Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis

Article Oncology

Exosomal transfer of miR-181b-5p confers senescence-mediated doxorubicin resistance via modulating BCLAF1 in breast cancer

Shaorong Zhao et al.

Summary: This study reveals the important role of exosomal miR-181b-5p in doxorubicin resistance in breast cancer, and suggests its potential as a prognostic biomarker and therapeutic target for doxorubicin-resistant BC patients.

BRITISH JOURNAL OF CANCER (2023)

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Article Medical Laboratory Technology

Exosomal lncRNAs in gastrointestinal cancer

Parisa Vosough et al.

Summary: Gastrointestinal cancer is a major global health issue and early diagnosis is difficult due to the lack of reliable biomarkers. However, circulating exosomes are showing promise as non-invasive diagnostic tools with limited risks. In particular, exosomal long non-coding RNAs are emerging as potential biomarkers in gastrointestinal cancer. This review provides an overview of the extraction and detection of exosomal lncRNAs, focusing on their role in gastrointestinal cancer.

CLINICA CHIMICA ACTA (2023)

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Review Biochemistry & Molecular Biology

Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer

K. Auxzilia Preethi et al.

Summary: This article reviews the use of exosomal miRNAs as biomarkers for cancer diagnosis and prognosis. Exosomal miRNAs are stable and can be used for early and minimally invasive diagnosis, providing important insights for cancer management.

MOLECULAR CANCER (2022)

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Article Pharmacology & Pharmacy

Exosomal ncRNAs: Novel therapeutic target and biomarker for diabetic complications

Yu-Xin Xu et al.

Summary: This article reviews the role of exosomal non-coding RNAs in diabetic complications and analyzes their potential as new biomarkers and cell-free therapies. It provides new ideas for the prevention, diagnosis, and treatment of diabetic complications.

PHARMACOLOGICAL RESEARCH (2022)

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Review Pharmacology & Pharmacy

Exosomal LncRNAs and hepatocellular Carcinoma: From basic research to clinical practice

Liangyun Li et al.

Summary: This review article highlights the role of exosomal lncRNAs in the development of HCC, showing their crucial involvement in the growth and progression of HCC and their potential as therapeutic targets.

BIOCHEMICAL PHARMACOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Small RNA sequencing and bioinformatics analysis of RAW264.7-derived exosomes after Mycobacterium Bovis Bacillus Calmette-Guerin infection

Xuehua Zhan et al.

Summary: The study found that the expression profiles of miRNA in exosomes derived from macrophages were altered after Mycobacterium Bovis Bacillus Calmette-Guerin infection, with differentially expressed miRNAs involved in multiple biological processes and signaling pathways. The up-regulated miRNAs were predominantly correlated with the regulation of apoptosis.

BMC GENOMICS (2022)

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Review Immunology

The Role of NcRNAs to Regulate Immune Checkpoints in Cancer

Yicun Jiang et al.

Summary: The treatment of cancer has always been a problem, and current conventional therapies are not effective enough. However, non-coding RNAs play crucial roles in various aspects of cancer biology, and targeting immune checkpoints through ncRNAs may provide a new strategy for cancer treatment.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects

Hongxia Jiang et al.

Summary: Exosomes are small vesicles that mediate intercellular communication by transferring various components. Hypoxia influences the content and effects of exosomes. Hypoxic exosomes derived from tumor cells lead to different biological effects depending on the recipient units. Understanding the characteristics of hypoxic exosomes provides new insight into the pathogenesis of hypoxia-related diseases.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Genetics & Heredity

New developments in non-exosomal and exosomal ncRNAs in coronary artery disease

Jingru Li et al.

Summary: This study provides a comprehensive review on the functions and mechanisms of non-exosomal and exosomal ncRNAs in coronary artery disease (CAD) over the past 3 years. The results show that these ncRNAs can not only serve as biomarkers for CAD diagnosis, but also regulate CAD progression through ceRNA mechanisms, indicating their potential as targets for early clinical intervention in CAD.

EPIGENOMICS (2022)

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Review Respiratory System

Diagnosing Tuberculosis: What Do New Technologies Allow Us to (Not) Do?

Shima M. Abdulgader et al.

