Dysregulation of miR-146a: a causative factor in epilepsy pathogenesis, diagnosis, and prognosis

Review Biochemistry & Molecular Biology

Expression Profile of miRs in Mesial Temporal Lobe Epilepsy: Systematic Review

Kristina D. Yakovleva et al.

Summary: This article systematically analyzes the role of miRs in the development of mesial TLE (mTLE) and provides an update on the existing knowledge about the biomarkers of this disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Cell Biology

Single-Nucleotide Variants in microRNAs Sequences or in their Target Genes Might Influence the Risk of Epilepsy: A Review

Renata Parissi Buainain et al.

Summary: The study reviewed the relationship between SNVs within miRNA sequences or their target genes and epilepsy susceptibility. It found that SNVs rs2910164 and rs57095329 may modify the expression level of miR-146a and the risk for epilepsy, while other SNVs could interfere in inflammatory pathway genes. The main limitation of the studies is the small sample size.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression

Cuiqin Fan et al.

Summary: This study reveals that microglia transfer miRNA (miR-146a-5p) via exosomes to inhibit neurogenesis in depression. MiR-146a-5p suppresses neurogenesis and excitatory neuron activity by targeting KLF4. Additionally, circular RNA ANKS1B acts as a miRNA sequester for miR-146a-5p to regulate KLF4 expression.

MOLECULAR THERAPY (2022)

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Review Cell Biology

Liquid biopsies in epilepsy: biomarkers for etiology, diagnosis, prognosis, and therapeutics

Jordan H. Whitlock et al.

Summary: Epilepsy is a common disease of the central nervous system, with surgery and antiepileptic drugs being treatment options. Liquid biopsies have been investigated to improve understanding of epilepsy in terms of etiology, diagnosis, prediction, and therapeutic monitoring.

HUMAN CELL (2022)

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Article Biotechnology & Applied Microbiology

Relationships between plasma expression levels of microRNA-146a and microRNA-132 in epileptic patients and their cognitive, mental and psychological disorders

Hui Huang et al.

Summary: This study aimed to explore the association between plasma levels of microRNA (miR)-146a and miR-132 in epileptic patients and cognitive, mental, and psychological disorders. The study found that epileptic patients had higher miR-146a and miR-132 levels compared to healthy controls. Cognitive dysfunction was positively associated with educational level, while negatively associated with disease course, duration, and type of administration. Anxiety was positively correlated with the frequency and duration of seizures. Depression was negatively correlated with educational level, but positively correlated with disease course and number of used drugs. The study also found that higher miR-132 expression was associated with more severe epilepsy and higher levels of anxiety and depression.

BIOENGINEERED (2022)

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Article Biochemistry & Molecular Biology

Detection of Deregulated miRNAs in Childhood Epileptic Encephalopathies

Aycan Unalp et al.

Summary: This study investigated the use of miRNAs as serum biomarkers for identifying and distinguishing epileptic encephalopathies. Whole blood samples from 54 individuals were analyzed, and expression levels of 10 miRNAs were determined. The results showed upregulation of one miRNA and downregulation of three miRNAs in the epileptic encephalopathy group compared to the healthy controls. These altered miRNAs were found to be important factors in epileptic seizures and seizure-induced neuronal death.

JOURNAL OF MOLECULAR NEUROSCIENCE (2022)

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Review Neurosciences

The Function of NF-Kappa B During Epilepsy, a Potential Therapeutic Target

Mengtan Cai et al.

Summary: NF-kappa B is a transcriptional regulator that plays important roles in inflammation, neuronal survival, and apoptosis. It is upregulated in epilepsy and causes functional changes in the central nervous system. Regulating NF-kappa B may be a safe and effective treatment strategy for epilepsy.

FRONTIERS IN NEUROSCIENCE (2022)

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Article Medicine, General & Internal

Antiepileptic Drugs and Their Dual Mechanism of Action on Carbonic Anhydrase

Calin Magheru et al.

Summary: This study found that major antiepileptic drugs can induce CA II inhibition both in vitro and in vivo, suggesting it might be one of the effective mechanisms of these anticonvulsant drugs.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Cell Biology

miR-874: An Important Regulator in Human Diseases

Qiudan Zhang et al.

Summary: miR-874 is frequently dysregulated in various cancers and non-cancer diseases, and its dysfunction is closely associated with the diagnosis, prognosis, and efficacy of chemotherapy drugs. It participates in ceRNA networks and regulates multiple signaling pathways involved in tumor cell processes. miR-874 has the potential to serve as a diagnostic and prognostic biomarker in cancer and has implications for clinical applications.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Neurosciences

miR-146a/KLF4 axis in epileptic mice: A novel regulator of synaptic plasticity involving STAT3 signaling

Ying Chen et al.

