Editorial: Soluble immune checkpoints: Novel physiological immunomodulators

Article Medical Laboratory Technology

Roles and correlations of TIM-3 and LAG-3 with cytokines and chemokines in alcoholic liver disease

Ailyn Fadriquela et al.

Summary: This study found that the levels of soluble TIM-3 and LAG-3 are associated with alcoholic liver disease (ALD). The results revealed that soluble TIM-3 was significantly increased, while soluble LAG-3 was significantly decreased in ALD patients. Moreover, the levels of G-CSF and IP-10 were significantly increased, while IL-4 and IL-12 were significantly decreased in ALD patients. These findings suggest that TIM-3, LAG-3, and IP-10 may serve as potential diagnostic and therapeutic targets for ALD.

CLINICA CHIMICA ACTA (2023)

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Article Substance Abuse

Characteristics of immune checkpoint regulators and potential role of soluble TIM-3 and LAG-3 in male patients with alcohol-associated liver disease

Ailyn Fadriquela et al.

Summary: This study revealed the involvement of sCTLA-4, sTIM-3, sCD27, sGITRL, sLAG-3, and sHVEM in distinguishing male patients with ALD. Expressions of sTIM-3 and sLAG-3 were correlated with liver fibrosis markers and significantly associated with ALD severity, which can be further studied as diagnostic markers and therapeutic targets in ALD.

ALCOHOL (2022)

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Review Oncology

Immune-checkpoint inhibitors from cancer to COVID-19: A promising avenue for the treatment of patients with COVID-19 (Review)

Silvia Vivarelli et al.

Summary: The treatment of COVID-19 is still lacking a clear and effective drug, but there is hope to use immune checkpoint inhibitors to restore the function of T cells in patients to combat viral infections.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

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Article Physiology

Soluble TIM3 and Its Ligands Galectin-9 and CEACAM1 Are in Disequilibrium During Alcohol-Related Liver Disease and Promote Impairment of Anti-bacterial Immunity

Antonio Riva et al.

Summary: The study found that patients with alcohol-related liver disease exhibit abnormally elevated levels of soluble TIM3, especially those with more severe conditions. Soluble TIM3 is strongly correlated with pro-inflammatory cytokines, gut bacterial translocation markers, and disease severity indicators. In addition, bacterial challenge leads to the overexpression of membrane TIM3 on immune cells.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Gastroenterology & Hepatology