4.8 Review

Emerging insights into the role of ferroptosis in the pathogenesis of autoimmune diseases

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Pathology

The Immune Response in Multiple Sclerosis

Sofia Rodriguez Murua et al.

Summary: Multiple sclerosis is a chronic disease affecting the central nervous system, characterized by immune dysregulation and resulting in demyelination, neuronal damage, and degeneration. Genetic and environmental factors are believed to play a role in the onset and progression of this disease.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2022)

Article Immunology

The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis

Yifei Wang et al.

Summary: The study reveals that the mTORC2-Akt-GSK3 beta axis plays a crucial role in maintaining long-term persistence of virus-specific memory CD4(+) T cells by preventing ferroptosis, thus promoting cell self-protection mechanisms.

NATURE IMMUNOLOGY (2022)

Article Rheumatology

Glycine increased ferroptosis via SAM-mediated GPX4 promoter methylation in rheumatoid arthritis

Hanzhi Ling et al.

Summary: This study revealed a decrease in ferroptosis in rheumatoid arthritis (RA) synovium and explored the mechanism by which glycine enhances ferroptosis through the regulation of glutathione peroxidase 4 (GPX4) methylation and ferritin expression.

RHEUMATOLOGY (2022)

Review Cell Biology

Double-edge sword roles of iron in driving energy production versus instigating ferroptosis

Shuping Zhang et al.

Summary: Iron is crucial for energy production and dysregulated iron homeostasis is the basis of many pathologies. Ferroptosis, an iron-dependent and lipid peroxidation-driven form of regulated cell death, has been implicated in various diseases. The mechanisms of ferroptosis are complex, involving well-established pathways as well as novel interactions related to cellular energy production. This review explores the contribution of iron to diverse metabolic activities and its connection to ferroptosis, emphasizing its role in driving energy production under both normal and pathological conditions.

CELL DEATH & DISEASE (2022)

Article Multidisciplinary Sciences

TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models

Jiao Wu et al.

Summary: In this study, the authors use a mouse model of rheumatoid arthritis (RA) and single-cell RNA sequencing to show that inducing ferroptosis and suppressing TNF signaling can reduce the number of fibroblasts in the synovium and improve experimental arthritis. They further identify two groups of fibroblasts with distinct susceptibility to ferroptosis and show that TNF signaling protects fibroblasts from ferroptosis through promoting cystine uptake and glutathione biosynthesis. Finally, the combination of low-dose ferroptosis inducer and TNF antagonist attenuates arthritis progression in the mouse model.

NATURE COMMUNICATIONS (2022)

Article Medicine, General & Internal

Contribution of ferroptosis and GPX4's dual functions to osteoarthritis progression

Yu Miao et al.

Summary: This study demonstrated the presence of ferroptosis in osteoarthritis (OA) and identified glutathione peroxidase 4 (GPX4) as a crucial regulator of OA. By downregulating GPX4 expression, the crosstalk between ferroptosis and extracellular matrix degradation pathways influenced the progression of OA.

EBIOMEDICINE (2022)

Article Oncology

CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

Peng Liao et al.

Summary: T cell-derived interferon gamma (IFN γ) in combination with arachidonic acid (AA) induces immunogenic tumor ferroptosis, serving as a mechanism for CD8(+) T cell-mediated tumor killing. This process involves IFN γ stimulation of ACSL4 and alteration of tumor cell lipid pattern.

CANCER CELL (2022)

Review Immunology

Context-dependent regulation of follicular helper T cell survival

Zhian Chen et al.

Summary: This article reviews recent advances in understanding the regulation of T-FH cell survival through cell death pathways that are closely connected with cellular metabolism. Such knowledge can be applied to guide strategies for modulating humoral immunity, including enhancing vaccine efficacy.

TRENDS IN IMMUNOLOGY (2022)

Review Immunology

Ferroptosis and Autoimmune Diseases

Benjamin Lai et al.

Summary: This review discusses the role and mechanisms of ferroptosis in autoimmune diseases and explores the potential of targeting ferroptosis as a therapeutic approach for these diseases.

FRONTIERS IN IMMUNOLOGY (2022)

Review Rheumatology

Synovial fibroblasts as potential drug targets in rheumatoid arthritis, where do we stand and where shall we go?

Tamas Nemeth et al.

Summary: Fibroblast-like synoviocytes (FLS) are crucial cellular components in the synovial membrane of joints, contributing to normal joint function. However, under inflammatory conditions like rheumatoid arthritis (RA), FLS can become overactive and promote inflammation. Therefore, understanding the role of FLS in RA is essential for disease treatment.

