4.8 Article

Leptin deficiency in CD8+ T cells ameliorates non-segmental vitiligo by reducing interferon-γ and Granzyme B

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Endocrinology & Metabolism

A Case-Control Study of the Association of Leptin Gene Polymorphisms with Plasma Leptin Levels and Obesity in the Kerala Population

Sudharmadevi K. K. Manju et al.

Summary: This study analyzed the polymorphisms in the human leptin gene and their association with obesity in the Kerala population, South India. The study found that certain mutations in the LEP gene were associated with morbid obesity and altered levels of serum leptin.

JOURNAL OF OBESITY (2022)

Article Immunology

Decreased GZMB, NRP1, ITPR1, and SERPINB9 Transcripts Lead to Reduced Regulatory T Cells Suppressive Capacity in Generalized Vitiligo Patients

Prashant S. Giri et al.

Summary: This study reveals for the first time the critical role of GZMB, NRP1, SERPINB9, and ITPR1 transcripts in decreased Treg suppressive capacity in GV pathogenesis, progression, and severity. Furthermore, it suggests a correlation between ITPR1 and decreased expression of GZMB and NRP1 in GV Tregs. Additionally, the study suggests that increased SERPINB9 transcripts may lead to endogenous granzyme B-mediated Tregs apoptosis and that calcium treatment of Tregs may improve their suppressive capacity.

JOURNAL OF IMMUNOLOGY RESEARCH (2022)

Article Endocrinology & Metabolism

The role of peroxisome proliferator-activated receptors (PPAR) in immune responses

Anthos Christofides et al.

Summary: PPARs are fatty acid-activated transcription factors that regulate energy metabolism, with three subtypes identified: PPAR alpha, PPAR gamma, and PPAR beta/delta. They play distinct roles in oxidative and adipose tissues, as well as in immune cells, contributing to immune cell differentiation and inflammation.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

Article Medicine, General & Internal

Role of adiponectin and leptin in patients with alopecia areata with scalp hair loss

Gamze Serarslan et al.

Summary: This study found that adiponectin and leptin may play a role in the pathogenesis of AA with scalp hair involvement. The results showed significantly higher serum levels of adiponectin and leptin in AA patients.

IRISH JOURNAL OF MEDICAL SCIENCE (2021)

Review Dermatology

Vitiligo: A focus on pathogenesis and its therapeutic implications

Christina Bergqvist et al.

Summary: Vitiligo is a common depigmenting disorder caused by genetic and environmental factors. Significant progress has been made in understanding its pathogenesis as an autoimmune disease in the past decade.

JOURNAL OF DERMATOLOGY (2021)

Article Endocrinology & Metabolism

Deciphering the Association Between Psoriasis and Obesity: Current Evidence and Treatment Considerations

Kyriaki Paroutoglou et al.

CURRENT OBESITY REPORTS (2020)

Article Multidisciplinary Sciences

Enhancement of immune maturation in suckling rats by leptin and adiponectin supplementation

Blanca Grases-Pinto et al.

SCIENTIFIC REPORTS (2019)

Article Medicine, General & Internal

No Association between Vitiligo and Obesity: A Case-Control Study

Federica Dragoni et al.

MEDICAL PRINCIPLES AND PRACTICE (2017)

Article Medicine, General & Internal

Chronic diseases among vitiligo patients A case control study

Abdullah O. Al Houssien et al.

SAUDI MEDICAL JOURNAL (2017)

Review Biochemistry & Molecular Biology

Leptin in inflammation and autoimmunity

Antonio La Cava

CYTOKINE (2017)

Article Endocrinology & Metabolism

Serum leptin concentration in women of reproductive age with euthyroid autoimmune thyroiditis

Artur Drobniak et al.

GYNECOLOGICAL ENDOCRINOLOGY (2016)

Article Medicine, General & Internal

Vitiligo

Khaled Ezzedine et al.

LANCET (2015)

Article Medicine, General & Internal

Serum Leptin and Adiponectin Levels in Korean Patients with Psoriasis

Yu Jin Oh et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2014)

Article Biochemistry & Molecular Biology

p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity

A. Molchadsky et al.

CELL DEATH AND DIFFERENTIATION (2013)

Article Immunology

Leptin promotes lupus T-cell autoimmunity

Gil Amarilyo et al.

CLINICAL IMMUNOLOGY (2013)

Article Biochemistry & Molecular Biology

Involvement of Interferon-Gamma Genetic Variants and Intercellular Adhesion Molecule-1 in Onset and Progression of Generalized Vitiligo

Mitesh Dwivedi et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2013)

Letter Dermatology

Patients with vitiligo present fewer cardiovascular risk factors: results from a case-control study

M. Rodriguez-Martin et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2013)

Article Dermatology

A review of the worldwide prevalence of vitiligo in children/adolescents and adults

Christian Krueger et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2012)

Article Dermatology

Childhood vitiligo: Treatment paradigms

AmrinderJit Kanwar et al.

INDIAN JOURNAL OF DERMATOLOGY (2012)

Article Dermatology

Insulin Resistance is Increased in Patients with Vitiligo

Ayse Serap Karadag et al.

ACTA DERMATO-VENEREOLOGICA (2011)

Article Biochemistry & Molecular Biology

Evidence for the ectopic synthesis of melanin in human adipose tissue

Manpreet Randhawa et al.

FASEB JOURNAL (2009)

Article Dermatology

Autoimmune Destruction of Skin Melanocytes by Perilesional T Cells from Vitiligo Patients

Jasper G. van den Boorn et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)

Article Endocrinology & Metabolism

Leptin replacement therapy modulates circulating lymphocyte subsets and cytokine responsiveness in severe lipodystrophy

EA Oral et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)

Review Cell Biology

Evidence for an autoimmune pathogenesis of vitiligo

K Ongenae et al.

PIGMENT CELL RESEARCH (2003)

Article Dermatology

Direct evidence to support the role of antigen-specific CD8+ T cells in melanoma-associated vitiligo

FA Le Gal et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2001)

Review Multidisciplinary Sciences

Nuclear receptors and lipid physiology: Opening the X-files

A Chawla et al.

SCIENCE (2001)

Article Cell Biology

Human leptin enhances activation and proliferation of human circulating T lymphocytes

C Martín-Romero et al.

CELLULAR IMMUNOLOGY (2000)