4.6 Article

Find-eat strategy targeting endothelial cells via receptor functionalized apoptotic body nanovesicle

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemical Research Methods

Single-particle assessment of six different drug-loading strategies for incorporating doxorubicin into small extracellular vesicles

Chen Chen et al.

Summary: Extracellular vesicles (EVs) have been explored as a promising drug delivery system, and evaluating the drug-loading process at the single-particle level is crucial due to the heterogeneity of EVs. By utilizing nano-flow cytometry, researchers found that coincubation and electroporation methods had higher drug encapsulation efficiency, while methods like extrusion, freeze-thawing, sonication, and surfactant treatment caused damage to the membrane proteins of EVs.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2023)

Article Oncology

Hypoxia-induced CXC chemokine ligand 14 expression drives protumorigenic effects through activation of insulin-like growth factor-1 receptor signaling in glioblastoma

Sung-Tai Wei et al.

Summary: Hypoxic tumor microenvironment (HTM) promotes a more aggressive and malignant state in glioblastoma. In this study, the researchers found that CXCL14, regulated by HIF and activated IGF-1R signaling pathway, plays a role in HTM-mediated glioblastoma progression. Targeting CXCL14 with siRNA nanoparticles can inhibit glioblastoma growth and extend survival time.

CANCER SCIENCE (2023)

Article Chemistry, Multidisciplinary

Augmenting Intracellular Cargo Delivery of Extracellular Vesicles in Hypoxic Tissues through Inhibiting Hypoxia-Induced Endocytic Recycling

Bide Tong et al.

Summary: The cargo delivery efficiency of MSC-sEVs was reduced under hypoxia in nucleus pulposus cells due to the activated endocytic recycling. The upregulation of RCP induced by HIF-1 promotes the Rab11a-dependent recycling of internalized MSC-sEVs under hypoxia. By loading si-RCP into MSC-sEVs, the engineered MSC-sEVs inhibit the endocytic recycling process and exhibit higher delivery efficiency under hypoxia, successfully treating IDD in a rat model.

ACS NANO (2023)

Article Engineering, Biomedical

Hypoxia-pretreated ADSC-derived exosome-embedded hydrogels promote angiogenesis and accelerate diabetic wound healing

Nan Hu et al.

Summary: Adipose-derived stem cell (ADSC)-originating exosomes (ADSC-Exos) have potential in diabetic wound repair, but their disadvantages limit their clinical application. This study developed hypoxia-pretreated ADSC-Exo (ADSC-HExo)-embedded GelMA hydrogels (GelMA-HExo) and demonstrated their therapeutic effects in promoting diabetic wound healing. These findings suggest a new therapeutic strategy for diabetic ulcers.

ACTA BIOMATERIALIA (2023)

Article Critical Care Medicine

Apoptotic bodies extracted from adipose mesenchymal stem cells carry microRNA-21-5p to induce M2 polarization of macrophages and augment skin wound healing by targeting KLF6

Jianrui Li et al.

Summary: This study found that adMSC-derived apoptotic bodies can accelerate skin wound healing and induce M2 polarization of macrophages. miR-21-5p targets KLF6 to induce this process.
Article Gastroenterology & Hepatology

Hypoxia-driven immunosuppression by Treg and type-2 conventional dendritic cells in HCC

Sheena Suthen et al.

Summary: This study analyzed the immune landscapes of hypoxic regions in hepatocellular carcinoma (HCC) and identified enriched immune subsets, including regulatory T cells, M2 macrophages, and HLA-DRlo cDC2, in hypoxia-high tumor regions. In contrast, hypoxia-low tumor regions showed an abundance of active granzyme B-hi PD-1(lo) CD8(+) T cells, indicating a relatively active immune landscape. The up-regulation of cancer-associated genes in tumor tissues and immunosuppressive genes in tumor-infiltrating leukocytes supported a highly pro-tumorigenic network in hypoxic HCC.

HEPATOLOGY (2022)

Article Medicine, Research & Experimental

Engineered extracellular vesicle-based sonotheranostics for dual stimuli-sensitive drug release and photoacoustic imaging-guided chemo-sonodynamic cancer therapy

Thuy Giang Nguyen Cao et al.

Summary: This study developed dual stimuli-responsive sonosensitizers using extracellular vesicles as carriers for safe and efficient chemo-sonodynamic combination cancer therapy and photoacoustic imaging.

