☆ 4.3 Article

Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Nanoscience & Nanotechnology

NIR irradiation enhances the apoptotic potentiality of quinacrine-gold hybrid nanoparticles by modulation of HSP-70 in oral cancer stem cells

Somya Ranjan Dash et al.

Summary: A study found that quinacrine-gold hybrid nanoparticles (QAuNP) combined with near-infrared irradiation can disrupt mitochondrial membrane potential, leading to DNA damage and apoptosis in oral squamous cell carcinoma (OSCC) cancer stem cells (CSCs). Additionally, this treatment can regulate the expression of key proteins, enhancing the apoptosis of CSCs. These findings have important implications for tumor therapy.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2022)

添加到收藏夹

Article Oncology

Combination of talazoparib and olaparib enhanced the curcumin-mediated apoptosis in oral cancer cells by PARP-1 trapping

Subhajit Chatterjee et al.

Summary: This study reveals the importance of DNA damage induction in the functioning of PARP inhibitors and shows that the combination treatment of BMN + Ola enhances the apoptotic potentiality of Cur in cancer cells by enhancing PARP-trapping activity.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2022)

添加到收藏夹

Article Oncology

Olaparib enhances the Resveratrol-mediated apoptosis in breast cancer cells by inhibiting the homologous recombination repair pathway

Saptarshi Sinha et al.

Summary: The combination of RES and OLA enhances cell death in HR-proficient breast cancer cells by increasing DNA damage and inhibiting the HR pathway.

EXPERIMENTAL CELL RESEARCH (2022)

添加到收藏夹

Review Oncology

Repurposing quinacrine for treatment-refractory cancer

Derek B. Oien et al.

Summary: Quinacrine, originally an antimalarial drug, has been rediscovered as an anticancer agent due to its multiple mechanisms including inhibition of cancer cell growth and DNA repair processes. Its potential in treating aggressive tumors such as high grade serous ovarian cancer has been highlighted in recent studies.

SEMINARS IN CANCER BIOLOGY (2021)

添加到收藏夹

Review Oncology

Anti-Cancer Agents in Medicinal Chemistry

Biswajit Das et al.

Summary: Cancer is a leading cause of death globally, often caused by various carcinogenic agents. The use of natural products as anticancer agents is essential, along with reducing risk factors to decrease cancer incidence. Conventional treatments may have adverse effects on normal tissues, highlighting the need for alternative and innovative cancer treatment methods with minimal side effects and improved efficiency.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Nano formulated Resveratrol inhibits metastasis and angiogenesis by reducing inflammatory cytokines in oral cancer cells by targeting tumor associated macrophages

Rajalaxmi Pradhan et al.

Summary: Tumor associated macrophages in the tumor microenvironment secrete cytokines that regulate cancer cells growth, while Resveratrol nanoparticles reduce the properties of cancer stem like cells. By decreasing cytokine levels, Res-NP inhibits invasion, proliferation, and growth of CSCs in vitro, in vivo, and ex vivo systems.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

添加到收藏夹

Article Cell Biology

PARP inhibitor Veliparib (ABT-888) enhances the anti-angiogenic potentiality of Curcumin through deregulation of NECTIN-4 in oral cancer: Role of nitric oxide (NO)

Subhajit Chatterjee et al.

Summary: This study investigates the anti-angiogenic effects of Curcumin and Veliparib in oral cancer, showing that the combination inhibits NECTIN-4 mediated angiogenesis. It highlights the potential of using Curcumin-Veliparib combination to suppress angiogenesis in cancer therapy by targeting the PI3K-AKT-eNOS pathway downstream of NECTIN-4.

CELLULAR SIGNALLING (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Nectin-4 promotes lymphangiogenesis and lymphatic metastasis in breast cancer by regulating CXCR4-LYVE-1 axis

Chinmayee Sethy et al.

Summary: Nectin-4 plays a predominant role in promoting tumor-induced lymphangiogenesis and lymphatic metastasis in invasive duct carcinoma (IDC), modulating the CXCR4/CXCL12-LYVE-1 axis.

VASCULAR PHARMACOLOGY (2021)

添加到收藏夹

Review Cell & Tissue Engineering

Signaling pathways governing breast cancer stem cells behavior

Kai Song et al.

