Primary central nervous system lymphoma

Article Oncology

NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022

Craig Horbinski et al.

Journal of the National Comprehensive Cancer Network (2023)

Article Oncology

Molecular and clinical diversity in primary central nervous system lymphoma

I. Hernandez-Verdin et al.

Summary: Through comprehensive multi-omic analysis, we identified and characterized four molecular patterns in PCNSL, which have a distinct prognostic impact and can guide future clinical stratification and targeted interventions.

ANNALS OF ONCOLOGY (2023)

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Article Hematology

CAR T-cell therapy in primary central nervous system lymphoma: the clinical experience of the French LOC network

Marion Alcantara et al.

BLOOD (2022)

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Article Hematology

MYD88L265P and CD79B double mutations type (MCD type) of diffuse large B-cell lymphoma: mechanism, clinical characteristics, and targeted therapy

Rongrong Chen et al.

Therapeutic Advances in Hematology (2022)

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Article Hematology

Safety and efficacy of tisagenlecleucel in primary CNS lymphoma: a phase 1/2 clinical trial

Matthew J. Frigault et al.

Summary: This study conducted a clinical trial of tisagenlecleucel in highly refractory patients with primary central nervous system lymphoma (PCNSL). The results showed that most patients responded well to the treatment and there were no severe side effects. This suggests that tisagenlecleucel is safe and effective in this patient population.

BLOOD (2022)

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Article Hematology

The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee

Elias Campo et al.

Summary: Since 1994, the classification of lymphoid neoplasms has been continuously updated through international efforts, with recent progress driven by genomic studies. This proposal presents the International Consensus Classification of mature lymphoid, histiocytic, and dendritic cell tumors, which has refined diagnostic criteria and incorporated new insights from genomics.

BLOOD (2022)

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Article Oncology

Primary central nervous system lymphoma high incidence and poor survival in Finnish population-based analysis

Inka Puhakka et al.

Summary: This study provides the first population-based incidence rates and prognosis of primary central nervous system lymphoma (PCNSL) in Finland. The results show that PCNSL incidence in Finland is among the highest reported worldwide, with an annual increase of 2.4%. The prognosis is still poor, especially for elderly patients.

BMC CANCER (2022)

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Article Oncology

Long-term efficacy, safety and neurotolerability of MATRix regimen followed by autologous transplant in primary CNS lymphoma: 7-year results of the IELSG32 randomized trial

Andres J. M. Ferreri et al.

Summary: This study reported the results of a trial involving 219 HIV-negative adults with primary CNS lymphoma (PCNSL). The results showed that MATRix significantly improves outcome in patients with PCNSL, with a long-term overall survival rate of 21%-56%. Addition of rituximab benefits patients, and the efficacy of whole-brain irradiation and autologous transplantation is comparable. Salvage therapy was ineffective. Importantly, MATRix and ASCT did not increase non-relapse mortality or second tumor incidence, and the side effects differed between WBRT and ASCT.

LEUKEMIA (2022)

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Article Hematology

Long-term patient-reported neurocognitive outcomes in adult survivors of hematopoietic cell transplant

Natalie L. Wu et al.

Summary: Survivors of hematopoietic cell transplant (HCT) generally have good neurocognitive function and quality of life, but those with hearing issues and sleep impairments are more likely to experience lower quality of life and impaired neurocognitive function.

BLOOD ADVANCES (2022)

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Article Oncology

Radiotherapy or Autologous Stem-Cell Transplantation for Primary CNS Lymphoma in Patients Age 60 Years and Younger: Long-Term Results of the Randomized Phase II PRECIS Study

Caroline Houillier et al.

Summary: In this study, a randomized phase II trial was conducted to evaluate the efficacy and toxicity of different treatment approaches in patients with newly diagnosed primary CNS lymphoma. The results showed that patients treated with ASCT had higher event-free survival and lower risk of relapse compared to those treated with WBRT, although the overall survival did not significantly differ between the two groups. Additionally, WBRT was associated with deterioration in balance and neurocognition compared to ASCT.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Review Oncology

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

Rita Alaggio et al.

Summary: This article provides an overview of the upcoming 5th edition of the World Health Organization classification of lymphoid tumors, highlighting changes from the previous edition such as reorganization of entities, modification of nomenclature, revision of diagnostic criteria, deletion of entities, introduction of new entities, and inclusion of tumor-like lesions.

LEUKEMIA (2022)

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Article Genetics & Heredity

Expression of Cas9 in a Syngeneic Model of Primary Central Nervous System Lymphoma Induces Intracerebral NK and CD8 T Cell-Mediated Lymphoma Cell Lysis Via Perforin

Manuel Montesinos-Rongen et al.

Summary: The development of CRISPR-Cas9 technology for gene modification provides new possibilities for studying diseases and developing therapies. However, the bacterial origin of the Cas9 protein may lead to unwanted immune responses. In this study, it was found that the expression of Cas9 in tumor cells triggered immune responses mediated by CD8 T cells and NK cells in the central nervous system, which may impact the effectiveness of CRISPR-Cas9-mediated tumor cell manipulation for specific diseases.

CRISPR JOURNAL (2022)

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Meeting Abstract Hematology

Effects on Survival of Non-Myeloablative Chemoimmunotherapy Compared to High-Dose Chemotherapy Followed By Autologous Stem Cell Transplantation (HDC-ASCT) As Consolidation Therapy in Patients with Primary CNS Lymphoma - Results of an International Randomized Phase III Trial (MATRix/IELSG43)

Gerald Illerhaus et al.

BLOOD (2022)

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Article Biochemistry & Molecular Biology

CXCR4, CXCR5 and CD44 May Be Involved in Homing of Lymphoma Cells into the Eye in a Patient Derived Xenograft Homing Mouse Model for Primary Vitreoretinal Lymphoma

Neele Babst et al.

