Naproxen chemoprevention induces proliferation of cytotoxic lymphocytes in Lynch Syndrome colorectal mucosa

Article Immunology

Systematic analysis of CD39, CD103, CD137, and PD-1 as biomarkers for naturally occurring tumor antigen-specific TILs

Monika A. Eiva et al.

Summary: The study evaluated common biomarkers in primary human ovarian tumor samples, showing that CD137 may be a more selective biomarker that accurately characterizes naturally occurring tumor-specific tumor-infiltrating lymphocytes (TILs).

EUROPEAN JOURNAL OF IMMUNOLOGY (2022)

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Review Oncology

Vaccines for immunoprevention of DNA mismatch repair deficient cancers

Alejandro Hernandez-Sanchez et al.

Summary: The development of cancer vaccines was initially inspired by the identification of tumor-antigen specific immune responses, but challenges such as weak immunogenicity and mutational heterogeneity have limited success. Predictable mutational neoantigens, particularly in DNA mismatch repair-deficient cancers, have renewed interest in cancer vaccines. Lynch syndrome represents a high-risk population for the potential development of a preventive cancer vaccine due to the predictability of frameshift peptide neoantigens.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Article Gastroenterology & Hepatology

Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa

Laura Reyes-Uribe et al.

Summary: Using naproxen for chemoprevention in patients with Lynch syndrome demonstrated decreased prostaglandin E2 levels in colorectal mucosa, activation of different immune cell types, and changes in intestinal crypt expression patterns. Gene expression profiles induced by naproxen may serve as predictive biomarkers for drug activity.

GUT (2021)

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Article Oncology

The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells

Prashant Bommi et al.

Summary: This study provides insights into the initiation of MMR-deficient colorectal carcinogenesis by analyzing the expression profile of MMRd intestinal stem cells. The findings suggest that the expression signatures of MMRd ISCs can recapitulate the initial steps of Lynch syndrome carcinogenesis and potentially serve as novel biomarkers for early cancer initiation.

CANCER RESEARCH (2021)

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Editorial Material Dermatology

Research Techniques Made Simple: Use of Imaging Mass Cytometry for Dermatological Research and Clinical Applications

Jesse Veenstra et al.

Summary: IMC technology, which allows for the simultaneous analysis of multiple protein markers and the generation of high-dimensional images, preserves tissue architecture and spatial cellular relationships to identify unique cell populations, cellular interactions, and insights into activation and behavioral status based on tissue location.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Biochemistry & Molecular Biology

Integrated analysis of multimodal single-cell data

Yuhan Hao et al.

Summary: The study introduces a weighted-nearest neighbor analysis framework to learn the relative utility of each data type in each cell, enabling integrative analysis of multiple modalities. Applied to a CITE-seq dataset, the method constructs a multimodal reference atlas of the circulating immune system and successfully identifies and validates previously unreported lymphoid subpopulations.

CELL (2021)

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Article Ophthalmology

Imaging mass cytometry for high-dimensional tissue profiling in the eye

Anja Schlecht et al.

Summary: Background Imaging Mass Cytometry (IMC) allows for highly multiplexed imaging of ocular samples at subcellular resolution, providing new insights into the biology and pathology of ocular diseases. By using isotope-coupled antibodies, IMC enables simultaneous analysis of up to 40 biomarkers in the same tissue section, offering a innovative and feasible method for studying ocular disease pathogenesis.

BMC OPHTHALMOLOGY (2021)

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Review Medicine, Research & Experimental

Vaccines for immunoprevention of cancer

Tomohiro Enokida et al.

Summary: Preventive cancer vaccines have shown promising results in targeting oncogenic viruses, such as HPV and HBV, but face challenges in eliminating established cancer. Ongoing research is also focusing on nonviral antigens to develop effective cancer-preventive vaccines.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Oncology