4.7 Article

Inhibition of spinal ferroptosis-like cell death alleviates hyperalgesia and spontaneous pain in a mouse model of bone cancer pain

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Intrathecal liproxstatin-1 delivery inhibits ferroptosis and attenuates mechanical and thermal hypersensitivities in rats with complete Freund's adjuvant-induced inflammatory pain

Yi-Fan Deng et al.

Summary: This study aimed to investigate the contribution of ferroptosis in the spinal cord and dorsal root ganglion to painful behaviors induced by complete Freund's adjuvant in rats. The results revealed that ferroptosis-related changes in iron overload, lipid peroxidation, and mitochondrial morphology were associated with the inflammatory pain model. Intrathecal administration of a ferroptosis inhibitor alleviated the pain behaviors in the rats.

NEURAL REGENERATION RESEARCH (2023)

Article Neurosciences

N-acetylcysteine treatment mitigates loss of cortical parvalbumin-positive interneuron and perineuronal net integrity resulting from persistent oxidative stress in a rat TBI model

Mustafa Q. Hameed et al.

Summary: Weeks-long post-traumatic NAC treatment can mitigate persistent oxidative stress and protect PVI integrity, as well as prevent pathological EEG changes, after traumatic brain injury.

CEREBRAL CORTEX (2023)

Review Cell Biology

Role of ferroptosis on tumor progression and immunotherapy

Deting Gong et al.

Summary: Ferroptosis, triggered by intracellular iron, leads to cell death through the accumulation of lipid peroxidation. Cancer cells can evade ferroptosis by activating antioxidant signaling pathways. Besides transcriptional regulation, ferroptosis can also be modulated by ubiquitination or autophagic degradation. Induction of ferroptosis enhances immune cell activity, but it may impair T cell activity as well. Therefore, rational combined therapy is crucial for cancer treatment.

CELL DEATH DISCOVERY (2022)

Article Anesthesiology

Inhibition of ferroptosis-like cell death attenuates neuropathic pain reactions induced by peripheral nerve injury in rats

Yue Guo et al.

Summary: The study discovered that ferroptosis plays a crucial role in neuropathic pain induced by peripheral nerve injury, and inhibiting ferroptosis with liproxstatin-1 could alleviate hypersensitivity, suggesting a potential therapeutic target for neuropathic pain.

EUROPEAN JOURNAL OF PAIN (2021)

Article Cell Biology

The circular RNA circSlc7a11 promotes bone cancer pain pathogenesis in rats by modulating LLC-WRC 256 cell proliferation and apoptosis

Han-Wen Chen et al.

Summary: This study identified that the circRNA circSlc7a11 regulates the development of rat BCP by influencing cell proliferation and apoptosis through multiple signaling mechanisms. Overexpression of circSlc7a11 promoted cell proliferation, while silencing it had the opposite effects on LLC-WRC 256 and UMR-106 cells. The changes in circSlc7a11 expression also led to substantial alterations in mRNA expression profiles of LLC-WRC 256 cells, linked to various apoptotic processes and signaling pathways.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

Review Physiology

BONEMETASTASIS: MECHANISMS, THERAPIES, AND BIOMARKERS

Philippe Clezardin et al.

Summary: Skeletal metastases are common complications of many cancers, significantly impacting patients' quality of life. The multistage process of bone metastasis involves various cellular and molecular mechanisms. While existing bone-targeted agents have made progress, further research and more effective treatment options are still needed.

PHYSIOLOGICAL REVIEWS (2021)

Article Biochemistry & Molecular Biology

Calpains play an essential role in mechanical ventilation-induced diaphragmatic weakness and mitochondrial dysfunction

Hayden W. Hyatt et al.

Summary: Mechanical ventilation is a life-saving intervention for critically ill patients, but it can lead to ventilator-induced diaphragm dysfunction (VIDD) due to oxidative stress activating major proteolytic systems. Calpain activation plays an essential role in VIDD development, leading to oxidative stress, muscle atrophy, and contractile dysfunction.

REDOX BIOLOGY (2021)

Article Cell Biology

Ferroptosis is involved in the development of neuropathic pain and allodynia

Huixing Wang et al.

Summary: The study in rats indicated that ferroptosis is involved in the development of neuropathic pain by blocking neuron and astrocyte activation in the spinal dorsal horn.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Ferroptosis: mechanisms and links with diseases

Hong-fa Yan et al.

Summary: Ferroptosis is a form of cell death that is iron-dependent and involves accumulation of lethal lipid species from lipid peroxidation. This review discusses the regulatory mechanisms of ferroptosis and its connections with iron, lipid, and cysteine metabolism pathways. Additionally, it explores the role of ferroptosis in diseases such as cancer, ischemia/reperfusion, Alzheimer's disease, and Parkinson's disease, and evaluates the potential therapeutic applications of ferroptosis inhibitors in clinical settings.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Biochemistry & Molecular Biology

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

Giovanni Miotto et al.

REDOX BIOLOGY (2020)

Review Pharmacology & Pharmacy

The Application of Ferroptosis in Diseases

Yangmin Qiu et al.

PHARMACOLOGICAL RESEARCH (2020)

Review Oncology

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Yanhua Mou et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Article Pharmacology & Pharmacy

The therapeutic potential of GABA in neuron-glia interactions of cancer-induced bone pain

Meng-Meng Ge et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Liproxstatin-1 Attenuates Morphine Tolerance through Inhibiting Spinal Ferroptosis-like Cell Death

Xuhui Chen et al.

ACS CHEMICAL NEUROSCIENCE (2019)

Review Oncology

Optimal pain management for patients with cancer in the modern era

Bethann M. Scarborough et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

CELL DEATH AND DIFFERENTIATION (2016)

Review Health Care Sciences & Services

Update on Prevalence of Pain in Patients With Cancer: Systematic Review and Meta-Analysis

Marieke H. J. van den Beuken-van Everdingen et al.

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT (2016)

Article Neurosciences

The interneuron energy hypothesis: Implications for brain disease

Oliver Kann

NEUROBIOLOGY OF DISEASE (2016)

Article Biotechnology & Applied Microbiology

Role of estrogen in lung cancer based on the estrogen receptor-epithelial mesenchymal transduction signaling pathways

Xiao-zhen Zhao et al.

ONCOTARGETS AND THERAPY (2015)

Review Oncology

Pain and Nociception: Mechanisms of Cancer-Induced Bone Pain

Sarah Falk et al.

JOURNAL OF CLINICAL ONCOLOGY (2014)

Article Chemistry, Multidisciplinary

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Rachid Skouta et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli et al.

NATURE CELL BIOLOGY (2014)

Review Health Care Sciences & Services

Bone cancer pain: from mechanism to therapy

Patrick W. Mantyh

CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE (2014)

Review Clinical Neurology

Cancer-Induced Oxidative Stress and Pain

Mina G. Nashed et al.

CURRENT PAIN AND HEADACHE REPORTS (2013)

Article Multidisciplinary Sciences

Perineuronal nets protect fast-spiking interneurons against oxidative stress

Jan-Harry Cabungcal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Review Pharmacology & Pharmacy

Pharmacotherapy for Breakthrough Cancer Pain

Sebastiano Mercadante

Article Behavioral Sciences

Pharmacological evaluation of opioid and non-opioid analgesics in a murine bone cancer model of pain

Mohammed El Mouedden et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2007)