Summary: This study found that CD20+ PCNSL lymphoma cells infiltrating the eye co-expressed distinct homing receptors, such as CXCR4 and CXCR5, in a PVRL homing mouse model. This suggests that these receptors may be involved in the process of PVRL homing into the eye.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Hematology

Cell free circulating tumor DNA in cerebrospinal fluid detects and monitors central nervous system involvement of B-cell lymphomas

Sabela Bobillo et al.

Summary: This study shows that CSF ctDNA can better detect CNS lesions and even detect residual disease after treatment. Additionally, CSF ctDNA can predict CNS relapse in CNS and systemic lymphomas.

HAEMATOLOGICA (2021)

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Article Oncology

Phase I/II study of tirabrutinib, a second-generation Bruton's tyrosine kinase inhibitor, in relapsed/refractory primary central nervous system lymphoma

Yoshitaka Narita et al.

Summary: The study evaluated the safety, tolerability, efficacy, and pharmacokinetics of tirabrutinib in patients with relapsed/refractory PCNSL. Results showed favorable efficacy with a 64% overall response rate and no dose-limiting toxicities observed. Differences in response rates and progression-free survival were noted among the different dosages used.

NEURO-ONCOLOGY (2021)

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Review Hematology

Consolidation Treatment for Primary Central Nervous System Lymphoma: Which Modality for Whom?

Osnat Bairey et al.

Summary: Primary central nervous system lymphoma is a rare aggressive disease that predominantly affects elderly patients with poor prognosis. The optimal treatment approach remains undefined, with the combination of high-dose methotrexate-based chemotherapy and whole-brain radiotherapy showing promising results but also significant neurotoxicity. Recent studies have compared alternative strategies such as reduced-dose radiotherapy and high-dose chemotherapy with autologous stem cell transplantation, showing similar progression-free survival and improved cognitive function with the latter approach. However, the use of intensive consolidation treatment remains low, leaving many unresolved issues in the field.

ACTA HAEMATOLOGICA (2021)

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Article Hematology

EBV-associated primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity

M. K. Gandhi et al.

Summary: Primary central nervous system lymphoma (PCNSL) is a rare brain lymphoma that has distinct immunobiological differences between EBV-associated PCNSL in immunosuppressed individuals and EBV-negative PCNSL. These differences are evident in cellular mutations and immune environments.

BLOOD (2021)

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Article Hematology

Exome sequencing identifies SLIT2 variants in primary CNS lymphoma

Leon D. Kaulen et al.

Summary: Novel SLIT2 variants were identified in PCNSL patients and associated with shorter survival times, suggesting a potential role for SLIT2 in the pathogenesis and progression of PCNSL that warrants further investigation.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

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Meeting Abstract Hematology

Implementation of Inpatient Palliative Care Consultation Triggers and Its Impact on Healthcare Use in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Jenny J. Xiang et al.

BLOOD (2021)

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Article Oncology

Changing Incidence and Survival of Primary Central Nervous System Lymphoma in Australia: A 33-Year National Population-Based Study

Alexandra L. Farrall et al.

Summary: This study analyzed the incidence and survival outcomes of primary central nervous system lymphoma (PCNSL) in Australia using data from the Australian Cancer Database. The incidence of PCNSL has been increasing at an average annual rate of 6.8% over the past four decades, with an overall low survival rate of only 33% at 5 years after diagnosis. Additionally, the study found that the increase in PCNSL incidence was driven by the diffuse large B-cell lymphoma (DLBCL) type, with survival outcomes improving but still lower than for non-CNS lymphoma.

CANCERS (2021)

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Article Hematology

MYD88 L265P mutation and interleukin-10 detection in cerebrospinal fluid are highly specific discriminating markers in patients with primary central nervous system lymphoma: results from a prospective study

Andres J. M. Ferreri et al.

Summary: This study found that high levels of mut-MYD88 and IL-10 in the CSF of patients with PCNSL reflect the MYD88 mutational status and expression of this IL in PCNSL tissue, showing very high sensitivity and specificity for detecting PCNSL at initial diagnosis and relapse. These biomarkers could have implications for patients with lesions unsuitable for biopsy.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

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Article Oncology

Consensus recommendations for MRI and PET imaging of primary central nervous system lymphoma: guideline statement from the International Primary CNS Lymphoma Collaborative Group (IPCG)

Ramon F. Barajas et al.

Summary: The article discusses the molecular and pathophysiologic characteristics of PCNSL, as well as critically reviewing the use of PET and MRI in diagnosis and treatment of PCNSL. Recommendations on standardized imaging practices are provided, along with ideal and minimum standard protocols for 3T and 1.5T MR systems to facilitate widespread adoption.

NEURO-ONCOLOGY (2021)

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Article Hematology

MATRix–RICE therapy and autologous haematopoietic stem-cell transplantation in diffuse large B-cell lymphoma with secondary CNS involvement (MARIETTA): an international, single-arm, phase 2 trial

Andrés J M Ferreri et al.

Lancet Haematology (2021)

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Article Oncology

Outcomes Associated With Thiotepa-Based Conditioning in Patients With Primary Central Nervous System Lymphoma After Autologous Hematopoietic Cell Transplant

Michael Scordo et al.

Summary: In this cohort study, thiotepa-based conditioning regimen was associated with higher rates of survival compared with BEAM, despite higher rates of early toxic effects and NRM. These findings may assist clinicians in choosing between TBC or TT-BCNU based on patient and disease characteristics.

JAMA ONCOLOGY (2021)

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Review Oncology

Breaching the Blood-Brain Tumor Barrier for Tumor Therapy

Fabrizio Marcucci et al.

Summary: The blood-brain tumor barrier (BBTB) is a major obstacle for delivering anticancer drugs to central nervous system tumors. Recent advances in various conjugates and drug delivery technologies have shown promising results in breaching the BBTB and increasing drug delivery to brain tumors, without significant adverse events.

