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COVID-19-induced neurological symptoms: focus on the role of metal ions

INFLAMMOPHARMACOLOGY (2023)

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Summary: Selenium is a vital element for human and animal health, playing a significant role in various bodily functions. However, excessive intake of selenium can be harmful. It supports antioxidant defense systems, hormone metabolism, reproductive functions, and neuroprotection. Optimizing selenium intake is important for preventing diseases related to selenium deficiency or excess.

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Shuaiwei Wang et al.

Summary: This study found that ILC family members are restricted in the brain. When the brain experiences ischemic injury, ILCs gather at the edge of the lesion and play a protective role. The study also identified the importance of blood-brain barrier-derived CXCL12 in attracting NK cells to ischemic brain lesions.

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The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination

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Summary: This study reveals the relationship between HECTD4, GluN2B, and MALT1 in ischemic stroke, showing that the downregulation of HECTD4 leads to calcium overload and brain injury due to the activation of GluN2B and the reduced ubiquitination of GluN2B and MALT1.

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Marco Vinceti et al.

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CDR1as regulates a-synuclein-mediated ischemic brain damage by controlling miR-7 availability

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Twice-Daily Oral Zinc in the Treatment of Patients With Coronavirus Disease 2019: A Randomized Double-Blind Controlled Trial

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COVID-19 Severity Is Associated with Selenium Intake among Young Adults with Low Selenium and Zinc Intake in North Carolina

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Iron and iron-related proteins in COVID-19

Erin Suriawinata et al.

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Ferritin-from iron, through inflammation and autoimmunity, to COVID-19

Naim Mahroum et al.

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Summary: Ferritin plays a crucial role in maintaining iron metabolism in the body, and high levels of ferritin are associated with inflammation and prognosis of COVID-19. Iron chelators can effectively treat iron overload and have potential therapeutic effects on COVID-19 patients.

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Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis

Felicia Ceban et al.

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Jing Jin et al.

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Tranilast, a Transient Receptor Potential Vanilloid 2 Channel (TRPV2) Inhibitor Attenuates Amyloid β-Induced Cognitive Impairment: Possible Mechanisms

Pavan Thapak et al.

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Peter Tsvetkov et al.

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Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia

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Effects of Selenium Supplementation in Patients with Mild Cognitive Impairment or Alzheimer's Disease: A Systematic Review and Meta-Analysis

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Role and mechanism of ferroptosis in neurological diseases

Mengmeng Ou et al.

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Iron-Induced Oxidative Stress in Human Diseases

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Zinc in Cognitive Impairment and Aging

Ruize Sun et al.

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SARS-CoV-2-induced hypomethylation of the ferritin heavy chain (FTH1) gene underlies serum hyperferritinemia in severe COVID-19 patients

Jibran Sualeh Muhammad et al.

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COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis

Allison L. Soung et al.

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Zhan Zhang et al.

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SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

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Summary: Neuropsychiatric manifestations are common in SARS-CoV-2 infection, but their mechanisms are unknown. Using a brain organoid model, researchers found that SARS-CoV-2 infection triggers neuronal cell death and disrupts circuit integrity through microglia-mediated synapse elimination, potentially contributing to cognitive impairments in COVID-19 patients.

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Long-term neurologic outcomes of COVID-19

Evan Xu et al.

Summary: Individuals with COVID-19 have an increased risk of developing a range of neurologic disorders at 12 months, even if they were not hospitalized during the acute phase of the infection.

NATURE MEDICINE (2022)

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Oxidation state-specific fluorescent copper sensors reveal oncogene-driven redox changes that regulate labile copper(II) pools

Aidan T. Pezacki et al.

Summary: This study presents an activity-based sensing strategy for the specific detection of Cu(II) through metal-directed acyl imidazole chemistry. The method enables the detection and analysis of labile Cu(II) pools, providing valuable information on its regulation and potential role in metal-dependent diseases.

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Reduction in Serum Magnesium Levels and Renal Function Are Associated with Increased Mortality in Obese COVID-19 Patients

Patricia Pulido Perez et al.

Summary: Several studies have shown that obesity is a significant risk factor for adverse outcomes in COVID-19. This retrospective cohort study involving 390 hospitalized COVID-19 patients found that obesity was associated with reduced renal function and lower serum magnesium levels. The study also showed a significant association between obesity and mortality, as well as a higher risk of death in obese patients with lower magnesium levels.