Summary: This study found that miR-146a promotes synaptic plasticity in epileptic mice by inhibiting KLF4 to activate STAT3.

BRAIN RESEARCH (2022)

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Article Biochemistry & Molecular Biology

An Emerging Role of miRNAs in Neurodegenerative Diseases: Mechanisms and Perspectives on miR146a

Navneet Ammal Kaidery et al.

Summary: Advancements in healthcare and increased lifespan have improved quality of life but also led to an increased incidence of neurodegenerative diseases. Recent evidence suggests that epigenetic processes can impact pathways related to NDs, with miRNAs being critical for normal neuron functioning. Future research may focus on developing miRNAs as potential biomarkers and therapeutic targets for neuroinflammation in NDs.

ANTIOXIDANTS & REDOX SIGNALING (2021)

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Article Biochemistry & Molecular Biology

Circulating microRNAs as Potential Novel Diagnostic Biomarkers to Predict Drug Resistance in Temporal Lobe Epilepsy: A Pilot Study

Selene De Benedittis et al.

Summary: The study evaluated the efficacy of six circulating miRNAs in the diagnosis of TLE and predicting response to antiepileptic drugs. It found that miR-142, miR-146a, and miR-223 were significantly upregulated in TLE patients, showing potential as biomarkers for distinguishing drug-sensitive and drug-resistant TLE.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Immunology

Efficient roles of miR-146a in cellular and molecular mechanisms of neuroinflammatory disorders: An effectual review in neuroimmunology

Mona Aslani et al.

Summary: miR-146a, as a gene expression regulator, plays a significant role in the pathogenesis and progression of neuroinflammatory disorders, regulating inflammation reactions, pain, hemorrhagic complications, etc. Its abnormal expression/function in these diseases may contribute to disease development. Therefore, miR-146a holds promise as an ideal biomarker and therapeutic target for diagnosis and treatment in these conditions.

IMMUNOLOGY LETTERS (2021)

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Article Chemistry, Medicinal

Neuroprotective effect of wild lowbush blueberry (Vaccinium angustifolium) on global cerebral ischemia/reperfusion injury in rats: Downregulation of iNOS/TNF-alpha and upregulation of miR-146a/miR-21 expression

Zahra Moradi et al.

Summary: This study demonstrated the neuroprotective effect of wild lowbush blueberry on cerebral ischemia-reperfusion injury in rats, by reducing oxidative stress levels, modulating inflammatory responses, and protecting neurons from ischemic death.

PHYTOTHERAPY RESEARCH (2021)

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Review Pharmacology & Pharmacy

Opportunities and challenges for microRNA-targeting therapeutics for epilepsy

Gareth Morris et al.

Summary: Epilepsy is a common and serious neurological disorder characterized by recurrent seizures. Current frontline pharmacotherapy with antiseizure drugs is ineffective in 30% of patients. MicroRNA (miRNA) is an emerging therapeutic target that shows promise in treating certain forms of epilepsy with complex underlying pathophysiology, such as temporal lobe epilepsy. Antisense oligonucleotides (ASOs) can inhibit miRNA and have potential for developing therapeutic miRNA-targeting molecules for epilepsy treatment.

TRENDS IN PHARMACOLOGICAL SCIENCES (2021)

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Article Cell Biology

miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases

Fabiola Olivieri et al.

Summary: Inflammaging is a key concept in understanding how aging contributes to the development of age-related diseases, with a focus on the role of miRNAs in regulating inflammatory pathways. The assessment of individual genetic make-up alone is insufficient to depict the trajectories of age-related inflammation, and studies have shown that circulating inflammamiRs could be used to measure the degree of inflammaging.

AGEING RESEARCH REVIEWS (2021)

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Review Medicine, Research & Experimental

The interaction between miRNAs/lncRNAs and Notch pathway in human disorders

Soudeh Ghafouri-Fard et al.

Summary: The Notch pathway plays a crucial role in cell proliferation, differentiation, development, and tissue homeostasis, and is also involved in regulating stem cell properties and cancer cell metastasis. Various long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) interact with the Notch signaling cascade, playing important functional roles in both cancer and non-neoplastic conditions.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Clinical Neurology

Monogenic Epilepsies Disease Mechanisms, Clinical Phenotypes, and Targeted Therapies

Renzo Guerrini et al.

Summary: A monogenic etiology can be identified in up to 40% of individuals with severe epilepsy, guiding treatment strategies based on implications on pathophysiology, natural history, comorbidities, and treatment choices. Evidence to guide ASM choices in genetic epilepsies is limited, with most treatment options based on inferences from observational studies. Phenotypic heterogeneity and functional consequences of genetic mutations complicate precision treatment approaches, while promising future directions include gene manipulation in early phase clinical development.