THERANOSTICS (2022)

Article Engineering, Biomedical

Encapsulation of Hydrophilic Compounds in Small Extracellular Vesicles: Loading Capacity and Impact on Vesicle Functions

Britta Franziska Hettich et al.

Summary: Different methods were explored to incorporate hydrophilic non-membrane permeable compounds into stem cell-derived small EV, with freeze-thawing and osmotic shock proving to be the most appropriate methods for high drug encapsulation while preserving structural and biological vesicle characteristics.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Chemistry, Multidisciplinary

Apoptotic Body-Mediated Intracellular Delivery Strategy for Enhanced STING Activation and Improved Tumor Immunogenicity

Peng Bao et al.

Summary: This study presents a nanovaccine platform that tackles the challenges of conventional STING agonists, leading to enhanced tumor-specific antigen presentation ability and improved immune response.

NANO LETTERS (2022)

Review Biotechnology & Applied Microbiology

Therapeutically harnessing extracellular vesicles

Lesley Cheng et al.

Summary: The field of extracellular vesicle (EV) research has rapidly developed and is now recognized for its potential in the treatment and diagnosis of diseases. This article provides an overview of the characteristics and physiological functions of EVs, their association with diseases, and the strategies for their therapeutic exploitation.

NATURE REVIEWS DRUG DISCOVERY (2022)

Article Chemistry, Multidisciplinary

Secretory Fluid-Aggregated Janus Electrospun Short Fiber Scaffold for Wound Healing

Shutong Qian et al.

Summary: A Janus electrospun short fiber scaffold has been fabricated, which can aggregate wound exudate and trigger the cascade release of curcumin, thus promoting the healing process of chronic wounds.
Article Multidisciplinary Sciences

Bio-inspired natural platelet hydrogels for wound healing

Yuanyuan Jiang et al.

Summary: In this research, a novel bionic hydrogel was developed by crosslinking natural platelet and alginate through covalent amidation for wound healing. The platelet-derived hydrogel exhibited excellent biocompatibility and blood compatibility, and could be customized for different wound environments. Silver nanoparticles could also be loaded into the hydrogel, providing superior anti-infective properties. The bio-inspired platelet hydrogel showed potential values in clinical applications by promoting hemostasis, preventing bacterial proliferation, and facilitating tissue healing.

SCIENCE BULLETIN (2022)

Review Biochemistry & Molecular Biology

Current Nanomedicine for Targeted Vascular Disease Treatment: Trends and Perspectives

Kyung-A Choi et al.

Summary: Nanomedicine is an innovative approach for treating vascular diseases by utilizing nanotechnology to deliver drugs effectively to the vascular system. Nanoparticles decorated with targeting molecules have shown promise in targeting inflamed endothelial cells and treating various vascular diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Chemistry, Multidisciplinary

Apoptotic bodies for advanced drug delivery and therapy

Min Zhou et al.

Summary: Extracellular vesicles (EVs), including apoptotic bodies (ABs), have emerged as promising candidates for various biomedical applications. ABs, derived from parent cells during the final stages of apoptosis, possess diverse sources and stable morphological features. They accommodate more functional biomolecules due to their larger volume and exhibit advantageous interactions with recipient cells through their predominant body surface ratio. ABs hold great potential in modulating and alleviating symptoms of numerous diseases, and have also been applied in disease diagnosis, immunotherapy, regenerative therapy, and drug delivery.

JOURNAL OF CONTROLLED RELEASE (2022)

Review Chemistry, Multidisciplinary

Stem cell membrane-coated abiotic nanomaterials for biomedical applications

Ines Ferreira-Faria et al.

Summary: This article introduces a novel strategy based on biomimetics to improve the pharmacokinetics and safety profile of nanosystems by using stem cell membrane coatings. These coatings provide targeting ability, protecting the nanoparticle cores from immune system elimination and enhancing drug accumulation at target sites, thereby improving therapeutic efficacy and safety.

JOURNAL OF CONTROLLED RELEASE (2022)

Article Engineering, Biomedical

A near-infrared light-responsive extracellular vesicle as a Trojan horse for tumor deep penetration and imaging-guided therapy

Zeng Xu et al.