NUTRIENTS (2022)

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Article Cell Biology

SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19

Danielle Beckman et al.

Summary: SARS-CoV-2 can directly infect the brain and induce neuroinflammation and neuronal damage, especially in aged, diabetic animals, which is crucial for reducing the short-term and long-term burden of COVID-19.

CELL REPORTS (2022)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir

Pinar Mesci et al.

Summary: SARS-CoV-2 can replicate in human brain cells and cause death of neural cells, leading to neurological symptoms including loss of excitatory synapses in neurons. The FDA-approved antiviral Sofosbuvir can inhibit viral replication and reverse these neuronal alterations, providing a cellular basis for treating COVID-19-related neurological defects.

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Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep

Daisuke Tone et al.

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Mohammed Kanan Alshammari et al.

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Article Biochemistry & Molecular Biology

Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

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Neutrophil-like Cell-Membrane-Coated Nanozyme Therapy for Ischemic Brain Damage and Long-Term Neurological Functional Recovery

Lishuai Feng et al.

Summary: This study introduces a neutrophil-like cell-membrane-coated mesoporous Prussian blue nanozyme, which improves the delivery of the nanozyme to the damaged brain for noninvasive active-targeting therapy in ischemic stroke. The long-term therapeutic efficacy of this nanozyme in ischemic stroke is demonstrated, with a detailed mechanism involving uptake by microglia leading to beneficial effects like microglia polarization, reduced recruitment of neutrophils, decreased neuron apoptosis, and neural cell proliferation. This strategy offers an approach for nanozyme therapy in brain diseases.

ACS NANO (2021)

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Article Biochemistry & Molecular Biology

Olfactory Disturbances as Presenting Manifestation Among Egyptian Patients with COVID-19: Possible Role of Zinc

Aida A. Abdelmaksoud et al.

Summary: This study found that serum zinc levels in COVID-19 patients did not significantly differ based on disease severity or the presence of olfactory/gustatory dysfunction. However, patients who received zinc therapy had a significantly shorter duration of recovery of olfactory/gustatory function compared to those who did not receive zinc.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

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Article Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb

Mona Khan et al.

Summary: Anosmia, the loss of smell, is a common symptom of COVID-19, but it is caused by the virus attacking sustentacular cells in the olfactory mucosa rather than infecting olfactory sensory neurons. This suggests that SARS-CoV-2 is not a neurotropic virus.

CELL (2021)

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Review Biochemistry & Molecular Biology

Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology

Deidiane Elisa Ribeiro et al.

Summary: Complications of COVID-19 may cause neuroinflammatory responses, triggering and exacerbating neurological disorders. Diseases associated with neuroimmune activation may increase susceptibility to SARS-CoV-2 infection and lead to severe conditions.

MOLECULAR PSYCHIATRY (2021)

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Article Biochemistry & Molecular Biology

The calcium-iron connection in ferroptosis-mediated neuronal death

Silvia Gleitze et al.

Summary: Iron plays a crucial role in the physiological function of biological systems, particularly in the development of normal cognitive functions in the brain, but its deregulation can lead to neuronal damage and death. Ferroptosis, a newly described iron-dependent cell death pathway, differs morphologically, biochemically, and genetically from other types of cell death. It involves iron-mediated lipid peroxidation, depletion of the endogenous antioxidant glutathione, and altered mitochondrial morphology.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Clinical Neurology

Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology

Shalini S. Rao et al.

Summary: Iron dysregulation may contribute to the formation of neurofibrillary tangles in tauopathies, and the iron chelator DFP has shown potential therapeutic advantages in improving cognitive function and reducing tau protein aggregation in neurons.

NEUROTHERAPEUTICS (2021)

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Article Cell Biology

Hepcidin Promoted Ferroptosis through Iron Metabolism which Is Associated with DMT1 Signaling Activation in Early Brain Injury following Subarachnoid Hemorrhage

Hongxia Zhang et al.

Summary: In a rat model of SAH, inhibition of DMT1 suppresses iron accumulation and lipid peroxidation, alleviating ferroptosis and early brain injury. Heparin downregulates hepcidin and DMT1 expression, increases FPN1, exerting protective effects equivalent to ebselen on ferroptosis and EBI. Furthermore, OSM increases hepcidin and DMT1 expression, decreases FPN1, aggravating ferroptosis and EBI, which can be reversed by ebselen.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Psychiatry

Suicide, self-harm and suicidal ideation during COVID-19: A systematic review

Saeed Farooq et al.

