Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasive Listeria monocytogenes infection

Article Medicine, General & Internal

Incidence of Dementia Following Hospitalization With Infection Among Adults in the Atherosclerosis Risk in Communities (ARIC) Study Cohort

Bruno Bohn et al.

Summary: This study found an association between hospitalization with infection and incident dementia, suggesting that infections are risk factors for dementia.

JAMA NETWORK OPEN (2023)

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Article Immunology

Systemic Inflammation Causes Microglial Dysfunction With a Vascular AD phenotype

Praveen Bathini et al.

Summary: Studies using the PolyI:C mouse model demonstrate that peripheral chronic inflammation causes cognitive deficits, tau hyperphosphorylation, increased neuroinflammation, and vascular remodeling, which are similar to the pathological features seen in human Alzheimer's disease and Vascular dementia. These findings suggest that early immune insults could play a crucial role in the development of neurodegenerative diseases.

BRAIN, BEHAVIOR, & IMMUNITY - HEALTH (2023)

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Article Geriatrics & Gerontology

Impaired Glymphatic Function and Pulsation Alterations in a Mouse Model of Vascular Cognitive Impairment

Mosi Li et al.

Summary: Large vessel disease and carotid stenosis are key mechanisms contributing to vascular cognitive impairment (VCI) and dementia. This study using rodent models found that bilateral common carotid stenosis (BCAS) leads to cognitive impairment via deterioration of the neuro-glial-vascular unit and accumulation of amyloid-beta (A beta) protein. Furthermore, impaired glymphatic function and reduced vascular pulsation were observed in the BCAS model. These findings suggest that glymphatic drainage and vascular pulsation should be considered in the treatment of VCI.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Geriatrics & Gerontology

Systemic Listeria monocytogenes infection in aged mice induces long-term neuroinflammation: the role of miR-155

Benjamin R. Cassidy et al.

Summary: This study aimed to investigate the mechanisms of infection-induced neuroinflammation in aged mice. The results showed that immune response and inflammation exhibited differences between young and aged mice, and anti-miR-155 could inhibit the accumulation of myeloid cells in aged mice but had no effect on CD8(+) bT(RM).

IMMUNITY & AGEING (2022)

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Article Public, Environmental & Occupational Health

Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts

Amanda E Paluch et al.

Lancet Public Health (2022)

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Review Immunology

Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and...guilty

Doron Merkler et al.

Summary: Tissue-resident memory T cells (T-RM) are a subset of T cells that are retained in tissues and play important roles in protection against reinfection and antitumor responses. The increased density of CD8 T-RM in the central nervous system (CNS) of patients with neuroinflammatory diseases suggests its potential contribution to the pathogenesis of these diseases.

CURRENT OPINION IN IMMUNOLOGY (2022)

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Review Immunology

Keeping T cell memories in mind

Madison R. Mix et al.

Summary: This review outlines the presence of adaptive immune cells, particularly memory T cells, in the mammalian central nervous system (CNS). It focuses on the tissue-resident memory phenotype of these T cells and discusses their generation, localization, maintenance, and function in the CNS. The study highlights the importance of understanding neuroimmunity and provides insights for future research.

TRENDS IN IMMUNOLOGY (2022)

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Article Neurosciences

Selective Ablation of Sod2 in Astrocytes Induces Sex-Specific Effects on Cognitive Function, D-Serine Availability, and Astrogliosis

Matthew P. Baier et al.

Summary: This study investigates the impact of reduced mitochondrial antioxidant response in astrocytes on cognitive function and neuronal activity. The findings suggest that decreasing antioxidant stress in astrocytes replicates age-related cognitive deficits, decreased availability of D-serine, and enhanced astrogliosis, indicating that improving astrocyte mitochondrial homeostasis may be a therapeutic target for addressing cognitive impairment in aging.

JOURNAL OF NEUROSCIENCE (2022)

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Article Clinical Neurology

Association of Daily Step Count and Intensity With Incident Dementia in 78 430 Adults Living in the UK

Borja del Pozo Cruz et al.

Summary: The study examines the association between daily step count and intensity and the incidence of all-cause dementia. The findings suggest that a higher number of steps, particularly below 10,000 steps per day, are associated with a lower risk of dementia. Steps performed at higher intensity show stronger associations.

JAMA NEUROLOGY (2022)

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Article Immunology

Infiltrated regulatory T cells and Th2 cells in the brain contribute to attenuation of sepsis-associated encephalopathy and alleviation of mental impairments in mice with polymicrobial sepsis

Masafumi Saito et al.