Summary: Breast cancer stem cells play a critical role in the metastasis and aggressiveness of breast cancer, making them a suitable target for treatment. Signaling pathways such as Wnt, NF kappa B, and miRNAs are key players in regulating BCSC self-renewal and metastasis. Targeting these pathways may offer a novel therapeutic approach for breast cancer diagnosis and therapy.

STEM CELL RESEARCH & THERAPY (2021)

添加到收藏夹

Article Immunology

Tumour angiogenesis and c-Met pathway activation - implications in breast cancer

Suvradeep Mitra et al.

APMIS (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Nanoformulated quinacrine regulates NECTIN-4 domain specific functions in cervical cancer stem cells

Subhajit Chatterjee et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

添加到收藏夹

Article Peripheral Vascular Disease

Cancer stem cells contribute to angiogenesis and lymphangiogenesis in serous adenocarcinoma of the ovary

Syama Krishnapriya et al.

ANGIOGENESIS (2019)

添加到收藏夹

Article Oncology

Breast cancer statistics, 2019

Carol E. DeSantis et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

添加到收藏夹

Review Public, Environmental & Occupational Health

Safety and Tolerability of c-MET Inhibitors in Cancer

Alberto Puccini et al.

DRUG SAFETY (2019)

添加到收藏夹

Article Oncology

Nanoquinacrine sensitizes 5-FU-resistant cervical cancer stem-like cells by down-regulating Nectin-4 via ADAM-17 mediated NOTCH deregulation

Anmada Nayak et al.

CELLULAR ONCOLOGY (2019)

添加到收藏夹

Review Gastroenterology & Hepatology

Recent developments of c-Met as a therapeutic target in hepatocellular carcinoma

Mohamed Bouattour et al.

HEPATOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities

Yazhuo Zhang et al.

MOLECULAR CANCER (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Bioimpedimetric analysis in conjunction with growth dynamics to differentiate aggressiveness of cancer cells

Aditya Parekh et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Review Cell Biology

Cancer stem cells as key drivers of tumour progression

Ain Zubaidah Ayob et al.

JOURNAL OF BIOMEDICAL SCIENCE (2018)

添加到收藏夹

Review Oncology

Cancer stem cells (CSCs), cervical CSCs and targeted therapies

Ruixia Huang et al.

ONCOTARGET (2017)

添加到收藏夹

Article Oncology

Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer

Julia Tchou et al.

CANCER IMMUNOLOGY RESEARCH (2017)

添加到收藏夹

Article Oncology

SURVIVIN as a marker for quiescent-breast cancer stem cells-An intermediate, adherent, pre-requisite phase of breast cancer metastasis

Sumit Siddharth et al.

CLINICAL & EXPERIMENTAL METASTASIS (2016)

添加到收藏夹

Article Genetics & Heredity

ABT-888 and quinacrine induced apoptosis in metastatic breast cancer stem cells by inhibiting base excision repair via adenomatous polyposis coli

Sumit Siddharth et al.

DNA REPAIR (2016)

添加到收藏夹

Article Oncology

Simm530, a novel and highly selective c-Met inhibitor, blocks c-Met-stimulated signaling and neoplastic activities

Ying Wang et al.

ONCOTARGET (2016)

添加到收藏夹

Article Pathology

Prognostic significance of c-Met in breast cancer: a meta-analysis of 6010 cases

Shunchao Yan et al.

DIAGNOSTIC PATHOLOGY (2015)

添加到收藏夹

Review Oncology

The clinical and functional significance of c-Met in breast cancer: a review

Colan M. Ho-Yen et al.

BREAST CANCER RESEARCH (2015)

添加到收藏夹

Review Pharmacology & Pharmacy

cMET in triple-negative breast cancer: is it a therapeutic target for this subset of breast cancer patients?

Patricia B. Gaule et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

添加到收藏夹

Article Multidisciplinary Sciences

FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-κB

Canhui Guo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

添加到收藏夹

Article Pathology

Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells

G Taraboletti et al.

AMERICAN JOURNAL OF PATHOLOGY (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.