期刊
CHEMCATCHEM
卷 7, 期 23, 页码 3838-3841出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201500785
关键词
amine dehydrogenase; asymmetric catalysis; biotransformations; cascade reaction; chiral amines
资金
- National Natural Science Foundation of China [21472045, 21276082, 31200050, 21536004]
- Ministry of Science and Technology, P. R. China [2011CB710800]
- Fundamental Research Funds for the Central Universities [22A201514043]
- Guangxi Key Laboratory of Biorefinery
Multienzyme cascade approaches for the synthesis of optically pure molecules from simple achiral compounds are desired. Herein, a cofactor self-sufficient cascade protocol for the asymmetric amination of racemic secondary alcohols to the corresponding chiral amines was successfully constructed by employing an alcohol dehydrogenase and a newly developed amine dehydrogenase. The compatibility and the identical cofactor dependence of the two enzymes led to an ingenious in situ cofactor recycling system in the one-pot synthesis. The artificial redox-neutral cascade process allowed the transformation of racemic secondary alcohols into enantiopure amines with considerable conversions (up to 94%) and >99% enantiomeric excess at the expense of only ammonia; this method thus represents a concise and efficient route for the asymmetric synthesis of chiral amines.
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