Surgical strategies of complicated pheochromocytomas/paragangliomas and literature review

Pheochromocytomas (PCC)/paragangliomas (PGL) are catecholamine (CA) -secreting neuroendocrine tumors, which are known as PPGL due to their histological and pathophysiological similarities. In addition to the typical triad of paroxysmal headache, palpitation, and sweating, PPGL may also be accompanied by symptoms and signs involving multiple organs and systems such as the cardiovascular system, digestive system, endocrine system, and nervous system. Currently, surgical resection is the first choice for PPGL. Safe and effective surgical management of complicated PPGL is the goal of clinical work. In this paper, we discuss this hot issue based on complicated PPGL cases, aiming to share our experience of the surgical management strategy of PPGL.

Automated summary

PCC/PGL are neuroendocrine tumors that secrete catecholamines, also known as PPGL due to their histological and pathophysiological similarities. In addition to the typical triad of symptoms, PPGL may also present with symptoms involving multiple organs and systems. Surgical resection is currently the preferred treatment for PPGL, with the goal of safe and effective management. This paper discusses the surgical management strategy based on complicated PPGL cases, aiming to share our experience.