Summary: This study conducted a systematic review and meta-analysis of studies on suicidal ideation during the COVID-19 pandemic, finding a higher prevalence rate compared to pre-pandemic levels. Main risk factors identified included low social support, high physical and mental exhaustion, sleep disturbances, loneliness, and mental health difficulties. The findings suggest that the COVID-19 pandemic may lead to an increase in future suicide rates.

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Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVID-19

Abhishek Jaywant et al.

Summary: Most COVID-19 patients who require acute rehabilitation prior to discharge exhibit cognitive impairment, with deficits commonly seen in working memory, set-shifting, divided attention, and processing speed. Interventions targeting attention and executive dysfunctions may be beneficial for this population.

NEUROPSYCHOPHARMACOLOGY (2021)

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Article Cell Biology

Zinc transporter ZIP7 is a novel determinant of ferroptosis

Po-Han Chen et al.

Summary: The study revealed that zinc is essential for ferroptosis in breast and renal cancer cells. The genetic determinant ZIP7 controls zinc transport and plays a crucial role in ferroptosis. Inhibition of ZIP7 can protect cells against ferroptosis, highlighting a potential therapeutic target for diseases involving ferroptosis and zinc dysregulation.

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The Neurobiology of Selenium: Looking Back and to the Future

Ulrich Schweizer et al.

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TRPM7 Kinase Is Essential for Neutrophil Recruitment and Function via Regulation of Akt/mTOR Signaling

Wiebke Nadolni et al.

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FRONTIERS IN IMMUNOLOGY (2021)

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Article Peripheral Vascular Disease

Chronic Blockade of NMDAR Subunit 2A in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Suppression of MEK/ERK/CREB Pathway

Ying Li et al.

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AMERICAN JOURNAL OF HYPERTENSION (2021)

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Review Medicine, Research & Experimental

The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators

Hosam M. Habib et al.

Summary: Iron overload is increasingly seen as a contributor to the pathogenesis of COVID-19, triggering inflammation, hypercoagulation, hyperferritinemia, and immune dysfunction. Iron chelators, including the naturally occurring lactoferrin, may hold therapeutic value in COVID-19 by modulating the immune response and blocking the entry of coronaviruses into host cells.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital

Kiran T. Thakur et al.

Summary: Many patients with SARS-CoV-2 infection exhibit neurological signs and symptoms, but autopsy results show that most brains have low levels of detectable virus and it does not correlate with the histopathological alterations.

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SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment

Chien-Ting Wu et al.

Summary: There is evidence suggesting a complex relationship between COVID-19 and diabetes, with SARS-CoV-2 being able to directly induce beta cell killing and this effect being rescued by NRP1 inhibition.

CELL METABOLISM (2021)

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Article Biochemistry & Molecular Biology

TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease

Jia Lu et al.

Summary: Microglia energy metabolism is suppressed during chronic A beta-tolerant processes, but pharmacological activation of TRPV1 can rescue microglial dysfunction and restore immune responses, leading to reduced amyloid pathology and reversed memory deficits in AD mice. This study suggests that TRPV1 is an important target for regulating metabolic reprogramming in microglial functions for AD treatment.

EMBO REPORTS (2021)

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Article Biochemistry & Molecular Biology

DIP2A is involved in SOD-mediated antioxidative reactions in murine brain

Lu-Lu Bai et al.

Summary: The study revealed the important role of DIP2A in regulating oxidative stress in patients with Autism Spectrum Disorder, by inhibiting SOD activity and increasing ROS levels to protect cells from damage, while also affecting mitochondrial morphology and metabolism.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Virology

COVID-19 encephalopathy: Clinical and neurobiological features

Marjolaine Uginet et al.

Summary: Among COVID-19 patients, 4.4% develop acute encephalopathy, with severe cases showing more severe headache symptoms; however, the severity of the encephalopathy is not associated with the severity of pneumonia.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Biology

Overexpression of Cu/Zn Superoxide Dismutase (Cu/Zn SOD) in Synechococcus elongatus PCC 7942 for Enhanced Azo Dye Removal through Hydrogen Peroxide Accumulation

ShylajaNaciyar Mohandass et al.

Summary: Synthetic azo dyes are widely used but their improper discharge poses a threat to the environment. Genetically modified cyanobacteria with enhanced H2O2 accumulation through SOD overexpression can effectively degrade these dyes, suggesting a valuable bioremediation strategy.