ANNALS OF THE RHEUMATIC DISEASES (2022)

Review Biochemistry & Molecular Biology

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Brent R. Stockwell

Summary: This review describes the key regulators of ferroptosis and provides an overview of metabolism, ROS biology, and iron biology. Additionally, it highlights the important concepts and unanswered questions in the field of ferroptosis. The future holds promise for further breakthroughs in understanding the mechanisms of ferroptosis and utilizing it for therapeutic purposes.
Review Physiology

Advancement in understanding the role of ferroptosis in rheumatoid arthritis

Li Long et al.

Summary: Rheumatoid arthritis (RA) is a chronic disease characterized by inflammatory synovitis, and ferroptosis may play a role in the pathogenesis and progression of RA. Targeting ferroptosis could be a potential therapeutic approach for treating RA.

FRONTIERS IN PHYSIOLOGY (2022)

Article Medicine, Research & Experimental

Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus

Xiaofei Gao et al.

Summary: Iron plays an important role in regulating pathogenic T cell differentiation and autoantibody production in SLE. High-iron diet promotes Tfh cell expansion, and the miR-21/BDH2 axis may be critical for iron accumulation during Tfh cell differentiation.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Review Rheumatology

Rheumatoid Arthritis Pathogenesis, Prediction, and Prevention: An Emerging Paradigm Shift

Kevin D. Deane et al.

Summary: The prevention of RA is a critical topic, involving predicting individuals who may develop clinically apparent RA in the future and discussions on clinical trials for prevention. Studies aimed at delaying or preventing clinically apparent IA/RA onset have gained attention, as making prevention of RA a future public health strategy has become a focus.

ARTHRITIS & RHEUMATOLOGY (2021)

Article Biochemistry & Molecular Biology

PPARG-mediated ferroptosis in dendritic cells limits antitumor immunity

Leng Han et al.

Summary: The study shows that elevated ferroptosis impairs the maturation and function of dendritic cells (DCs), limiting their role in antitumor immunity. However, genetic depletion of PPARG restores the function of DCs, enhancing their antitumor immune activity.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2

Xiang Luo et al.

Summary: This study establishes a novel pathway for the phagocytic clearance of ferroptotic cells and identifies key molecules involved in the process. The results demonstrate that SAPE-OOH on the surface of ferroptotic cells acts as an eat-me signal and initiates phagocytosis by macrophages through TLR2 recognition.

CELL DEATH AND DIFFERENTIATION (2021)

Article Cell Biology

Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis

Yun Pyo Kang et al.

Summary: Cysteine plays a crucial role in maintaining cellular redox homeostasis and protecting against ferroptosis. Deprivation of cysteine leads to the unexpected accumulation of g-glutamyl-peptides in non-small-cell lung cancer cell lines as a protective mechanism against ferroptosis.

CELL METABOLISM (2021)

Review Cell Biology

Ferroptosis: molecular mechanisms and health implications

Daolin Tang et al.

Summary: Cell death can be executed through different subroutines, such as ferroptosis which is an iron-dependent form of non-apoptotic cell death. Ferroptosis can occur through two major pathways, driven by redox imbalance and abnormal expression of redox-active enzymes. The process is precisely regulated at multiple levels, with the transcription factor NFE2L2 playing a central role in anti-ferroptotic defense.

CELL RESEARCH (2021)

Article Oncology

Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells

Jefte M. Drijvers et al.

Summary: Metabolic vulnerabilities of CD8(+) T cells and cancer cells were identified through a high-throughput in vitro pharmacologic screening platform, with CD8(+) T cells found to be more sensitive to ferroptosis induction. The screening platform may also be useful for rapid testing of compounds targeting antitumor CD8(+) T-cell function and potential therapeutic targets.

CANCER IMMUNOLOGY RESEARCH (2021)

Article Immunology

Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression

Yu Cui et al.

Summary: The study found that the ferroptosis inducer RSL3 can inhibit the inflammatory response of microglia and macrophages, but also trigger inflammation through conditioned medium. Different types of microglia and macrophages vary in sensitivity to RSL3-induced ferroptosis.

JOURNAL OF NEUROINFLAMMATION (2021)

Article Biochemistry & Molecular Biology

Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal

Wan-Yang Sun et al.