Summary: The study aimed to clarify the influence of immune cells, especially T cells, on the development and recovery of sepsis-associated encephalopathy and mental impairments. Results showed that infiltrated regulatory T cells and Th2 cells help attenuate sepsis-associated encephalopathy and alleviate mental disorders by resolving neuroinflammation.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Clinical Neurology

Burden of Neurological Disorders Across the US From 1990-2017 A Global Burden of Disease Study

Valery L. Feigin et al.

Summary: There is a large and increasing burden of noncommunicable neurological disorders in the US, with up to a 5-fold variation in the burden of and trends in particular neurological disorders across the US states. The information reported in this article can be used by health care professionals and policy makers at the national and state levels to advance their health care planning and resource allocation to prevent and reduce the burden of neurological disorders.

JAMA NEUROLOGY (2021)

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Article Behavioral Sciences

Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives

Fabrizio Grieco et al.

Summary: The reproducibility crisis in the field of behavioral neuroscience, particularly in biomedical research, is influenced by various environmental factors and human interference. Automated home-cage monitoring systems have been developed to reduce human interference and provide continuous measures of spontaneous behavior for analysis across multiple time scales. These systems address technical issues related to behavioral data acquisition and offer advantages such as opportunities for within-subject analyses and circadian activity assessments.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2021)

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Review Neurosciences

The Role of Inflammation and Infection in Age-Related Neurodegenerative Diseases: Lessons From Bacterial Meningitis Applied to Alzheimer Disease and Age-Related Macular Degeneration

Lay Khoon Too et al.

Summary: Age-related neurodegenerative diseases such as AD and AMD have diverse genetic and environmental risk factors, with evidence linking microbial infection to the development of cognitive impairment. Neuroinflammation is a common pathological event in the early stages of AD and AMD, potentially triggered by parainfectious events.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Article Clinical Neurology

Neural Injury and Repair in a Novel Neonatal Mouse Model of Listeria Monocytogenes Meningoencephalitis

Jana Seele et al.

Summary: Neonatal mice with Listeria monocytogenes (LM) meningitis/meningoencephalitis exhibit increased neuronal apoptosis, impaired neurogenesis, and tissue damage caused by immune response. This model is suitable for studying therapies against long-term sequelae of neonatal LM meningitis.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2021)

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Review Medicine, General & Internal

Community-acquired bacterial meningitis

Diederik van de Beek et al.

Summary: Progress has been made in the prevention and treatment of community-acquired bacterial meningitis, but the disease burden remains high globally. Diagnosis and treatment should take into account the unique clinical characteristics and various examinations, with treatment plans being adjusted according to local conditions.

LANCET (2021)

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Article Infectious Diseases

Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort

Pyry N. Sipila et al.

Summary: Infections requiring hospital treatment have been found to increase the long-term risk of dementia, including vascular dementia and Alzheimer's disease, with no specificity in infection type. The association is driven by general inflammation rather than specific microbes, and there is evidence of dose-response relationships between infectious disease burden and dementia risk.

LANCET INFECTIOUS DISEASES (2021)

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Review Neurosciences

Neuronal Damage and Neuroinflammation, a Bridge Between Bacterial Meningitis and Neurodegenerative Diseases

Kristine Farmen et al.

Summary: Bacterial meningitis is an inflammation of the meninges caused by blood-borne bacteria that penetrate the blood-brain barrier and interact with neurons in the brain, leading to neuronal death. Clinical studies suggest that meningitis may lead to dementia and affect the onset of neurodegenerative diseases.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Article Pediatrics

Neurological sequelae remain frequent after bacterial meningitis in children

Morten B. Svendsen et al.

ACTA PAEDIATRICA (2020)

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Article Infectious Diseases

Long-term neurologic and cognitive outcome and quality of life in adults after pneumococcal meningitis

A. T. Kloek et al.

CLINICAL MICROBIOLOGY AND INFECTION (2020)

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Article Medicine, General & Internal

Association of Daily Step Count and Step Intensity With Mortality Among US Adults

Pedro F. Saint-Maurice et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Immunology

Peripherally induced brain tissue-resident memory CD8+T cells mediate protection against CNS infection

Stina L. Urban et al.

NATURE IMMUNOLOGY (2020)

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Article Immunology

NeuroinvasiveListeria monocytogenesinfection triggers accumulation of brain CD8+tissue-resident memory T cells in a miR-155-dependent fashion

Benjamin R. Cassidy et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Review Geriatrics & Gerontology

Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?