BIOLOGY-BASEL (2021)

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Review Neurosciences

The emerging association between COVID-19 and acute stroke

Laura K. Stein et al.

Summary: Prior to COVID-19, only two human-tropic coronaviruses resulted in epidemics and cerebrovascular disease was rarely reported. Evidence now suggests that 1-6% of hospitalized COVID-19 patients develop stroke. Concerningly, outcomes of COVID-19-related stroke are often worse than in stroke patients without COVID-19. Etiology of stroke in COVID-19 patients is likely multifactorial, related to coagulopathy, inflammation, platelet activation, and alterations to the vascular endothelium. Further research is needed to better understand the pathogenesis of COVID-19-related stroke and develop optimal prevention strategies.

TRENDS IN NEUROSCIENCES (2021)

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Article Medicine, General & Internal

Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19-A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium

Sherry H. -Y. Chou et al.

Summary: This study included patients with clinically diagnosed or laboratory-confirmed COVID-19 at 28 centers across 13 countries and 4 continents from March 1 to September 30, 2020. Neurological manifestations were prevalent among hospitalized patients with COVID-19 and were associated with higher in-hospital mortality. Patients with preexisting neurological disorders were at increased risk of developing neurological signs and/or syndromes in COVID-19.

JAMA NETWORK OPEN (2021)

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Article Clinical Neurology

COVID-19-related neuropathology and microglial activation in elderly with and without dementia

Tino Emanuele Poloni et al.

Summary: The study compared 9 COVID-19 cases and 6 non-COVID controls, finding non-specific changes in COVID-19 patients such as hypoxic-agonal alterations and various degrees of neurodegeneration. COVID-19 brains exhibited increased microglial activation, with a possible boosting of innate immunity and suppression of adaptive immunity. The microglial hyperactivation in the brainstem and hippocampus of COVID-19 patients with delirium appears to be a specific topographical phenomenon, potentially representing the neuropathological basis of COVID-19 encephalopathic syndrome in the elderly.

BRAIN PATHOLOGY (2021)

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Article Biochemistry & Molecular Biology

Glycyrrhetinic acid induces oxidative/nitrative stress and drives ferroptosis through activating NADPH oxidases and iNOS, and depriving glutathione in triple-negative breast cancer cells

Yi Wen et al.

Summary: 18-beta-glycyrrhetinic acid can promote the production of ROS and RNS through activating NADPH oxidases and iNOS, decreasing GSH and GPX activity, subsequently exacerbating lipid peroxidation and triggering ferroptosis in triple-negative breast cancer cells.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Immunology

Phthalide derivative CD21 attenuates tissue plasminogen activator-induced hemorrhagic transformation in ischemic stroke by enhancing macrophage scavenger receptor 1-mediated DAMP (peroxiredoxin 1) clearance

Dong-Ling Liu et al.

Summary: The phthalide derivative CD21 attenuates tPA-induced hemorrhagic transformation in acute ischemic stroke by promoting MSR1-induced DAMP clearance and inhibition of the TLR4/NF-kappa B pathway and neuroinflammation.

JOURNAL OF NEUROINFLAMMATION (2021)

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Article Cell Biology

Mitochondrial calcium signaling in the brain and its modulation by neurotropic viruses

Rituparna Chaudhuri et al.

Summary: Calcium channels in brain cells play a crucial role in regulating ATP generation and cell death, also influencing viral infection and dissemination.

MITOCHONDRION (2021)

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Article Clinical Neurology

Characterization of Selenium Compounds for Anti-ferroptotic Activity in Neuronal Cells and After Cerebral Ischemia-Reperfusion Injury

Qing-Zhang Tuo et al.

Summary: The emergence of ferroptosis as a cell death pathway associated with brain disorders highlights the importance of developing therapeutics targeting the brain and protecting neurons. Selenium compounds have shown to be effective in inhibiting ferroptosis, with organic selenium compounds like methylselenocysteine providing protection against neuronal damage in ischemia-reperfusion injury in vivo. This suggests the potential use of ferroptosis inhibitors and specific selenium compounds in preventing neuronal damage in ischemic stroke and other related brain diseases.

NEUROTHERAPEUTICS (2021)

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Article Plant Sciences

Regulatory functions of ROS dynamics via glutathione metabolism and glutathione peroxidase activity in developing rice zygote

Kasidit Rattanawong et al.