Summary: New tuberculosis diagnostic technologies are facing challenges due to the diversion of resources caused by COVID-19. However, some technologies, especially non-invasive non-sputum-based tests, show promise in efficiently triaging and confirming tuberculosis near point-of-care. These tests are progressing slowly and will take years to reach patients and health workers. In this state-of-the-art review, the strengths, limitations, and outstanding research questions of these technologies are critically appraised.

RESPIRATION (2022)

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Article Immunology

Comparative Profiling of Circulating Exosomal Small RNAs Derived From Peruvian Patients With Tuberculosis and Pulmonary Adenocarcinoma

Heinner Guio et al.

Summary: Tuberculosis is a fatal infectious disease with a third of the global population infected. Cured tuberculosis patients are at a higher risk for developing pulmonary adenocarcinoma. Analysis of small RNAs extracted from blood samples of Peruvian patients revealed 24 perturbed microRNAs that may serve as potential biomarker candidates for the Peruvian population.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Review Immunology

Therapeutic Vaccines for Tuberculosis: An Overview

Rania Bouzeyen et al.

Summary: Tuberculosis is a deadly bacterial infection and drug resistance poses a threat to successful treatment. Therapeutic vaccination, as a new treatment modality, holds potential as a useful adjunct therapy.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Medicine, General & Internal

Testing and Treating Mycobacterium tuberculosis Infection

Edgar Ortiz-Brizuela et al.

MEDICAL CLINICS OF NORTH AMERICA (2022)

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Review Immunology

Immune regulation and emerging roles of noncoding RNAs in Mycobacterium tuberculosis infection

Shufan Liang et al.

Summary: This article reviews the role of noncoding RNAs (ncRNAs) in Mycobacterium tuberculosis infection, highlighting their impact through immune response modulation, and their potential as biomarkers for tuberculosis diagnosis, drug resistance identification, treatment evaluation, and adverse drug reaction prediction.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Exosomes in the tumor microenvironment: Promoting cancer progression

Ye Jin et al.

Summary: Exosomes, produced by endosomes, play a crucial role in intercellular communication. Over the past few decades, there has been growing recognition of the importance of exosomes in the tumor microenvironment and their connection to cancer development. This paper discusses the composition, generation, uptake, and roles of exosomes in tumor metastasis, angiogenesis, and immunosuppression. Understanding the biological characteristics of exosomes and their functions in tumor development is significant for identifying new diagnostic biomarkers and therapeutic targets for cancer.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

MicroRNAs as immune regulators and biomarkers in tuberculosis

Lulu Wang et al.

Summary: miRNAs play important roles in TB by regulating host cell metabolism, inflammatory responses, apoptosis, and autophagy to impact the survival of Mycobacterium tuberculosis. Additionally, differential miRNA expression levels can be used to distinguish healthy individuals, TB patients, and latent TB patients.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Immune cell interactions in tuberculosis

JoAnne L. Flynn et al.

Summary: Despite being identified as the cause of tuberculosis in 1882, Mycobacterium tuberculosis still remains poorly understood in terms of the protective immune response and effective vaccine development. Recent advancements in technology and experimental models have provided new insights into the heterogeneity of the bacteria and the host response. This review emphasizes the significance of a holistic approach in understanding the interaction between M. tuberculosis and the diverse host cells that contribute to the development of protective immunity.

CELL (2022)

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Review Microbiology

Mycobacterium tuberculosisextracellular vesicles: exploitation for vaccine technology and diagnostic methods

Roghayeh Mohammadzadeh et al.

Summary: Tuberculosis is a deadly epidemic disease caused by Mycobacterium tuberculosis, and issues such as multidrug resistance and extensively drug-resistant tuberculosis have made efficient vaccines and diagnostic biomarkers essential. Extracellular vesicles, with their various cargos, are recognized as promising tools for designing novel vaccines, diagnostic biomarkers, and drug delivery systems in the fight against TB.

CRITICAL REVIEWS IN MICROBIOLOGY (2021)

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Article Cell Biology

Exosome long non-coding RNA SOX2-OT contributes to ovarian cancer malignant progression by miR-181b-5p/SCD1 signaling

Yongjing Lai et al.

