☆ 4.8 Review

Sex-biased immunological processes drive hidradenitis suppurativa

FRONTIERS IN IMMUNOLOGY (2023)

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Article Dermatology

Interleukin-17RA blockade by brodalumab decreases inflammatory pathways in hidradenitis suppurativa skin and serum

Kristina Navrazhina et al.

Summary: This study reveals that brodalumab, a human anti-IL-17 receptor A monoclonal antibody, effectively reduces inflammation and improves related pathways in Hidradenitis suppurativa (HS) patients. The response to treatment is best assessed in perilesional skin, and baseline expression levels of LCN2 and IL-17A can be used as predictive biomarkers for treatment response.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Review Dermatology

Antimicrobial peptides in hidradenitis suppurativa: a systematic review

Y. Yao et al.

Summary: The review highlights the diversity of AMPs in HS, with consistent findings of dysregulation of AMPs in HS skin. The included studies demonstrate an overexpression of certain AMPs in HS, while others show a decreased expression.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Review Dermatology

Sex Bias and Autoimmune Diseases

Enze Xing et al.

Summary: Sex bias in immune function is significant, with women showing heightened immunity but also a predisposition for autoimmune diseases. This review explores the evolutionary and molecular factors underlying sexual dimorphism in immunity, with the aim of facilitating the development of targeted therapeutics.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Article Biochemistry & Molecular Biology

Unraveling the Role of Sex Hormones on Keratinocyte Functions in Human Inflammatory Skin Diseases

Rossella Gratton et al.

Summary: The skin is the first line of defense for the human body, providing physical, chemical, and immune barriers. Keratinocytes, the main cell type of the skin, play a crucial role in maintaining skin integrity and immune responses. Sex hormones have multiple effects on the skin by binding to intracellular receptors in different skin cell populations, including keratinocytes. This review focuses on the role of sex hormones in keratinocyte function in five different inflammatory skin diseases, aiming to identify potential targets for therapeutic interventions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Immunology

The X in seX-biased immunity and autoimmune rheumatic disease

Nikhil Jiwrajka et al.

Summary: Sexual dimorphism in the human immune system is influenced by sex hormones and the X chromosome, and it has significant implications for autoimmune diseases.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

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Letter Dermatology

Gut Microbiome Perturbations in Patients with Hidradenitis Suppurativa: A Case Series

Sarah Kam et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Letter Dermatology

Development or exacerbation of hidradenitis suppurativa in two transgender men after initiation of testosterone therapy

M. Buonomo et al.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Review Dermatology

The Microbiome in Hidradenitis Suppurativa: A Review

Kirsty J. L. Wark et al.

Summary: A chronic autoinflammatory skin disease called Hidradenitis suppurativa (HS) is characterized by the development of abscesses and nodules in intertriginous anatomical sites. Bacteria play a role in disease pathogenesis. Research found studies examining the cutaneous microbiome and gut microbiome in HS, with potential for further research into the oral microbiome and relationship with co-morbidities. Metagenomics-focused studies may identify new pathways of disease pathogenesis and potential therapeutic targets.

DERMATOLOGY AND THERAPY (2021)

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Review Biochemistry & Molecular Biology

Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis

Irmina Olejniczak-Staruch et al.

Summary: Numerous scientific studies have shown significant skin and gut dysbiosis in patients with psoriasis, with changes in abundance of specific bacterial taxa. Treatments for psoriasis have been found to significantly influence skin and gut microbiome, with orally administered probiotics having a positive impact on the course of the disease. Further research is needed to understand the influence of microbiome on the development of inflammatory skin diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases

Maddalena Napolitano et al.

Summary: Aryl Hydrocarbon Receptor (AhR) is an evolutionary transcription factor that plays a crucial role in the physiology of the skin and has been implicated in the development of inflammatory skin diseases. The evidence suggests both beneficial and harmful effects of AhR signaling.

CELLS (2021)

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Review Biochemistry & Molecular Biology

Sex-Related Overactivation of NLRP3 Inflammasome Increases Lethality of the Male COVID-19 Patients

Hongliang Zhang et al.

Summary: The COVID-19 pandemic caused by SARS-CoV-2 infection poses a significant threat to human life and economic well-being globally, with male patients showing a higher probability of severe symptoms and mortality. The NLRP3 inflammasome likely plays a critical role in this process.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Medicine, General & Internal

Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa

Paula Mariottoni et al.

Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent abscesses, nodules, and sinus tracts in areas of high hair follicle and sweat gland density. The dysregulation of monocytes/macrophages pathways may serve as therapeutic targets and biomarkers in HS treatment.

FRONTIERS IN MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Insights into the Pathogenesis of HS and Therapeutical Approaches

Elia Rosi et al.

Summary: Hidradenitis suppurativa (HS) is a chronic, inflammatory disease primarily affecting apocrine gland-rich areas of the body. The pathogenic mechanisms of HS involve multiple factors, with the terminal follicle being the main target. Research has focused on investigating the role of inflammation, genetics, lifestyle, hormonal status, microbiome, and immune systems in HS pathogenesis to develop potential medical therapies for patients.