Summary: This study highlights the importance of ROS dynamics, GPX antioxidant activity, and glutathione redox metabolism during zygotic/embryonic development in rice. Inhibition of ROS production or interference with GPX activity can impact the development of zygotes and early embryos.

PLANT JOURNAL (2021)

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Article Multidisciplinary Sciences

NAD plus supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING

Yujun Hou et al.

Summary: Research reveals that levels of NAD* decrease, and inflammation increases in the brains of Alzheimer's disease patients, while treatment with NR can increase brain NAD* levels, reduce inflammation, and improve cellular senescence. NR treatment is beneficial for neuroinflammation and cellular senescence through a cGAS-STING dependent pathway, inducing mitophagy and improving cognitive function.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Oncology

Role of endolysosome function in iron metabolism and brain carcinogenesis

Peter W. Halcrow et al.

Summary: Iron is a crucial microelement in the human brain, playing essential roles in regulating cellular mechanisms. However, imbalanced iron homeostasis can lead to accumulation of excess reactive oxygen species in endolysosomes, causing damage to mitochondria and DNA, ultimately promoting carcinogenesis. Understanding the impact of endolysosome iron accumulation on cancer development may aid in the development of effective therapeutic strategies for cancer treatment and prevention.

SEMINARS IN CANCER BIOLOGY (2021)

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Review Neurosciences

The calcium-dependent protease calpain in neuronal remodeling and neurodegeneration

Elsayed Metwally et al.

Summary: Calpains are Ca2+-activated cysteine proteases that act at neutral pH, with tightly regulated activity. Genetic mutations in calpain genes are associated with human diseases, and elevated Ca2+ levels can promote calpain activation in pathologies.

TRENDS IN NEUROSCIENCES (2021)

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Article Immunology

Inhibition of IP3R/Ca2+Dysregulation Protects Mice From Ventilator-Induced Lung Injury via Endoplasmic Reticulum and Mitochondrial Pathways

Liu Ye et al.

Summary: Disruption of intracellular calcium homeostasis is implicated in inflammatory responses. High tidal volume mechanical ventilation leads to increased IP3R expression, disrupted Ca2+ homeostasis, and inflammatory responses. Targeting IP3R/Ca2+ or maintaining Ca2+ homeostasis may be a potential treatment approach for ventilator-induced lung injury.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Iron overload in the motor cortex induces neuronal ferroptosis following spinal cord injury

Zhou Feng et al.

Summary: The study demonstrated that activated microglia in the motor cortex induced iron overload after SCI, triggering motor neuronal ferroptosis and impeding motor functional recovery. Iron chelator and inhibitors could reduce iron overload-induced neuronal death, potentially offering novel therapeutic strategies for SCI.

REDOX BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration

Ling Zhang et al.

Summary: The study found evidence supporting that SARS-CoV-2 can cross the blood-brain barrier in transcellular pathways based on experiments in mice and hamsters. The transmission pathway involves disrupted basement membrane without obvious alteration of tight junctions.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Cell Biology

TP53-induced glycolysis and apoptosis regulator alleviates hypoxia/ischemia-induced microglial pyroptosis and ischemic brain damage

Lan-Lan Tan et al.

Summary: The study revealed that TIGAR plays a protective role in neonatal HIBD by inhibiting microglial pyroptosis. Application of NADPH can increase NADPH level and reduce oxidative stress, counteracting the effects of TIGAR knockdown.

NEURAL REGENERATION RESEARCH (2021)

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Review Biochemistry & Molecular Biology

The versatile Kv channels in the nervous system: actions beyond action potentials

Louis W. C. Chow et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Regulation of NRF2 by Na+/K+-ATPase: implication of tyrosine phosphorylation of Src

Le Ba Nam et al.

FREE RADICAL RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

Alexandr A. Kapralov et al.

NATURE CHEMICAL BIOLOGY (2020)

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Review Cell Biology

Host Calcium Channels and Pumps in Viral Infections

Xingjuan Chen et al.

CELLS (2020)

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Review Immunology

Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis

Sofia Pappa et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

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Article Multidisciplinary Sciences

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Xiuyuan Ou et al.

NATURE COMMUNICATIONS (2020)

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Article Neurosciences

Role of zinc dyshomeostasis in inflammasome formation in cultured cortical cells following lipopolysaccharide or oxygen-glucose deprivation/reperfusion exposure

Hyun-Seo Park et al.

