Targeting regulatory T cells for cardiovascular diseases

Article Cardiac & Cardiovascular Systems

2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Jennifer S. Lawton et al.

Summary: Additional digital content can be found in the text.

CIRCULATION (2022)

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Article Cardiac & Cardiovascular Systems

CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells

Guoshuai Feng et al.

Summary: This study identified CCL17 as a proinflammatory mediator in CCR2(+) macrophages and dendritic cells, and suggested that inhibiting CCL17 could promote Treg recruitment and suppress myocardial inflammation.

CIRCULATION (2022)

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Article Immunology

The absence of B cells disrupts splenic and myocardial Treg homeostasis in coxsackievirus B3-induced myocarditis

Jing Lu et al.

Summary: B cells play a crucial role in regulating Treg cell responses, controlling immune reactions and autoimmune diseases by maintaining Treg cell numbers. B-cell knockout leads to reduction in Tregs, impairing their activation and immune function, but the effects can be reversed by adoptive transfer of B cells.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2022)

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Article Surgery

Low-dose IL-2 prevents murine chronic cardiac allograft rejection: Role for IL-2-induced T regulatory cells and exosomes with PD-L1 and CD73

Ranjithkumar Ravichandran et al.

Summary: Low-dose IL-2 treatment delays chronic cardiac allograft rejection and induces the generation of regulatory cells and circulating exosomes with immunoregulatory molecules.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Review Cardiac & Cardiovascular Systems

2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Paul A. Heidenreich et al.

Summary: The 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure is an updated version of the 2013 and 2017 guidelines, aiming to provide patient-centric recommendations for the prevention, diagnosis, and management of heart failure. This guideline is based on contemporary evidence and presents an evidence-based approach to improve quality of care and align with patients' interests.

CIRCULATION (2022)

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Article Cardiac & Cardiovascular Systems

Prevalence, Characteristics, and Outcomes of COVID-19-Associated Acute Myocarditis

Enrico Ammirati et al.

Summary: The prevalence of acute myocarditis (AM) in COVID-19 patients is estimated to be between 2.4 and 4.1 per 1000 hospitalized patients. Most cases of AM occur in the absence of pneumonia and are often complicated by hemodynamic instability.

CIRCULATION (2022)

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Article Pharmacology & Pharmacy

Bacteroides fragilis prevents aging-related atrial fibrillation in rats via regulatory T cells-mediated regulation of inflammation

Yun Zhang et al.

Summary: This study found that the abundance of B. fragilis was lower in elderly patients with AF. Oral administration of B. fragilis significantly attenuated inflammatory response by increasing Treg cells, thereby preventing atrial structural remodeling and inhibiting AF promotion. This study provides experimental evidence for the effectiveness of targeting gut microbes in the prevention of aging-related AF.

PHARMACOLOGICAL RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response

Marco Piroth et al.

Summary: The study reveals that hyaluronan synthase 3 (HAS3) plays a crucial role in cardiac healing after myocardial infarction by supporting the necessary physiological T cell response.

MATRIX BIOLOGY (2022)

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Article Medicine, General & Internal

Th17/Treg imbalance in patients with primary hyperaldosteronism and resistant hypertension

Anna M. Imiela et al.

Summary: This study investigated the quantities of peripheral blood Treg lymphocytes and Th17 subsets in individuals with primary hyperaldosteronism (PHA) and resistant hypertension (RHT) compared to normotensive controls, finding that elevated 24 h SBP in PHA was associated with increased numbers of CD4(+)IL-17 and CD4(+)CD25(+)FOXP3(+) T cells.

POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ (2022)

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Article Medicine, Research & Experimental

CD4+FoxP3+CD73+ regulatory T cell promotes cardiac healing post-myocardial infarction

Rulin Zhuang et al.

Summary: Research suggests that FoxP3(+)CD73(+) Tregs play a crucial role in inflammation resolution and cardiac healing post-myocardial infarction. CD73 deficiency in Tregs affects tissue tropism and immunosuppressive function.

THERANOSTICS (2022)

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Article Medicine, Research & Experimental

Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation

Theresa Failer et al.

Summary: DEL-1, an endogenous anti-inflammatory factor, improves endothelial function, prevents cardiovascular remodeling, and inhibits the progression of hypertension.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Cardiac & Cardiovascular Systems

Adoptive transfer of CX3CR1 transduced-T regulatory cells improves homing to the atherosclerotic plaques and dampens atherosclerosis progression

Fabrizia Bonacina et al.