Summary: By hydrolyzing 15-HpETE-PE, iPLA(2)beta prevents ferroptosis, while its dysfunction increases cellular sensitivity to ferroptosis. Mutations in PLA2G6 gene may be implicated in the pathogenesis of Parkinson's disease.

NATURE CHEMICAL BIOLOGY (2021)

Article Biology

Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism

Leonie Zeitler et al.

Summary: IL4i1 is an amino acid oxidase that inhibits ferroptotic oxidative cell death by generating I3P from tryptophan, thus activating a cell protective gene expression program.
Article Multidisciplinary Sciences

The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3

Qing Zhang et al.

Summary: Phosphatidylcholine (PC) undergoes re-acylation catalyzed by lysophosphatidylcholine acyltransferases (LPCAT), with LPCAT3 introducing polyunsaturated acyl to modulate membrane fluidity and membrane protein functions. The structures of LPCAT3 reveal a reaction chamber and tunnels for substrate positioning, providing insights into the re-acylation mechanism.

NATURE COMMUNICATIONS (2021)

Article Hematology

Dimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 signaling in DLBCL

Anja Schmitt et al.

Summary: The study demonstrates the broad antitumor effect of dimethyl fumarate (DMF) on both subtypes of DLBCL by inducing ferroptosis, especially in GCB DLBCL. In ABC DLBCL cells, DMF treatment efficiently inhibits the activity of the IKK complex and Janus kinases. Additionally, the combination of BCL-2-specific BH3 mimetic ABT-199 and an inhibitor of ferroptosis suppressor protein 1 synergize with DMF in inducing cell death in DLBCL.
Article Cell Biology

Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment

Sophie M. Poznanski et al.

Summary: NK cells play a central role in anti-tumor immunity, but their dysfunction in the tumor microenvironment is a major barrier for cancer immunotherapies. Research showed that human NK cell dysfunction in the tumor microenvironment is caused by suppression of glucose metabolism, and activating the antioxidant pathway can restore NK cell function and enhance anti-tumor activity. Additionally, expanded NK cells with metabolic flexibility not only sustained metabolic fitness but also improved tumor killing in response to nutrient deprivation, showing the potential for exploiting metabolic flexibility in cancer immunotherapy.

CELL METABOLISM (2021)

Review Immunology

Programmed Cell Death Pathways in the Pathogenesis of Idiopathic Inflammatory Myopathies

Jia Shi et al.

Summary: Research has shown that dysregulated cell death and impaired clearance of dead cells contribute to the pathogenesis of idiopathic inflammatory myopathy, leading to immune responses and tissue damages. This provides evidence for potential therapeutic targets in treating IIM.

FRONTIERS IN IMMUNOLOGY (2021)

Article Medicine, General & Internal

Idiopathic inflammatory myopathies

Ingrid E. Lundberg et al.

Summary: Idiopathic inflammatory myopathies, also known as myositis, are a group of autoimmune disorders with heterogeneous clinical manifestations and organ involvement. Different subtypes have varying prognoses, treatment responses, and organ manifestations, highlighting the importance of understanding the underlying pathophysiological mechanisms.

NATURE REVIEWS DISEASE PRIMERS (2021)

Article Urology & Nephrology

The extent of tubulointerstitial inflammation is an independent predictor of renal survival in lupus nephritis

Manuel Ferreira Gomes et al.

Summary: A retrospective study of 166 patients with biopsy-proven LN in a Spanish referral center showed that the prevalence of tubulointerstitial lesions was 69.3%. Patients with features of tubulointerstitial inflammation had shorter renal survival. The extent of tubulointerstitial inflammation emerged as an independent predictor of renal survival after adjusting for other factors.

JOURNAL OF NEPHROLOGY (2021)

Article Multidisciplinary Sciences

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Chao Mao et al.

Summary: The study reveals the mechanism of ferroptosis induced by inhibiting GPX4 in cancer cells, as well as the potential pathways to enhance or inhibit ferroptosis by intervening in relevant metabolic pathways. Therapeutic strategies targeting different levels of GPX4 expression could be a promising new approach for cancer treatment.

NATURE (2021)

Article Multidisciplinary Sciences

Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1

Alexander Beatty et al.

Summary: Inhibition of lipid peroxidase GPX4 promotes ferroptotic cell death. A complementary approach using conjugated linolenic fatty acids has been identified, triggering lipid peroxidation and ferroptosis via ACSL1, DGAT1/2, and neutral lipids. This may provide a potential therapeutic strategy for cancer treatment.