NEUROLOGY (2021)

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Article Biochemistry & Molecular Biology

Exosomes in Epilepsy of Tuberous Sclerosis Complex: Carriers of Pro-Inflammatory MicroRNAs

Daniela Cukovic et al.

Summary: Exosomes, small secreted extracellular vesicles, play a role in the neuroinflammatory cascade of epilepsy by carrying microRNAs that activate toll-like receptors. Understanding the molecular mechanisms behind drug-resistant epilepsy may lead to the development of novel biomarkers and therapeutic approaches.

NON-CODING RNA (2021)

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Article Cell Biology

The implications of hippocampal neurogenesis in adolescent rats after status epilepticus: a novel role of notch signaling pathway in regulating epileptogenesis

Ping Yuan et al.

CELL AND TISSUE RESEARCH (2020)

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Article Clinical Neurology

The single nucleotide variant n.60G > C in the microRNA-146a associated with susceptibility to drug-resistant epilepsy

Matheus Negri Boschiero et al.

EPILEPSY RESEARCH (2020)

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Article Clinical Neurology

Circulating microRNAs as potential biomarkers for genetic generalized epilepsies: a three microRNA panel

R. Martins-Ferreira et al.

EUROPEAN JOURNAL OF NEUROLOGY (2020)

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Article Immunology

MiR-146a Promotes Tolerogenic Properties of Dendritic Cells and through Targeting Notch1 Signaling

Haocheng Tang et al.

IMMUNOLOGICAL INVESTIGATIONS (2020)

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Article Clinical Neurology

Circulating miR-146a and miR-134 in predicting drug-resistant epilepsy in patients with focal impaired awareness seizures

Maria Leontariti et al.

EPILEPSIA (2020)

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Review Pathology

Is there a role for microRNAs in epilepsy diagnostics?

Sebastian Bauer et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2020)

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Review Neurosciences

Mechanisms of action of currently used antiseizure drugs

Graeme J. Sills et al.

NEUROPHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Relationship between miR-155 and miR-146a polymorphisms and susceptibility to multiple sclerosis in an Egyptian cohort

Marwa Ahmed Ali et al.

BIOMEDICAL REPORTS (2020)

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Review Neurosciences

Epilepsy biomarkers - Toward etiology and pathology specificity

Asia Pitkanen et al.

NEUROBIOLOGY OF DISEASE (2019)

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Review Cell Biology

miR-146a-5p: Expression, regulation, and functions in cancer

Joseph R. Lacona et al.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2019)

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Article Pharmacology & Pharmacy

MicroRNA-146a-5p Downregulates the Expression of P-Glycoprotein in Rats with Lithium-Pilocarpine-Induced Status Epilepticus

Xiaolin Deng et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2019)

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Article Neurosciences

Network and Pathway-Based Analysis of Single-Nucleotide Polymorphism of miRNA in Temporal Lobe Epilepsy

Wenbiao Xiao et al.

MOLECULAR NEUROBIOLOGY (2019)

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Review Neurosciences

microRNA dysregulation in neurodegenerative diseases: A systematic review

Camille A. Juzwik et al.

PROGRESS IN NEUROBIOLOGY (2019)

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Article Immunology

Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production

Mate G. Kiss et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Biochemistry & Molecular Biology

Long Non-Coding RNAs and Related Molecular Pathways in the Pathogenesis of Epilepsy

Chiara Villa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Increased expression of long non-coding RNA SNHG16 correlates with tumor progression and poor prognosis in non-small cell lung cancer

Wei Han et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Neurosciences

Silencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1

Hui Huang et al.

MOLECULAR BRAIN (2019)

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Article Neurosciences

An Image-Based miRNA Screen Identifies miRNA-135s As Regulators of CNS Axon Growth and Regeneration by Targeting Kruppel-like Factor 4

Eljo Y. van Battum et al.

JOURNAL OF NEUROSCIENCE (2018)

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Article Cell Biology

The role of the microRNA-146a/complement factor H/interleukin-1β-mediated inflammatory loop circuit in the perpetuate inflammation of chronic temporal lobe epilepsy

Tao-Ran Li et al.

DISEASE MODELS & MECHANISMS (2018)

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Article Clinical Neurology

Intracerebroventricular injection of miR-146a relieves seizures in an immature rat model of lithium-pilocarpine induced status epilepticus

Xiaole Wang et al.

EPILEPSY RESEARCH (2018)

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Article Oncology

Antagonist targeting microRNA-146a protects against lithium-pilocarpine-induced status epilepticus in rats by nuclear factor-κB pathway

Huilong Zhang et al.

