Atrial Fibrillation Ablation for Heart Failure With Preserved Ejection Fraction A Randomized Controlled Trial

Article Cardiac & Cardiovascular Systems

Atrial Fibrillation and Dapagliflozin Efficacy in Patients With Preserved or Mildly Reduced Ejection Fraction

Jawad H. Butt et al.

Summary: This study examined the effects of dapagliflozin in patients with atrial fibrillation (AF) and found that its benefits were consistent across different types of AF.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

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Review Cardiac & Cardiovascular Systems

Interpretation of clinical studies in electronilysiology: statistical considerations for the clinician

David Chieng et al.

Summary: Understanding the importance of clinical research design and statistical analysis in improving the management of atrial fibrillation patients, focusing on study design types, sample size calculation, and the selection of primary endpoints, is crucial for enhancing the effectiveness of clinical practice.

EUROPACE (2021)

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Article Cardiac & Cardiovascular Systems

Ablation Versus Drug Therapy for Atrial Fibrillation in Heart Failure Results From the CABANA Trial

Douglas L. Packer et al.

Summary: The CABANA trial showed that catheter ablation in patients with heart failure and atrial fibrillation can significantly improve survival, reduce AF recurrence, and enhance quality of life compared to drug therapy.

CIRCULATION (2021)

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Article Cardiac & Cardiovascular Systems

A prospective STudy using invAsive haemodynamic measurements foLLowing catheter ablation for AF and early HFpEF: STALL AF-HFpEF

Hariharan Sugumar et al.

Summary: This study found that atrial fibrillation ablation in early heart failure patients can improve symptoms and exercise hemodynamic parameters. Restoration of sinus rhythm in patients with AF and HFpEF can lead to improvements in haemodynamic parameters and symptoms.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

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Article Cardiac & Cardiovascular Systems

Treatment-Related Changes in Left Atrial Structure in Atrial Fibrillation Findings From the CABANA Imaging Substudy

Maryam E. Rettmann et al.

Summary: The CABANA trial included a prospective imaging substudy to investigate changes in left atrial and pulmonary vein dimensions in atrial fibrillation patients undergoing catheter ablation versus drug therapy. While changes in left atrial and PV dimensions did not predict the primary study endpoint, reductions in left atrial volume index and mean PV diameter were associated with a decreased risk of AF recurrence. Ablation patients showed more significant atrial structural changes compared to drug therapy patients, suggesting a relationship between structural features and AF generation.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Catheter ablation for atrial fibrillation in HFpEF patients-A propensity-score-matched analysis

Manuel Rattka et al.

Summary: This study compared outcomes of HFpEF patients with AF who underwent CA versus received medical therapy, finding that CA group had significantly lower arrhythmia recurrence, reduced heart failure hospitalization and death, and improved clinical and echocardiographic parameters of HFpEF. Reassessment at follow-up showed resolution of HFpEF in a higher percentage of patients in CA group compared to medical therapy group.

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2021)

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Article Medicine, General & Internal

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

Stefan D. Anker et al.

Summary: Empagliflozin reduces the risk of cardiovascular death or hospitalization for heart failure in patients with heart failure and a preserved ejection fraction, regardless of the presence or absence of diabetes.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Heart failure with preserved ejection fraction: An alternative paradigm to explain the clinical implications of atrial fibrillation

Jonathan P. Ariyaratnam et al.

Summary: Atrial fibrillation (AF) is associated with exercise intolerance, stroke, and all-cause mortality. Heart failure with preserved ejection (HFpEF) commonly coexists with AF and may contribute to the poor outcomes associated with AF. The presence of left atrial (LA) myopathy is closely linked to both AF burden and worsening HFpEF, with potential prognostic implications for patients with these conditions.

HEART RHYTHM O2 (2021)

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Article Cardiac & Cardiovascular Systems