Antioxidants: an approach for restricting oxidative stress induced neurodegeneration in Alzheimer's disease

Alzheimer's disease (AD) is the leading cause of dementia, affecting millions of people worldwide. Oxidative stress contributes towards induction of neurodegeneration. It is one of the reasons behind initiation and progression of Alzheimer's disease. Understanding of oxidative balance and restoration of oxidative stress has demonstrated its effectiveness in the management of AD. Various natural and synthetic molecules have been found to be effective in different models of AD. Some clinical studies also support the use of antioxidants for prevention of neurodegeneration in AD. In this review we are summarizing the development of antioxidants to restrict oxidative stress induced neurodegeneration in AD.

Automated summary

Alzheimer's disease (AD) is a major cause of dementia, affecting millions of people worldwide. Oxidative stress is a crucial factor in the induction and progression of AD. Understanding and managing oxidative stress has proven effective in AD treatment, with various natural and synthetic molecules showing promise. Clinical studies also support the use of antioxidants in preventing neurodegeneration in AD. This review summarizes the development of antioxidants for restricting oxidative stress-induced neurodegeneration in AD.