TIGAR deficiency induces caspase-1-dependent trophoblasts pyroptosis through NLRP3-ASC inflammasome

Article Endocrinology & Metabolism

Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation

Ying Zhao et al.

Summary: The study found that Sirt6 mediates acetylation of Caveolin-1 and inhibits LDL transcytosis under high glucose stimulation through the autophagic degradation mechanism, thus slowing down the progression of atherosclerosis.

METABOLISM-CLINICAL AND EXPERIMENTAL (2022)

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Article Pharmacology & Pharmacy

The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus

Yadong Yin et al.

Summary: The study demonstrates that MOTS-c can effectively treat GDM by alleviating hyperglycemia, improving insulin sensitivity and glucose tolerance. Additionally, MOTS-c was found to protect pancreatic beta-cells from injury.

PHARMACOLOGICAL RESEARCH (2022)

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Article Engineering, Environmental

Regulated-biofilms enhance the permeate flux and quality of gravity-driven membrane (GDM) by in situ coagulation combined with activated alumina filtration

Peng Du et al.

Summary: Treating algae-contaminated surface water for drinking water production is a critical challenge. This study systematically assessed the impact of in situ coagulation, activated alumina filtration, and their combination on the performance of gravity-driven membrane during a 105-day operation. The results showed that the combination of coagulation and activated alumina filtration significantly enhanced membrane flux and reduced fouling, leading to improved water production.

WATER RESEARCH (2022)

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Article Microbiology

IL-6 Prevents Lung Macrophage Death and Lung Inflammation Injury by Inhibiting GSDME- and GSDMD-Mediated Pyroptosis during Pneumococcal Pneumosepsis

Xuemei Gou et al.

Summary: This study reveals a novel mechanism for the development of pneumosepsis caused by Streptococcus pneumoniae and the critical protective role of IL-6. IL-6 prevents macrophage death and lung inflammation injury during pneumococcal pneumosepsis. These findings are important for the early identification and treatment of pneumococcal pneumosepsis.

MICROBIOLOGY SPECTRUM (2022)

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Review Oncology

The role of ROS in tumour development and progression

Eric C. Cheung et al.

Summary: Eukaryotic cells have complex systems to regulate reactive oxygen species (ROS), which are deregulated in cancer cells. ROS also modulate the tumor environment and affect stromal cells supporting metabolism, blood supply, and immune responses. The response to ROS is complex and depends on multiple factors, including ROS characteristics and tumor characteristics. Understanding the complexity of ROS in cancers is key to developing ROS-targeting therapies for cancer treatment.

NATURE REVIEWS CANCER (2022)

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Article Medicine, General & Internal

Early gestational diabetes mellitus (GDM) is associated with worse pregnancy outcomes compared with GDM diagnosed at 24-28 weeks gestation despite early treatment

M. Mustafa et al.

Summary: The study revealed that women with early GDM (<24 weeks) and their offspring have a higher risk of adverse pregnancy outcomes, including pregnancy-induced hypertension, post-partum hemorrhage, and gestational diabetes. These findings emphasize the importance of early diagnosis and intervention to improve the quality of pregnancy outcomes.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2021)

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Article Immunology

Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis

Yuanjie Li et al.

Summary: The results showed that miRNA-27a expression was reduced in the serum of depressed patients and in animal models of depression. Isoliquiritin demonstrated significant antidepressant effects by decreasing NLRP3-mediated pyroptosis through the miRNA-27a/SYK/NF-kappa B axis.

JOURNAL OF NEUROINFLAMMATION (2021)

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Review Cell & Tissue Engineering

Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate

Ram Prosad Chakrabarty et al.

Summary: Mitochondrial metabolism plays a crucial role in determining stem cell fate and function, beyond its traditional roles in ATP production and support for stem cell survival and growth. This review focuses on key conceptual ideas regarding how mitochondria control mammalian stem cell fate and function through mechanisms such as reactive oxygen species generation and TCA cycle metabolite production.

CELL STEM CELL (2021)

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Review Nutrition & Dietetics

Nutrition as Prevention Factor of Gestational Diabetes Mellitus: A Narrative Review

Radzislaw Mierzynski et al.

Summary: Nutritional prevention strategies may have some benefit in reducing the risk of GDM, but further research is needed to validate their effectiveness.