CANCERS (2021)

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Review Hematology

Primary vitreoretinal lymphoma: a diagnostic and management challenge

Carole Soussain et al.

Summary: Primary vitreoretinal lymphoma (PVRL) is a rare form of primary central nervous system lymphoma that affects the intraocular compartment without brain involvement. Despite its indolent clinical course, PVRL can lead to permanent vision loss and CNS relapse, the major cause of death in patients. The pathophysiology of PVRL remains unknown and its diagnosis is challenging, requiring close coordination between ophthalmologists and cytologists.

BLOOD (2021)

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Meeting Abstract Oncology

Myeloablative versus non-myeloablative consolidative chemotherapy for newly diagnosed primary central nervous system lymphoma: Results of CALGB 51101 (Alliance).

Tracy Batchelor et al.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma

Marco Fangazio et al.

Summary: The loss of MHC-I in DLBCL is associated with somatic inactivation of HLA-I loci and has a significant impact on neoantigen and mutational burden. There is a multistep process of HLA-I loss in DLBCL development involving both germline and somatic events.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Oncology

Liquid Biopsy and Other Non-Invasive Diagnostic Measures in PCNSL

Alexander Baraniskin et al.

Summary: Primary central nervous system lymphoma (PCNSL) is a rare and highly aggressive form of non-Hodgkin lymphoma that requires a high level of suspicion for diagnosis due to its variable clinical presentation. While stereotactic brain biopsy remains the gold standard for diagnosis, potential procedural risks and delays in treatment initiation need to be considered. Novel diagnostic approaches, such as mutation analyses in circulating tumor DNA and determination of microRNAs and cytokine levels in body fluids, are being investigated to improve PCNSL diagnosis.

CANCERS (2021)

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Article Hematology

Induction therapy with the MATRix regimen in patients with newly diagnosed primary diffuse large B-cell lymphoma of the central nervous system - an international study of feasibility and efficacy in routine clinical practice

Elisabeth Schorb et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

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Article Oncology

Impact of maintenance rituximab on duration of response in primary central nervous system lymphoma

Prakash Ambady et al.

JOURNAL OF NEURO-ONCOLOGY (2020)

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Article Clinical Neurology

Molecular Subtypes and Genomic Profile of Primary Central Nervous System Lymphoma

Csaba Bodor et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2020)

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Review Oncology

Consensus recommendations for a standardized brain tumor imaging protocol for clinical trials in brain metastases

Timothy J. Kaufmann et al.

NEURO-ONCOLOGY (2020)

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Article Clinical Neurology

Management and outcome of primary CNS lymphoma in the modern era An LOC network study

Caroline Houillier et al.

NEUROLOGY (2020)

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Article Clinical Neurology

Expression of the ghrelin/growth hormone secretagogue receptor axis and its functional role in promoting tumor growth in primary central nervous system lymphomas

Hiroko Muta et al.

NEUROPATHOLOGY (2020)

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Article Multidisciplinary Sciences

Regulation of B cell receptor-dependent NF-κB signaling by the tumor suppressor KLHL14

Jaewoo Choi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Ophthalmology

Eye involvement in primary central nervous system lymphoma

Alexandra L. Farrall et al.

SURVEY OF OPHTHALMOLOGY (2020)

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Article Oncology

PD-L1 and PD-L2 expression in the tumor microenvironment including peritumoral tissue in primary central nervous system lymphoma

Motomasa Furuse et al.

BMC CANCER (2020)

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Article Hematology

Outcomes of older patients with primary central nervous system lymphoma treated in routine clinical practice in the UK: methotrexate dose intensity correlates with response and survival

Nicolas Martinez-Calle et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

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Article Oncology

A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications

George W. Wright et al.

CANCER CELL (2020)

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Article Oncology

In-depth characterization of the tumor microenvironment in central nervous system lymphoma reveals implications for immune-checkpoint therapy

Lukas Marcelis et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

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Article Oncology

Randomized phase II study of rituximab, methotrexate (MTX), procarbazine, vincristine, and cytarabine (R-MPV-A) with and without low-dose whole-brain radiotherapy (LD-WBRT) for newly diagnosed primary CNS lymphoma (PCNSL).

Antonio Marcilio Padula Omuro et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Oncology

Use of FDG-PET/CT for systemic assessment of suspected primary central nervous system lymphoma: a LOC study

Marc Bertaux et al.

JOURNAL OF NEURO-ONCOLOGY (2020)

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Review Oncology

On point in primaryCNSlymphoma

Mazie Tsang et al.

HEMATOLOGICAL ONCOLOGY (2020)

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Review Oncology

The Efficacy and Safety of Cytarabine on Newly Diagnosed Primary Central Nervous System Lymphoma: A Systematic Review and Meta-Analysis

Xiaohong Zheng et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Hematology

High-dose chemotherapy and autologous stem cell transplant in elderly patients with primary CNS lymphoma: a pilot study

Elisabeth Schorb et al.

BLOOD ADVANCES (2020)

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Article Hematology

Improving the antitumor activity of R-CHOP with NGR-hTNF in primary CNS lymphoma: final results of a phase 2 trial

Andres J. M. Ferreri et al.

BLOOD ADVANCES (2020)

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Article Oncology

Repolarization of tumor infiltrating macrophages and increased survival in mouse primary CNS lymphomas after XPO1 and BTK inhibition

Isabel Jimenez et al.

JOURNAL OF NEURO-ONCOLOGY (2020)

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Article Oncology

Diagnostic delay and outcome in immunocompetent patients with primary central nervous system lymphoma in Spain: a multicentric study

R. Velasco et al.

JOURNAL OF NEURO-ONCOLOGY (2020)

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Review Oncology

Consensus recommendations for a dynamic susceptibility contrast MRI protocol for use in high-grade gliomas

Jerrold L. Boxerman et al.

