期刊
PROBIOTICS AND ANTIMICROBIAL PROTEINS
卷 -, 期 -, 页码 -出版社
SPRINGER
DOI: 10.1007/s12602-023-10047-9
关键词
Lactobacillus plantarum; Escherichia coli; Mastitis; Tight junction; Inflammation; NF-kappa B; MAPK
In this study, the preventive effect of Lactobacillus plantarum 17-5 on Escherichia coli-induced mastitis in mice was evaluated. The results showed that L. plantarum 17-5 maintained the integrity of tight junctions, improved inflammatory injury, decreased MPO activity and the mRNA expression levels of IL1 beta, IL6, and TNF alpha, and inhibited the NF-kappa B and MAPK signaling pathways in mice mammary tissue. This indicates that Lactobacillus plantarum 17-5 has excellent anti-inflammatory activities and can be developed into a microecological preparation for clinical use to prevent mastitis.
Mastitis is the most economically important disease affecting the dairy industry worldwide. Lactobacillus plantarum, an important probiotic with a wide range of applications, has potential anti-inflammatory properties and has become a currently strong candidate for mastitis therapies. In the current study, we evaluated the prevention effect of Lactobacillus plantarum 17-5 on Escherichia coli-induced mastitis in mice. The results showed that pretreatment with L. plantarum 17-5 maintained the integrity of tight junctions; improved inflammatory injury; decreased MPO activity and the mRNA expression levels of IL1 beta, IL6, and TNF alpha; and inhibited the NF-kappa B and MAPK signaling pathways in mice mammary tissue. The results indicated that Lactobacillus plantarum 17-5 had excellent anti-inflammatory activities and could be developed into microecological preparation for clinical use to prevent mastitis.
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