NEUROBIOLOGY OF DISEASE (2020)

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Editorial Material Biochemistry & Molecular Biology

Calcium Channel Blockers: A Possible Potential Therapeutic Strategy for the Treatment of Alzheimer's Dementia Patients with SARS-CoV-2 Infection

Chhanda Charan Danta

ACS CHEMICAL NEUROSCIENCE (2020)

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Editorial Material Biochemistry & Molecular Biology

CNS Penetration Ability: A Critical Factor for Drugs in the Treatment of SARS-CoV-2 Brain Infection

Chhanda Charan Danta

ACS CHEMICAL NEUROSCIENCE (2020)

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Review Immunology

Brain abnormalities in COVID-19 acute/subacute phase: A rapid systematic review

Anna Rita Egbert et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

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Review Biochemistry & Molecular Biology

Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement

Deirdre Nolfi-Donegan et al.

REDOX BIOLOGY (2020)

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Article Multidisciplinary Sciences

Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1

Rebecca F. Krall et al.

SCIENCE ADVANCES (2020)

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Article Cell & Tissue Engineering

SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids

Laura Pellegrini et al.

CELL STEM CELL (2020)

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Article Nutrition & Dietetics

Selenium Deficiency Is Associated with Mortality Risk from COVID-19

Arash Moghaddam et al.

NUTRIENTS (2020)

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Article Psychology, Developmental

Remote Learning During COVID-19: Examining School Practices, Service Continuation, and Difficulties for Adolescents With and Without Attention-Deficit/Hyperactivity Disorder

Stephen P. Becker et al.

JOURNAL OF ADOLESCENT HEALTH (2020)

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Article Neurosciences

Activity Dependent Inhibition of AMPA Receptors by Zn2+

Elisa Carrillo et al.

JOURNAL OF NEUROSCIENCE (2020)

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Article Multidisciplinary Sciences

Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants

Jing Yan et al.

SCIENCE (2020)

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Article Biochemistry & Molecular Biology

Glutathionylated and Fe-S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain

Venkata Ramana Thiriveedi et al.

REDOX BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Selenium and selenoproteins in viral infection with potential relevance to COVID-19

Jinsong Zhang et al.

REDOX BIOLOGY (2020)

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Review Cell Biology

Ca2+ Dyshomeostasis Disrupts Neuronal and Synaptic Function in Alzheimer's Disease

John McDaid et al.

CELLS (2020)

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Article Biochemistry & Molecular Biology

CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

Ke Wang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Respiratory System

ACE2: The Major Cell Entry Receptor for SARS-CoV-2

Filippo Scialo et al.

LUNG (2020)

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Review Biochemistry & Molecular Biology

Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration

Shashank Masaldan et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

Ishraq Alim et al.

CELL (2019)

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Article Neurosciences

Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes

Jee Hoon Lee et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

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Review Biochemistry & Molecular Biology

Magnesium Is a Key Player in Neuronal Maturation and Neuropathology

Ryu Yamanaka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Neurosciences

Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases

Steven William Bothwell et al.

FLUIDS AND BARRIERS OF THE CNS (2019)

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Article Multidisciplinary Sciences

Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients

Yuan Lin et al.

NATURE COMMUNICATIONS (2019)

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Review Biochemistry & Molecular Biology

The redox biology of redox-inert zinc ions

Wolfgang Maret

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Review Neurosciences

Na+/K+-pump and neurotransmitter membrane receptors

Arkady S. Pivovarov et al.

INVERTEBRATE NEUROSCIENCE (2019)

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Article Neurosciences

Zinc reduces antiseizure activity of neurosteroids by selective blockade of extrasynaptic GABA-A receptor-mediated tonic inhibition in the hippocampus

Shu-Hui Chuang et al.

NEUROPHARMACOLOGY (2019)

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Article Neurosciences

Immunization with alpha-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model

Javier Villadiego et al.

GLIA (2018)

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Article Immunology

Role of MCP-1 and CCR2 in ethanol-induced neuroinflammation and neurodegeneration in the developing brain

Kai Zhang et al.

JOURNAL OF NEUROINFLAMMATION (2018)

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Article Biochemistry & Molecular Biology

Zinc aspartate suppresses proliferation and Thl/Th2/Th17 cytokine production of pre-activated human T cells in vitro

Karina Guttek et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2018)

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Article Neurosciences

Magnesium Reduces Blood-Brain Barrier Permeability and Regulates Amyloid-beta Transcytosis

Donghui Zhu et al.