NATURE COMMUNICATIONS (2021)

Review Medicine, General & Internal

Iron Metabolism: An Under Investigated Driver of Renal Pathology in Lupus Nephritis

Ewa Wlazlo et al.

Summary: This review discusses tubulointerstitial injury in lupus nephritis and the regulation of intracellular iron levels by renal tubular cells, emphasizing the role of iron imbalance in proximal tubules as a driver of tubulointerstitial injury. Iron catalyzes reactive oxygen species, leading to accumulation of lipid hydroperoxides in proximal tubular cells, and exacerbates inflammation and immune cell infiltration. This may explain the interplay between glomerular permeability, tubular injury, inflammation, and progression to renal failure in lupus nephritis, suggesting potential for new therapies targeting iron metabolism.

FRONTIERS IN MEDICINE (2021)

Review Cell Biology

IFNγ-mediated repression of system xc- drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells

Rui Kong et al.

Summary: IFN gamma released from CD8(+) T cells or natural killer cells plays an important role in antitumor immunity. Studies have shown that IFN gamma is involved in regulating tumor cell proliferation and apoptosis, and in this study, it was found to enhance glutathione depletion and sensitize hepatocellular carcinoma cells to ferroptosis through various mechanisms such as cell cycle arrest and lipid peroxidation. These findings suggest a potential application of IFN gamma in cancer treatment.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

Article Immunology

Selenium-GPX4 axis protects follicular helper T cells from ferroptosis

Yin Yao et al.

Summary: Researchers found that T follicular helper (T-FH) cells are highly sensitive to ferroptosis, and this process is regulated by the activity of the selenoenzyme GPX4. Selenium supplementation can increase GPX4 expression, leading to an increase in T-FH cell numbers and antibody responses.

NATURE IMMUNOLOGY (2021)

Article Immunology

Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity

Pengchong Li et al.

Summary: This study identifies a role for GPX4-regulated ferroptosis in neutrophils from SLE patients, triggered by interferons and autoreactive antibodies, contributing to lupus pathogenesis. The mechanism involves enhanced binding of a transcriptional repressor to the Gpx4 promoter leading to elevated lipid-reactive oxygen species. Neutrophil ferroptosis is shown to be a significant driver of neutropenia in SLE and heavily contributes to disease manifestations.

NATURE IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

The iron chaperone and nucleic acid-binding activities of poly(rC)-binding protein 1 are separable and independently essential

Sarju J. Patel et al.

Summary: The multifunctional adaptor protein PCBP1 coordinates single-stranded nucleic acids and iron-glutathione complexes, with separate activities controlling cell cycle progression and DNA damage suppression while maintaining cell viability. Amino acid residues required for iron coordination on each structural domain of PCBP1 were identified, confirming their essential function in binding target proteins. The coevolution of RNA/DNA binding and iron chaperone activities provides an advantage for nucleic acid processing dependent on iron cofactors.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Cell Biology

Sestrin2 protects dendrite cells against ferroptosis induced by sepsis

Jing-yan Li et al.

Summary: This study demonstrates the protective effect of Sesn2 on ferroptosis in DCs and its correlation with the ATF4-CHOP-CHAC1 pathway, indicating a potential antioxidative role for Sesn2 in suppressing ferroptosis in sepsis.

CELL DEATH & DISEASE (2021)

Article Multidisciplinary Sciences

The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses

Jun Deng et al.

Summary: Leptin levels are associated with reduced vaccine responses, as it promotes T-FH differentiation and IL-21 production. Leptin deficiency impairs T-FH generation and antibody responses, increasing the risk of vaccine failure.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

Delin Chen et al.

Summary: The study identifies iPLA2 beta as a critical regulator for p53-driven ferroptosis independent of GPX4. Loss of iPLA2 beta does not have obvious effect on normal cells, but it plays an essential role in regulating ferroptosis upon ROS-induced stress. iPLA2 beta is a promising therapeutic target for activating ferroptosis-mediated tumor suppression without serious toxicity concerns.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

Chengxian Xu et al.

Summary: Research shows that Gpx4 plays a crucial role in protecting Treg cells from lipid peroxidation and ferroptosis, regulating immune homeostasis and antitumor immunity. Deletion of Gpx4 can lead to lipid peroxidation and ferroptosis of Treg cells, affecting immune homeostasis and antitumor immunity. Neutralization of lipid peroxides and blockade of iron availability rescue ferroptosis of Gpx4-deficient Treg cells.