Aging-US (2021)

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Review Oncology

Exosomes and exosomal RNAs in breast cancer: A status update

Sreerenjini Lakshmi et al.

Summary: Exosomes and their RNA have potential roles in breast cancer biology and treatment, participating in breast cancer tumorigenesis and progression through the transfer of miRNAs and LncRNAs. The diagnostic and therapeutic applications of exosomal miRNAs/LncRNAs in breast cancer have been highlighted in numerous publications.

EUROPEAN JOURNAL OF CANCER (2021)

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Article Cell Biology

Exosomes derived from mycobacterium tuberculosis-infected MSCs induce a pro-inflammatory response of macrophages

Min Liu et al.

Summary: This study demonstrated that M.tb infection promoted the generation of Exo-MSCs-M.tb, which induced a pro-inflammatory response in macrophages by enhancing the production of inflammatory factors. The effect exhibited a time-dependent pattern with the peak inflammatory response observed at 72 hours post-infection of MSCs.

AGING-US (2021)

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Review Immunology

The Research Progress in Immunotherapy of Tuberculosis

Jie Mi et al.

Summary: Tuberculosis is a serious global public health problem, and research progress in TB-specific immunotherapy agents can effectively address issues with long-term drug use and provide a new approach to treatment, ultimately achieving the goal of ultra-short course chemotherapy.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Review Cell Biology

The exosome journey: from biogenesis to uptake and intracellular signalling

Sonam Gurung et al.

Summary: Exosomes have vast potential in clinical applications, and understanding their biology is crucial. The processes of exosome biogenesis, transport, and uptake involve numerous influencing factors.

CELL COMMUNICATION AND SIGNALING (2021)

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Article Immunology

A Dual Marker for Monitoring MDR-TB Treatment: Host-Derived miRNAs and M. tuberculosis-Derived RNA Sequences in Serum

Claudia Carranza et al.

Summary: Dual markers composed of host-derived miR-let7e-5p and M. tuberculosis-derived RNA could serve as indicators of treatment failure or relapse in MDR-TB patients. MiR-let7e-5p could be used as a long-term monitoring biomarker for MDR-TB treatment, and the combination of host-derived miRNA and M. tuberculosis RNA in serum EVs may be a promising approach for monitoring TB treatment.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Advancing Adjuvants for Mycobacterium tuberculosis Therapeutics

Ana B. Enriquez et al.

Summary: Tuberculosis remains a leading cause of death worldwide, with recent advancements in vaccine research showing potential for more effective vaccines in the future. More research and development are needed to improve TB vaccine efficacy.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Identification of differentially expressed lncRNAs as potential plasma biomarkers for active tuberculosis

Yalun Fang et al.

Summary: The study identified four differentially expressed lncRNAs in the plasma of TB patients that could serve as potential diagnostic biomarkers for TB, showing promise for improving TB diagnosis.

TUBERCULOSIS (2021)

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Review Immunology

Host-Directed Therapies: Modulating Inflammation to Treat Tuberculosis

Stefanie Krug et al.

Summary: Following infection with Mycobacterium tuberculosis, a balanced immune response is crucial to containing the infection and avoiding progression to active TB disease, as excessive pro-inflammatory responses may lead to granuloma enlargement and tissue damage, prolonging treatment duration and permanently diminishing lung function.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Biochemical Research Methods

Exosomal ncRNAs profiling of mycobacterial infection identified miRNA-185-5p as a novel biomarker for tuberculosis

Aman Chandra Kaushik et al.

Summary: The study indicates that exosomal ncRNAs may serve as useful functional biomarkers in tuberculosis, with miR-185-5p identified as a potential biomarker for tuberculosis.

BRIEFINGS IN BIOINFORMATICS (2021)

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Review Biochemistry & Molecular Biology

Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications

Xiao-Huan Tang et al.

Summary: Exosomes, a subpopulation of the tumour microenvironment (TME), are crucial for intercellular communication and are enriched with noncoding RNAs that play important roles in the tumorigenesis, progression, and drug resistance of gastric cancer (GC). Regulating exosomal ncRNAs levels could potentially serve as therapeutic targets for GC treatment.

