期刊
FRONTIERS IN GENETICS
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2023.952379
关键词
ovarian clear cell carcinoma; genomics; epigenomics; gynecological oncology; review
In this article, we reviewed studies on the genomics and epigenetics of Ovarian clear cell carcinoma (OCCC), including gene mutation, copy number variations, DNA methylation, and histone modifications. OCCC is a rare subtype of epithelial ovarian cancer with unique molecular characteristics, specific biological and clinical behavior, poor prognosis, and high resistance to chemotherapy.
Ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian cancer with unique molecular characteristics, specific biological and clinical behavior, poor prognosis and high resistance to chemotherapy. Pushed by the development of genome-wide technologies, our knowledge about the molecular features of OCCC has been considerably advanced. Numerous studies are emerging as groundbreaking, and many of them are promising treatment strategies. In this article, we reviewed studies about the genomics and epigenetics of OCCC, including gene mutation, copy number variations, DNA methylation and histone modifications.
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