in obesity and fatty liver, independently of intestinal bacteria.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effects of 1,25(OH)2D3 on lipid droplet growth in adipocytes

Wei Xiang et al.

BIOFACTORS (2020)

添加到收藏夹

Review Endocrinology & Metabolism

CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential

Isabel R. Schlaepfer et al.

ENDOCRINOLOGY (2020)

添加到收藏夹

Article Cell Biology

The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα

Ting Li et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

添加到收藏夹

Article Nutrition & Dietetics

Vitamin D Supplementation Improves Adipose Tissue Inflammation and Reduces Hepatic Steatosis in Obese C57BL/6J Mice

Alexandra Marziou et al.

NUTRIENTS (2020)

添加到收藏夹

Review Medicine, General & Internal

Nonalcoholic Steatohepatitis: A Review

Adam C. Sheka et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Metabolite profiling of mice under long-term fructose drinking and vitamin D deficiency: increased risks for metabolic syndrome and nonalcoholic fatty liver disease

Wenwen Li et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2020)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

New dual peroxisome proliferator activated receptor agonistSaroglitazar in diabetic dyslipidemia and non-alcoholic fatty liver disease: integrated analysis of the real world evidence

Upendra Kaul et al.

CARDIOVASCULAR DIABETOLOGY (2019)

添加到收藏夹

Review Gastroenterology & Hepatology

Modulation of Insulin Resistance in Nonalcoholic Fatty Liver Disease

Reenam S. Khan et al.

HEPATOLOGY (2019)

添加到收藏夹

Article Nutrition & Dietetics

Beneficial Effects of Vitamin D Treatment in an Obese Mouse Model of Non-Alcoholic Steatohepatitis

Daniel Jahn et al.

NUTRIENTS (2019)

添加到收藏夹

Article Immunology

PPARα/γ antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats

Xi Zhao et al.

INFLAMMOPHARMACOLOGY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Dihydrocurcumin ameliorates the lipid accumulation, oxidative stress and insulin resistance in oleic acid-induced L02 and HepG2 cells

Qingqing Yu et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of peroxisome proliferator-activated receptors in non-alcoholic fatty liver disease inflammation

Amanda Karolina Soares Silva et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

Dietary supplementation of vitamin D prevents the development of western diet-induced metabolic, hepatic and cardiovascular abnormalities in rats

Giovanna Mazzone et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2018)

添加到收藏夹

Article Medicine, General & Internal

No Evidence for Lower Levels of Serum Vitamin D in the Presence of Hepatic Steatosis. A Study on the Portuguese General Population

Jorge Leitao et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2018)

添加到收藏夹

Article Endocrinology & Metabolism

1,25( OH)2D3 Attenuates Hepatic Steatosis by Inducing Autophagy in Mice

Renlong Li et al.

OBESITY (2017)

添加到收藏夹

Article Neurosciences

The effects of vitamin D administration on brain inflammatory markers in high fat diet induced obese rats

Mahdieh Abbasalizad Farhangi et al.

BMC NEUROSCIENCE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

From fat to FAT (CD36/SR-B2): Understanding the regulation of cellular fatty acid uptake

Jan F. C. Glatz et al.

BIOCHIMIE (2017)

添加到收藏夹

Article Endocrinology & Metabolism

Low vitamin D status is associated with advanced liver fibrosis in patients with nonalcoholic fatty liver disease

Bing-Bing Yang et al.

ENDOCRINE (2017)

添加到收藏夹

Review Gastroenterology & Hepatology

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

Michal Pawlak et al.

JOURNAL OF HEPATOLOGY (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Recent insights into the biological functions of liver fatty acid binding protein 1

GuQi Wang et al.

JOURNAL OF LIPID RESEARCH (2015)

添加到收藏夹

Article Gastroenterology & Hepatology

Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity

Fang Yan et al.

JOURNAL OF HEPATOLOGY (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Regulation of energy metabolism by long-chain fatty acids

Manabu T. Nakamura et al.

PROGRESS IN LIPID RESEARCH (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes

Moon-Sun Kim et al.

LIVER INTERNATIONAL (2013)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes

Erik Salum et al.

CARDIOVASCULAR DIABETOLOGY (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886

JP Kehrer et al.

BIOCHEMICAL JOURNAL (2001)

添加到收藏夹

Vitamin D improves hepatic steatosis in NAFLD via regulation of fatty acid uptake and β-oxidation

相关参考文献

导出引文

分享论文