相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign
Sandra Johannsen et al.
CHEMMEDCHEM (2023)
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
Christopher J. L. Murray et al.
LANCET (2022)
First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization
Robin M. Gierse et al.
SCIENTIFIC REPORTS (2022)
Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors
Paul Beroza et al.
NATURE COMMUNICATIONS (2022)
Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening
Di Zhu et al.
CHEMICAL SCIENCE (2022)
Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties
Robin M. Gierse et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)
Structural basis of substrate recognition and thermal protection by a small heat shock protein
Chuanyang Yu et al.
NATURE COMMUNICATIONS (2021)
Towards the sustainable discovery and development of new antibiotics
Marcus Miethke et al.
NATURE REVIEWS CHEMISTRY (2021)
Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase
Ravindra P. Jumde et al.
CHEMICAL SCIENCE (2021)
X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate
Percival Yang-Ting Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Enamide Prodrugs of Acetyl Phosphonate Deoxy-D-xylulose-5-phosphate Synthase Inhibitors as Potent Antibacterial Agents
David Bartee et al.
ACS INFECTIOUS DISEASES (2019)
Targeting the Unique Mechanism of Bacterial 1-Deoxy-D-xylulose-5-phosphate Synthase
David Bartee et al.
BIOCHEMISTRY (2018)
Toward Understanding the Chemistry and Biology of 1-Deoxy-D-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism
David Bartee et al.
ACCOUNTS OF CHEMICAL RESEARCH (2018)
Phage Display on the Anti-infective Target 1-Deoxy-d-xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor
Alessio Marcozzi et al.
CHEMBIOCHEM (2018)
Conformational dynamics of 1-deoxy-D-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS
Jieyu Zhou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-D-xylulose 5-Phosphate Synthase
Sara Sanders et al.
ACS INFECTIOUS DISEASES (2017)
Polder maps: improving OMIT maps by excluding bulk solvent
Dorothee Liebschner et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2017)
Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate
Jessica M. Smith et al.
JOURNAL OF ANTIBIOTICS (2014)
Development of Inhibitors of the 2C-Methyl-D-erythritol 4-Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective Agents
Tiziana Masini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Advantages of crystallographic fragment screening: Functional and mechanistic insights from a powerful platform for efficient drug discovery
Disha Patel et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2014)
How good are my data and what is the resolution?
Philip R. Evans et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2013)
Lessons Learned in Empirical Scoring with smina from the CSAR 2011 Benchmarking Exercise
David Ryan Koes et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2013)
Optimal fine phi-slicing for single-photon-counting pixel detectors
Marcus Mueller et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2012)
Observation of Thiamin-Bound Intermediates and Microscopic Rate Constants for Their Interconversion on 1-Deoxy-D-xylulose 5-Phosphate Synthase: 600-Fold Rate Acceleration of Pyruvate Decarboxylation by D-Glyceraldehyde-3-phosphate.
Hetalben Patel et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Selective inhibition of E. coli 1-deoxy-D-xylulose-5-phosphate synthase by acetylphosphonates
Jessica M. Smith et al.
MEDCHEMCOMM (2012)
Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?
Qinglin Du et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2011)
1-Deoxy-D-xylulose 5-Phosphate Synthase Catalyzes a Novel Random Sequential Mechanism
Leighanne A. Brammer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Origins and Early Evolution of the Mevalonate Pathway of Isoprenoid Biosynthesis in the Three Domains of Life
Jonathan Lombard et al.
MOLECULAR BIOLOGY AND EVOLUTION (2011)
XDS
Wolfgang Kabsch
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
Crystal structure of 1-deoxy-d-xylulose 5-phosphate synthase, a crucial enzyme for isoprenoids biosynthesis
Song Xiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Fragment-based lead discovery using X-ray crystallography
MJ Hartshorn et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Coot:: model-building tools for molecular graphics
P Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
Essential role of residue H49 for activity of Escherichia coli 1-deoxy-D-xylulose 5-phosphate synthase, the enzyme catalyzing the first step of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid synthesis
J Querol et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
1-deoxy-D-xylulose-5-phosphate synthase, a limiting enzyme for plastidic isoprenoid biosynthesis in plants
JM Estévez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)