CELL REPORTS (2021)

Article Biochemistry & Molecular Biology

Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism

Po-Han Chen et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Cell Biology

Energy-stress-mediated AMPK activation inhibits ferroptosis

Hyemin Lee et al.

NATURE CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

Alexandr A. Kapralov et al.

NATURE CHEMICAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

Yilong Zou et al.

NATURE CHEMICAL BIOLOGY (2020)

Article Cell Biology

Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis

Minyi Xu et al.

CELL DEATH & DISEASE (2020)

Article Chemistry, Multidisciplinary

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

Vanessa A. N. Kraft et al.

ACS CENTRAL SCIENCE (2020)

Article Medicine, General & Internal

Lupus nephritis

Hans-Joachim Anders et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

Review Immunology

Transcriptional Control of Mature B Cell Fates

Hongsheng Wang et al.

TRENDS IN IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease

Lisa Mayr et al.

NATURE COMMUNICATIONS (2020)

Article Medicine, Research & Experimental

Curculigoside inhibits ferroptosis in ulcerative colitis through the induction of GPX4

Shujun Wang et al.

LIFE SCIENCES (2020)

Article Multidisciplinary Sciences

PLA2G6 guards placental trophoblasts against ferroptotic injury

Ofer Beharier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Cell Biology

The Metabolic Underpinnings of Ferroptosis

Jiashuo Zheng et al.

CELL METABOLISM (2020)

Article Pharmacology & Pharmacy

Ferroptosis involves in renal tubular cell death in diabetic nephropathy

Yue Wang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Article Neurosciences

Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination

Priya Jhelum et al.

JOURNAL OF NEUROSCIENCE (2020)

Article Multidisciplinary Sciences

Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression

Patricia P. Yee et al.

NATURE COMMUNICATIONS (2020)

Article Endocrinology & Metabolism

MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis

Chien-Kuang Cornelia Ding et al.

NATURE METABOLISM (2020)

Review Immunology

Dendritic cells in cancer immunology and immunotherapy

Stefanie K. Wculek et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Chemistry, Medicinal

Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4

Cong Li et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Biochemistry & Molecular Biology

Role of GPX4 in ferroptosis and its pharmacological implication

Tobias M. Seibt et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Gastroenterology & Hepatology

Association between dietary iron and zinc intake and development of ulcerative colitis: A case-control study in Japan

Yumie Kobayashi et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2019)

Article Multidisciplinary Sciences

Chaperone-mediated autophagy is involved in the execution of ferroptosis

Zheming Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Medicine, Research & Experimental

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

Wenjun Li et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Oncology

Mitochondrial dysfunction and role of harakiri in the pathogenesis of myositis

Jessica F. Boehler et al.

JOURNAL OF PATHOLOGY (2019)

Article Multidisciplinary Sciences

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

A PCBP1-BolA2 chaperone complex delivers iron for cytosolic [2Fe-2S] cluster assembly

Sarju J. Patel et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Multidisciplinary Sciences

FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll et al.

NATURE (2019)

Article Multidisciplinary Sciences

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Kirill Bersuker et al.

NATURE (2019)

Article Cell Biology

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

Caitlin W. Brown et al.

DEVELOPMENTAL CELL (2019)

Review Biochemistry & Molecular Biology

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

Sofie Voet et al.

TRENDS IN MOLECULAR MEDICINE (2019)

Review Biochemistry & Molecular Biology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Matthew Dodson et al.

REDOX BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model

Yan Zhang et al.

CELL CHEMICAL BIOLOGY (2019)

Review Immunology

Immunometabolism and natural killer cell responses

Katie L. O'Brien et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State

Leslie Magtanong et al.

CELL CHEMICAL BIOLOGY (2019)

Article Immunology

B1a B cells require autophagy for metabolic homeostasis and self-renewal

Alexander J. Clarke et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Review Urology & Nephrology

Renal tubule injury: a driving force toward chronic kidney disease

Bi-Cheng Liu et al.

KIDNEY INTERNATIONAL (2018)

Review Rheumatology

Classification of myositis

Ingrid E. Lundberg et al.

NATURE REVIEWS RHEUMATOLOGY (2018)

Review Immunology

Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin

A. Kovtun et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2018)

Article Chemistry, Multidisciplinary

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

Ron Shah et al.