NEURO-ONCOLOGY (2020)

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Meeting Abstract Hematology

Phase 1 Study of Escalating Doses of Ibrutinib and Temozolomide, Etoposide, Liposomal Doxorubicin, Dexamethasone, Rituximab (TEDDI-R) with Isavuconazole for Relapsed and Refractory Primary CNS Lymphoma

Mark Roschewski et al.

BLOOD (2020)

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Review Pathology

HIV prevalence in primary central nervous system lymphoma: A systematic review and meta-analysis

Raduan Ahmed Franca et al.

PATHOLOGY RESEARCH AND PRACTICE (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Differentiating between Glioblastoma and Primary CNS Lymphoma Using Combined Whole-tumor Histogram Analysis of the Normalized Cerebral Blood Volume and the Apparent Diffusion Coefficient

Shixing Bao et al.

MAGNETIC RESONANCE IN MEDICAL SCIENCES (2019)

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Article Ophthalmology

MYD88 L265P MUTATION DETECTION IN THE AQUEOUS HUMOR OF PATIENTS WITH VITREORETINAL LYMPHOMA

Elisabetta Miserocchi et al.

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES (2019)

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Article Hematology

Primary CNS lymphoma patient-derived orthotopic xenograft model capture the biological and molecular characteristics of the disease

Frederic Pouzoulet et al.

BLOOD CELLS MOLECULES AND DISEASES (2019)

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Letter Hematology

Low-dose lenalidomide maintenance after induction therapy in older patients with primary central nervous system lymphoma

Khoan Vu et al.

BRITISH JOURNAL OF HAEMATOLOGY (2019)

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Article Oncology

Primary central nervous system lymphoma in patients with and without HIV infection: a multicenter study and comparison with U.S national data

Dima Dandachi et al.

CANCER CAUSES & CONTROL (2019)

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Article Hematology

R-CHOP preceded by blood-brain barrier permeabilization with engineered tumor necrosis factor-α in primary CNS lymphoma

Andres J. M. Ferreri et al.

BLOOD (2019)

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Article Oncology

Temozolomide as a Single Agent Maintenance Therapy in Elderly Patients With Primary CNS Lymphoma

Geraldine Faivre et al.

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2019)

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Article Oncology

Radiotherapy or Autologous Stem-Cell Transplantation for Primary CNS Lymphoma in Patients 60 Years of Age and Younger: Results o the Intergroup ANOCEF-GOELAMS Randomized Phase II PRECIS Study

Caroline Houillier et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Article Oncology

Differential expression of N-linked oligosaccharides in methotrexate-resistant primary central nervous system lymphoma cells

Yasuo Takashima et al.

BMC CANCER (2019)

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Article Oncology

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention

Tracy O'Connor et al.

CANCER CELL (2019)

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Review Oncology

Rituximab in primary central nervous system lymphoma-A systematic review and meta-analysis

Andreas M. Schmitt et al.

HEMATOLOGICAL ONCOLOGY (2019)

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Article Oncology

Longitudinal cognitive assessment in patients with primary CNS lymphoma treated with induction chemotherapy followed by reduced-dose whole-brain radiotherapy or autologous stem cell transplantation

Denise D. Correa et al.

JOURNAL OF NEURO-ONCOLOGY (2019)

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Article Multidisciplinary Sciences

Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice

Matthias Mulazzani et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Hematology

MYC, BCL2, and BCL6 rearrangements in primary central nervous system lymphoma of large B cell type

Anahita Nosrati et al.

ANNALS OF HEMATOLOGY (2019)

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Article Hematology

Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma

Christian Grommes et al.

BLOOD (2019)

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Letter Hematology

Guidelines for the diagnosis and management of primary central nervous system diffuse large B-cell lymphoma

Christopher P. Fox et al.

BRITISH JOURNAL OF HAEMATOLOGY (2019)

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Article Oncology

Rituximab in patients with primary CNS lymphoma (HOVON 105/ALLG NHL 24): a randomised, open-label, phase 3 intergroup study

Jacoline E. C. Bromberg et al.

LANCET ONCOLOGY (2019)

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Review Oncology

Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma

Christian Grommes et al.

NEURO-ONCOLOGY (2019)

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Article Oncology

CD19 and CD70 Dual-Target Chimeric Antigen Receptor T-Cell Therapy for the Treatment of Relapsed and Refractory Primary Central Nervous System Diffuse Large B-Cell Lymphoma

Sanfang Tu et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Hematology

MYD88 L265P mutation and CDKN2A loss are early mutational events in primary central nervous system diffuse large B-cell lymphomas

Naema Nayyar et al.

BLOOD ADVANCES (2019)

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Article Hematology

Primary central nervous system lymphoma: initial features, outcome, and late effects in 75 children and adolescents

Andishe Attarbaschi et al.

BLOOD ADVANCES (2019)

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Article Hematology

Molecular features of a large cohort of primary central nervous system lymphoma using tissue microarray

Diego Villa et al.

BLOOD ADVANCES (2019)

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Article Hematology

Increasing incidence of primary central nervous system lymphoma but no improvement in survival in Sweden 2000-2013

Sandra Eloranta et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2018)

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Article Oncology

The elderly left behind-changes in survival trends of primary central nervous system lymphoma over the past 4 decades

Joe S. Mendez et al.

NEURO-ONCOLOGY (2018)

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Article Clinical Neurology

The perivascular microenvironment in Epstein-Barr virus positive primary central nervous system lymphoma: The role of programmed cell death 1 and programmed cell death ligand 1

Yasuo Sugita et al.

NEUROPATHOLOGY (2018)

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Article Oncology

MicroRNA-30c as a novel diagnostic biomarker for primary and secondary B-cell lymphoma of the CNS

Alexander Baraniskin et al.

JOURNAL OF NEURO-ONCOLOGY (2018)

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Article Biochemistry & Molecular Biology

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Bjoern Chapuy et al.

