A potential therapeutic approach for ulcerative colitis: targeted regulation of macrophage polarization through phytochemicals

Ulcerative colitis (UC), a type of inflammatory bowel disease characterized by recurring and incurable symptoms, causes immense suffering and economic burden for patients due to the limited treatment options available. Therefore, it is imperative to develop novel and promising strategies, as well as safe and effective drugs, for the clinical management of UC. Macrophages play a critical role as the initial line of defense in maintaining intestinal immune homeostasis, and their phenotypic transformation significantly influences the progression of UC. Scientific studies have demonstrated that directing macrophage polarization toward the M2 phenotype is an effective strategy for the prevention and treatment of UC. Phytochemicals derived from botanical sources have garnered the interest of the scientific community owing to their distinct bioactivity and nutritional value, which have been shown to confer beneficial protective effects against colonic inflammation. In this review, we explicated the influence of macrophage polarization on the development of UC and collated data on the significant potential of natural substances that can target the macrophage phenotype and elucidate the possible mechanism of action for its treatment. These findings may provide novel directions and references for the clinical management of UC.

Automated summary

Ulcerative colitis (UC) is a recurring and incurable inflammatory bowel disease that causes great suffering and economic burden for patients due to limited treatment options. This review highlights the importance of macrophage polarization in the development of UC and explores the potential of natural substances to target macrophage phenotype and elucidate the mechanism for its treatment. These findings may provide novel directions and references for the clinical management of UC.