NUTRIENTS (2021)

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Article Nutrition & Dietetics

Serum and Amniotic Fluid Metabolic Profile Changes in Response to Gestational Diabetes Mellitus and the Association with Maternal-Fetal Outcomes

Yalin Zhou et al.

Summary: This study identified significant changes in the metabolic profiles of serum and amniotic fluid in response to gestational diabetes mellitus, with alterations particularly observed in lipids and lipid-like molecules. The co-occurrence network analysis revealed common differential metabolites across several metabolism pathways, indicating the potential for predicting fetal health outcomes through detecting maternal metabolites exposed to GDM.

NUTRIENTS (2021)

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Article Environmental Sciences

Integrating granular activated carbon (GAC) to gravity-driven membrane (GDM) to improve its flux stabilization: Respective roles of adsorption and biodegradation by GAC

Xiaobin Tang et al.

Summary: The integrated GAC/GDM process shows promising potential for decentralized drinking water supply with improved flux stability, water quality, pollutant removal, reduced biofouling layer concentrations, and formation of highly heterogeneous structures.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Gestational Diabetes Mellitus (GDM) Risk for Declared Family History of Diabetes, in Combination with BMI Categories

Malgorzata Lewandowska

Summary: Some categories of family history of diabetes are independent risk factors for GDM-1 or GDM-2. Cumulative assessment of diabetes in parents and/or grandparents was not related to increased GDM risk, except for simultaneous diabetes in mother and grandmothers. In subgroups of different BMI categories, paternal diabetes was an independent risk factor for GDM in pregnant women with normal BMI, while the risk was higher in overweight and/or obese women with diabetes in both parents. The study also suggests a significant influence of paternal diabetes on GDM risk, even in lean pregnant women.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Biochemistry & Molecular Biology

Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway

Chengjun Hu et al.

Summary: The study reveals that Nox2 deficiency facilitates angiogenesis by inhibiting the VEGF-A and STAT3 pathway, and reducing VEGF-A expression through inducing ROS production in pigs' vascular endothelial cells. The findings suggest that Nox2 could be a potential therapeutic target for increasing VEGF-A expression to promote angiogenesis, and also serve as a prognostic indicator for fetus with IUGR.

REDOX BIOLOGY (2021)

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Review Oncology

Pyroptosis, metabolism, and tumor immune microenvironment

Tiantian Du et al.

Summary: GSDM proteins play crucial roles in pyroptosis, and the impact of inflammatory characteristics induced by pyroptosis on the host depends on the context, timing, and response degree. Targeting pyroptosis may uncover potential therapeutic avenues in various metabolic diseases and the tumor microenvironment.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Pyroptosis: mechanisms and diseases

Pian Yu et al.

Summary: Pyroptosis has gained attention for its association with innate immunity and diseases. The discovery of the gasdermin family has expanded the research scope of pyroptosis, revealing its potential effects on tumor development. Pyroptosis serves as a double-edged sword in tumors, with the rational utilization of its dual effect providing insights for new drug development and understanding tumor formation and progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Endocrinology & Metabolism

Association of Maternal Folate and Vitamin B-12 in Early Pregnancy With Gestational Diabetes Mellitus: A Prospective Cohort Study

Xiaotian Chen et al.

Summary: The study found that higher levels of maternal RBC folate and vitamin B-12 in early pregnancy are significantly associated with GDM risk, while the balance of folate/vitamin B-12 is not significantly associated with GDM.

DIABETES CARE (2021)

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Article Medicine, Research & Experimental

Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

Meng Zhao et al.

Summary: Reducing mtROS levels attenuated renal dysfunction, mitochondrial damage, and inflammation in IRI-AKI mice. The loss of TFAM can impact mtDNA maintenance, mitochondrial energy metabolism, and cytokine release. Insights into the role of mtROS and TFAM in IRI-AKI provide potential therapeutic targets for renal repair.

THERANOSTICS (2021)

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Article Biochemistry & Molecular Biology

Oxidative stress: Normal pregnancy versus preeclampsia

Delia Chiarello et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

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Editorial Material Oncology

Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects

Sarah-Maria Fendt et al.

CANCER CELL (2020)

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Article Oncology

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

Eric C. Cheung et al.

CANCER CELL (2020)

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Article Oncology

NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors

Kirsty Ford et al.

CANCER RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

Kun Wang et al.