NATURE MEDICINE (2018)

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Article Oncology

Identification of novel recurrent ETV6-IgH fusions in primary central nervous system lymphoma

Aurelie Bruno et al.

NEURO-ONCOLOGY (2018)

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Article Hematology

Phase 1 study of pomalidomide and dexamethasone for relapsed/refractory primary CNS or vitreoretinal lymphoma

Han W. Tun et al.

BLOOD (2018)

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Article Hematology

Hyper-N-glycosylated SAMD14 and neurabin-I as driver autoantigens of primary central nervous system lymphoma

Lorenz Thurner et al.

BLOOD (2018)

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Article Oncology

Pretreatment dynamic contrast-enhanced MRI biomarkers correlate with progression-free survival in primary central nervous system lymphoma

Vaios Hatzoglou et al.

JOURNAL OF NEURO-ONCOLOGY (2018)

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Article Oncology

Characterization of genomic alterations in primary central nervous system lymphomas

Soheil Zorofchian et al.

JOURNAL OF NEURO-ONCOLOGY (2018)

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Review Oncology

Cognitive functioning and health-related quality of life in patients with newly diagnosed primary CNS lymphoma: a systematic review

Matthijs van der Meulen et al.

LANCET ONCOLOGY (2018)

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Article Oncology

Analysis of Genomic Alteration in Primary Central Nervous System Lymphoma and the Expression of Some Related Genes

Yangying Zhou et al.

NEOPLASIA (2018)

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Article Surgery

Incidence and outcomes of primary central nervous system lymphoma in solid organ transplant recipients

Parag Mahale et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2018)

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Article Hematology

The expression of PD-1 ligands and IDO1 by macrophage/microglia in primary central nervous system lymphoma

Yuko Miyasato et al.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY (2018)

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Letter Hematology

Immune checkpoint inhibition by anti-PDCD1 (anti-PD1) monoclonal antibody has significant therapeutic activity against central nervous system lymphoma in an immunocompetent preclinical model

Yushi Qiu et al.

BRITISH JOURNAL OF HAEMATOLOGY (2018)

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Article Oncology

High-dose methotrexate-based immuno-chemotherapy for elderly primary CNS lymphoma patients (PRIMAIN study)

K. Fritsch et al.

LEUKEMIA (2017)

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Letter Oncology

Improved survival in primary central nervous system lymphoma up to age 70 only: a population-based study on incidence, primary treatment and survival in the Netherlands, 1989-2015

M. van der Meulen et al.

LEUKEMIA (2017)

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Article Oncology

CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014

Quinn T. Ostrom et al.

NEURO-ONCOLOGY (2017)

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Article Hematology

Whole-brain radiotherapy or autologous stem-cell transplantation as consolidation strategies after high-dose methotrexate-based chemoimmunotherapy in patients with primary CNS lymphoma: results of the second randomisation of the International Extranodal Lymphoma Study Group-32 phase 2 trial

Andres J. M. Ferreri et al.

LANCET HAEMATOLOGY (2017)

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Meeting Abstract Oncology

Updated results of single-agent ibrutinib in recurrent/refractory primary (PCNSL) and secondary CNS lymphoma (SCNSL).

Christian Grommes et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

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Article Hematology

The prognostic role of CD68 and FoxP3 expression in patients with primary central nervous system lymphoma

Hyunsoo Cho et al.

ANNALS OF HEMATOLOGY (2017)

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Article Oncology

Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma

Michail S. Lionakis et al.

CANCER CELL (2017)

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Article Hematology

PD-1 blockade with nivolumab in relapsed/refractory primary central nervous system and testicular lymphoma

Lakshmi Nayak et al.

BLOOD (2017)

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Article Hematology

Targetable genetic features of primary testicular and primary central nervous system lymphomas

Bjoern Chapuy et al.

BLOOD (2016)

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Article Clinical Neurology

Genomic characterization of primary central nervous system lymphoma

Kazutaka Fukumura et al.

ACTA NEUROPATHOLOGICA (2016)

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Review Hematology

The role of whole brain radiation in primary CNS lymphoma

Benjamin Kasenda et al.

BLOOD (2016)

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Review Hematology

The role of autologous stem cell transplantation in primary central nervous system lymphoma

Andres J. M. Ferreri et al.

BLOOD (2016)

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Article Oncology

High-dose chemotherapy and autologous stem cell transplant compared with conventional chemotherapy for consolidation in newly diagnosed primary CNS lymphoma-a randomized phase III trial (MATRix)

Elisabeth Schorb et al.

BMC CANCER (2016)

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Article Hematology

Trends in primary central nervous system lymphoma incidence and survival in the US

Meredith S. Shiels et al.

BRITISH JOURNAL OF HAEMATOLOGY (2016)

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Article Oncology

Primary CNS lymphoma at first relapse/progression: characteristics, management, and outcome of 256 patients from the French LOC network

Sophie Langner-Lemercier et al.

NEURO-ONCOLOGY (2016)

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Article Hematology

Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial

Andres J. M. Ferreri et al.

LANCET HAEMATOLOGY (2016)

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Article Hematology

High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial

Gerald Illerhaus et al.

Lancet Haematology (2016)

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Editorial Material Clinical Neurology

TERT promoter mutations in primary central nervous system lymphoma are associated with spatial distribution in the splenium

Aurelie Bruno et al.

ACTA NEUROPATHOLOGICA (2015)

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Review Oncology

First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)-a systematic review and individual patient data meta-analysis

B. Kasenda et al.

ANNALS OF ONCOLOGY (2015)

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Article Hematology

R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma

Antonio Omuro et al.

BLOOD (2015)

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Article Hematology

High frequency of MYD88 mutations in vitreoretinal B-cell lymphoma: a valuable tool to improve diagnostic yield of vitreous aspirates

Irina Bonzheim et al.