Summary: Adoptive cell therapy with Tregulatory cells engineered to selectively migrate in atherosclerotic plaque shows promise in targeting immune activation and improving inflammation-resolving pathways in animal models of familial hypercholesterolaemia.

CARDIOVASCULAR RESEARCH (2021)

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Article Cell Biology

Role of formyl peptide receptor 2 (FPR2) in modulating immune response and heart inflammation in an experimental model of acute and chronic Chagas disease

Rafaela das Dores Pereira et al.

Summary: In this study, the researchers found that FPR2 plays a crucial role in controlling the progression of Chagas disease and various immune responses in the body. Deficiency of FPR2 may enhance the activity of macrophages against the parasite, while FPR2-deficient mice exhibit a more severe inflammatory response during the chronic phase.

CELLULAR IMMUNOLOGY (2021)

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Article Immunology

Combination of matrine and tacrolimus alleviates acute rejection in murine heart transplantation by inhibiting DCs maturation through ROS/ERK/ NF-KB pathway

Sihao Zheng et al.

Summary: Matrine, an alkaloid derived from traditional Chinese herbs, has been found to have protective effects against oxidative stress injury and inflammation in heart transplantation, prolonging post-transplant survival and inhibiting inflammatory cell infiltration. Additionally, it can suppress DCs maturation, reduce oxidative damage and apoptosis in allograft hearts, and modulate NF-KB and ERK1/2 signaling pathways.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Immunology

Vagus nerve plays a pivotal role in CD4+T cell differentiation during CVB3-induced murine acute myocarditis

Li Yue-Chun et al.

Summary: In viral myocarditis, the vagus nerve modulates the inflammatory response by regulating CD4(+) T cell differentiation, with vagotomy resulting in an increase in Th1 and Th17 cell proportions and a decrease in Th2 and Treg cell proportions, exacerbating cardiac lesions.

VIRULENCE (2021)

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Article Environmental Sciences

Parental PM2.5 exposure changes Th17/Treg cells in offspring, is associated with the elevation of blood pressure

Kun Pan et al.

Summary: The study found that parental exposure to PM2.5 can lead to elevated blood pressure in offspring, affecting the expression of related proteins in the vasculature and kidneys, and potentially mediating through Th17- and Treg-related immune microenvironment.

ENVIRONMENTAL TOXICOLOGY (2021)

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Article Biochemistry & Molecular Biology

Attenuating Effects of Dieckol on Endothelial Cell Dysfunction via Modulation of Th17/Treg Balance in the Intestine and Aorta of Spontaneously Hypertensive Rats

Seyeon Oh et al.

Summary: The study demonstrates that ECE or DK can alleviate the Treg/Th17 cell imbalance induced by hypertension in rats, improve gut and aortic barriers, and decrease endothelial cell dysfunction.

ANTIOXIDANTS (2021)

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Article Cell Biology

Augmenting ATG14 alleviates atherosclerosis and inhibits inflammation via promotion of autophagosome-lysosome fusion in macrophages

Hui Zhang et al.

Summary: The dysfunction of autophagy in macrophages contributes to the development of atherosclerosis, with ATG14 playing a crucial role in regulating the fusion of autophagosomes with lysosomes. Impaired autophagy function due to reduced ATG14 expression was observed in macrophages of atherosclerotic plaques, and overexpression of ATG14 promoted autophagy, lipid degradation, and reduced inflammation, thereby alleviating atherosclerotic lesions in mice.

AUTOPHAGY (2021)

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Review Immunology

Immunomodulation for the Treatment of Chronic Chagas Disease Cardiomyopathy: A New Approach to an Old Enemy

Emanuelle de Souza Santos et al.

Summary: Chagas disease caused by Trypanosoma cruzi can lead to Chronic Chagas cardiomyopathy (CCC) with severe complications like arrhythmias, heart failure, and death. Despite over a hundred years of discovery, there is still no effective treatment, especially for CCC. Immunomodulatory agents are considered a rational alternative due to the systemic inflammation causing cardiac tissue damage, showing potential in modulating inflammation and improving myocarditis in CCC models.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Immunology

Elevated Peripheral T Helper Cells Are Associated With Atrial Fibrillation in Patients With Rheumatoid Arthritis

Xin Wang et al.