ACS CENTRAL SCIENCE (2018)

Article Biochemistry & Molecular Biology

The ferroptosis inducer erastin promotes proliferation and differentiation in human peripheral blood mononuclear cells

Ding Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Pharmacology & Pharmacy

Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy

Cong Li et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Physiology

Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells

Oreoluwa Adedoyin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Immunology

Dendritic cells as gatekeepers of tolerance

Ari Waisman et al.

SEMINARS IN IMMUNOPATHOLOGY (2017)

Article Gastroenterology & Hepatology

Characterization of Ferroptosis in Murine Models of Hemochromatosis

Hao Wang et al.

HEPATOLOGY (2017)

Review Medicine, General & Internal

Crohn's disease

Joana Torres et al.

LANCET (2017)

Article Multidisciplinary Sciences

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Vasanthi S. Viswanathan et al.

NATURE (2017)

Article Multidisciplinary Sciences

Renal iron accumulation occurs in lupus nephritis and iron chelation delays the onset of albuminuria

Eileen S. Marks et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation

Satoshi Yotsumoto et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

Sally E. Wenzel et al.

Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

Review Immunology

Dying cells actively regulate adaptive immune responses

Nader Yatim et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Biochemistry & Molecular Biology

Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

Rachel P. Abrams et al.

ACS CHEMICAL BIOLOGY (2016)

Review Immunology

Follicular Helper T Cells

Carola G. Vinuesa et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 34 (2016)

Article Cell Biology

Autophagy promotes ferroptosis by degradation of ferritin

Wen Hou et al.

AUTOPHAGY (2016)

Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

CELL DEATH AND DIFFERENTIATION (2016)

Article Cell Biology

Ferroptosis is an autophagic cell death process

Minghui Gao et al.

CELL RESEARCH (2016)

Review Medicine, General & Internal

Rheumatoid arthritis

Josef S. Smolen et al.

LANCET (2016)

Article Biochemistry & Molecular Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Kenichi Shimada et al.

NATURE CHEMICAL BIOLOGY (2016)

Review Immunology

Immunometabolism of regulatory T cells

Ryan Newton et al.

NATURE IMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

Igor Theurl et al.

NATURE MEDICINE (2016)

Article Multidisciplinary Sciences

Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

Yang Ou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Wan Seok Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Oncology

Regulatory T Cells: Differentiation and Function

George Plitas et al.

CANCER IMMUNOLOGY RESEARCH (2016)

Review Immunology

Clearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLE

Aparna Mahajan et al.

FRONTIERS IN IMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

Scott J. Dixon et al.

ACS CHEMICAL BIOLOGY (2015)

Article Immunology

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

Mai Matsushita et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Article Clinical Neurology

Mitochondrial and inflammatory changes in sporadic inclusion body myositis

K. A. Rygiel et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2015)

Review Biochemistry & Molecular Biology

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

L. Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2015)

Review Immunology

Dendritic cell metabolism

Edward J. Pearce et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Review Biochemistry & Molecular Biology

The role of iron and reactive oxygen species in cell death

Scott J. Dixon et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Multidisciplinary Sciences

Synchronized renal tubular cell death involves ferroptosis

Andreas Linkermann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Biochemistry & Molecular Biology

Bone Morphogenetic Protein (BMP) signaling in development and human diseases

Richard N. Wang et al.

GENES & DISEASES (2014)

Article Gastroenterology & Hepatology

Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium

Claudia Guenther et al.

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Medicine, General & Internal

Ulcerative colitis

Ingrid Ordas et al.

LANCET (2012)

Article Multidisciplinary Sciences

Activated human CD4+ T cells express transporters for both cysteine and cystine

Trine Boegh Levring et al.

SCIENTIFIC REPORTS (2012)

Article Biochemistry & Molecular Biology

Differential Dependence on Cysteine from Transsulfuration versus Transport During T Cell Activation

Sanjay K. Garg et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

Article Immunology

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

Pingxin Li et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

Review Biochemistry & Molecular Biology

Acyl-CoA: Lysophospholipid Acyltransferases

Hideo Shindou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Recent progress on acyl CoA: lysophospholipid acyltransferase research

Hideo Shindou et al.

JOURNAL OF LIPID RESEARCH (2009)

Article Multidisciplinary Sciences

Autophagy regulates lipid metabolism

Rajat Singh et al.

NATURE (2009)

Article Multidisciplinary Sciences

Discovery essential of a lysophospholipid acyltransferase family for membrane asymmetry and diversity

Daisuke Hishikawa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Biochemistry & Molecular Biology

Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology

Hed Harizi et al.

TRENDS IN MOLECULAR MEDICINE (2008)