CXCL8 and the peritoneal metastasis of ovarian and gastric cancer

CXCL8 is the most representative chemokine produced autocrine or paracrine by tumor cells, endothelial cells and lymphocytes. It can play a key role in normal tissues and tumors by activating PI3K-Akt, PLC, JAK-STAT, and other signaling pathways after combining with CXCR1/2. The incidence of peritoneal metastasis in ovarian and gastric cancer is extremely high. The structure of the peritoneum and various peritoneal-related cells supports the peritoneal metastasis of cancers, which readily produces a poor prognosis, low 5-year survival rate, and the death of patients. Studies show that CXCL8 is excessively secreted in a variety of cancers. Thus, this paper will further elaborate on the mechanism of CXCL8 and the peritoneal metastasis of ovarian and gastric cancer to provide a theoretical basis for the proposal of new methods for the prevention, diagnosis, and treatment of cancer peritoneal metastasis.

Automated summary

CXCL8 is a chemokine that is predominantly produced by tumor cells, endothelial cells, and lymphocytes in an autocrine or paracrine manner. Upon binding with CXCR1/2, it activates various signaling pathways, including PI3K-Akt, PLC, JAK-STAT, and others, playing important roles in normal tissues and tumors. Peritoneal metastasis is highly prevalent in ovarian and gastric cancer, resulting in poor prognosis, low 5-year survival rate, and mortality. Studies have shown excessive secretion of CXCL8 in various cancers. Therefore, this paper aims to further elucidate the mechanism of CXCL8 and peritoneal metastasis in ovarian and gastric cancer, providing a theoretical basis for the development of new approaches for the prevention, diagnosis, and treatment of cancer peritoneal metastasis.