Summary: This study aimed to compare changes in peripheral T cells in patients with RA affected with and without AF. Results showed that Th1 cell absolute number, Th17 cell absolute number, and Th1/Treg ratio were significantly associated with a higher risk of AF in RA patients.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections

Hani Harb et al.

Summary: This study demonstrates that increased expression of Notch4 on Treg cells in COVID-19 patients is associated with disease severity, and inhibition of Notch4 can help restore immune dysregulation and reduce disease morbidity and mortality.

IMMUNITY (2021)

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Article Medicine, Research & Experimental

Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance

Toshihito Hirai et al.

Summary: The study demonstrates an innovative approach to enhance the expansion and target cell stimulation ability of Treg cells through engineered orthogonal IL-2/IL-2R pair, which improves the potential for organ transplantation tolerance.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Cardiac & Cardiovascular Systems

Preventing alloimmune rejection using circular RNA FSCN1-silenced dendritic cells in heart transplantation

Bowen Wang et al.

Summary: Silencing circFSCN1 leads to the generation of Tol-DCs that can prevent transplant rejection and prolong allograft survival in heart transplantation. This study provides a promising therapeutic target for combating transplant rejection and enhances our understanding of circRNA in the immune system.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2021)

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Article Cardiac & Cardiovascular Systems

Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population

Goran Bergstrom et al.

Summary: Through conducting a study using CCTA on a random sample of individuals aged 50 to 64, we found that silent coronary atherosclerosis is common in this population, particularly in individuals with higher CAC scores.

CIRCULATION (2021)

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Article Medicine, General & Internal

Prevalence and clinical outcomes of myocarditis and pericarditis in 718,365 COVID-19 patients

Benjamin J. R. Buckley et al.

Summary: This study found that patients with COVID-19 who develop myocarditis/pericarditis have an increased risk of major adverse events and new-onset cardiovascular sequelae.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Plant Sciences

Effect of Si-Miao-Yong-An decoction on the differentiation of monocytes, macrophages, and regulatory T cells in ApoE-/- mice

Xin-Nong Chen et al.

Summary: Si-Miao-Yong-An decoction (SMYAD) has been shown to improve the pathological changes associated with atherosclerosis and inhibit lipid deposition in ApoE-/- mice. The possible mechanism involves inhibiting the differentiation and recruitment of monocytes and macrophages, promoting the differentiation and recruitment of Treg cells, and reducing the secretion of pro-inflammatory factors.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Regulatory T cell activation, proliferation, and reprogramming induced by extracellular vesicles

Akbarshakh Akhmerov et al.

Summary: The study demonstrates that EVs secreted by heart stromal/progenitor cells can selectively influence the phenotype, activity, and proliferation of regulatory T cells, leading to mitigated cardiac inflammation and functional decline in experimental autoimmune myocarditis.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2021)

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Article Medicine, General & Internal

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

Bin Zhou et al.

Summary: Global prevalence of hypertension doubled from 1990 to 2019, with significant improvements in detection, treatment, and control rates. In 2019, 59% of women and 49% of men with hypertension were previously diagnosed, while treatment rates were 47% for women and 38% for men, with control rates at 23% for women and 18% for men. Disparities exist across countries, with some middle-income nations now outperforming high-income countries in hypertension management.

LANCET (2021)

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Article Biotechnology & Applied Microbiology

Hydrogel-load exosomes derived from dendritic cells improve cardiac function via Treg cells and the polarization of macrophages following myocardial infarction

Youming Zhang et al.

Summary: A novel drug delivery system incorporating alginate hydrogel was developed to continuously release DEXs, enhancing the therapeutic effects of DEXs in improving cardiac function after MI.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Medicine, Research & Experimental

Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency

Silvia C. Trevelin et al.

Summary: Nox2 deletion in Tregs enhances their suppressive ability and migration to heart allografts, suggesting that inhibiting Nox2 in Tregs may be a useful approach to improve therapeutic efficacy.

JCI INSIGHT (2021)

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Article Oncology

Tregs-derived interleukin 35 attenuates endothelial proliferation through STAT1 in pulmonary hypertension

Naifu Wan et al.

Summary: IL-35 plays a crucial role in the development of pulmonary hypertension by reducing the proliferation of endothelial cells, which can reverse pulmonary vascular remodeling and alleviate the progression of the disease.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Immunology

β-Hydroxybutyrate Mitigated Heart Failure with Preserved Ejection Fraction by Increasing Treg Cells via Nox2/GSK-3β

Shengen Liao et al.

