Amino acid polymorphisms in human histocompatibility leukocyte antigen class II and proinsulin epitope have impacts on type 1 diabetes mellitus induced by immune-checkpoint inhibitors

Article Endocrinology & Metabolism

Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline

Shintaro Iwama et al.

Summary: The study revealed that the incidence of thyroid immune-related adverse events was high after PD-1/CTLA-4-Abs treatment even in patients negative for ATAs at baseline.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

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Article Endocrinology & Metabolism

Human Leukocyte Antigens and Biomarkers in Type Diabetes Mellitus Induced by Immune-Checkpoint Inhibitors

Hidefumi Inaba et al.

Summary: This study evaluated the clinical course and immunological status of patients with type 1 diabetes mellitus induced by immune-checkpoint inhibitors (ICI-T1DM). The study identified high-risk HLA alleles and peripheral blood factors that may serve as biomarkers for ICI-T1DM.

ENDOCRINOLOGY AND METABOLISM (2022)

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Article Immunology

Characterization of immune checkpoint inhibitor-associated fulminant type 1 diabetes associated with autoantibody status and ethnic origin

Junlin Qiu et al.

Summary: IFD is relatively common in Caucasian population where TFD is very rare or almost absent. The occurrence of IFD is significantly related to islet autoantibody status and ethnic origin.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Medicine, General & Internal

Analysis of Human Leukocyte Antigen DR Alleles, Immune-Related Adverse Events, and Survival Associated With Immune Checkpoint Inhibitor Use Among Patients With Advanced Malignant Melanoma

Halis Kaan Akturk et al.

Summary: This study suggests that immune-related adverse events (irAEs) are associated with treatment response rates and increased survival after immune checkpoint inhibitor (ICI) therapy for advanced melanoma. Specific HLA-DR alleles are associated with different types of irAEs.

JAMA NETWORK OPEN (2022)

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Article Immunology

HLA class II peptide-binding-region analysis reveals funneling of polymorphism in action

Constantina A. Sarri et al.

Summary: This study investigated the pocket variability of five HLA class II proteins, revealing that the observed number of pocket variants combinations is much lower than the possible inferred, suggesting that PBR formation is under strict funneling. Additionally, in the majority of reported alleles in all populations, a significantly less polymorphic pocket core was found.

IMMUNOLOGY LETTERS (2021)

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Article Oncology

Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors

Tomoko Kobayashi et al.

Summary: This study identified distinct and overlapping patterns of APAs and HLA alleles between ICI-IAD and ICI-H. Positive APAs at baseline and after treatment, together with susceptible HLA alleles, could potentially serve as predictive biomarkers for ICI-IAD and ICI-H.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Endocrinology & Metabolism