CELL (2020)

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Article Endocrinology & Metabolism

An extra virgin olive oil-enriched diet improves maternal, placental, and cord blood parameters inGDMpregnancies

Dalmiro Gomez Ribot et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2020)

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Editorial Material Immunology

Mitochondrial GSDMD Pores DAMPen Pyroptosis

Katherine C. Barnett et al.

IMMUNITY (2020)

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Article Multidisciplinary Sciences

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

Mausita Karmakar et al.

NATURE COMMUNICATIONS (2020)

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Review Oncology

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Rong Tang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Review Cell Biology

The Complex Interplay between Antioxidants and ROS in Cancer

Isaac S. Harris et al.

TRENDS IN CELL BIOLOGY (2020)

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Review Immunology

Human Autoinflammatory Diseases Mediated by NLRP3-, Pyrin-, NLRP1-, and NLRC4-Inflammasome Dysregulation Updates on Diagnosis, Treatment, and the Respective Roles of IL-1 and IL-18

Sara Alehashemi et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Medicine, Research & Experimental

Emerging role of NRF2 in ROS-mediated tumor chemoresistance

Danfeng Xue et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Chemistry, Multidisciplinary

Reactive Oxygen Species (ROS)-Based Nanomedicine

Bowen Yang et al.

CHEMICAL REVIEWS (2019)

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Review Medicine, Research & Experimental

Inflammasomes in neuroinflammatory and neurodegenerative diseases

Sofie Voet et al.

EMBO MOLECULAR MEDICINE (2019)

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Article Urology & Nephrology

The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury

Naijun Miao et al.

KIDNEY INTERNATIONAL (2019)

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Article Biochemistry & Molecular Biology

TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury

Ding-Mei Zhang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Review Cell Biology

Role of pyroptosis in cardiovascular disease

Zeng Zhaolin et al.

CELL PROLIFERATION (2019)

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Review Biochemistry & Molecular Biology

ROS and the DNA damage response in cancer

Upadhyayula Sai Srinivas et al.

REDOX BIOLOGY (2019)

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Article Cell Biology

Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation

Yufang Wang et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2019)

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Review Cardiac & Cardiovascular Systems

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

Alena Grebe et al.

CIRCULATION RESEARCH (2018)

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Article Endocrinology & Metabolism

Prevalence of gestational diabetes and subsequent Type 2 diabetes among US women

Sarah Stark Casagrande et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

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Review Biochemistry & Molecular Biology

ROS signaling and ER stress in cardiovascular disease

Cristhiaan D. Ochoa et al.

MOLECULAR ASPECTS OF MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

Jianjin Shi et al.

TRENDS IN BIOCHEMICAL SCIENCES (2017)

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Review Cell Biology

Gasdermins: Effectors of Pyroptosis

Stephen B. Kovacs et al.

TRENDS IN CELL BIOLOGY (2017)

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Review Plant Sciences

ROS Are Good

Ron Mittler

TRENDS IN PLANT SCIENCE (2017)

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Article Cell Biology

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

Katharina S. Schneider et al.

CELL REPORTS (2017)

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Review Biochemistry & Molecular Biology

Mechanism and Regulation of NLRP3 Inflammasome Activation

Yuan He et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

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Article Cell Biology

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

Geou-Yarh Liou et al.

CELL REPORTS (2016)

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Article Cell Biology

IL-6 in Inflammation, Immunity, and Disease

Toshio Tanaka et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

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Review Oncology

Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

Simran S. Sabharwal et al.

NATURE REVIEWS CANCER (2014)

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Review Biochemistry & Molecular Biology

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

Matthew Dodson et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

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Article Cardiac & Cardiovascular Systems

Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy

Dao-Fu Dai et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)

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Article Biochemistry & Molecular Biology

Decidual NK cells regulate key developmental processes at the human fetal-maternal interface

Jacob Hanna et al.

NATURE MEDICINE (2006)

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Article Biochemistry & Molecular Biology

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

Karim Bensaad et al.

CELL (2006)

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Article Multidisciplinary Sciences

Extension of murine life span by overexpression of catalase targeted to mitochondria

SE Schriner et al.

SCIENCE (2005)

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Article Endocrinology & Metabolism

Hyperglycaemia in vitro alters the proliferation and mitochondrial activity of the choriocarcinoma cell lines BeWo, JAR and JEG-3 as models for human first-trimester trophoblast

U Weiss et al.

DIABETOLOGIA (2001)

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TIGAR deficiency induces caspase-1-dependent trophoblasts pyroptosis through NLRP3-ASC inflammasome

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