MOLECULAR MEDICINE REPORTS (2018)

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Article Genetics & Heredity

Role of miR-146a in neural stem cell differentiation and neural lineage determination: relevance for neurodevelopmental disorders

Lam Son Nguyen et al.

MOLECULAR AUTISM (2018)

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Article Biochemistry & Molecular Biology

Long non-coding RNA NIFK-AS1 inhibits M2 polarization of macrophages in endometrial cancer through targeting miR-146a

Yun-xiao Zhou et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

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Article Neurosciences

HIF-1α is Critical for the Activation of Notch Signaling in Neurogenesis During Acute Epilepsy

Yushuang Li et al.

NEUROSCIENCE (2018)

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Article Multidisciplinary Sciences

miR-146a regulates the crosstalk between intestinal epithelial cells, microbial components and inflammatory stimuli

Andrea Anzola et al.

SCIENTIFIC REPORTS (2018)

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Article Cell Biology

Intranasal Delivery of miR-146a Mimics Delayed Seizure Onset in the Lithium-Pilocarpine Mouse Model

Hua Tao et al.

MEDIATORS OF INFLAMMATION (2017)

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Article Neurosciences

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

Valentina Iori et al.

NEUROBIOLOGY OF DISEASE (2017)

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Review Cell Biology

MiR-146a/b: a family with shared seeds and different roots

Mark R. Paterson et al.

PHYSIOLOGICAL GENOMICS (2017)

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Article Biochemistry & Molecular Biology

Modulation of miR-146a/complement factor H-mediated inflammatory responses in a rat model of temporal lobe epilepsy

Fang He et al.

BIOSCIENCE REPORTS (2016)

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Review Immunology

MicroRNAs mediating CNS inflammation: Small regulators with powerful potential

Wei Su et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

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Article Clinical Neurology

Elevated serum miR-106b and miR-146a in patients with focal and generalized epilepsy

Ning An et al.

EPILEPSY RESEARCH (2016)

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Article Biochemistry & Molecular Biology

Inhibition of p38 mitogen-activated protein kinase signaling reduces multidrug transporter activity and anti-epileptic drug resistance in refractory epileptic rats

Yiye Shao et al.

JOURNAL OF NEUROCHEMISTRY (2016)

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Article Clinical Neurology

Association of the genetic polymorphisms in pre-microRNAs with risk of childhood epilepsy in a Chinese population

Yang Li et al.

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2016)

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Article Oncology

MicroRNA-21 regulates cell proliferation and apoptosis in H2O2-stimulated rat spinal cord neurons

Genlong Jiao et al.

MOLECULAR MEDICINE REPORTS (2015)

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Article Clinical Neurology

A functional polymorphism of the microRNA-146a gene is associated with susceptibility to drug-resistant epilepsy and seizures frequency

Lili Cui et al.

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2015)

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Article Multidisciplinary Sciences

Genome-wide circulating microRNA expression profiling indicates biomarkers for epilepsy

Jun Wang et al.

SCIENTIFIC REPORTS (2015)

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Article Multidisciplinary Sciences

MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy - comparison with human epileptic samples

Paolo Roncon et al.

SCIENTIFIC REPORTS (2015)

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Article Neurosciences

Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy

Jan A. Gorter et al.

NEUROBIOLOGY OF DISEASE (2014)

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Article Clinical Neurology

The effects of sleep deprivation on microRNA expression in rats submitted to pilocarpine-induced status epilepticus

Gabriela Matos et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2014)

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Article Genetics & Heredity

Relationship between genetic variant in pre-microRNA-146a and genetic predisposition to temporal lobe epilepsy: A case-control study

Ida Manna et al.

GENE (2013)

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Article Clinical Neurology

Interleukin-1β and microRNA-146a in an immature rat model and children with mesial temporal lobe epilepsy

Ahmed Omran et al.

EPILEPSIA (2012)

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Article Neurosciences

Spreading of Alzheimer's disease inflammatory signaling through soluble micro-RNA

Walter J. Lukiw et al.

NEUROREPORT (2012)

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Article Neurosciences

Temporal lobe epilepsy induces differential expression of hippocampal miRNAs including let-7e and miR-23a/b

Yi-jun Song et al.

BRAIN RESEARCH (2011)

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Article Neurosciences

Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells

Yuan Yuan Li et al.

NEUROSCIENCE LETTERS (2011)

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Article Neurosciences

Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy

E. Aronica et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2010)

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Article Neurosciences

Complement activation in experimental and human temporal lobe epilepsy

E. Aronica et al.

NEUROBIOLOGY OF DISEASE (2007)

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Article Multidisciplinary Sciences

NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

Konstantin D. Taganov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Dysregulation of miR-146a: a causative factor in epilepsy pathogenesis, diagnosis, and prognosis

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