Case report: Continuous spinal cord physiologic monitoring following traumatic spinal cord injury-A report from the Winnipeg Intraspinal Pressure Study (WISP)

Article Critical Care Medicine

Impact of Chronological Age and Biological Sex on Cerebrovascular Reactivity in Moderate/Severe Traumatic Brain Injury: A CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Study

Carleen Batson et al.

Summary: This study investigates the impact of age and biological sex on cerebral physiology and finds a positive linear correlation between PAx, RAC, and age, but no relationship between PRx and age.

JOURNAL OF NEUROTRAUMA (2023)

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Article Critical Care Medicine

Optimal bispectral index level of sedation and cerebral oximetry in traumatic brain injury: a non-invasive individualized approach in critical care?

Logan Froese et al.

Summary: This study suggests that COx_a is capable of detecting the relationship between depth of sedation and autoregulatory capacity, providing important guidance for individualized sedation in neuroprotection.

INTENSIVE CARE MEDICINE EXPERIMENTAL (2022)

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Article Multidisciplinary Sciences

The Winnipeg Intraspinal Pressure Monitoring Study (WISP): A protocol for validation of fiberoptic pressure monitoring for acute traumatic spinal cord injury

Perry Dhaliwal et al.

Summary: This article describes the design of the Winnipeg Intraspinal Pressure Monitoring Study (WISP), which aims to validate the technique of intraspinal pressure monitoring at the site of injury using a fiberoptic pressure monitor. The study involves measuring various physiological parameters and recruiting 20 eligible patients for a 12-month follow-up.

PLOS ONE (2022)

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Article

Significance of spinal cord perfusion pressure following spinal cord injury: A systematic scoping review

Cameron M. Gee et al.

Journal of Clinical Orthopaedics and Trauma (2022)

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Article Critical Care Medicine

Targeting Autoregulation-Guided Cerebral Perfusion Pressure after Traumatic Brain Injury (COGiTATE): A Feasibility Randomized Controlled Clinical Trial

Jeanette Tas et al.

Summary: This study evaluated the feasibility and safety of CA-guided CPP management in TBI patients requiring intracranial pressure monitoring and therapy. The results demonstrate that targeting an individual and dynamic CA-guided CPP is feasible and safe in TBI patients, encouraging further prospective trials powered for clinical outcomes.

JOURNAL OF NEUROTRAUMA (2021)

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Article Clinical Neurology

Impact of Age and Biological Sex on Cerebrovascular Reactivity in Adult Moderate/Severe Traumatic Brain Injury: An Exploratory Analysis

Carleen Batson et al.

Summary: Age and biological sex can impact cerebrovascular reactivity post-TBI, with age showing a positive linear relationship with certain cerebrovascular function measures. In this study, biological sex did not have a significant impact on cerebrovascular reactivity indices. Further research is needed to validate these findings and explore the utility of different cerebrovascular reactivity indices, with PAx and RAC potentially being better metrics for detecting impaired cerebrovascular reactivity in elderly patients.

NEUROTRAUMA REPORTS (2021)

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Article Clinical Neurology