Summary: BHB protected against the progression of HFpEF by increasing cardiac Treg cells via modulation of the NOX2/GSK-3 beta pathway, improving diastolic function, fibrosis, and cardiac remodeling in HFpEF.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Nutrition & Dietetics

Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats

Inaki Robles-Vera et al.

Summary: The study showed that DOX can reduce blood pressure, improve endothelial dysfunction, and decrease oxidative stress and inflammation in DOCA-salt hypertensive rats. Additionally, DOX can modulate gut microbiota composition, enhance intestinal barrier integrity, and maintain normal levels of endotoxemia and noradrenaline.

NUTRIENTS (2021)

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Review Cardiac & Cardiovascular Systems

In flammation in Hypertension

Liang Xiao et al.

CANADIAN JOURNAL OF CARDIOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Cardiac monocytes and macrophages after myocardial infarction

Claire Peet et al.

CARDIOVASCULAR RESEARCH (2020)

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Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association

Salim S. Virani et al.

CIRCULATION (2020)

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Article Cardiac & Cardiovascular Systems

Intensive statin treatment ameliorate the Th17/Treg functional imbalance in patients with non-ST elevation acute coronary syndrome underwent percutaneous coronary intervention

Xiaojing Ma et al.

CLINICAL CARDIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

LCK inhibitor attenuates atherosclerosis in ApoE-/- mice via regulating T cell differentiation and reverse cholesterol transport

Jichen Liu et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

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Article Biochemistry & Molecular Biology

MicroRNA-223-3p modulates dendritic cell function and ameliorates experimental autoimmune myocarditis by targeting the NLRP3 inflammasome

Liangqi Chen et al.

MOLECULAR IMMUNOLOGY (2020)

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Editorial Material Cardiac & Cardiovascular Systems

Towards precision disease-modelling in experimental myocarditis

Alexandros Protonotarios et al.

CARDIOVASCULAR RESEARCH (2020)

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Article Cardiac & Cardiovascular Systems

Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis

Xiumeng Hua et al.

CIRCULATION (2020)

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Article Cardiac & Cardiovascular Systems

Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression

Monika Sharma et al.

CIRCULATION RESEARCH (2020)

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Article Pharmacology & Pharmacy

Anti-Atherosclerosis Effect of Angong Niuhuang Pill via Regulating Th17/Treg Immune Balance and Inhibiting Chronic Inflammatory on ApoE-/- Mice Model of Early and Mid-Term Atherosclerosis

Qinghong Fan et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Immunology

Tolerogenic Dendritic Cells Reduce Cardiac Inflammation and Fibrosis in Chronic Chagas Disease

Emanuelle de Souza Santos et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Physiology

Th17/Treg imbalance modulates rat myocardial fibrosis and heart failure by regulating LOX expression

Min Lu et al.

ACTA PHYSIOLOGICA (2020)

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Article Integrative & Complementary Medicine

Electroacupuncture Improves Blood Pressure in SHRs by Regulating the Immune Balance between Th17 and Treg

Yang Wang et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

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Review Immunology

T Cells in Fibrosis and Fibrotic Diseases

Mengjuan Zhang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

Jose A. Nicolas-Avila et al.

CELL (2020)

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Article Cardiac & Cardiovascular Systems

CD4+ T-Cell Endogenous Cystathionine γ Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation

Changting Cui et al.

CIRCULATION (2020)

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Article Cardiac & Cardiovascular Systems

A Unique Population of Regulatory T Cells in Heart Potentiates Cardiac Protection From Myocardial Infarction

Ni Xia et al.

CIRCULATION (2020)

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Review Cardiac & Cardiovascular Systems

Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019 Update From the GBD 2019 Study

Gregory A. Roth et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Cell Biology

Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species

Ufuk Karakus et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Pediatrics

Th17 and Treg Balance in Children With Obesity and Metabolically Altered Status

Valeria Calcaterra et al.

FRONTIERS IN PEDIATRICS (2020)

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Review Biotechnology & Applied Microbiology

Th17/Treg Imbalance and Atherosclerosis

Xin He et al.

DISEASE MARKERS (2020)

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Article Plant Sciences

Curcumin ameliorates atherosclerosis in apolipoprotein E deficient asthmatic mice by regulating the balance of Th2/Treg cells

Gao Shanshan et al.

