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Review
Biochemistry & Molecular Biology
Nela Pavlikova
Summary: Caffeic acid is a polyphenol compound that is commonly consumed in the form of coffee. Despite being less explored than caffeic acid phenethyl ester, it still has various positive effects on human health. Caffeic acid can influence cancer, diabetes, atherosclerosis, Alzheimer's disease, as well as bacterial and viral infections. This review focuses on the molecular mechanisms through which caffeic acid achieves its effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Dajana Kucic Grgic et al.
Summary: In this study, a microbial consortium was screened for its efficacy in degrading LDPE/TPS. The consortium was composed of bacteria and fungi isolated from activated sludge, river sediment, and compost. The experiments showed that the microorganisms were able to degrade polymeric materials, with the mixed culture completely degrading TPS. The weight loss and analysis results demonstrated that degradation was more intense in the experiment using microorganisms from compost.
Review
Biochemistry & Molecular Biology
Hazem S. S. Elshafie et al.
Summary: Natural products, including primary metabolites (PMs) and secondary metabolites (SMs), play crucial roles in plant growth, reproduction, defense, and adaptation. SMs, including terpenoids, phenolics, and nitrogen-containing compounds, possess various biological activities and can be used as flavoring agents, food additives, and plant-disease control. This review focuses on the significance, biosynthesis, classification, biochemical characterization, and medical/pharmaceutical uses of plant SMs. Additionally, the potential of SMs as eco-friendly substitutes for synthetic pesticides and their role in enhancing plant resistance are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Aisha Nawaf AlBalawi et al.
Summary: This study aimed to investigate the potential antioxidant, phytochemical, and antimicrobial properties of aniseed extracts against multidrug-resistant (MDR) bacteria. The results showed that aniseed extracts contain various compounds that contribute to their antimicrobial activity, mainly phenolic compounds and flavonoids. Moreover, aniseed extracts demonstrated strong antioxidant activity and inhibited the growth of MDR bacteria.
Article
Infectious Diseases
Francisco Cortez Nunes et al.
Summary: This study aimed to assess the presence of antibiotic resistance genes previously reported in Helicobacter pylori in gastric samples from 36 pigs where DNA of H. pylori-like organisms had been detected. Based on PCR and sequencing analysis, two samples were positive for the 16S rRNA mutation gene conferring tetracycline resistance, and one sample was positive for the frxA gene conferring metronidazole resistance. These findings indicate the potential occurrence of acquired antimicrobial resistance in H. pylori-like organisms associated with pigs.
Review
Biology
Ragi Jadimurthy et al.
Summary: Antimicrobial resistance is the process by which many microorganisms develop resistance to drugs through different mechanisms. The discovery of new antimicrobials is crucial to combat drug-resistant pathogens. This article discusses the antimicrobial properties of plant-derived compounds against drug-resistant human pathogens, including bacteria, fungi, and viruses. The emergence of antimicrobial resistance has significantly reduced the effectiveness of existing standard antimicrobials, posing a global public health threat. Therefore, it is important to explore plant metabolites as potential therapeutic agents against drug-resistant microbes.
Article
Chemistry, Multidisciplinary
Felicia Suciu et al.
Summary: The phenolic compounds from different parts of Lysimachia nummularia L. plant were analyzed using HPLC technique. The extracts from root, aerial part, and flowers were obtained through ethanol extraction and their polyphenol content and antioxidant activity were evaluated. The hydroethanolic extract from flowers showed the highest content of total polyphenols (22.10 +/- 1.48 mg/g gallic acid) and exhibited remarkable antioxidant activity.
APPLIED SCIENCES-BASEL
(2023)
Review
Immunology
Sirui Yang et al.
Summary: Oral microbial dysbiosis is a major cause of oral infectious diseases, and researchers have developed antimicrobial small molecules that can inhibit the virulence of oral microbiota and restore microbial ecological balance, showing potential applications in the treatment of oral diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Analytical
Iuliana Stoicescu et al.
Summary: In this study, a HPLC method was validated for the quantification of phenolic compounds in the roots, leaves, kernel, and shell fruit of Trapa natans L.
ANALYTICAL LETTERS
(2022)
Article
Plant Sciences
Ji Eun Kang et al.
Summary: Antibiotic resistance is becoming more common in the environment, necessitating the search for alternative strategies for disease treatment and prevention. Modulating bacterial virulence or enhancing plant innate immunity can be a promising drug target. Plant-produced natural products such as resveratrol oligomers have the potential to regulate bacterial virulence and plant immunity.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Infectious Diseases
Kenneth P. Klinker et al.
Summary: Antimicrobial resistance is a global public health threat, especially with gram-negative bacteria. Shortening the time to effective antimicrobial therapy is important and the antibiogram can help improve patient outcomes. Guidance is lacking for validating susceptibility to new antibacterial agents, and novel antibiogram approaches are needed to improve susceptibility testing and treatment.
Article
Infectious Diseases
Aline Silva Braga et al.
Summary: This study investigated the effects of herbal toothpaste on bacterial counts and enamel demineralization. The results showed that toothpaste containing different herbal ingredients can significantly reduce bacterial counts and minimize enamel demineralization.