BLOOD (2015)

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Article Immunology

Primary Central Nervous System (CNS) Lymphoma B Cell Receptors Recognize CNS Proteins

Manuel Montesinos-Rongen et al.

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Article Clinical Neurology

NIMG-24HIGH SPATIOTEMPORAL DYNAMIC SUSCEPTIBILITY CONTRAST (DSC) PERFUSION MRI USING MULTIBAND ECHOPLANAR IMAGING (MB-EPI)

Benjamin Ellingson et al.

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Prognostic impact of B-cell lymphoma 6 in primary CNS lymphoma

Stephan Kreher et al.

NEURO-ONCOLOGY (2015)

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Article Hematology

Methotrexate and temozolomide versus methotrexate, procarbazine, vincristine, and cytarabine for primary CNS lymphoma in an elderly population: an intergroup ANOCEF-GOELAMS randomised phase 2 trial

Antonio Omuro et al.

LANCET HAEMATOLOGY (2015)

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Article Oncology

The perivascular microenvironment in primary central nervous system lymphomas: the role of chemokines and the endothelin B receptor

Yasuo Sugita et al.

BRAIN TUMOR PATHOLOGY (2015)

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Article Hematology

Successful change of treatment strategy in elderly patients with primary central nervous system lymphoma by de-escalating induction and introducing temozolomide maintenance: results from a phase II study by The Nordic Lymphoma Group

Elisa J. Pulczynski et al.

HAEMATOLOGICA (2015)

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The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing

I. Vater et al.

LEUKEMIA (2015)

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Article Clinical Neurology

PD1 (CD279) and PD-L1 (CD274, B7H1) expression in primary central nervous system lymphomas (PCNSL)

Anna Sophie Berghoff et al.

CLINICAL NEUROPATHOLOGY (2014)

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Article Clinical Neurology

Immunoglobulin Repertoire of Primary Lymphomas of the Central Nervous System

Manuel Montesinos-Rongen et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2014)

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Review Clinical Neurology

CNS Lymphoma: A Practical Diagnostic Approach

Caterina Giannini et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2014)

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Article Oncology

Mutational analysis of primary central nervous system lymphoma

Aurelie Bruno et al.

ONCOTARGET (2014)

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Letter Clinical Neurology

Frequent triple-hit expression of MYC, BCL2, and BCL6 in primary lymphoma of the central nervous system and absence of a favorable MYClowBCL2low subgroup may underlie the inferior prognosis as compared to systemic diffuse large B cell lymphomas

Anna Brunn et al.

ACTA NEUROPATHOLOGICA (2013)

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Article Clinical Neurology

Combined Diffusion and Perfusion MR Imaging as Biomarkers of Prognosis in Immunocompetent Patients with Primary Central Nervous System Lymphoma

F. E. Valles et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2013)

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Article Surgery

Primary CNS Posttransplant Lymphoproliferative Disease (PTLD): An International Report of 84 Cases in the Modern Era

A. M. Evens et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2013)

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Article Hematology

CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma

James L. Rubenstein et al.

BLOOD (2013)

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Acute Cognitive Impairment in Patients With Multiple Myeloma Undergoing Autologous Hematopoietic Stem Cell Transplant

Desiree Jones et al.

CANCER (2013)

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Rituximab, Methotrexate, Procarbazine, and Vincristine Followed by Consolidation Reduced-Dose Whole-Brain Radiotherapy and Cytarabine in Newly Diagnosed Primary CNS Lymphoma: Final Results and Long-Term Outcome

Patrick G. Morris et al.

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Article Oncology

Intensive Chemotherapy and Immunotherapy in Patients With Newly Diagnosed Primary CNS Lymphoma: CALGB 50202 (Alliance 50202)

James L. Rubenstein et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

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Article Oncology

A Reappraisal of the Diagnostic and Therapeutic Management of Uncommon Histologies of Primary Ocular Adnexal Lymphoma

Maurilio Ponzoni et al.

ONCOLOGIST (2013)

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Article Clinical Neurology

Expression of B-cell activating factor, a proliferating inducing ligand and its receptors in primary central nervous system lymphoma

Tobias Birnbaum et al.

NEUROLOGY INTERNATIONAL (2013)

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Article Clinical Neurology

Correlations between Perfusion MR Imaging Cerebral Blood Volume, Microvessel Quantification, and Clinical Outcome Using Stereotactic Analysis in Recurrent High-Grade Glioma

L. S. Hu et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2012)

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Article Oncology

Immunochemotherapy with Intensive Consolidation for Primary CNS Lymphoma: A Pilot Study and Prognostic Assessment by Diffusion- Weighted MRI

Matthew J. Wieduwilt et al.

CLINICAL CANCER RESEARCH (2012)

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Article Oncology

Recurrent Mutations of MYD88 and TBL1XR1 in Primary Central Nervous System Lymphomas

Alberto Gonzalez-Aguilar et al.

CLINICAL CANCER RESEARCH (2012)

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Article Oncology

Aquaporin-4 expression in primary human central nervous system lymphomas correlates with tumour cell proliferation and phenotypic heterogeneity of the vessel wall

Beatrice Nico et al.

EUROPEAN JOURNAL OF CANCER (2012)

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Article Oncology

MicroRNAs in cerebrospinal fluid as biomarker for disease course monitoring in primary central nervous system lymphoma

Alexander Baraniskin et al.

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Article Oncology

Outcomes of the oldest patients with primary CNS lymphoma treated at Memorial Sloan-Kettering Cancer Center

Mary R. Welch et al.

NEURO-ONCOLOGY (2012)

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Article Oncology

Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging

Ramon F. Barajas et al.

NEURO-ONCOLOGY (2012)

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Article Hematology

Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma

Chang Ohk Sung et al.

BLOOD (2011)

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Article Hematology

Identification of microRNAs in the cerebrospinal fluid as marker for primary diffuse large B-cell lymphoma of the central nervous system

Alexander Baraniskin et al.