PHYTOMEDICINE (2019)

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Article Biochemistry & Molecular Biology

Treg cells depletion is a mechanism that drives microvascular dysfunction in mice with established hypertension

Eman Radwan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

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Article Cardiac & Cardiovascular Systems

C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function

Yong Wang et al.

CIRCULATION (2019)

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Article Immunology

Immunologic balance of regulatory T cell/T helper 17 responses in gastrointestinal infectious diseases: Role of miRNAs

Mohammad Mehdi Adibzadeh Sereshgi et al.

MICROBIAL PATHOGENESIS (2019)

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Article Physiology

Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats

Marta Toral et al.

ACTA PHYSIOLOGICA (2019)

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Article Cardiac & Cardiovascular Systems

Menopause and FOXP3+ Treg cell depletion eliminate female protection against T cell-mediated angiotensin II hypertension

Dennis P. Pollow et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Long noncoding RNA NEAT1 modulates immune cell functions and is suppressed in early onset myocardial infarction patients

Martina Gast et al.

CARDIOVASCULAR RESEARCH (2019)

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Letter Cardiac & Cardiovascular Systems

Response by Bansal et al to Letter Regarding Article, Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy

Shyam S. Bansal et al.

CIRCULATION (2019)

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Letter Cardiac & Cardiovascular Systems

Letter by Wang et al Regarding Article, Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy

Daxin Wang et al.

CIRCULATION (2019)

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Review Pharmacology & Pharmacy

An evaluation of benznidazole as a Chagas disease therapeutic

Ivo S. Caldas et al.

EXPERT OPINION ON PHARMACOTHERAPY (2019)

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Article Pharmacology & Pharmacy

Protosappanin A protects against experimental autoimmune myocarditis, and induces metabolically reprogrammed tolerogenic DCs

Jian Wu et al.

PHARMACOLOGICAL RESEARCH (2019)

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Article Medicine, Research & Experimental

Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses

Max Rieckmann et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Cell Biology

IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome

Xiaobo Mao et al.

MEDIATORS OF INFLAMMATION (2019)

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Article Cardiac & Cardiovascular Systems

Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy

Shyam S. Bansal et al.

CIRCULATION (2019)

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Editorial Material Cardiac & Cardiovascular Systems

Protean Functions and Phenotypic Plasticity of Regulatory T Cells in Chronic Ischemic Heart Failure

Nikolaos G. Frangogiannis

CIRCULATION (2019)

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Review Cardiac & Cardiovascular Systems

Immunity and Inflammation in Atherosclerosis

Dennis Wolf et al.

CIRCULATION RESEARCH (2019)

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Article Integrative & Complementary Medicine

Yangyin Qingre Huoxue Method in Traditional Chinese Medicine Ameliorates Atherosclerosis in ApoE-/- Mice Suffering from High-Fat Diet and HSP65 Aggression

Runze Qiu et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

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Article Pharmacology & Pharmacy

New drugs in preclinical and early stage clinical development in the treatment of heart failure

Juan Tamargo et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2019)

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Article Cardiac & Cardiovascular Systems

Single-Cell Sequencing of Mouse Heart Immune Infiltrate in Pressure Overload-Driven Heart Failure Reveals Extent of Immune Activation

Elisa Martini et al.

CIRCULATION (2019)

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Article Virology

LAP+ Treg is a better biomarker than total Treg in viral myocarditis

Xinggang Wang et al.

JOURNAL OF MEDICAL VIROLOGY (2019)

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Review Cardiac & Cardiovascular Systems

Myocarditis in Humans and in Experimental Animal Models

Przemyslaw Blyszczuk

FRONTIERS IN CARDIOVASCULAR MEDICINE (2019)

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Article Medicine, Research & Experimental

Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner

Jiatao Li et al.

THERANOSTICS (2019)

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Article Cardiac & Cardiovascular Systems

Th17/Treg Ratio in Serum Predicts Onset of Postoperative Atrial Fibrillation After Off-Pump Coronary Artery Bypass Graft Surgery

Yi He et al.

HEART LUNG AND CIRCULATION (2018)

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Article Biology

PD-1/PD-L1 regulates Treg differentiation in pregnancy-induced hypertension

Lai Jiang et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2018)

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Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2018 Update A Report From the American Heart Association

Emelia J. Benjamin et al.

CIRCULATION (2018)

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Article Cardiac & Cardiovascular Systems

Deficiency of Complement C3a and C5a Receptors Prevents Angiotensin II-Induced Hypertension via Regulatory T Cells

Xiao-Hui Chen et al.