MOLECULAR NEUROBIOLOGY (2018)

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Article Neurosciences

TIGAR inhibits ischemia/reperfusion-induced inflammatory response of astrocytes

Jieyu Chen et al.

NEUROPHARMACOLOGY (2018)

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Review Nutrition & Dietetics

Zinc and Skin Disorders

Youichi Ogawa et al.

NUTRIENTS (2018)

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Article Cell Biology

Modulation of P2X7 purinergic receptor activity by extracellular Zn2+ in cultured mouse hippocampal astroglia

Gergely Kovacs et al.

CELL CALCIUM (2018)

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Article Neurosciences

Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters

Hsin-Wei Lu et al.

NEURON (2017)

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Article Neurosciences

Cadmium-induced IL-6 and IL-8 expression and release from astrocytes are mediated by MAPK and NF-κB

Suttinee Phuagkhaopong et al.

NEUROTOXICOLOGY (2017)

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Review Pharmacology & Pharmacy

Metabotropic glutamate receptors and neurodegenerative diseases

Fabiola M. Ribeiro et al.

PHARMACOLOGICAL RESEARCH (2017)

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Article Neurosciences

Blockade of RyRs in the ER Attenuates 6-OHDA-Induced Calcium Overload, Cellular Hypo-Excitability and Apoptosis in Dopaminergic Neurons

Lu Huang et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2017)

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Article Neurosciences

Copper Enhances Zinc-Induced Neurotoxicity and the Endoplasmic Reticulum Stress Response in a Neuronal Model of Vascular Dementia

Ken-ichiro Tanaka et al.

FRONTIERS IN NEUROSCIENCE (2017)

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Article Medicine, Research & Experimental

Inhibition of neuronal ferroptosis protects hemorrhagic brain

Qian Li et al.

JCI INSIGHT (2017)

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Article Biochemistry & Molecular Biology

Stabilization of native amyloid β-protein oligomers by Copper and Hydrogen peroxide Induced Cross-linking of Unmodified Proteins (CHICUP)

Thomas L. Williams et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2016)

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Article Neurosciences

Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity

Nicholas L. Weilinger et al.

NATURE NEUROSCIENCE (2016)

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Article Biochemistry & Molecular Biology

How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD

Johannes W. Hell

SCIENCE SIGNALING (2016)

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Article Biochemistry & Molecular Biology

How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD

Johannes W. Hell

SCIENCE SIGNALING (2016)

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Review Biochemistry & Molecular Biology

The Role of Copper Chaperone Atox1 in Coupling Redox Homeostasis to Intracellular Copper Distribution

Yuta Hatori et al.

ANTIOXIDANTS (2016)

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Article Biochemistry & Molecular Biology

Prion Protein and Copper Cooperatively Protect Neurons by Modulating NMDA Receptor Through S-nitrosylation

Lisa Gasperini et al.

ANTIOXIDANTS & REDOX SIGNALING (2015)

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Article Cardiac & Cardiovascular Systems

Distinct mPTP activation mechanisms in ischaemia-reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate

Lea K. Seidlmayer et al.

CARDIOVASCULAR RESEARCH (2015)

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Article Cardiac & Cardiovascular Systems

TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1

Bernhard Doleschal et al.

CARDIOVASCULAR RESEARCH (2015)

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Article Geriatrics & Gerontology

Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging

Orit Bar-Am et al.

NEUROBIOLOGY OF AGING (2015)

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Review Biochemistry & Molecular Biology

Copper at synapse: Release, binding and modulation of neurotransmission

Nadia D'Ambrosi et al.

NEUROCHEMISTRY INTERNATIONAL (2015)

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Article Multidisciplinary Sciences

AMPA receptor inhibition by synaptically released zinc

Bopanna I. Kalappa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Review Clinical Neurology

Therapeutic Targets for Cerebral Ischemia Based on the Signaling Pathways of the GluN2B C Terminus

Yongjun Sun et al.

STROKE (2015)

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Article Toxicology

Lead exposure induced microgliosis and astrogliosis in hippocampus of young mice potentially by triggering TLR4-MyD88-NFκB signaling cascades

Jin-Tao Liu et al.

TOXICOLOGY LETTERS (2015)

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Review Neurosciences

Metabolism and functions of copper in brain

Ivo F. Scheiber et al.

