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Acupuncture for tension-type headache: a systematic review and meta-analysis of randomized controlled trials

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FRONTIERS IN NEUROLOGY
卷 13, 期 -, 页码 -

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FRONTIERS MEDIA SA
DOI: 10.3389/fneur.2022.943495

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acupuncture; safety; tension-type headache; systematic review; meta-analysis; clinical effects

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This systematic review and meta-analysis updated the evidence of acupuncture for tension-type headache (TTH). Acupuncture may be an effective and safe treatment for TTH patients. However, more rigorous randomized controlled trials are needed to verify the efficacy and safety of acupuncture.
Background: Tension-type headache (TTH) is the most common neurologic disease worldwide. Acupuncture is commonly applied to treat TTH, but evidence of acupuncture for TTH is contradictory based on previous meta-analyses. Therefore, we conducted this systematic review and meta-analysis to update the evidence of acupuncture for TTH and aimed to provide a valuable reference for clinical application. Methods: We searched 9 electronic databases from their inceptions to July 1, 2022 for randomized controlled trials (RCTs) of acupuncture for TTH. We also manually searched reference lists and relevant websites, and the experts in this field were consulted for possible eligible studies. Two independent reviewers conducted literature screening, data extraction, and risk of bias assessment. The revised Cochrane risk-of-bias tool (ROB 2) was used to assess the risk of bias of included studies. Subgroup analyses were carried out based on frequency of acupuncture, total sessions, treatment duration, needle retention, types of acupuncture and categories of medication. Data synthesis was performed using Review Manager 5.3 and Stata 16. The Grading of Recommendations Assessment, Development and Evaluation Approach (GRADE) was used to evaluate the certainty of evidence of each outcome. Meanwhile, the Standards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) was used to assess the reporting quality of interventions in clinical trials of acupuncture. Results: 30 RCTs involving 2,742 participants were included. According to ROB 2, 4 studies were considered as lowrisk, and the rest studies were some concerns. After treatment, compared with sham acupuncture, acupuncture had greater e ect in improvement of responder rate [3 RCTs, RR = 1.30, 95%CI (1.13, 1.50), I-2 = 2%, moderate certainty] and headache frequency [5 RCTs, SMD=-0.85, 95%CI (-1.58, -0.12), I-2 = 94%, very low certainty]. In contrast to medication, acupuncture was more e ective to reduce pain intensity [9 RCTs, SMD = -0.62, 95%CI (-0.86, -0.38), I-2 = 63%, low certainty]. Adverse events were evaluated in 16 trials, and no serious event associated with acupuncture occurred. Conclusions: Acupuncture may be an e ective and safe treatment for TTH patients. Due to low or very low certainty of evidence and high heterogeneity, more rigorous RCTs are needed to verify the e ect and safety of acupuncture in the management of TTH.

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