MOLECULAR CANCER (2021)

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Review Immunology

Exosomes and Melatonin: Where Their Destinies Intersect

Adriana Alonso Novais et al.

Summary: Exosomes and melatonin play important roles in cell-to-cell communication, and their combination can improve various pathological processes, including inflammation, hepatic metabolic disturbance, immunosuppression, etc.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

The Role of microRNAs and Long Non-Coding RNAs in the Regulation of the Immune Response to Mycobacterium tuberculosis Infection

Manikuntala Kundu et al.

Summary: Non-coding RNAs, including miRNAs and lncRNAs, play crucial roles in the host immune response to tuberculosis infection, regulating host defense mechanisms and impacting the outcome of infection. miRNAs are involved in regulating host signaling pathways linked to inflammation, autophagy, apoptosis, and macrophage polarization upon infection with M. tuberculosis, while lncRNAs interact with chromatin remodelers, regulate gene expression, and function as miRNA sponges.Targeting miRNAs is an emerging option for host-directed therapies, and understanding the role of non-coding RNAs is essential for the development of RNA-based thera

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Monocyte and Macrophage miRNA: Potent Biomarker and Target for Host-Directed Therapy for Tuberculosis

Pavithra Sampath et al.

Summary: The utilization of miRNA as essential biomarkers in early diagnosis and treatment of tuberculosis highlights their importance in studying disease progression and immune regulation. The research on monocytes provides valuable insight into tuberculosis pathogenesis and biomarker efficiency.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

Chen Li et al.

Summary: Exosomes act as mediators of cell-to-cell communication, playing a crucial role in regulating human health and diseases through non-coding RNA. Changes in exosomal ncRNAs may lead to tissue dysfunction, aging, and diseases.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Medicine, Research & Experimental

Exosome-inflammasome crosstalk and their roles in inflammatory responses

Chadanat Noonin et al.

Summary: The inflammasome is a complex of proteins in the cytoplasm of cells activated by infectious and non-infectious stimuli, while exosomes are extracellular vesicles that play important roles in intercellular communication. The review discusses the interaction between exosomes and inflammasomes in inflammatory responses, highlighting the effects of inflammasome activation on exosomal secretion. Additionally, it explores the dual effects of exosomes on inhibiting and promoting inflammasome activation, and provides insights into the therapeutic potential of exosomes in human diseases.

THERANOSTICS (2021)

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Review Biochemistry & Molecular Biology

Exosomal circRNAs as novel cancer biomarkers: Challenges and opportunities

Shuai Wang et al.

Summary: Exosomal circRNAs have emerged as potential biomarkers in cancer diagnosis and prognosis, with the ability to influence target cells or organs by regulating tumor development and metastasis. The high stability of circRNAs in exosomes makes them promising candidates for early and minimally invasive cancer diagnosis and prognosis evaluation.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Biochemistry & Molecular Biology

CircRNA: a rising star in gastric cancer

Rong Li et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

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Article Infectious Diseases

Screening and identification of plasma lncRNAs uc.48+and NR_105053 as potential novel biomarkers for cured pulmonary tuberculosis

Zhi-Bin Li et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Immunology

Effects of Mycobacterium tuberculosis Rv1096 on mycobacterial cell division and modulation on macrophages

Guoying Deng et al.

MICROBIAL PATHOGENESIS (2020)

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Review Biochemistry & Molecular Biology

Advances in diagnosis of Tuberculosis: an update into molecular diagnosis of Mycobacterium tuberculosis

Bodhraj Acharya et al.

MOLECULAR BIOLOGY REPORTS (2020)

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Article Medicine, General & Internal

Tuberculosis in 2020 — New Approaches to a Continuing Global Health Crisis

Ahmad Zaheen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Immunology

Host-Directed Therapy in Tuberculosis: Targeting Host Metabolism

Jae-Sung Kim et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Nanoscience & Nanotechnology

Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications

Yi Zhang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Nanoscience & Nanotechnology

Cancer-Derived Exosomes: Their Role in Cancer Biology and Biomarker Development

Victor C. Kok et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Cell Biology

Tuberculosis-Associated MicroRNAs: From Pathogenesis to Disease Biomarkers

Alessandro Sinigaglia et al.