Katie Mayne et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

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Article Microbiology

Neurotropic Lineage III Strains of Listeria monocytogenes Disseminate to the Brain without Reaching High Titer in the Blood

Taylor E. Senay et al.

MSPHERE (2020)

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Review Immunology

The Use of Adjunctive Steroids in Central Nervous Infections

Shalini Gundamraj et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Article Clinical Neurology

Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Valery L. Feigin et al.

LANCET NEUROLOGY (2019)

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Article Neurosciences

T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses

Charise Garber et al.

NATURE NEUROSCIENCE (2019)

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Article Cell Biology

Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice

Karin Steinbach et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Article Clinical Neurology

Associations of Physical Activity and β-Amyloid With Longitudinal Cognition and Neurodegeneration in Clinically Normal Older Adults

Jennifer S. Rabin et al.

JAMA NEUROLOGY (2019)

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Article Immunology

Long-Term Microgliosis Driven by Acute Systemic Inflammation

Alissa Trzeciak et al.

JOURNAL OF IMMUNOLOGY (2019)

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Article Geriatrics & Gerontology

Accelerated decline in cognition in a mouse model of increased oxidative stress

Sreemathi Logan et al.

GEROSCIENCE (2019)

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Article Immunology

Antibiotics and the nervous system: More than just the microbes?

Kevin Champagne-Jorgensen et al.

BRAIN BEHAVIOR AND IMMUNITY (2019)

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Article Multidisciplinary Sciences

Characterization of the pathogenesis and immune response to Listeria monocytogenes strains isolated from a sustained national outbreak

Pallab Ghosh et al.

SCIENTIFIC REPORTS (2019)

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Article Multidisciplinary Sciences

Recall Responses from Brain-Resident Memory CD8+ T Cells (bTRM) Induce Reactive Gliosis

Sujata Prasad et al.

ISCIENCE (2019)

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Review Microbiology

Listeria monocytogenes: towards a complete picture of its physiology and pathogenesis

Lilliana Radoshevich et al.

NATURE REVIEWS MICROBIOLOGY (2018)

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Review Immunology

Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance

Thomas Gebhardt et al.

IMMUNOLOGICAL REVIEWS (2018)

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Article Geriatrics & Gerontology

Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice

Sreemathi Logan et al.

GEROSCIENCE (2018)

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Article Biochemistry & Molecular Biology

Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping

Giovanni Di Liberto et al.

CELL (2018)

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Article Immunology

Characterization of a Listeria monocytogenes meningitis mouse model

Merel M. Koopmans et al.

JOURNAL OF NEUROINFLAMMATION (2018)

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Article Immunology

Neuroinvasive Listeria monocytogenes Infection Triggers IFN-Activation of Microglia and Upregulates Microglial miR-155

Miao Zhang et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Immunology

CD11c-Expressing Cells Affect Regulatory T Cell Behavior in the Meninges during Central Nervous System Infection

Carleigh A. O'Brien et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Infectious Diseases

Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study

Caroline Charlier et al.

LANCET INFECTIOUS DISEASES (2017)

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Review Behavioral Sciences

Why estrogens matter for behavior and brain health

Liisa A. M. Galea et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2017)

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Article Immunology

CD103+ CD8 T Cells in the Toxoplasma-Infected Brain Exhibit a Tissue-Resident Memory Transcriptional Profile

Tyler A. Landrith et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Review Immunology

CD69: from activation marker to metabolic gatekeeper

Danay Cibrian et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2017)

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Article Biochemical Research Methods

AHCODA-DB: a data repository with web-based mining tools for the analysis of automated high-content mouse phenomics data

Bastijn Koopmans et al.

BMC BIOINFORMATICS (2017)

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Review Immunology

Infectious immunity in the central nervous system and brain function

Robyn S. Klein et al.

NATURE IMMUNOLOGY (2017)

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Review Neurosciences

Role of Microglial Activation in the Pathophysiology of Bacterial Meningitis

Tatiana Barichello et al.

MOLECULAR NEUROBIOLOGY (2016)

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Article Infectious Diseases

ESCMID guideline: diagnosis and treatment of acute bacterial meningitis

D. van de Beek et al.

CLINICAL MICROBIOLOGY AND INFECTION (2016)

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Article Immunology

Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury

Rodney M. Ritzel et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Infectious Diseases

Neurological sequelae of bacterial meningitis

Marjolein J. Lucas et al.

