期刊
FRONTIERS IN IMMUNOLOGY
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2023.1147674
关键词
macrophages regulate intestinal motility dysfunction sepsis; immunity; neutrophils; muscular neurons; intestinal muscular macrophages
类别
This study aimed to investigate the mechanisms that activate immune and neuronal cells, and the contribution of macrophages to the recovery of intestinal motility dysfunction after sepsis. The results showed that muscular neutrophil infiltration led to neuronal loss and intestinal motility dysfunction after pneumonia sepsis, and reducing neutrophil infiltration did not improve the dysfunction. Additionally, macrophage depletion aggravated gut motility dysfunction, while the addition of macrophages to smooth muscle helped in the recovery of intestinal motility.
IntroductionGut motility dysfunction, the most common complication of post-septic organ dysfunction, depends on immune and neuronal cells. This study aimed to investigate the mechanisms that activate these cells and the contribution of macrophages to the recovery of intestinal motility dysfunction after sepsis. Materials and methodsPostoperative gut motility dysfunction was induced by establishing Klebsiella pneumonia sepsis in mice with selective deletion of neutrophils and macrophages in the gut. The distribution of orally administered fluorescein isothiocyanate-dextran and carmine excretion time was used to determine the severity of small bowel disease. The effect of macrophages on intestinal motility was evaluated after prostaglandin E2 therapy. ResultsWe found that muscular neutrophil infiltration leading to neuronal loss in the intestine muscle triggered intestinal motility dysfunction after pneumonia sepsis; however, reduced neutrophil infiltration did not improve intestinal motility dysfunction. Moreover, macrophage depletion aggravated gut motility dysfunction. The addition of macrophages directly to a smooth muscle was responsible for the recovery of intestinal motility. ConclusionOur results suggest that a direct interaction between macrophages and smooth muscle is neurologically independent of the restoration of intestinal dysmotility.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据