CIRCULATION RESEARCH (2018)

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Article Oncology

Progranulin ameliorates coxsackievirus-B3-induced viral myocarditis by downregulating Th1 and Th17 cells

Li Li et al.

EXPERIMENTAL CELL RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Immunomodulation by adoptive regulatory T-cell transfer improves Coxsackievirus B3-induced myocarditis

Kathleen Pappritz et al.

FASEB JOURNAL (2018)

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Article Medicine, Research & Experimental

Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling

Amber Emmerson et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Cardiac & Cardiovascular Systems

The ratio of circulating regulatory cluster of differentiation 4 T cells to endothelial progenitor cells predicts clinically significant acute rejection after heart transplantation

Dong-Hyun Choi et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2018)

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Review Cardiac & Cardiovascular Systems

Myocardial Interstitial Fibrosis in Heart Failure Biological and Translational Perspectives

Arantxa Gonzalez et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Article Food Science & Technology

The Probiotic Lactobacillus fermentum Prevents Dysbiosis and Vascular Oxidative Stress in Rats with Hypertension Induced by Chronic Nitric Oxide Blockade

Inaki Robles-Vera et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2018)

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Review Cardiac & Cardiovascular Systems

Therapeutic approaches for cardiac regeneration and repair

Hisayuki Hashimoto et al.

NATURE REVIEWS CARDIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Effect of Aerobic Exercise on Treg and Th17 of Rats with Ischemic Cardiomyopathy

Zhisong Chen et al.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2018)

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Article Immunology

Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice

Maria J. Forteza et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Pediatrics

Astragalus mongholicus (Fisch.) Bge Improves Peripheral Treg Cell Immunity Imbalance in the Children With Viral Myocarditis by Reducing the Levels of miR-146b and miR-155

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FRONTIERS IN PEDIATRICS (2018)

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Review Medicine, General & Internal

Cardiac Troponin - diagnostic problems and impact on cardiovascular disease

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ANNALS OF MEDICINE (2018)

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Interleukin-17 enhances cardiac ventricular remodeling via activating MAPK pathway in ischemic heart failure

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JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2018)

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Article Immunology

The cholinergic anti-inflammatory pathway ameliorates acute viral myocarditis in mice by regulating CD4+ T cell differentiation

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Fasudil exerts a cardio-protective effect on mice with coxsackievirus B3-induced acute viral myocarditis

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SGK1-FoxO1 Signaling Pathway Mediates Th17/Treg Imbalance and Target Organ Inflammation in Angiotensin II-Induced Hypertension

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GDF15 Regulates Malat-1 Circular RNA and Inactivates NFκB Signaling Leading to Immune Tolerogenic DCs for Preventing Alloimmune Rejection in Heart Transplantation

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Decreased frequencies and impaired functions of the CD31+ subpopulation in Treg cells associated with decreased FoxP3 expression and enhanced Treg cell defects in patients with coronary heart disease

L. Huang et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2017)

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EUROPEAN JOURNAL OF HEART FAILURE (2017)

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EUROPEAN JOURNAL OF HEART FAILURE (2017)

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INFLAMMATION RESEARCH (2017)

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Association of High-Sensitivity Cardiac Troponin I Concentration With Cardiac Outcomes in Patients With Suspected Acute Coronary Syndrome

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

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Interleukin-37 Ameliorates Coxsackievirus B3-induced Viral Myocarditis by Modulating the Th17/Regulatory T cell Immune Response

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Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis

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Sirtinol regulates the balance of Th17/Treg to prevent allograft rejection

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Exogenous interleukin 37 ameliorates atherosclerosis via inducing the Treg response in ApoE-deficient mice

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Pioglitazone stabilizes atherosclerotic plaque by regulating the Th17/Treg balance in AMPK-dependent mechanisms

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IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation

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BASIC RESEARCH IN CARDIOLOGY (2017)

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Infarcted Myocardium-Primed Dendritic Cells Improve Remodeling and Cardiac Function After Myocardial Infarction by Modulating the Regulatory T Cell and Macrophage Polarization

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Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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Cardiac-deleterious role of galectin-3 in chronic angiotensin II-induced hypertension

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Fenofibrate treatment of rats with experimental autoimmune myocarditis by alleviating Treg/Th17 disorder