JOURNAL OF INFECTION (2016)

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Article Infectious Diseases

Community-acquired bacterial meningitis in adults in the Netherlands, 2006-14: a prospective cohort study

Merijn W. Bijlsma et al.

LANCET INFECTIOUS DISEASES (2016)

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Review Immunology

Targets for adjunctive therapy in pneumococcal meningitis

Tatiana Barichello et al.

JOURNAL OF NEUROIMMUNOLOGY (2015)

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Article Multidisciplinary Sciences

Tregs Modulate Lymphocyte Proliferation, Activation, and Resident-Memory T-Cell Accumulation within the Brain during MCMV Infection

Sujata Prasad et al.

PLOS ONE (2015)

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Review Immunology

Listeria monocytogenes: a model pathogen to study antigen-specific memory CD8 T cell responses

Shaniya H. Khan et al.

SEMINARS IN IMMUNOPATHOLOGY (2015)

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Article Microbiology

Interferon-γ from Brain Leukocytes Enhances Meningitis by Type 4 Streptococcus pneumoniae

Elena Pettini et al.

FRONTIERS IN MICROBIOLOGY (2015)

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Article Immunology

The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis

L. K. Too et al.

BRAIN BEHAVIOR AND IMMUNITY (2014)

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Review Health Care Sciences & Services

False discovery rate control is a recommended alternative to Bonferroni-type adjustments in health studies

Mark E. Glickman et al.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2014)

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Article Immunology

Regulatory T Cells Shape the Resident Memory T Cell Response to Virus Infection in the Tissues

Jessica B. Graham et al.

JOURNAL OF IMMUNOLOGY (2014)

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Article Immunology

Infiltrating Regulatory B Cells Control Neuroinflammation following Viral Brain Infection

Manohar B. Mutnal et al.

JOURNAL OF IMMUNOLOGY (2014)

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Article Multidisciplinary Sciences

Sheltering Behavior and Locomotor Activity in 11 Genetically Diverse Common Inbred Mouse Strains Using Home-Cage Monitoring

Maarten Loos et al.

PLOS ONE (2014)

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Article Immunology

Listeria monocytogenes Sequence Type 6 and Increased Rate of Unfavorable Outcome in Meningitis: Epidemiologic Cohort Study

Merel M. Koopmans et al.

CLINICAL INFECTIOUS DISEASES (2013)

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Article Immunology

Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss

Mario Kreutzfeldt et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

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Article Immunology

Inflammasome-Dependent IFN-γ Drives Pathogenesis in Streptococcus pneumoniae Meningitis

Andrew J. Mitchell et al.

JOURNAL OF IMMUNOLOGY (2012)

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Review Neurosciences

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

John F. Cryan et al.

NATURE REVIEWS NEUROSCIENCE (2012)

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Review Neurosciences

Reversal learning and attentional set-shifting in mice

Gregory B. Bissonette et al.

NEUROPHARMACOLOGY (2012)

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Review Immunology

Targeting of the central nervous system by Listeria monocytogenes

Olivier Disson et al.

VIRULENCE (2012)

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Article Infectious Diseases

Three-year multicenter surveillance of community-acquired listeria monocytogenes meningitis in adults

Rosario Amaya-Villar et al.

BMC INFECTIOUS DISEASES (2010)

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Article Clinical Neurology

Mechanisms of injury in bacterial meningitis

Joachim Gerber et al.

CURRENT OPINION IN NEUROLOGY (2010)

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Article Clinical Neurology

Adjunctive dexamethasone in bacterial meningitis: a meta-analysis of individual patient data

Diederik van de Beek et al.

LANCET NEUROLOGY (2010)

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Article Multidisciplinary Sciences

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

Linda M. Wakim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Clinical Neurology

Systemic inflammation and disease progression in Alzheimer disease

C. Holmes et al.

NEUROLOGY (2009)

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Review Immunology

Listeria monocytogenes:: epidemiology, human disease, and mechanisms of brain invasion

Douglas A. Drevets et al.

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY (2008)

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Article Immunology

Innate responses to systemic infection by intracellular bacteria trigger recruitment of Ly-6Chigh monocytes to the brain

Douglas A. Drevets et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Multidisciplinary Sciences

A specific gene expression program triggered by gram-positive bacteria in the cytosol

RL McCaffrey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasive Listeria monocytogenes infection

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