Article
Agronomy
Stephen O. Duke
Summary: Resveratrol and pterostilbene, produced by various plant species, have antimicrobial and nutraceutical properties. Pterostilbene appears to be more active and bioavailable for most effects. However, dietary levels of these compounds are insufficient for health benefits, requiring supplementation or genetically modified crops.
Article
Infectious Diseases
Antonella Migliaccio et al.
Summary: Resveratrol can reverse tolerance and restore susceptibility to CHX and BZK in the majority of microorganisms causing HAI. The efflux pump inhibitor reduced the MIC and MBC of CHX and BZK in most strains, while resveratrol dose-dependently decreased the MIC and MBC of the biocides.
Article
Infectious Diseases
Zahid Majeed et al.
Summary: The rise of methicillin-resistant Staphylococcus epidermidis (MRSE) has made it challenging to treat infections. The study found that rosin maleic anhydride nanoparticles effectively interfered with the surface of MRSE and demonstrated bacteriostatic action.
Article
Engineering, Biomedical
Claire El Hachem et al.
Summary: This study compared the physicochemical and antibacterial properties of three root canal filling materials for primary teeth. The results showed that these materials had differences in pH, solubility, and crystalline microstructure. However, none of them had optimal properties, indicating a need for the development of new filling materials.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Naji Kharouf et al.
Summary: This study evaluated the properties of epoxy-resin sealers containing polyphenols. The results showed that the incorporation of polyphenols into the epoxy resin improved its mechanical properties. Pyrogallol exhibited better antioxidant and antibacterial activities compared to resveratrol, although it also showed higher cytotoxicity. Pyrogallol doped epoxy resin had a rougher surface and higher water absorption than resveratrol doped epoxy resin.
BIOENGINEERING-BASEL
(2022)
Article
Microbiology
Mohamed El-Telbany et al.
Summary: Phage therapy offers a promising alternative to antibiotics to combat multi-drug resistant bacteria. The isolated phage vB_ZEFP showed potential in controlling the growth of Enterococcus faecalis, especially in preventing infection after root canal treatment.
Review
Infectious Diseases
Sana Alibi et al.
Summary: The vegetal world is a major source of chemical products with antibacterial properties, but the process of identifying and applying these compounds is complex. Research focuses on compounds that can combat multidrug-resistant bacteria and their synergistic effects with traditional antibiotics.
Article
Microbiology
Fan Wan et al.
Summary: Caffeic acid (CA) effectively alleviates DSS-induced colitis by improving defense against oxidative stress and inflammatory response, potentially through regulating related pathways and altering gut microbiome composition.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marco A. Lugo-Flores et al.
Summary: The review discusses the antibacterial and antioxidant properties of synthetic and plant-derived substances for formulating dental products. Synthetic compounds like chlorhexidine and hydrogen peroxide have negative effects on sensory acceptability, while plant metabolites offer a better alternative with antimicrobial and antioxidant properties. Plant-derived substances have potential for use in toothpaste, mouth rinses, denture cleansers-fixatives, and saliva substitutes.
Review
Chemistry, Medicinal
Pratibha Pandey et al.
Summary: Cancer is a complex disease with various intrinsic and extrinsic pathways, and recent research has shown an interest in developing plant-based cancer therapeutics. Rutin, a flavonoid glycoside abundantly found in plants, has shown potential as an anticancer compound, but further investigation is needed to understand its mechanisms of action in regulating oncogenic pathways.
Article
Chemistry, Multidisciplinary
Gabriela Ciavoi et al.
Summary: Commercial mouthwash and herbal infusion were both effective in reducing dental plaque and gingival index. The fluoride in commercial mouthwash helped lower plaque index, while herbal infusion performed better in gingival inflammation.
APPLIED SCIENCES-BASEL
(2021)
Article
Pharmacology & Pharmacy
Elis Ionus et al.
Summary: Ajuga chamaepitys, also known as yellow bugle, is a perennial species native to the Dobrogea region of Romania and is associated with traditional phytotherapy. This study found that the flowers of the plant have higher levels of flavones, phenolic acids, and total polyphenols compared to other plant organs.
Article
Biotechnology & Applied Microbiology
Shijia Liu et al.
Summary: The study found that the aqueous extract of Lysimachia christinae can prevent cholesterol gallstones induced by a high-fat and high-cholesterol diet, as well as have positive effects on body weight, serum lipid profile, visceral organ indexes, and histomorphology. Furthermore, it was observed to influence the composition of intestinal microflora, which may play a role in its therapeutic effects.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jana Al Azzaz et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Chemistry, Medicinal
Maia Merlani et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2019)
Review
Medicine, General & Internal
Zeeshan A. Khan et al.
Article
Plant Sciences
Ying Wang et al.
Article
Environmental Sciences
Ina Saliasi et al.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2018)
Article
Chemistry, Analytical
Sabine Crunaire et al.
Article
Biochemistry & Molecular Biology
Irma Podolak et al.
CARBOHYDRATE RESEARCH
(2013)
Review
Biochemistry & Molecular Biology
Michael Wink