BLOOD (2011)

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Article Oncology

Age, gender, and racial differences in incidence and survival in primary CNS lymphoma

J. L. Villano et al.

BRITISH JOURNAL OF CANCER (2011)

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Article Oncology

Primary Central Nervous System Lymphomas: A Validation Study of Array-Based Comparative Genomic Hybridization in Formalin-Fixed Paraffin-Embedded Tumor Specimens

Esteban Braggio et al.

CLINICAL CANCER RESEARCH (2011)

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Article Hematology

Tumor-infiltrating macrophages correlate with adverse prognosis and Epstein-Barr virus status in classical Hodgkin's lymphoma

Peter Kamper et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2011)

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Article Oncology

Ocular involvement in patients with primary CNS lymphoma

Jung Taeck Hong et al.

JOURNAL OF NEURO-ONCOLOGY (2011)

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Letter Oncology

Whole-brain radiotherapy in primary CNS lymphoma

Andres J. M. Ferreri et al.

LANCET ONCOLOGY (2011)

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Article Clinical Neurology

Primary intramedullary spinal cord lymphoma

E. P. Flanagan et al.

NEUROLOGY (2011)

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Article Oncology

Primary Vitreoretinal Lymphoma: A Report from an International Primary Central Nervous System Lymphoma Collaborative Group Symposium

Chi-Chao Chan et al.

ONCOLOGIST (2011)

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Article Clinical Neurology

Mutations of CARD11 but not TNFAIP3 may activate the NF-κB pathway in primary CNS lymphoma

Manuel Montesinos-Rongen et al.

ACTA NEUROPATHOLOGICA (2010)

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Article Clinical Neurology

Diffusion-Weighted MR Imaging Derived Apparent Diffusion Coefficient Is Predictive of Clinical Outcome in Primary Central Nervous System Lymphoma

R. F. Barajas et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2010)

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Review Hematology

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

Laurent Brault et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2010)

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Article Oncology

Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: T-cell infiltration and positioning of malignant B cells

Daniel Venetz et al.

INTERNATIONAL JOURNAL OF CANCER (2010)

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Article Oncology

High-dose methotrexate with or without whole brain radiotherapy for primary CNS lymphoma (G-PCNSL-SG-1): a phase 3, randomised, non-inferiority trial

Eckhard Thiel et al.

LANCET ONCOLOGY (2010)

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Article Oncology

Meningeal dissemination in primary CNS lymphoma: diagnosis, treatment, and survival in a large monocenter cohort

Philipp Kiewe et al.

NEURO-ONCOLOGY (2010)

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Article Pathology

Primary central nervous system lymphoma: a clinicopathological study of 75 cases

Matthias Preusser et al.

PATHOLOGY (2010)

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Article Ophthalmology

Retinal Fluorescein, Indocyanine Green Angiography, and Optic Coherence Tomography in Non-Hodgkin Primary Intraocular Lymphoma

Christine Fardeau et al.

AMERICAN JOURNAL OF OPHTHALMOLOGY (2009)

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Article Oncology

Pathologic Correlates of Primary Central Nervous System Lymphoma Defined in an Orthotopic Xenograft Model

Cigall Kadoch et al.

CLINICAL CANCER RESEARCH (2009)

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Article Oncology

Early relapses in primary CNS lymphoma after response to polychemotherapy without intraventricular treatment: results of a phase II study

Hendrik Pels et al.

JOURNAL OF NEURO-ONCOLOGY (2009)

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Article Pathology

Specific expression of miR-17-5p and miR-127 in testicular and central nervous system diffuse large B-cell lymphoma

Jan-Lukas Robertus et al.

MODERN PATHOLOGY (2009)

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Article Oncology

Chromosomal imbalances and partial uniparental disomies in primary central nervous system lymphoma

H. Schwindt et al.

LEUKEMIA (2009)

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Letter Oncology

Maintenance therapy for central nervous system lymphoma with rituximab

Douglas E. Ney et al.

LEUKEMIA & LYMPHOMA (2009)

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Article Ophthalmology

Intravitreal methotrexate for treating vitreoretinal lymphoma: 10 years of experience

S. Frenkel et al.

BRITISH JOURNAL OF OPHTHALMOLOGY (2008)

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Article Oncology

Del(6)(q22) and BCL6 Rearrangements in primary CNS lymphoma are indicators of an aggressive clinical course

Francois M. Cady et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

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Article Oncology

Genomic alterations and gene expression in primary diffuse large B-cell lymphomas of immune-privileged sites: the importance of apoptosis and immunomodulatory pathways

M. Booman et al.

JOURNAL OF PATHOLOGY (2008)

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Article Clinical Neurology

Meningeal dissemination in primary CNS lymphoma -: Prospective evaluation of 282 patients

L. Fischer et al.

NEUROLOGY (2008)

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Article Clinical Neurology

Primary CNS lymphoma with intraocular involvement International PCNSL Collaborative Group Report

S. A. Grimm et al.

NEUROLOGY (2008)

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Article Oncology

Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell

M. Montesinos-Rongen et al.

LEUKEMIA (2008)

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Article Oncology

Temozolomide and methotrexate for primary central nervous system lymphoma in the elderly

Antonio M. P. Omuro et al.

JOURNAL OF NEURO-ONCOLOGY (2007)

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Article Oncology

Primary intraocular lymphoma: an international primary central nervous system lymphoma collaborative group report

S. A. Grimm et al.

ANNALS OF ONCOLOGY (2007)

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Article Oncology

Increasing incidence and continued dismal outcome of primary central nervous system lymphoma in Norway 1989-2003 - Time trends in a 15-year national survey

Ingfrid S. Haldorsen et al.

CANCER (2007)

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Article Oncology

Angiogenesis in primary central nervous system lymphoma (PCNSL)

Hiroaki Takeuchi et al.