CELLS (2020)

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Review Oncology

Isolation and characterization of exosomes for cancer research

Le Zhu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Review Biochemistry & Molecular Biology

Exosomes: key players in cancer and potential therapeutic strategy

Jie Dai et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Biotechnology & Applied Microbiology

Serum Exosomal miRNAs Are Associated with Active Pulmonary Tuberculosis

Shamila D. Alipoor et al.

DISEASE MARKERS (2019)

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Article Biochemistry & Molecular Biology

Extracellular vesicles deliver Mycobacterium RNA to promote host immunity and bacterial killing

Yong Cheng et al.

EMBO REPORTS (2019)

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Article Biochemistry & Molecular Biology

LOC152742 as a biomarkerin the diagnosis of pulmonary tuberculosis infection

LiMin Wang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Medicine, General & Internal

Integrating exosomal microRNAs and electronic health data improved tuberculosis diagnosis

Xuejiao Hu et al.

EBIOMEDICINE (2019)

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Review Biochemistry & Molecular Biology

Exosomes in cancer development, metastasis, and immunity

Lin Zhang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

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Article Microbiology

Small RNA Profiles of Serum Exosomes Derived From Individuals With Latent and Active Tuberculosis

Lingna Lyu et al.

FRONTIERS IN MICROBIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Exosomal circRNAs: biogenesis, effect and application in human diseases

Yangxia Wang et al.

MOLECULAR CANCER (2019)

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Article Biochemistry & Molecular Biology

Identification of unique key genes and miRNAs in latent tuberculosis infection by network analysis

Yan Lin et al.

MOLECULAR IMMUNOLOGY (2019)

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Review Genetics & Heredity

The biogenesis, biology and characterization of circular RNAs

Lasse S. Kristensen et al.

NATURE REVIEWS GENETICS (2019)

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Review Immunology

Developing new TB biomarkers, are miRNA the answer?

Jessica L. Pedersen et al.

TUBERCULOSIS (2019)

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Review Immunology

Extracellular Vesicles in Mycobacterial Infections: Their Potential as Molecule Transfer Vectors

Jianjun Wang et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Cell Biology

Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease

Marcelo A. Mori et al.

CELL METABOLISM (2019)

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Review Cell Biology

Exosomes in tuberculosis: Still terra incognita?

Shima Hadifar et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Biochemistry & Molecular Biology

The roles of exosomal miRNAs and lncRNAs in lung diseases

Yang Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)

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Review Medicine, Research & Experimental

Circular RNAs in immune responses and immune diseases

Xu Chen et al.

THERANOSTICS (2019)

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Article Critical Care Medicine

Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis

Sara Suliman et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Exosomes and Ectosomes in Intercellular Communication

Jacopo Meldolesi

CURRENT BIOLOGY (2018)

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Article Cell Biology

Dysregulated circRNAs in plasma from active tuberculosis patients

Zhengjun Yi et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

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Article Geriatrics & Gerontology

Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis

Jose Manuel Matamala et al.

NEUROBIOLOGY OF AGING (2018)

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Article Immunology

Existing blood transcriptional classifiers accurately discriminate active tuberculosis from latent infection in individuals from south India

Samantha Leong et al.

TUBERCULOSIS (2018)

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Article Immunology

Considerations for biomarker-targeted intervention strategies for tuberculosis disease prevention

Andrew Fiore-Gartland et al.

TUBERCULOSIS (2018)

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Article Multidisciplinary Sciences

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

Daniel Torralba et al.

NATURE COMMUNICATIONS (2018)

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Review Immunology

Exosomes in Pathogen Infections: A Bridge to Deliver Molecules and Link Functions

Wenchao Zhang et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Medicine, General & Internal

Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis

Zhongqing Qian et al.

EBIOMEDICINE (2018)

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Article Immunology

Salmonella enterica Serovar Typhimurium Alters the Extracellular Proteome of Macrophages and Leads to the Production of Proinflammatory Exosomes

Winnie W. Hui et al.

INFECTION AND IMMUNITY (2018)

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Article Biotechnology & Applied Microbiology

Outdoor air pollution affects tuberculosis development based on geographical information system modeling

Esmaeil Rajaei et al.