PROGRESS IN NEUROBIOLOGY (2014)

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Review Neurosciences

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

Ted Weita Lai et al.

PROGRESS IN NEUROBIOLOGY (2014)

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Article Biochemistry & Molecular Biology

Oxidative inhibition of the vascular Na+-K+ pump via NADPH oxidase-dependent pi-subunit glutathionylation: Implications for angiotensin β1-induced vascular dysfunction

Chia-Chi Liu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

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Review Biochemistry & Molecular Biology

Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators

Orly Weinreb et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

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Article Biochemistry & Molecular Biology

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

Pamela Urrutia et al.

JOURNAL OF NEUROCHEMISTRY (2013)

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Article Neurosciences

Modulation of NMDAR Subunit Expression by TRPM2 Channels Regulates Neuronal Vulnerability to Ischemic Cell Death

Ishraq Alim et al.

JOURNAL OF NEUROSCIENCE (2013)

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Review Physiology

Voltage-gated Na+ channels in chemoreceptor afferent neurons-Potential roles and changes with development

David F. Donnelly

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2013)

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Article Cardiac & Cardiovascular Systems

Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia

Ting Zhang et al.

BASIC RESEARCH IN CARDIOLOGY (2012)

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Article Biochemistry & Molecular Biology

Zinc Suppressed the Airway Inflammation in Asthmatic Rats: Effects of Zinc on Generation of Eotaxin, MCP-1, IL-8, IL-4, and IFN-γ

Hongyan Lu et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2012)

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Article Cell Biology

Rapamycin Sensitive ROS Formation and Na+/H+ Exchanger Activity in Dendritic Cells

Anand Rotte et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2012)

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Review Nutrition & Dietetics

Zinc and Regulation of Inflammatory Cytokines: Implications for Cardiometabolic Disease

Meika Foster et al.

NUTRIENTS (2012)

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Review Chemistry, Multidisciplinary

CaMKII in cerebral ischemia

Steven J. Coultrap et al.

ACTA PHARMACOLOGICA SINICA (2011)

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Article Ecology

In situ spatio-temporal changes in pollution-induced community tolerance to zinc in autotrophic and heterotrophic biofilm communities

Ahmed Tlili et al.

ECOTOXICOLOGY (2011)

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Article Biochemistry & Molecular Biology

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

Weihong Tu et al.

CELL (2010)

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Article Biochemistry & Molecular Biology

Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95

Li Zhou et al.

NATURE MEDICINE (2010)

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Article Biochemical Research Methods

Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue

Christine J. Weydert et al.

NATURE PROTOCOLS (2010)

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Article Clinical Neurology

Treatment with the Iron Chelator, Deferoxamine Mesylate, Alters Serum Markers of Oxidative Stress in Stroke Patients

Magdy Selim

TRANSLATIONAL STROKE RESEARCH (2010)

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Review Neurosciences

Hot flash: TRPV channels in the brain

Julie A. Kauer et al.

TRENDS IN NEUROSCIENCES (2009)

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Article Pharmacology & Pharmacy

Deferoxamine decreases the excitatory amino acid levels and improves the histological outcome in the hippocampus of neonatal rats after hypoxia-ischemia

Georgios Papazisis et al.

PHARMACOLOGICAL RESEARCH (2008)

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Article Pharmacology & Pharmacy

Inhibition of TRPC5 channels by intracellular ATP

Michael Dattilo et al.

MOLECULAR PHARMACOLOGY (2008)

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Article Neurosciences

Inhibition of Na+/K+ ATPase potentiates synaptic transmission in tactile sensory neurons of the leech

Rossana Scuri et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2007)

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Article Neurosciences

Peptidergic counter-regulation of Ca2+- and Na+-dependent K+ currents modulates the shape of action potentials in neurosecretory insect neurons

D Wicher et al.

JOURNAL OF NEUROPHYSIOLOGY (2006)

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Article Neurosciences

Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons

VL Arvanian et al.

JOURNAL OF NEUROPHYSIOLOGY (2004)

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Review Neurosciences

Mitochondrial formation of reactive oxygen species

JF Turrens

JOURNAL OF PHYSIOLOGY-LONDON (2003)

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Article Critical Care Medicine

Desmethyl tirilazad improves neurologic function after hypoxic ischemic brain injury in piglets

YZ Feng et al.

CRITICAL CARE MEDICINE (2000)

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