Summary: Developed a near-infrared light-responsive extracellular vesicle nanoplatform that can deeply penetrate tumor tissues and be rapidly eliminated from the body post-treatment, enhancing therapeutic efficacy. Similar to a Trojan horse, the nanoplatform hides anti-tumor agents in macrophage cell-secreted vesicles and utilizes NIR fluorescence imaging for in vivo biodistribution monitoring.

BIOMATERIALS (2021)

Review Biochemistry & Molecular Biology

Phagocytic clearance of apoptotic, necrotic, necroptotic and pyroptotic cells

Georgia K. Atkin-Smith

Summary: The clearance of dying cells is a well-defined process involving molecular factors and different mechanisms for different types of cell death. It is essential for preventing excessive release of pro-inflammatory mediators and inflammatory diseases.

BIOCHEMICAL SOCIETY TRANSACTIONS (2021)

Review Biotechnology & Applied Microbiology

A systematic review on the modifications of extracellular vesicles: a revolutionized tool of nano-biotechnology

Alok Raghav et al.

Summary: This study systematically reviewed various methods for modifying EVs, including click chemistry, co-incubation, chemical transfection, electroporation, sonication, microfluidics, and freeze-thaw methods. Freeze-thaw approach was found to be convenient and popular for EVs modification, but producing clinical-grade EVs with GCPs remains challenging, and more research is needed to determine the best approach for cargo loading of EVs.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Cell Biology

Active cargo loading into extracellular vesicles: Highlights the heterogeneous encapsulation behaviour

Chaoxiang Chen et al.

Summary: Extracellular vesicles have unique advantages as nanocarriers for drug delivery, but their cargo encapsulation efficiency is often below expectations, especially for hydrophilic chemotherapeutic drugs. This study introduced a new method named SEAL, which significantly enhances drug encapsulation efficiency of EVs, and single-particle analysis techniques were used to uncover the encapsulation heterogeneity of EVs.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

Article Engineering, Biomedical

Programmable immune activating electrospun fibers for skin regeneration

Lu Chen et al.

Summary: The study developed an Inner-Outer IL-10-loaded electrospun fiber with cascade release behavior, which programmatically activated sequential immune responses during wound healing by releasing IL-10 and anti-fibrotic cytokines secreted by polarized M2c, leading to scarless skin regeneration.

BIOACTIVE MATERIALS (2021)

Review Nanoscience & Nanotechnology

Extracellular vesicles as a next-generation drug delivery platform

Inge Katrin Herrmann et al.

Summary: Extracellular vesicles play a crucial role in cell-to-cell communication and can serve as drug carriers with advantages over synthetic carriers. However, clinical translation of extracellular vesicle-based therapies remains challenging, requiring further research and development efforts.

NATURE NANOTECHNOLOGY (2021)

Article Pharmacology & Pharmacy

Engineered extracellular vesicles with synthetic lipids via membrane fusion to establish efficient gene delivery

Yong-Yu Jhan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Review Engineering, Biomedical

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

Ruoyu Cheng et al.

BIOMATERIALS (2020)

Review Biochemistry & Molecular Biology

Hypoxia Alters the Expression of CC Chemokines and CC Chemokine Receptors in a Tumor-A Literature Review

Jan Korbecki et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Bioclickable and mussel adhesive peptide mimics for engineering vascular stent surfaces

Zhilu Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Editorial Material Multidisciplinary Sciences

Targeting angiogenic metabolism in disease

Xuri Li et al.

SCIENCE (2018)

Review Cell Biology

Disassembly of the Dying: Mechanisms and Functions

Georgia K. Atkin-Smith et al.

TRENDS IN CELL BIOLOGY (2017)

Article Biotechnology & Applied Microbiology

Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes

Kasper Bendix Johnsen et al.

CYTOTECHNOLOGY (2016)

Article Cell & Tissue Engineering

Pharmacological priming of adipose-derived stem cells for paracrine VEGF production with deferoxamine

Guei-Sheung Liu et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2016)

Article Biochemistry & Molecular Biology

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

Tian Tian et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Biochemistry & Molecular Biology

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

Bence Gyoergy et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

Review Immunology

Ectosomes as modulators of inflammation and immunity

S. Sadallah et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2011)

Article Cell Biology

Eat me signals of apoptotic bodies

V Depraetere

NATURE CELL BIOLOGY (2000)