BIOMEDICAL AND BIOTECHNOLOGY RESEARCH JOURNAL (2018)

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Article Biochemistry & Molecular Biology

Aberrantly Expressed Long Non-Coding RNAs In CD8+ T Cells Response to Active Tuberculosis

Yurong Fu et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

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Article Medicine, Research & Experimental

Bovis Bacillus Calmette-Guerin (BCG) infection induces exosomal miRNA release by human macrophages

Shamila D. Alipoor et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

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Article Medicine, General & Internal

Identification of differential expressed PE exosomal miRNA in lung adenocarcinoma, tuberculosis, and other benign lesions

Yan Wang et al.

MEDICINE (2017)

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Article Immunology

Differential expression of long non-coding RNAs in patients with tuberculosis infection

Jianan He et al.

TUBERCULOSIS (2017)

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Article Immunology

Host blood RNA signatures predict the outcome of tuberculosis treatment

Ethan G. Thompson et al.

TUBERCULOSIS (2017)

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Article Oncology

Exosomal microRNA in plasma as a non-invasive biomarker for the recurrence of non-small cell lung cancer

Hitoshi Dejima et al.

ONCOLOGY LETTERS (2017)

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Article Microbiology

RNA Profiling Analysis of the Serum Exosomes Derived from Patients with Active and Latent Mycobacterium tuberculosis Infection

Lingna Lv et al.

FRONTIERS IN MICROBIOLOGY (2017)

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Article Medicine, General & Internal

Unbiased Identification of Blood-based Biomarkers for Pulmonary Tuberculosis by Modeling and Mining Molecular Interaction Networks

Awanti Sambarey et al.

EBIOMEDICINE (2017)

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Article Medicine, General & Internal

Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial

G. B. Sigal et al.

EBIOMEDICINE (2017)

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Article Multidisciplinary Sciences

Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection

Victoria L. Smith et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

Screening and identification of lncRNAs as potential biomarkers for pulmonary tuberculosis

Zhong-liang Chen et al.

SCIENTIFIC REPORTS (2017)

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Article Medicine, Research & Experimental

Concise gene signature for point-of-care classification of tuberculosis

Jeroen Maertzdorf et al.

EMBO MOLECULAR MEDICINE (2016)

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Article Pharmacology & Pharmacy

The roles of miRNAs as potential biomarkers in lung diseases

Shamila D. Alipoor et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

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Review Medicine, Research & Experimental

Extracellular vesicles and infectious diseases: new complexity to an old story

Jeffrey S. Schorey et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Editorial Material Medicine, General & Internal

Predicting active tuberculosis progression by RNA analysis

Michael Levin et al.

LANCET (2016)

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Article Medicine, General & Internal

A blood RNA signature for tuberculosis disease risk: a prospective cohort study

Daniel E. Zak et al.

LANCET (2016)

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Review Cell Biology

Exosomes and Exosomal miRNA in Respiratory Diseases

Shamila D. Alipoor et al.

MEDIATORS OF INFLAMMATION (2016)

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Article Genetics & Heredity

An expanding universe of noncoding RNAs between the poles of basic science and clinical investigations

Patrick P. Weil et al.

EPIGENOMICS (2016)

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Article Oncology

Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells

Anna Gutkin et al.

ONCOTARGET (2016)

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Article Critical Care Medicine

Genome-wide expression for diagnosis of pulmonary tuberculosis: a multicohort analysis

Timothy E. Sweeney et al.

LANCET RESPIRATORY MEDICINE (2016)

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Review Physiology

Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy

Stella Kourembanas

ANNUAL REVIEW OF PHYSIOLOGY, VOL 77 (2015)

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Review Cell Biology

Tumour-derived exosomes: Tinyenvelopesfor big stories

Isabella V. Miller et al.

BIOLOGY OF THE CELL (2015)

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Letter Cell Biology

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

Yan Li et al.

CELL RESEARCH (2015)

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Article Multidisciplinary Sciences

Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection

Yang Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Cell Biology

Exosomal RNA from Mycobacterium tuberculosis-Infected Cells Is Functional in Recipient Macrophages

Prachi Pratap Singh et al.

TRAFFIC (2015)

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