JOURNAL OF NEURO-ONCOLOGY (2007)

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Article Hematology

Reactive perivascular T-cell infiltrate predicts survival in primary central nervous system B-cell lymphomas

M. Ponzoni et al.

BRITISH JOURNAL OF HAEMATOLOGY (2007)

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Review Oncology

Cognitive functions in primary central nervous system lymphoma: literature review and assessment guidelines

D. D. Correa et al.

ANNALS OF ONCOLOGY (2007)

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Article Clinical Neurology

CSF flow cytometry greatly improves diagnostic accuracy in CNS hematologic malignancies

J. E. C. Bromberg et al.

NEUROLOGY (2007)

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Article Clinical Neurology

Rising incidence of primary central nervous system lymphoma in Kumamoto, Japan

Keishi Makino et al.

SURGICAL NEUROLOGY (2006)

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Article Oncology

Relapse of primary central nervous system lymphoma: clinical features, outcome and prognostic factors

Kristoph Jahnke et al.

JOURNAL OF NEURO-ONCOLOGY (2006)

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Article Immunology

Trends in cancer risk among people with AIDS in the United States 1980-2002

Eric A. Engels et al.

AIDS (2006)

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Article Hematology

Gene expression and angiotropism in primary CNS lymphoma

JL Rubenstein et al.

BLOOD (2006)

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Article Radiology, Nuclear Medicine & Medical Imaging

FDG-PET in immunocompetent patients with primary central nervous system lymphoma: correlation with MRI and clinical follow-up

H Palmedo et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2006)

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Article Hematology

A uniform activated B-cell-like in-immunophenotype might explain the poor prognosis of primary central nervous system lymphomas: analysis of 83 cases

S Camilleri-Broet et al.

BLOOD (2006)

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Article Hematology

First-line autologous transplantation in stem cell primary CNS lymphoma

M Brevet et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2005)

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Article Clinical Neurology

Delayed neurotoxicity in primary central nervous system lymphoma

AMP Omuro et al.

ARCHIVES OF NEUROLOGY (2005)

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Article Oncology

Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma

LE Abrey et al.

JOURNAL OF CLINICAL ONCOLOGY (2005)

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Article Oncology

Primary central nervous system lymphomas (PCNSL):: MRI features at presentation in 100 patients

W Küker et al.

JOURNAL OF NEURO-ONCOLOGY (2005)

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Article Oncology

Results of whole-brain radiation as salvage of methotrexate failure for immunocompetent patients with primary CNS lymphoma

PL Nguyen et al.

JOURNAL OF CLINICAL ONCOLOGY (2005)

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Article Oncology

High-dose methotrexate toxicity in elderly patients with primary central nervous system lymphoma

K Jahnke et al.

ANNALS OF ONCOLOGY (2005)

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Article Oncology

Changing incidence and prognostic factors of survival in AIDS-related non-Hodgkin's lymphoma in the era of highly active antiretroviral therapy (HAART)

T Wolf et al.

LEUKEMIA & LYMPHOMA (2005)

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Article Hematology

Primary diffuse large B-cell lymphomas of the central nervous system are targeted by aberrant somatic hypermutation

M Montesinos-Rongen et al.

BLOOD (2004)

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Article Clinical Neurology

Treatment-induced leukoencephalopathy in primary CNS lymphoma - A clinical and autopsy study

R Lai et al.

NEUROLOGY (2004)

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Article Hematology

Ocular presentation of primary central nervous system lymphoma: diagnosis and treatment

A Hormigo et al.

BRITISH JOURNAL OF HAEMATOLOGY (2004)

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Article Medicine, General & Internal

Pseudouveitis -: A clue to the diagnosis of primary central nervous system lymphoma in immunocompetent patients

SPS Abad et al.

MEDICINE (2004)

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Article Ophthalmology

Primary intraocular lymphoma

SE Coupland et al.

OPHTHALMOLOGE (2004)

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Article Oncology

Primary central nervous system lymphoma: Results of a pilot and phase II study of systemic and intraventricular chemotherapy with deferred radiotherapy

H Pels et al.

JOURNAL OF CLINICAL ONCOLOGY (2003)

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Article Oncology

Intensive methotrexate and cytarabine followed by high-dose chemotherapy with autologous stem-cell rescue in patients with newly diagnosed primary CNS lymphoma: An intent-to-treat analysis

LE Abrey et al.

JOURNAL OF CLINICAL ONCOLOGY (2003)

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Article Oncology

Chemotherapy alone as initial treatment for primary CNS lymphoma in patients older than 60 years: A multicenter phase II study (26952) of the European Organization for Research and Treatment of Cancer Brain Tumor Group

K Hoang-Xuan et al.

JOURNAL OF CLINICAL ONCOLOGY (2003)

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Article Oncology

Summary statement on primary central nervous system lymphomas from the Eighth International Conference on Malignant Lymphoma, Lugano, Switzerland, June 12 to 15, 2002

AJM Ferreri et al.

JOURNAL OF CLINICAL ONCOLOGY (2003)

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Article Oncology

CpG island methylation of tumor-related genes in three primary central nervous system lymphomas in immunocompetent patients

P Gonzalez-Gomes et al.

CANCER GENETICS AND CYTOGENETICS (2003)

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Article Oncology

Is intrathecal methotrexate necessary in the treatment of primary CNS lymphoma?

RB Khan et al.

JOURNAL OF NEURO-ONCOLOGY (2002)

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Article Clinical Neurology

A multicenter study of treatment of primary CNS lymphoma

AJM Ferreri et al.

NEUROLOGY (2002)

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Article Multidisciplinary Sciences

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

AA Alizadeh et al.

NATURE (2000)

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Article Clinical Neurology

Primary intracerebral malignant lymphoma: report of 248 cases

B Bataille et al.

JOURNAL OF NEUROSURGERY (2000)

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