4.6 Article

A Candidemia Case Caused by a Novel Drug-Resistant Candida auris with the Y132F Mutation in Erg11 in Mainland China

期刊

INFECTION AND DRUG RESISTANCE
卷 16, 期 -, 页码 3065-3072

出版社

DOVE MEDICAL PRESS LTD
DOI: 10.2147/IDR.S409708

关键词

Candida auris; candidemia; drug-resistant; mutation; morphologies

向作者/读者索取更多资源

This article reports a case of candidemia caused by a novel drug-resistant Candida auris strain. The strain belongs to the South Asian clade and carries the Y132F mutation in the Erg11 protein. The strain is resistant to fluconazole and amphotericin B and not susceptible to caspofungin. In addition, it exhibits multiple colony and cellular morphologies under different culture conditions.
Background: Candida auris is a pathogen first found in external ear canal, becoming a major threat to global health. Here, we describe a candidemia case caused by a novel drug-resistant Candida auris strain. Case Presentation: An 80-year-old patient, with multiple serious medical conditions, was suffered from candidemia caused by Candida auris, died 9 days after admission in our hospital. Phylogenetic analysis indicates that this C. auris isolate (designated BJCA003) belongs to the South Asian clade, carries the Y132F mutation in the protein Erg11. And antibiotic susceptibility test indicated that BJCA003 is resistant to fluconazole and amphotericin B, not susceptible to caspofungin. In addition, this strain has multiple colony and cellular morphologies under different culture conditions. Conclusion: Strain BJCA003 is a novel drug resistant C. auris strain in mainland China, the Y132F mutation in Erg11 may attribute to fluconazole-resistance, alarming that we still face more challenges about C. auris.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据