BIOMEDICINES (2021)

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Article Dermatology

Psoriasis as a comorbidity of hidradenitis suppurativa

Rune Kjaersgaard Andersen et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2020)

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Article Dermatology

Epidemiology, clinical presentation, and pathogenesis

Samantha R. Goldburg et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Review Dermatology

The epidemiology of hidradenitis suppurativa

John R. Ingram

BRITISH JOURNAL OF DERMATOLOGY (2020)

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Article Dermatology

Phenotypes and Pathophysiology of Syndromic Hidradenitis Suppurativa: Different Faces of the Same Disease? A Systematic Review

Georgios Nikolakis et al.

DERMATOLOGY (2020)

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Review Dermatology

What causes hidradenitis suppurativa ?-15 years after

Christos C. Zouboulis et al.

EXPERIMENTAL DERMATOLOGY (2020)

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Article Medicine, Research & Experimental

Dysregulation of tryptophan catabolism at the host-skin microbiota interface in hidradenitis suppurativa

Laure Guenin-Mace et al.

JCI INSIGHT (2020)

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Review Immunology

The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

Taoming Liu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Gastroenterology & Hepatology

Sex-based differences in inflammatory bowel diseases: a review

Sheila D. Rustgi et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2020)

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Review Dermatology

Is There a Role for Antiandrogen Therapy for Hidradenitis Suppurativa? A Systematic Review of Published Data

Georgios Nikolakis et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2019)

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Review Biophysics

Mitochondria as a possible target for nicotine action

Dominika Malinska et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2019)

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Review Dermatology

Association of Hidradenitis Suppurativa With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Wei-Ti Chen et al.

JAMA DERMATOLOGY (2019)

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Editorial Material Dermatology

A Call to Accelerate Hidradenitis Suppurativa Research and Improve Care-Moving Beyond Burden

Haley B. Naik et al.

JAMA DERMATOLOGY (2019)

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Review Rheumatology

Sex bias in autoimmunity

Allison C. Billi et al.

CURRENT OPINION IN RHEUMATOLOGY (2019)

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Review Medicine, Research & Experimental

Systematic review of immunomodulatory therapies for hidradenitis suppurativa

Shi Yu Derek Lim et al.

BIOLOGICS-TARGETS & THERAPY (2019)

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Article Medicine, Research & Experimental

The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity

Allison C. Billi et al.

JCI INSIGHT (2019)

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Article Dermatology

Hidradenitis suppurativa and the metabolic syndrome

Tulin Ergun

CLINICS IN DERMATOLOGY (2018)

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Article Dermatology

MABp1 Targeting IL-1α for Moderate to Severe Hidradenitis Suppurativa Not Eligible for Adalimumab: A Randomized Study

Theodora Kanni et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

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Article Dermatology

Prevalence and comorbidities associated with hidradenitis suppurativa in Korea: a nationwide population-based study

J. H. Lee et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2018)

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Article Dermatology

Association of Hidradenitis Suppurativa With T Helper 1/T Helper 17 Phenotypes A Semantic Map Analysis

Rahel Thomi et al.

JAMA DERMATOLOGY (2018)

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Article Dermatology

Demographic and clinical features of hidradenitis suppurativa in Korea

Ji Hoon Yang et al.

JOURNAL OF DERMATOLOGY (2018)

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Review Immunology

Hidradenitis Suppurativa: A Systematic Review Integrating Inflammatory Pathways Into a Cohesive Pathogenic Model

Allard R. J. V. Vossen et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Immunology

A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases

Yun Liang et al.

NATURE IMMUNOLOGY (2017)

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Article Dermatology

The Follicular Skin Microbiome in Patients With Hidradenitis Suppurativa and Healthy Controls

Hans Christian Ring et al.

JAMA DERMATOLOGY (2017)

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Article Dermatology

Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa

A. L. Lima et al.

BRITISH JOURNAL OF DERMATOLOGY (2016)

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Article Dermatology

Inflammasomes and dermatology

Daniel Coelho de Sa et al.

ANAIS BRASILEIROS DE DERMATOLOGIA (2016)

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Article Medicine, General & Internal

Two Phase 3 Trials of Adalimumab for Hidradenitis Suppurativa

Alexa B. Kimball et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Dermatology

Safety and Efficacy of Anakinra in Severe Hidradenitis Suppurativa A Randomized Clinical Trial

Vassiliki Tzanetakou et al.

JAMA DERMATOLOGY (2016)

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Review Dermatology

Cardiovascular disease risk factors in patients with hidradenitis suppurativa: a systematic review and meta-analysis of observational studies

T. Tzellos et al.

BRITISH JOURNAL OF DERMATOLOGY (2015)

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Letter Dermatology

Questionnaire surveillance of hidradenitis suppurativa in Japan

Ichiro Kurokawa et al.

JOURNAL OF DERMATOLOGY (2015)

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Article Dermatology

Correlation of inflammatory serum markers with disease severity in patients with hidradenitis suppurativa (HS)

Schapoor Hessam et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

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Article Multidisciplinary Sciences

The Influence of Age and Gender on Skin-Associated Microbial Communities in Urban and Rural Human Populations

Shi Ying et al.

PLOS ONE (2015)

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What is the role of antimicrobial peptides (AMP) in acne vulgaris?

Juergen Harder et al.

EXPERIMENTAL DERMATOLOGY (2013)

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Article Multidisciplinary Sciences

Sex Bias in Infectious Disease Epidemiology: Patterns and Processes

Felipe Guerra-Silveira et al.

PLOS ONE (2013)

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Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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The influence of sex, handedness, and washing on the diversity of hand surface bacteria

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