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Atherosclerosis-Driven Treg Plasticity Results in Formation of a Dysfunctional Subset of Plastic IFNγ+ Th1/Tregs

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Deficiency of T-regulatory cells exaggerates angiotensin II-induced microvascular injury by enhancing immune responses

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Inhibition of microRNA-155 ameliorates experimental autoimmune myocarditis by modulating Th17/Treg immune response

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Regulation of the T Cell Response by CD39

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TRENDS IN IMMUNOLOGY (2016)

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Valproic acid ameliorates coxsackievirus-B3-induced viral myocarditis by modulating Th17/Treg imbalance

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Interleukin-2/Anti-Interleukin-2 Immune Complex Attenuates Cardiac Remodeling after Myocardial Infarction through Expansion of Regulatory T Cells

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A Shift in the Balance of Regulatory T and T Helper 17 Cells in Rheumatic Heart Disease

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Simvastatin combined with aspirin increases the survival time of heart allograft by activating CD4+CD25+ Treg cells and enhancing vascular endothelial cell protection

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IL-34 is a Treg-specific cytokine and mediates transplant tolerance

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Decreased proportion of Foxp3+CD4+ regulatory T cells contributes to the development of hypertension in genetically hypertensive rats

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Viral myocarditis-diagnosis, treatment options, and current controversies

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Regulatory T cells in rheumatoid arthritis showed increased plasticity toward Th17 but retained suppressive function in peripheral blood

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ANNALS OF THE RHEUMATIC DISEASES (2015)

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Valsartan Attenuates Atherosclerosis via Upregulating the Th2 Immune Response in Prolonged Angiotensin II-Treated ApoE(-/-) Mice

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MOLECULAR MEDICINE (2015)

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Treating Atherosclerosis With Regulatory T Cells

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Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function

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TGF-beta Activation and Function in Immunity

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ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

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Treatment with telmisartan/rosuvastatin combination has a beneficial synergistic effect on ameliorating Th17/Treg functional imbalance in hypertensive patients with carotid atherosclerosis

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ATHEROSCLEROSIS (2014)

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Regression of atherosclerosis with anti-CD3 antibody via augmenting a regulatory T-cell response in mice

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Heart Disease and Stroke Statistics-2014 Update A Report From the American Heart Association

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The Th17/Treg imbalance in patients with cardiogenic shock

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Catechin ameliorates cardiac dysfunction in rats with chronic heart failure by regulating the balance between Th17 and Treg cells

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INFLAMMATION RESEARCH (2014)

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Oleanolic acid modulates the immune-inflammatory response in mice with experimental autoimmune myocarditis and protects from cardiac injury. Therapeutic implications for the human disease

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Anti-Inflammatory Strategies for Ventricular Remodeling Following ST-Segment Elevation Acute Myocardial Infarction

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Pathogenic conversion of Foxp3(+) T cells into T(H)17 cells in autoimmune arthritis

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Effect of Th17 and Treg Axis Disorder on Outcomes of Pulmonary Arterial Hypertension in Connective Tissue Diseases

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Experimental Myocardial Infarction Induces Altered Regulatory T Cell Hemostasis, and Adoptive Transfer Attenuates Subsequent Remodeling

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Interleukin-2/Anti-Interleukin-2 Immune Complex Expands Regulatory T Cells and Reduces Angiotensin II-Induced Aortic Stiffening

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Th17/Treg imbalance induced by increased incidence of atherosclerosis in patients with Systemic Lupus Erythematosus (SLE)

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Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy

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FASEB JOURNAL (2013)

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VEGF165 attenuates the Th17/Treg imbalance that exists when transplanting allogeneic skeletal myoblasts to treat acute myocardial infarction

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INFLAMMATION RESEARCH (2013)

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Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis

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JOURNAL OF CLINICAL INVESTIGATION (2013)

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Article Cardiac & Cardiovascular Systems

Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction

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JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2013)

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Adoptive Transfer of Regulatory T Cells Protects against Coxsackievirus B3-Induced Cardiac Fibrosis

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Regulatory T cells ameliorate cardiac remodeling after myocardial infarction

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Inflammation in Myocardial Diseases

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CIRCULATION RESEARCH (2012)

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Susceptibility to autoimmune myocarditis is associated with intrinsic differences in CD4+T cells

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CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2012)

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IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction - A comparative study of human clinical-applicable DC

Martine A. Boks et al.

