4.6 Article

Transcriptomic insights into adenoid cystic carcinoma via RNA sequencing

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FRONTIERS IN GENETICS
卷 14, 期 -, 页码 -

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FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2023.1144945

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adenoid cystic carcinoma (ACC); RNA sequencing; gene fusions; cancer germline antigens; mRNA

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This study investigated the underlying mechanisms of adenoid cystic carcinoma (ACC) at the transcriptome level. A new gene fusion, TVP23C-CDRT4, was found to be highly expressed in ACC. PRAME may serve as a potential target for ACC immunotherapy.
Background: The aim of this study was to investigate the underlying mechanisms of adenoid cystic carcinoma (ACC) at the transcriptome level.Materials and methods: We obtained paired tumor and normal salivary gland tissues from 15 ACC patients, which were prepared for RNA sequencing.Results: Gene enrichment analysis revealed that the upregulated pathways were mainly involved in axonogenesis, and the downregulated pathways were mainly related to leukocyte migration, the adaptive immune response, lymphocyte-mediated immunity, and the humoral immune response. T-cells, B-cells and NK cells showed low infiltration in ACC tissues. In addition to the gene fusions MYB-NFIB and MYBL1-NFIB, a new gene fusion, TVP23C-CDRT4, was also detected in 3 ACC tissues. PRAME was significantly upregulated in ACC tissues, while antigen-presenting human leukocyte antigen (HLA) genes were downregulated.Conclusion: We found a new gene fusion, TVP23C-CDRT4, that was highly expressed in ACC. PRAME may be an attractive target for ACC immunotherapy.

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