Nutrients and rheumatoid arthritis: From the perspective of neutrophils

Neutrophils are considered as core immune cells involve in the early stage of rheumatoid arthritis (RA) and participate in the disease progression. The underlining mechanisms include the elevated chemotaxis and infiltration of neutrophils, the increase in the reactive oxygen species and the promotion of neutrophil extracellular traps formation. Accumulating studies demonstrated the important role of nutrients intake played in the initiation and progression of RA. This study summarized the effects of several macronutrients and micronutrients on regulating RA through the modulation of activated neutrophils and appealed for a healthy diet in RA-risk individuals as well as RA patients.

Automated summary

Neutrophils are core immune cells involved in the early stage of rheumatoid arthritis and play a role in disease progression. Mechanisms include increased neutrophil chemotaxis and infiltration, elevated reactive oxygen species, and enhanced formation of neutrophil extracellular traps. Various nutrients have been found to regulate rheumatoid arthritis by modulating activated neutrophils, emphasizing the importance of a healthy diet for individuals at risk of or suffering from rheumatoid arthritis.