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Review Biochemistry & Molecular Biology

Naturally occurring regulatory T cells: markers, mechanisms, and manipulation

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FASEB JOURNAL (2012)

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IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKCβ/Erk1/2/NF-κB-dependent signaling pathway

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Expression of functional T-cell markers and T-cell receptor Vbeta repertoire in endomyocardial biopsies from patients presenting with acute myocarditis and dilated cardiomyopathy

Michel Noutsias et al.

EUROPEAN JOURNAL OF HEART FAILURE (2011)

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Review Pathology

Immunological aspect of cardiac remodeling: T lymphocyte subsets in inflammation-mediated cardiac fibrosis

Liu Wei

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Characterization of Interleukin-17-Producing Regulatory T Cells in Inflamed Intestinal Mucosa From Patients With Inflammatory Bowel Diseases

Zaruhi Hovhannisyan et al.

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Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis

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CCR5 Signaling Suppresses Inflammation and Reduces Adverse Remodeling of the Infarcted Heart, Mediating Recruitment of Regulatory T Cells

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Treatment and Prevention of Experimental Autoimmune Myocarditis with CD28 Superagonists

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CARDIOLOGY (2010)

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Regulatory T Cells Protect Mice Against Coxsackievirus-Induced Myocarditis Through the Transforming Growth Factor β-Coxsackie-Adenovirus Receptor Pathway

Yu Shi et al.

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The Th17/Treg imbalance exists in patients with heart failure with normal ejection fraction and heart failure with reduced ejection fraction

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CLINICA CHIMICA ACTA (2010)

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The Th17/Treg functional imbalance during atherogenesis in ApoE-/- mice

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CYTOKINE (2010)

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Review Immunology

The PD-1 pathway in tolerance and autoimmunity

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IMMUNOLOGICAL REVIEWS (2010)

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IL-17-producing human peripheral regulatory T cells retain suppressive function

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BLOOD (2009)

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Gonadectomy of male BALB/c mice increases Tim-3+ alternatively activated M2 macrophages, Tim-3+ T cells, Th2 cells and Treg in the heart during acute coxsackievirus-induced myocarditis

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Article Cardiac & Cardiovascular Systems

Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE-/- mice

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CARDIOVASCULAR RESEARCH (2009)

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Regulatory T Cells Modulate Postischemic Neovascularization

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CIRCULATION (2009)

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Regulatory T Cells Ameliorate Angiotensin II-Induced Cardiac Damage

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CIRCULATION (2009)

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Differential Macrophage Polarization in Male and Female BALB/c Mice Infected With Coxsackievirus B3 Defines Susceptibility to Viral Myocarditis

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CIRCULATION RESEARCH (2009)

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Review Immunology

Plasticity of CD4(+) FoxP3(+) T cells

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CURRENT OPINION IN IMMUNOLOGY (2009)

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PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

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Cardiac fibroblasts: At the heart of myocardial remodeling

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Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1-and TH17-mediated autoimmunity

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Review Biochemistry & Molecular Biology

Regulatory T cells and immune tolerance

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CELL (2008)

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The Th17/Treg imbalance in patients with acute coronary syndrome

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CLINICAL IMMUNOLOGY (2008)

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Article Immunology

The involvement of CD4+CD25+ T cells in the acute phase of Trypanosoma cruzi infection

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MICROBES AND INFECTION (2008)

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Article Immunology

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

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Review Cardiac & Cardiovascular Systems

Pathogenesis of chronic Chagas heart disease

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Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule

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CIRCULATION (2006)

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Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes

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Alternatively activated dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig

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Natural regulatory T cells and parasites: a common quest for host homeostasis

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Role of T lymphocytes in hypertension-induced cardiac extracellular matrix remodeling

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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Natural regulatory T cells control the development of atherosclerosis in mice

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NATURE MEDICINE (2006)

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CD28 superagonists put a break on autoimmunity by preferentially activating CD4(+)CD25(+) regulatory T cells

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AUTOIMMUNITY REVIEWS (2006)

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Superagonistic anti-CD28 antibodies:: potent activators of regulatory T cells for the therapy of autoimmune diseases

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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Review Immunology

Naturally arising Foxp3-expressing CD25+ CD4+ regulatory T cells in immunological tolerance to self and non-self

S Sakaguchi

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Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism

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BLOOD (2004)

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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NATURE IMMUNOLOGY (2003)

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Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist

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Control of regulatory T cell development by the transcription factor Foxp3

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

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